• smallWig: Tool for parallel compression of RNA-seq WIG files.  Available here.

We developed a new lossless compression method for WIG data, named smallWig, offering the best known compression rates for RNA-seq data and featuring random access functionalities that enable visualization, summary statistics analysis, and fast queries from the compressed files. Our approach results in order of magnitude improvements compared to bigWig. More details of the software is available in the following paper.

Zhiying Wang, Tsachy Weissman, and Olgica Milenkovic, “smallWig: parallel compression of RNA-seq WIG files”, Bioinformatics, 32(2), pp.173-180, 2016.