Gavin Herbert Eye Institute 6th Annual Colloquium October 2012

Dr. BenMohamed has given a presentation on ocular herpes vaccine developent at the Gavin Herbert Eye Institute 6th Annual Colloquium October 2012

 

You are invited to view UCI Ophthalmology’s photo album: Gavin Herbert Eye Institute 6th Annual Colloquium October 2012

Gavin Herbert Eye Institute 6th Annual Colloquium October 2012

Oct 12, 2012
by UCI Ophthalmology

Gavin Herbert Eye Institute 6th Annual Colloquium October 12 & 13, 2012 Hyatt Regency Newport Beach

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Genital Herpes vaccine paper just accepted to be published in The Journal of Immunology

Targeting the mucosal immune system of the genital tract (GT) with subunit vaccines failed to induce potent and durable local immune response, crucial for protection against many sexually transmitted viral (STV) pathogens, including herpes simplex virus type 2 (HSV-2) that causes genital herpes. In this study, we investigated the potential of a novel lipopeptide/adenovirus type 5 (Lipo/rAdv5) prime/boost mucosal vaccine for induction of CD8+ T cell immunity to protect the female genital tract from herpes.  The findings indicate that targeting the GT with a Lipo/rAdv5 prime/boost vaccine elicits a potent and long-lasting mucosal CD8+ T cell protective immunity against sexually transmitted herpes infection and disease.

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New member of Cellular and Molecular Immunology Lab

Dr. Huma Qureshi, from UC Davis, has recently joined our lab. She worked as a post-doctoral fellow in Dr. Christopher Miller’s lab for last 4 years. She was involved in pre-clinical development studies using an adenovirus vector to vaccinate against HIV and AIDS. As An Assistant Specialist, Dr. Qureshi will now be involved in vaccine development against ocular and genital herpes. She will focus on studying effector and regulatory T cell responses against newly discovered herpes epitopes, during both acute and latent infection, and in both animal models and humans.

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New publications from Cellular and Molecular Immunology Lab

For an update on herpes vaccine development; check out our recent clinical review in Clinical and Developmental Immunology Journal: Chentoufi AA, Kritzer E, Yu DM, Nesburn AB, BenMohamed L. Towards a rational design of an asymptomatic clinical herpes vaccine: the old, the new, and the unknown. Clin Dev Immunol. 2012; 2012:187585.

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