Published this week in Communications Biology…
Celebrating our recent herbal medicine paper publication!
Molecular basis for autism and developmental delay in siblings with a novel KCNB1 variant
The Abbott Bioelectricity Laboratory, in collaboration with Dr. Rich Sidlow and colleagues, has discovered that a novel KCNB1 gene variant that produces an S114R substitution in the Kv2.1 N-terminus causes slowing of channel activation, deactivation and inactivation. The paper has been published in Frontiers in Cellular Neuroscience. Dr. Sidlow and colleagues found the variant in…
Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin and empagliflozin-induced arterial relaxation
The Greenwood lab, in collaboration with the Abbott, Jepps and Rosenbaum labs and others, has discovered the molecular basis for arterial relaxation by SGLT2 inhibitors: these drugs relax mesenteric arteries by promoting the release of CGRP from sensory nerves in a NHE1-dependent manner. The work provides a crucial piece of evidence as to how these…
Abbott Bioelectricity Lab Medicinal Plant Collection Field Trip 042 Sequoia National Park April 2024
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Ophthalmate discovered to be novel regulator of motor function
The Alachkar lab, with collaborators in the Abbott and Civelli labs, has discovered a novel role for ophthalmate in motor function, with potential implications for the treatment of Parkinson’s disease. Journal Article…
