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The Raffatellu Lab focuses on the interaction between the pathogen Salmonella and the intestinal mucosa.

The mucosal immune response has the important function of containing an infection and preventing dissemination of pathogens to systemic sites. However, there is increasing evidence that mucosal pathogens achieve greater colonization during inflammation.

We are particularly interested in investigating this dichotomy of the host response, and understanding which responses constitute the mucosal barrier during S. typhimurium infection and which ones favor S. typhimurium colonization of the inflamed gut.