Acoustic-electric shear orbiting poration (AESOP)
AESOP is a platform that modulates acoustic and electric fields to induce size-controlled membrane pores for non-viral intracellular delivery (NIGMS (R01GM145987-01). The AESOP device has allowed us to control dosage and sequentially deliver multiple genetic coding cargoes into cells efficiently and gently.
Arrayed-droplet optical projection tomography (ADOPT)
ADOPT is a platform capable of capturing the 3D morphology of single cells both of the membrane as well as the intracellular organelles. This platform is poised to be the focal point of research in our lab as it is expected to provide rich biological content for cellular studies and cell-based medicine.
Artificial antigen presenting cells (aAPCs)
aAPCs is a platform that can conjugate targeting ligands that form cell-to-cell synapses for antigen-specific T cell activation (R33CA267258-01A1). This aAPC platform enables the de novo design of cells for various research applications with potential biomedical applications in cell therapy for cancer, autoimmune diseases, and even Alzheimer’s Disease.