Alachkar A*, Phan A, Dabbous T, Alhassen S, Alhassen W, Reynolds B, Rubinstein M, Ferré S, Civelli O*; 2024, Humanized dopamine D4.7 receptor male mice display risk-taking behavior and deficits of social recognition and working memory in light/dark-dependent manner; Journal of Neuroscience research, accepted in Jan 2024. * Corresponding Authors
Lee, J., S. Chen, R. V. Monfared, P. Derdeyn, K. Leong, T. Chang, K. Beier, P. Baldi and A. Alachkar (2023). “Reanalysis of primate brain circadian transcriptomics reveals connectivity-related oscillations.” iScience 26(10): 107810.
Monfared, R. V., S. Abdelkarim, P. Derdeyn, K. Chen, H. Wu, K. Leong, T. Chang, J. Lee, S. Versales, S. Nauli, K. Beier, P. Baldi* and A. Alachkar* (2023). “Spatiotemporal Mapping of Brain Cilia Reveals Region-Specific Oscillation of Length and Orientation.” bioRxiv.
Angel, M., A. Patel, A. Alachkar* and P. Baldi* (2023). “Clinical Knowledge and Reasoning Abilities of AI Large Language Models in Pharmacy: A Comparative Study on the NAPLEX Exam.” bioRxiv: 2023.2006.2007.544055. * Corresponding authors
Chen, K. J., R. Yoshimura, C. A. Edmundo, T. M. Truong, O. Civelli, A. Alachkar* and G. W. Abbott* (2023). “Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice.” Front Mol Neurosci 16: 1192628. * Corresponding authors
Sajid, M. I., F. J. Nunez, F. Amirrad, M. R. Roosan, T. Vojtko, S. McCulloch, A. Alachkar* and S. M. Nauli* (2023). “Untargeted metabolomics analysis on kidney tissues from mice reveals potential hypoxia biomarkers.” Sci Rep 13(1): 17516.* Corresponding authors
Alhassen, W., S. Alhassen, J. Chen, R. V. Monfared and A. Alachkar (2023). “Cilia in the Striatum Mediate Timing-Dependent Functions.” Mol Neurobiol 60(2): 545-565.
Alachkar, A. (2022). “Aromatic patterns: Tryptophan aromaticity as a catalyst for the emergence of life and rise of consciousness.” Phys Life Rev 42: 93-114.
Alachkar, A., J. Lee, K. Asthana, R. Vakil Monfared, J. Chen, S. Alhassen, M. Samad, M. Wood, E. A. Mayer and P. Baldi (2022). “The hidden link between circadian entropy and mental health disorders.” Transl Psychiatry 12(1): 281.
Ramamoorthy, K., R. Yoshimura, S. Al-Juburi, K. Y. Anandam, R. Kapadia, A. Alachkar, G. W. Abbott and H. M. Said (2022). “Alzheimer’s disease is associated with disruption in thiamin transport physiology: A potential role for neuroinflammation.” Neurobiol Dis 171: 105799.
Alachkar, A., S. Agrawal, M. Baboldashtian, K. Nuseir, J. Salazar and A. Agrawal (2022). “L-methionine enhances neuroinflammation and impairs neurogenesis: Implication for Alzheimer’s disease.” J Neuroimmunol 366: 577843. * Corresponding Author
Alachkar*, A., S. Alhassan and M. Senel* (2022). “Lab-In-A-Syringe: A Novel Electrochemical Biosensor for On-Site and Real-Time Monitoring of Dopamine in Freely Behaving Mice.” ACS Sens 7(1): 331-337. * Corresponding Authors
Alhassen, S., M. Senel* and A. Alachkar* (2022). “Surface Plasmon Resonance Identifies High-Affinity Binding of l-DOPA to Siderocalin/Lipocalin-2 through Iron-Siderophore Action: Implications for Parkinson’s Disease Treatment.” ACS Chem Neurosci 13(1): 158-165. * Corresponding Authors
Alhassen, W., Y. Kobayashi, J. Su, B. Robbins, H. Nguyen, T. Myint, M. Yu, S. M. Nauli, Y. Saito and A. Alachkar (2022). “Regulation of Brain Primary Cilia Length by MCH Signaling: Evidence from Pharmacological, Genetic, Optogenetic, and Chemogenic Manipulations.” Mol Neurobiol 59(1): 245-265.
Pierre Baldi, Wedad Alhassen, Siwei Chen, Henry Nguyen, Mohammad Khoudari, Amal Alachkar (2021). “Large-Scale Analysis Reveals Spatiotemporal Circadian Patterns of Cilia Transcriptomes in the Primate Brain“, Journal of Neuroscience Research
Ashraf M. Mohieldin, Amal Alachkar, John Yates, Surya Nauli; (2021). Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins; Communicative & Integrative Biology
Monfared, R.V.; Alhassen, W.; Truong, T.M.; Gonzales, M.A.M.; Vachirakorntong, V.; Chen, S.; Baldi, P.; Civelli, O.; Alachkar, A (2021). Transcriptome Profiling of Dysregulated GPCRs Reveals Overlapping Patterns across Psychiatric Disorders and Age-Disease Interactions. Cells 2021, 10, 2967.
Chen S, Alhassen W, Monfared R, Vachirakorntong B, Nauli S, Baldi P, Alachkar A (2021). “Dynamic Changes of Brain Cilia Transcriptomes across the Human Lifespan”. International Journal of Molecular Sciences
Chen, Siwei; Lee, Justine; Truong, Tri Minh; Alhassen, Sammy; Baldi, Pierre; Alachkar, Amal (2021). “Age-Related Neurometabolomic Signature of Mouse Brain“. ACS Chemical Neuroscience
Alhassen, S., S. Chen, A. Phan, M. Khoudari, A. De Silva, H. Barhoosh, Z. Wang, C. Parrocha, E. Shapiro, C. Henrich, Z. Wang, L. Mutesa, P. Baldi, G. W. Abbott and A. Alachkar (2021). “Intergenerational Trauma Transmission is Associated with Brain Metabotranscriptome Remodeling and Mitochondrial Dysfunction.”, Communications Biology May 2021
Wedad Alhassen, Siwei Chen, Marquis Vawter, Brianna Kay Robbins, Henry Nguyen, Thant Nyi Myint, Yumiko Saito, Anton Schulmann, Surya M. Nauli, Olivier Civelli, Pierre Baldi, Amal Alachkar, 2021. Patterns of Cilia Gene Dysregulations in Major Psychiatric Disorders. Progress in Neuropsychopharmacology & Biological Psychiatry, in press January 2021
Senel, M. and A. Alachkar, Lab-in-a-pencil graphite: A 3D-printed microfluidic sensing platform for real-time measurement of antipsychotic clozapine level. Lab on a Chip, 2021. 21(2): p. 405-411.
Mehmet Senel, Zehra Durmus, Amal Alachkar, 2021, A novel electrochemical sensing method of the antipsychotic Clozapine using Reduced graphene oxide nanocomposites (Au/Pd/Pt) electrodes. Electroanalysis, in press
Sanathara, N., Alhassen, L., Marmouzi, I., Khoudari, M., Phan, J., Alhassen, W., Civelli, O., Alachkar, A., 2021. Oxytocin-MCH Circuit Regulates Monosynaptic Inputs to MCH Neurons and Modulates Social Recognition Memory. Neuropharmacology
Chena S, Alhassena W, Yoshimura R, De Silva A, Abbott GW, Baldi P, Alachkar A: Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis. Communications Biology 2020, 3(1):409. a: these authors contributed equally to this work,
Phana, L. Alhassena, A. Argelagos, W.Alhassen, B. Vachirakorntong, Z. Lin, N. Sanathara, A. Alachkar, 2020, Mating and parenting experiences sculpture mood-modulating effects of oxytocin- MCH signaling, In Press, Scientific Reports
Senel, M., E. Dervisevic , S. Alhassen , M. Dervisevic, A. Alachkar*, V. Cadarso, and N. Voelcker, 2020, Microfluidic electrochemical sensor for CSF and blood dopamine detection in a mouse model of Parkinson’s disease, In Press: Analytical Chemistry, *Corresponding author
Musanabaganwa, C., S. Jansen, S. Fatumo, E. Rutembesa, J. Mutabaruka, D. Gishoma, A. Uwineza, Y. Kayiteshonga, A. Alachkar, D. Wildman, M. Uddin and L. Mutesa (2020). Burden of post-traumatic stress disorder in postgenocide Rwandan population following exposure to 1994 genocide against the Tutsi: A meta-analysis. J Affect Disord 275: 7-13.
Senel M, Dervisevic M, Alhassen S, Alachkar A, Voelcker NH. (2020), Electrochemical Micropyramid Array-Based Sensor for In Situ Monitoring of Dopamine Released from Neuroblastoma Cells. Analytical chemistry 92:7746-7753.
Vawter* M.P., A. Schulmann, L Alhassen, W Alhassen, A.R Hamzeh, J Sakr, L Pauluk, R Yoshimura, X Wang, Q Dai, N Sanathara, O Civelli, A Alachkar*. (2020), “Melanin Concentrating Hormone Signaling Deficits in Schizophrenia: Association with Memory and Social Impairments and Abnormal Sensorimotor Gating”. The International Journal of Neuropsychopharmacology. In press *Corresponding author
Vawter, Marquis P. , Abdul Rezzak Hamzeh, Edgar Muradyan, Olivier Civelli, Geoffrey W. Abbott*, Amal Alachkar* (2019). ” Association of Myoinositol Transporters with Schizophrenia and Bipolar Disorder: Evidence from Human and Animal Studies“. Molecular Neuropsychiatry, DOI: 10.1159/000501125
Lien Wang, Yan Zhang, Chaoran Wang, Xiuli Zhang, Zhiwei Wang, Xinmiao Liang, Amal Alachkar*, Olivier Civelli*, (2019), A Natural Product with high affinity to Sigma and 5-HT7 Receptors as Novel Therapeutic Drug for Negative and Cognitive Symptoms of Schizophrenia, Neurochemical Research, doi.org/10.1007/s11064-019-02873-7. *Corresponding Author
Alhassen, L., A. Phan, W. Alhassen, P. Nguyen, A. Lo, H. Shaharuddin, N. Sanathara, O. Civelli and A. Alachkar* (2019). “The role of Olfaction in MCH-regulated spontaneous maternal responses.” Brain Research 1719: 71-76. *Corresponding author
Alachkar A*, Wang L, Yoshimura R, Hamzeh AR, Wang Z, Sanathara N, Lee SM, Xu X, Abbott GW, Civelli O., (2018), Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits. Molecular psychiatry; 23:282-294.*Corresponding author
Zhang Y, Liu Y, Wu L, Fan C, Wang Z, Zhang X, Alachkar A, Liang X, Civelli O., (2018), Receptor-specific cross talk between prostanoid 3 and bombesin subtype 3 receptors. FASEB journal. fj201700337RR
Sanathara, N. M., C. Garau, A. Alachkar, L. Wang, Z. Wang, K. Nishimori, X. Xu and O. Civelli (2018). “Melanin concentrating hormone modulates oxytocin-mediated marble burying.” Neuropharmacology 128: 22-32.
Alachkar, A.*, Alhassen, L., Wang, Z., Wang, L., Onouye, K., Sanathara, N., Civelli, O., (2016), Inactivation of the MCH system impairs maternal behavior, European Journal of Neuropsychopharmacology * 26(11): 1826-1835. *Corresponding author
Wang L, L., Y. Zhang, Z. Wang, N. Gong, T. D. Kweon, B. Vo, C. Wang, X. Zhang, J. Y. Chung, Alachkar A., X. Liang, D. Z. Luo and O. Civelli ., (2016), The Antinociceptive Properties of the Corydalis yanhusuo Extract.” PLoS One 11(9): e0162875.
Wang L*, Alachkar A*, Sanathara N, Belluzzi JD, Wang Z, Civelli O, (2015), “A Methionine-induced Animal Model of Schizophrenia: Face and predictive validity.” International Journal of Neuropsychopharmacology, 19;18(12), *those author contributed equally to the work.
Alachkar, A., Jiang, D. Harrison, M. Zhou, Y. Chen, G. Mao, Y., (2013). “An EJC factor RBM8a regulates anxiety behaviors.” Curr Mol Med 13(6): 887-899.
Lajin B, Alachkar A., Michati R, Sakur A., (2013), Association between Polymorphisms in Genes for Tumor Suppressor Protein p53 and its Regulator NAD(P)H:Quinone Oxidoreductase 1 (NQO1) and Schizophrenia in a Syrian Study Cohort, Arch Med Res 44(2): 121-126.
Lajin, B., Alhaj Sakur, A., Michati, R., Alachkar, A., (2012) Association between MTHFR C677T and A1298C, and MTRRA66G polymorphisms and susceptibility to schizophrenia in a Syrian study cohort, Asian Journal of Psychiatry. 5(2):144-9
Lajin, B. and Alachkar, A., 2013, “The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis.” Br J Cancer 109(5): 1325-1337.
Alachkar, A., J. Brotchie, O. T. Jones, (2012), Changes in the mRNA levels of alpha2A and alpha2C Adrenergic Receptors in Rat Models of Parkinson’s Disease and L-DOPA-induced Dyskinesia, J Mol Neurosci. 46(1):145-52
Mustafa, O. H., A. R. Hamzeh, Ghabreau, L. Akil, N. Almoustafa, A. E. Alachkar, A., (2013). “Allele Frequencies of the Epidermal Growth Factor Receptors Polymorphism R521K in Colorectal Cancer Patients and Healthy Subjects Indicate a Risk-Reducing Effect of K521 in Syrian Population.” N Am J Med Sci 5(3): 202-206
Lajin, B.; Alhaj Sakur, A.; Alachkar, A., (2013), Association between polymorphisms in apoptotic genes and susceptibility for developing breast cancer in Syrian women, Breast Cancer Res Treat, 138: 2, 611-9
Lajin, B., Alhaj Sakur, A., Ghabreau, L., Alachkar A., (2012), Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women. Tumour Biol, 33(4):1133-9
Lajin*, B., Alachkar*, A., Hamzeh, AR., Michati, L., Alhaj, H., (2011). No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population. North Am J Med Sci, 3: 176-178.* those author contributed equally to the work.
Alachkar, A., J. M. Brotchie, O.T. Jones. (2010) “Locomotor response to L-DOPA in reserpine-treated rats following central inhibition of aromatic L-amino acid decarboxylase: further evidence for non-dopaminergic actions of L-DOPA and its metabolites.” Neurosci Res 68(1): 44-50.
Lajin, B., Sakur, A.A., Hamzeh, A.R., Alachkar, A., (2010). Genotype distribution of the single nucleotide polymorphism Val158Met of the COMT gene in the Syrian population. J. Biol. Sci., 10: 701-704
Alachkar, A., J. M. Brotchie, O.T. Jones .(2010). “Binding of dopamine and 3-methoxytyramine as l-DOPA metabolites to human alpha (2)-adrenergic and dopaminergic receptors.” Neurosci Res 67(3): 245-9.
Alachkar, A., J. Brotchie, O. T. Jones (2006). “Alpha2-Adrenoceptor-mediated modulation of the release of GABA and noradrenaline in the rat substantia nigra pars reticulata.” Neurosci Lett 395(2): 138-42.