The impact of green tea polyphenols on development and reproduction in Drosophila melanogaster
Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico. Experimental Gerontology
Green Tea Polyphenols Extend the Lifespan of Male Drosophila melanogaster While Impairing Reproductive Fitness
Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction
Why extend lifespan and improve health span?
Slowing the aging process delays the progression of diseases of aging such as cancer, Alzheimer¹s, and heart disease. The ultimate goal of our work is not to just increase the lifespan but to also increase the health span and add healthy years to human life.
Why work with the fruit fly (Drosophila melanogaster) to study anti-aging?
- Fruit fly is an established model system to study aging
- We share about 75% of our disease genes with fruit flies
- 50% of fly protein sequences have mammalian homologs
- Fruit flies have been used to study and identify drug targets for several human diseases including Parkinson’s, Huntington’s, Alzheimer’s, diabetes, cancer, and drug abuse
- Fruit flies mimic many aspects of human physiology such as displaying imbalance after excessive consumption of alcohol!
Over the past 10 years, using fruit flies as as our model system, we have
developed an algorithm and a number of bioassays to identify anti-aging
compounds that not only increased the lifespan but also improved the
health span. issue.
Why work with plants and botanical extracts?
While some studies have shown that dietary supplements and botanical extracts may impact age-related diseases such as cancer, heart disease and neurodegenerative disorders, there are large gaps in the human knowledge about the mechanisms through which these products modulate aging. Our research hopes to bridge that gap in knowledge.