Katie gave an excellent thesis talk and passed her PhD thesis defense exam, in which she discussed her work in the Abbott Bioelectricity Lab researching the molecular mechanisms of KCNQ potassium channel modulation by plant metabolites and its role in botanical folk medicines….
A collaborative project between the Abbott, Alachkar and Said labs, published in Neurobiology of Disease, reveals expression and activity of vitamin B1 (thiamin) transporters are decreased in Alzheimer’s disease, at least partially due to exposure to inflammatory cytokines. Reciprocally, thiamin influences expression of genes linked to Alzheimer’s disease. The results suggest a possible role for…
In a Matters Arising paper recently published in Communications Biology, we discuss recent assignments of viral proteins from SARS-COV-2 as “viroporins” and suggest guidelines for establishing true ion channel status….
September 2022 – in a paper published in FASEB Journal, we demonstrate that activation of the vascular KCNQ5 potassium channel by tannins in tree and shrub barks explains some medicinal properties discovered by Native Americans….
The Abbott Bioelectricity Lab has collaborated with Dr. Rich Sidlow at Valley Children’s Hospital to discover and decipher the underlying mechanism for the first reported KCNA1 potassium channel N-terminal domain gene sequence variant causing the inherited movement disorder, Episodic Ataxia Type 1 (EA1). The paper was published 8/9/22 in Frontiers in Neurology – congratulations to…
