Freddie served in the Navy as a cryptologic technician and graduated with a B.S. in Biology from DePaul University, where he did research in a molecular biology lab. After graduating in 2013, he gained some experience in neuroscience research in a neurobiology lab at Northwestern University. His research focuses on the wide variation in age at onset of dementia in Alzheimer’s disease (AD), which suggests that additional genetic, biological and environmental factors modify the rate and degree of amyloid-beta peptide deposition or clearance. These factors may be important modifiers of risk and may accelerate or slow disease progression. He uses psychiatric assessments combined with multimodal imaging (structural, functional, and diffusion MRI), and integrates amyloid and tau imaging to examine the human brain. Freddie is interested in identifying accurate and reliable diagnostic and prognostic biomarkers of AD-related dementia status in adults, specifically in populations where the incidence of AD is unusually high or rare. He seeks to understand associations and pathways implicated in AD pathogenesis, and to develop a model for predicting risk. In addition to the research that he is performing, Freddie has a particular interest in advocating for scientific research through various policy-focused careers. He looks forward to engaging with the community and working with others to foster public understanding of scientific research.
Awards and Honors:
- Graduate Research Fellowship – National Science Foundation (2017-2020)
- Bridge to the Doctorate Award – National Science Foundation (2015-2017)
- Eugene Cota-Robles Fellowship – UC Irvine Graduate Division (2017-2019)
(Please click the title or contact Freddie if you would like to read a paper!)
- Flores, E. N., Duggan, A., Madathany, T., Hogan, A.K., Márquez, F., Kumar, G., Seal, R., Edwards, R, Liberman, M.C., García-Añoveros, J. A Non-Canonical Pathway for Auditory Nociception. Current Biology. 2015 March 2.
Abstracts, Posters, and Presentations:
- Marquez, F., Francis, M., Silliker, M. RNA editing in Didymium iridis mitochondrial genes. Chicago Area Undergraduate Research Symposium. April 6, 2013.
- Marquez, F., Schneider, C., and Stutzmann, G. The effect of dantrolene treatment on synapse preservation in Alzheimer’s disease mice. DePaul University’s Natural Sciences, Mathematics and Technology Showcase. Chicago, IL. November 9, 2012.