Aging Innate and Adaptive Immune Response to SARS-CoV-2
We have continued developing the pilot research project recently published in our paper on sex-related differences in innate and adaptive immune responses to SARS-CoV-2. Results showed decreased activation of pDCs, mDCs, and monocytes and the delayed and prolonged IFN-a secretion along with increased CXCL-10 secretion may be responsible for the increased morbidity and mortality of males to COVID-19. These results provide significant bases to continue investigating age-related differences in innate and adaptive immune response to SARS-CoV-2.