Approach
Spatial Frequency Domain Imaging |
Spatially resolved maps of in-vivo optical properties and tissue chromophores will reveal biological indices in disease activity. Changes in vascularity, osmotic forces, and collagen remodeling will be measured to establish novel endpoints to quantify and understand the range of disease activity. Evolving strategies in medical optimization and surgical management , and recent advances in targeted immunotherapy and biophotonics create an opportunity to study the efficacy of these interventions to provide customized care to patients. Spatial frequency domain imaging (SFDI) is poised to non-invasively and quickly interrogate tissue impacted by inflammatory, infiltrative, and cicatricial change.
Pathology
Thyroid Eye Disease |
A range from mild to devastating orbital and soft tissue changes occur in the periocular region as a result of thyroid eye disease (TED). Proptosis, restrictive strabismus, periorbital soft tissue changes, exposure keratopathy, and optic neuropathy, which can result in pain, double vision, corneal scarring, and irreversible vision loss, are some of the more incapacitating sequelae of TED.
Basal Cell Carcinoma |
The most common eyelid and periorbital malignancy can present along a spectrum, ranging from madarosis, telangiectasia formation, skin ulceration, and distortion of eyelid architecture. These changes can result in eyelid malposition, nasolacrimal obstruction, exposure keratopathy, and other severe sequelae based upon extent of disease.
