Using the Kcne2 knockout mouse model that we generated, combined with techniques ranging from positron emission tomography to patch-clamp electrophysiology, we have discovered a crucial role of KCNQ1-KCNE2 channels in the thyroid gland. KCNQ1-KCNE2 is required for normal iodide uptake through the sodium/iodide symporter (NIS), and we found that Kcne2 deletion causes hypothyroidism, especially during…
The role of KCNQ1-KCNE2 in the thyroid
