The Greenwood lab, in collaboration with the Abbott, Jepps and Rosenbaum labs and others, has discovered the molecular basis for arterial relaxation by SGLT2 inhibitors: these drugs relax mesenteric arteries by promoting the release of CGRP from sensory nerves in a NHE1-dependent manner. The work provides a crucial piece of evidence as to how these…
Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin and empagliflozin-induced arterial relaxation
