Publications

Metrics:

Alex Chan’s ORCID ID: 0000-0003-4391-4219 ; Pubmed

h-index : 47 (Google Scholar); total peer-reviewed publications = 280 (5/7/2024)

Selected Publications:

Biomarkers in Cancer-Related Cognitive Impairment (aka Chemobrain)

_{Relationship between cytokines and brain-derived neurotrophic factor (BDNF) in trajectories of cancer related cognitive impairment}

^{Extracellular Vesicle Proteome of Breast Cancer Patients with and Without Cognitive Impairment Following Anthracycline-based Chemotherapy: An Exploratory Study}

^{Evidence of brain-derived neurotrophic factor in ameliorating cancer-related cognitive impairment: A systematic review of human studies}

^{Associations of plasma brain‑derived neurotrophic factor (BDNF) and Val66Met polymorphism (rs6265) with long‑term cancer‑related cognitive impairment in survivors of breast cancer}

^{An Evaluation of DNA Methyltransferase 1 (DNMT1) Single Nucleotide Polymorphisms and Chemotherapy-Associated Cognitive Impairment: A Prospective, Longitudinal Study}

^{Distinct cytokine profiles across trajectories of self-perceived cognitive impairment among early stage breast cancer survivors}

^{Prechemotherapy Levels of Plasma
Dehydroepiandrosterone and Its Sulfated Form as Predictors of Cancer-Related Cognitive Impairment in Patients with Breast Cancer Receiving Chemotherapy}

^{Replication and Meta-analysis of the Association between BDNF
Val66Met Polymorphism and Cognitive Impairment in Patients
Receiving Chemotherapy}

^{Impact of Adjuvant Anthracycline Based and Taxane-Based Chemotherapy on Plasma VEGF Levels and Cognitive Function in Breast Cancer Patients: A Longitudinal Study}

^{Association of mitochondrial DNA content in peripheral blood with cancer‑related fatigue and chemotherapy‑related cognitive impairment in early‑stage breast cancer patients: a prospective cohort study}

^{Evaluation of plasma brain-derived neurotrophic factor levels and self-perceived cognitive impairment post-chemotherapy: a longitudinal study}

^{Impact of TNF-α (rs1800629) and IL-6 (rs1800795) Polymorphisms on Cognitive Impairment in Asian Breast Cancer Patients}

^{Brain-derived neurotrophic factor genetic polymorphism (rs6265)
is protective against chemotherapy-associated cognitive impairment
in patients with early-stage breast cancer}

^{Association of proinflammatory cytokines and chemotherapy associated cognitive impairment in breast cancer patients: a multi centered, prospective, cohort study}

^{The genetic variants underlying breast cancer treatment-induced chronic and late toxicities: A systematic review}

^{Role of Exosomes in Cancer-Related Cognitive Impairment}

_{BDNF Augmentation Using Riluzole Reverses Doxorubicin‑Induced
Decline in Cognitive Function and Neurogenesis}

^{Brain‑derived neurotrophic factor
as a biomarker in cancer‑related
cognitive impairment
among adolescent and young adult
cancer patients}

^{Cognitive impairment in adolescent and young adult cancer
patients: Pre-treatment
findings of a longitudinal study}

^{Longitudinal evaluation
of dehydroepiandrosterone
(DHEA), its sulfated form
and estradiol with cancer‑related
cognitive impairment in early‑stage
breast cancer patients receiving
chemotherapy}

Etiology and Management of Cancer-Related Cognitive Impairment

^{Self-reported cognitive outcomes among adolescent and young adult patients with non-central nervous system cancers}

^{Distinct and heterogeneous trajectories of self‐perceived
cognitive impairment among Asian breast cancer survivors}

^{Systematic review of pharmacologic and non-pharmacologic interventions to manage cognitive alterations after chemotherapy for breast cancer}

^{Minimal clinically important difference (MCID) for the functional
assessment of cancer therapy: Cognitive function (FACT-Cog) in breast cancer patients}

^{Psychometric Properties and Measurement Equivalence of the English and Chinese Versions of the Functional Assessment of Cancer Therapy-Cognitive in Asian Patients With Breast Cancer}

^{Effects of Chemotherapy and Psychosocial Distress on Perceived Cognitive Disturbances in Asian Breast Cancer Patients}

^{An evaluation on the neuropsychological tests
used in the assessment of postchemotherapy cognitive
changes in breast cancer survivors}

^{Cognitive changes in multiethnic Asian breast cancer patients: a focus group study}

^{Cancer-related cognitive impairment in patients with non-central nervous system malignancies: an overview for oncology providers from the MASCC Neurological Complications Study Group}

Substance Use Among Young Adult
Survivors of Childhood Cancer With Cognitive
Impairment: An Analysis of the Project
Forward Cohort

^{Research Attitude and Interest among Cancer Survivors
with or without Cognitive Impairment}

Research in Chemotherapy-induced Peripheral Neuropathy

^{Impact of Cryotherapy on Sensory,
Motor, and Autonomic Neuropathy inBreast Cancer Patients Receiving
Paclitaxel: A Randomized, Controlled Trial}

^{Minimal clinically important difference of the EORTC QLQ-CIPN20 for worsening peripheral neuropathy in patients receiving neurotoxic chemotherapy}

^{Psychometric testing of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group—Neurotoxicity (FACT/
GOG-Ntx) subscale in a longitudinal study of cancer patients treated with chemotherapy}

^{Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview}

Research in Cancer-Related Fatigue

^{Association of mitochondrial DNA content and displacement loop region} ^{sequence variations with cancer-related fatigue in breast cancer survivors} ^{receiving chemotherapy}

^{Association of plasma leptin, pro‐inflammatory adipokines and cancer‐related fatigue in early‐stage breast cancer patients: A prospective cohort study}

^{Minimal Clinically Important Difference of the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF) for Fatigue Worsening in Asian Breast Cancer Patients}

^{Psychometric properties and measurement equivalence of the Multidimensional
Fatigue Syndrome Inventory- Short Form (MFSI-SF) amongst breast cancer and
lymphoma patients in Singapore}

^{Impact of cancer-related fatigue on chemotherapy-induced nausea and
vomiting in Asian cancer patients}

Research in Chemotherapy-Induced Nausea and Vomiting

^{Cost-effectiveness analysis of olanzapine-containing antiemetic therapy} ^{for managing highly emetogenic chemotherapy in Southeast Asia: a multinational study}

^{Applicability of the National
Comprehensive Cancer Network/Multinational Association of Supportive Care in Cancer Guidelines for Prevention and Management of Chemotherapy-
Induced Nausea and Vomiting in Southeast Asia: A Consensus Statement}

^{2016 Updated MASCC/ESMO Consensus Recommendations:
Prevention of Nausea and Vomiting Following High Emetic Risk Chemotherapy}

^{Feasibility and Acceptance of a Pharmacist-Run Tele-oncology
Service for Chemotherapy-Induced Nausea and Vomiting
in Ambulatory Cancer Patients}

^{Trajectory and risk factors for chemotherapy-induced nausea and vomiting in Asian
patients with head and neck cancer}

^{Assessment of the Relationship Between Adherence with Antiemetic
Drug Therapy and Control of Nausea and Vomiting in Breast Cancer Patients Receiving Anthracycline-Based Chemotherapy}

^{Thalidomide for Delayed Chemotherapy-Induced Nausea and Vomiting: Where Is Its Place in
Therapy?}

Other toxicities associated with Anti-Cancer Therapies

^{Chemotherapy drug concentrations in hair follicles: a potential
biomarker to monitor the effectiveness of scalp cooling
for chemotherapy-induced alopecia}

^{Role of Procalcitonin in Differentiating between Infectious
and Noninfectious Fevers among Patients with Lymphoma}

^{Therapeutic Use of Filgrastim for Established Febrile Neutropenia Is Cost Effective Among Patients With Solid Tumors and Lymphomas}

^{Incidence and Management of Toxicity Associated with
L-Asparaginase in the Treatment of ALL and NK/T-Cell Lymphoma: an Observational Study}

^{Routine Primary Prophylaxis for Febrile Neutropenia with Biosimilar Granulocyte
Colony-Stimulating Factor (Nivestim) or Pegfilgrastim Is Cost Effective in Non- Hodgkin Lymphoma Patients undergoing Curative-Intent R-CHOP Chemotherapy}

^{Role of sunitinib and SU12662 on dermatological toxicities
in metastatic renal cell carcinoma patients: in vitro, in vivo, and outcomes investigation}

^{Clinical practice guidelines for the prevention and treatment
of acute and late radiation reactions from the MASCC Skin Toxicity Study Group}

^{Incidence of febrile neutropenia among early-stage breast cancer patients receiving anthracycline-based chemotherapy}

^{To SMILE or Not: Supportive
Care Matters}

^{Impact of colony-stimulating factors to reduce febrile
neutropenic events in breast cancer patients receiving
docetaxel plus cyclophosphamide chemotherapy}

^{How well does the MESTT correlate with CTCAE scale
for the grading of dermatological toxicities associated with oral tyrosine kinase inhibitors?}

^{Survey of topical oral solutions for the treatment of
chemo-induced oral mucositis}

^{Systemic Anticoagulant Prophylaxis for Central Catheter–Associated Venous Thrombosis in Cancer Patients}

^{Increased incidence of Pegaspargase-induced hypertriglyceridemia and
associated pancreatitis observed in the Hispanic adult patient population}

^{Prediction of gastrointestinal symptoms trajectories using omega‑3
and inflammatory biomarkers in early‑stage breast cancer patients
receiving chemotherapy}

Research in Adolescent and Young Adults Cancer Patients & Survivors

^{Feasibility of Cognitive Training to Promote Recovery in Cancer-Related Cognitive Impairment} ^{in Adolescent and Young Adult Patients}

^{Optimizing Survivorship Care Services for Asian Adolescent
and Young Adult Cancer Survivors: A Qualitative Study}

^{Assessment of psychological distress among Asian adolescents and young adults (AYA) cancer patients using the distress thermometer: a prospective, longitudinal study}

^{Work- and insurance-related issues among Asian adolescent and young-adult cancer survivors: a qualitative study}

^{Neuropsychiatric complications and associated
management in adolescent and young adult cancer
survivors: An All of Us study}

^{Unmet Needs, Barriers, and Facilitators for Conducting
Adolescent and Young Adult Cancer Survivorship
Research in Southern California:
A Delphi Survey}

Optimizing Delivery of Cancer Survivorship Care

^{Investigating how cancer‑related symptoms influence work outcomes
among cancer survivors: a systematic review}

^{Adherence to Cancer Survivorship Care Guidelines and Health Care Utilization Patterns Among Nonmetastatic Breast Cancer Survivors in Singapore}

^{Cancer Supportive and Survivorship Care in Singapore: Current Challenges and Future Outlook}

^{A culturally adapted survivorship programme for Asian early
stage breast cancer patients in Singapore: A randomized,
controlled trial}

^{Medication use by early-stage breast cancer survivors: a 1-year longitudinal study}

^{Symptom burden and medication use in adult sarcoma patients}

^{Practitioners’ perspectives on community-based breast cancer survivorship care in Singapore: A focus group study}

^{Decision aids for cancer survivors’ engagement with survivorship care
services after primary treatment: a systematic review}

^{Roles and recommendations from primary care physicians towards managing low-risk breast cancer survivors in a shared-care model with specialists in Singapore—a qualitative study}

^{Reporting adherence, validity and physical activity measures of wearable
activity trackers in medical research: A systematic review}

^{Barriers and facilitators to exercise among adult cancer survivors in Singapore}

Development and pilot testing of a decision
aid for navigating breast cancer survivorship
care

^{Implementing an Inclusive,
Multidisciplinary Supportive
Care Model to Provide
Integrated Care to Breast
and Gynaecological Cancer
Survivors: A Case Study at an
Asian Ambulatory Cancer Centre}

Pharmacy Practice-Related Research

Health Disparities in Pharmacy
Practice Within the Community: Let’s Brainstorm for Solutions

^{Impact of coronavirus of 2019 on the delivery of pharmacy services to patients with cancer: An international survey of oncology pharmacy practitioners}

^{Clinical pharmacy services and research for lymphoma patients at a cancer center}

^{Complementary and alternative medicine (CAM) usage in Singaporean adult cancer patients}

^{Evolving roles of oncology pharmacists in Singapore: A survey on prescribing patterns of
antiemetics for chemotherapy induced nausea and vomiting (CINV) at a cancer centre}

^{Global oncology pharmacy response to COVID-19 pandemic: Medication access and safety}

^{Impact of a pharmacist-led education and follow-up service on anticoagulation control and safety outcomes at a tertiary hospital in China: a randomised controlled trial}

^{Managing Pharmacotherapy in People Living With HIV and Concomitant Malignancy}

Pharmacy Education-Related Research

^{Supporting COVID-19 Vaccine Rollout before Charter Class
Arrives: The University of California, Irvine Experience}

^{Perception of electronic peer review of SOAP notes among
pharmacy students enrolling in their first pharmacotherapeutics course}

^{Pharmacy students’ perceptions toward peer assessment and its use
in teaching patient presentation skills}

^{Assessing biosimilar education needs among oncology pharmacy practitioners worldwide: An ISOPP membership survey}

^{Perceptions of pharmacy students and pharmacists on SOAP note education and utility in pharmacy practice}

Implementing a cancer survivorship seminar course to non‑healthcare
professional undergraduate students

Adverse Drug Events Related Research

^{Current and recommended practices for evaluating adverse drug events using electronic health records: A systematic review}

^{Identifying Potentially Avoidable Readmissions: A Medication-Based 15-Day Readmission Risk
Stratification Algorithm}

^{Prevalence and characteristics of adverse drug reactions at admission to hospital: a prospective observational study}

^{Costs and Length of Stay of Drug-Related Hospital Admissions in Cancer Patients}

^{Characteristics of unplanned hospital admissions due
to drug-related problems in cancer patients}

^{Polypharmacy in elderly patients with cancer: clinical
implications and management}

^{Clinically Significant Drug–Drug Interactions Between Oral Anticancer Agents and Nonanticancer Agents:
Profiling and Comparison of Two Drug Compendia}

^{Evaluation of in vitro Cytochrome P450 Inhibition and Hepatotoxicity Potential of a Herbal Formula (Xiang Bei Yang Rong Tang) for Treatment of Cancer‑Related Fatigue}

Pharmacogenomics-Related Research (Cancer and Non-Cancer)

^{Economic burden of adverse drug reactions and potential for pharmacogenomic testing in Singaporean adults}

^{BSA and ABCB1 polymorphism affect the pharmacokinetics
of sunitinib and its active metabolite in Asian mRCC patients
receiving an attenuated sunitinib dosing regimen}

^{Effect of the CYP3A5 and ABCB1 genotype on exposure, clinical response and manifestation of toxicities from sunitinib in Asian patients}

Continual Education

^{PSAP: Breast Cancer}

^{ACSAP: Cancer Survivorship}

^{Dipiro Textbook Chapter: Lymphoma}

White Papers

^{ACCP: Recommendations for Aligning PGY2 Pharmacy Residency Training and Pharmacy Specialist Board Certification}

^{ACCP: Minimum Qualifications for Clinical Pharmacy Practice
Faculty}

^{International society of oncology pharmacy practitioners (ISOPP) position statement: The role of oncology pharmacy practitioners in immunotherapy treatment
with immune checkpoint inhibitors for malignant conditions}

^{2019 Update to the American College of Clinical Pharmacy Pharmacotherapy Didactic Curriculum Toolkit}

^{International Society of Oncology Pharmacy Practitioners (ISOPP) position statement: Role of the oncology pharmacy team in cancer care}

^{International Society of Oncology Pharmacy Practitioners global position on the use of biosimilars in cancer treatment and supportive care}