2025
Malone, H., Bhatti, M.S., Huynh, K.H. and Frostig, R.D. The role of spontaneous and evoked neuronal activity in protection from impending ischemic stroke during the hyperacute state, Scientific Reports, in press, 2025. Click for PDF.
Sayfoori, R., Huang, M-H., Naderi, A., Bhatti, M., Frostig, R.D. and Cao, H. High-Precision UWB Sensor-Based Real-Time Locating System for Rodent Behavioral Studies. IEEE Sensors Journal, in press, 2025. Click for PDF.
2024
Jiao, S., Frostig, R.D., Ombao, H. Filtered common principal components analysis of multigroup functional data. The Annals of Applied Statistics, vol 18 no.2 1160-1177, https://doi.org/10.1214/23-AOAS1827, 2024.
2023
Bhatti, M.S. and Frostig, R.D. Astrocyte-neuron lactate shuttle plays a pivotal role in sensory-based neuroprotection in a rat model of permanent middle cerebral artery occlusion. Scientific Reports, doi.org/10.1038/s41598-023-39574-9, 2023.
Chu, S.S., Nguyen, H.A., Lin, D., Bhatti, M. Jones-Tinsley, C.E., Do, A.H., Frostig, R.D., Nenadic, Z., Xu, X., Lim, M.M., Cao H., Development of highly sensitive, flexible dual L-glutamate and GABA microsensors for in vivo brain sensing. Biosensors and Bioelectronics, doi.org/10.1016/j.bios.2022.11494, 2023.
2022
Jiao, S. Frostig R.D. and Ombao, H. Variation pattern classification of functional data. Canadian Journal of Statistics, doi.org/10.1002/cjs.11738, 2022.
Bhatti, M.S., Malone., H., Hui, G., and Frostig, R.D. Head implant for the neuroimaging of awake, head-fixed rats. Journal of Visual Experiment (JOVE), doi: 10.3791/64324, 2022.
Jiao, S. Frostig R.D. and Ombao, H. Break point detection for functional covariance. Scandinavian Journal of Statistics, DOI: 10.1111/sjos.12589, 1-36, 2022.
Rasheed, W., Wodeyar, A., Srinivasan, R. and Frostig, R.D. Sensory stimulation-based protection from impending stroke following MCA occlusion is correlated with desynchronization of widespread spontaneous local field potentials. Scientific Reports doi.org/10.1038/s41598-022-05604-112:1744, 2022.
2020
Wann, E.G., Wodeyar, A., Srinivasan, R. and Frostig, R.D. Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia. Scientific Reports, DOI: 10.1038/s41598-020-78179-4, 2020.
Sundararajan, R.R., Frostig, R.D. and Ombao, H. Modeling Spectral Properties in Stationary Processes of Varying Dimensions with Applications to Brain Local
Field Potential Signals. Entropy, 22, 1375; doi:10.3390/e22121375, 2020.
Gao, X., Shen, W., Zhang, L., Hu, J., Fortin, N.J., Frostig, R.D. and Ombao, H. Regularized matrix data clustering and its application to image analysis. Biometrics, 1-13, DOI: 10.1111/biom.13354, 2020.
2019
Zhu, J., Hancock, A.M., Qi. L., Telkmann, K., Shahbaba, B., Chen, Z. and Frostig, R.D. Spatiotemporal dynamics of pial collateral blood flow following permanent middle cerebral artery occlusion in a rat model of sensory-based protection: a Doppler optical coherence tomography study. Neurophotonics 6(4), 045012 (2019), doi: 10.1117/1. NPh.6.4.045012.
Fontaine, C., Frostig, R.D. and Ombao, H. Modeling non-linear spectral domain dependence using copulas with applications to rat local field potentials. Econometrics and Statistics, https://doi.org/10.1016/j.ecosta.2019.06.003, 2019.
2018
Hancock, A.M. and Frostig, R.D. Hypertension prevents a sensory stimulation-based collateral therapeutic from protecting the cortex from impending ischemic stroke damage in a spontaneously hypersensitive rat model. PLoS ONE,13(10): doi: e0206291, 2018.
Johnson, B.A. and Frostig, R.D. Long-range, border-crossing, horizontal axon radiations are a common feature of rat neocortical regions that differ in cytoarchitecture. Frontiers in Neuroanatomy, doi.org/10.3389/fnana.2018.00050, 2018.
2017
Hancock, A.M. and Frostig, R.D. Testing the effects of sensory stimulation as collateral based therapeutics for ischemic stroke in C57BL/6J and CD1 mouse strains. PLoS One, 12(9): e0183909. doi: 10.1371/journal.pone.0183909, 2017.
Frostig, R.D. and Petersen, C.C.H. Special Section Guest Editorial: Pioneers in Neurophotonics: Special Section Honoring Professor Amiram Grinvald. Neurophotonics, doi: 10.1117/1. NPh.4.3.031200, 2017.
Jacobs, N.S. and Frostig, R.D. Prominent lateral spread of imaged evoked activity beyond cortical columns in barrel cortex provides foundation for coding whisker identity. Neurophotonics, 4(3) 031218, 2017.
2016
Qi, L., Zhu, J., Hancock, A.M., Dai, C., Zhang, X., Frostig, R.D. and Chen, Z. Fully distributed absolute blood flow velocity measurement for middle cerebral arteries using Doppler optical coherence tomography. Biomedical Optics Express, 7(2), DOI:10.1364/BOE.7.000601, 2016.
Johnson, B. and Frostig, R.D. Long, intrinsic horizontal axons radiating through and beyond rat barrel cortex have spatial distributions similar to horizontal spreads of activity evoked by whisker stimulation. Brain Structure and Function, (DOI) 10.1007/s00429-015-1123-7, 2016.
2015
Konecky, S.D., Wilson R.H., Hagen N., Mazhar, A., Tkaczyk, T.S., Frostig, R.D., and Tromberg, B.J. Hyperspectral optical tomography of intrinsic signals in the rat cortex. Neurophotonics 2(4), 045003, 1-11, 2015.
Jacobs, N.S., Chen-Bee, C.H. and Frostig R.D. Emergence of spatiotemporal invariance in large neuronal ensembles in rat barrel cortex. Frontiers in Neural Circuits, doi: 10.3389/fncir.2015.00034, 2015.
Johnson, B. and Frostig, R.D. Photonics meets Connectomics: case of diffuse, long-range horizontal projections in rat cortex. Neurophotonics, doi: 10.1117/1.NPh.2.4.041403, 2015.
2014
Lay, C.C. and Frostig, R.D. Complete protection from impending stroke following permanent middle cerebral artery occlusion in awake, behaving rats. European Journal of Neuroscience. 40(9):3413-212014. doi: 10.1111/ejn.12723, 2014.
Stehberg J, Dang PT, Frostig, R.D. Unimodal primary sensory cortices are directly connected by long-range horizontal projections in the rat sensory cortex. Frontiers in Neuroanatomy 8:93, 2014.
2013
Hancock, A., Lay, C.C., Davis, M.F. and Frostig, R.D. A Sensory stimulation-based complete protection from ischemic stroke remains stable at 4 months post-occlusion of MCA. Journal of Neurological Disorders, 1: 135. doi:10.4172/2329-6895.1000135, 2013.
Lay, C.C., Jacobs, N., Hancock, A.M., Zhou, Y. and Frostig, R.D. Complete sensory-induced protection from ischemic stroke under isoflurane anesthesia. doi: 10.1111/ejn.12217. European Journal of Neuroscience, 2013.
Davis, M.F., Lay, C.C., and Frostig, R.D. Permanent Cerebral Vessel Occlusion Via Double Ligature and Transection. Journal of Visualized Experiments, e50418, doi:10.3791/50418, 2013.
Frostig, R.D., Lay, C.C., and Davis, M.F. A rat’s whiskers point the way towards a novel stimulus-dependent, protective stroke therapy. The Neuroscientist, DOI: 10.1177/1073858412462607, 2013.
2012
Chen-Bee, C.H., Zhou, Y, Jacobs, N., Lim, B. and Frostig, R.D. Whisker array functional representation in the rat barrel cortex: transcendence of one-to-one topography and its underlying mechanism. Frontiers in Neural Circuits, doi: 10.3389/fncir, 2012.
Lay, C.C., Davis, M.F., Chen-Bee, C.H. and Frostig, R.D. Mild sensory stimulation protects the aged rodent from cortical ischemic stroke following permanent middle cerebral artery occlusion. Journal of the American Heart Association (JAMA), DOI – 10.1161/JAHA.112.001255, 2012.
(Chosen for evaluation, ‘Recommended’ by the “Faculty of 1000”)
2011
Lay, C.C., Davis, M.F., Chen-Bee, C.H. and Frostig, R.D. Mild sensory stimulation re-establishes cortical function during the acute phase of ischemia. Journal of Neuroscience, 31:11495-11504, 2011.
Gomez-Pinilla, F., Ying, Z., Agoncillo, T. and Frostig, R.D. The influence of naturalistic experience on plasticity in somatosensory cortex and hippocampus: effects of whisker use. Brain Research, 1388:39-47, 2011.
Davis, M.F., Lay, C.C., Chen-Bee, C.H. and Frostig, R.D. Amount but not pattern of protective sensory stimulation alters recovery after permanent middle cerebral artery occlusion. Stroke, 42; 792-798, 2011.
2010
Lay, C.C., Davis, M.F., Chen-Bee, C.H. and Frostig, R.D. Mild sensory stimulation completely protects the adult rodent cortex from ischemic stroke. PLoS-ONE, 5(6): e11270. doi:10.1371/journal.pone.0011270, 2010.
(Chosen for evaluation – ‘Must Read’ 6.0 – by the “Faculty of 1000”).
2009
Abookasis, D., Lay, C., Mathews, M.S., Davis, M., Linskey, M.E., Frostig, R.D., and Tromberg, B.J. Imaging cortical absorption, scattering and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination Journal of Biomedical Optics 14 (2), 14(2):024033 1-9, 2009.
2008
Frostig, R.D., Xiong, Y, Chen-Bee, C.H., Kvasnak, E., and Stehberg, J. Large-scale organization of rat sensorimotor cortex based on a motif of large activation spreads. Journal of Neuroscience, 28(49):13274-13284, 2008. (Chosen for evaluation by the “Faculty of 1000”)
2007
Chen-Bee, C.H., Agoncillo, T., Xiong, Y., and Frostig, R.D., The tri-phasic intrinsic signal: implications for functional imaging. Journal of Neuroscience, 27 (17): 4572 – 4586, 2007.
2006
Frostig, R.D. Functional organization and plasticity in the adult rat barrel cortex: moving out-of-the-box. Current Opinion in Neurobiology, 16, 445-50, 2006.
2005
Polley, D.B., Rickert, J., and Frostig, R.D. Whisker-based discrimination of object orientation determined with a rapid training paradigm. Neurobiology of Learning and Memory, 83, 134-142, 2005.
2004
Prakash, N and Frostig, R.D. What has intrinsic signal optical imaging taught us about NGF-induced rapid plasticity in adult cortex and its relationship to the cholinergic system? Molecular Imaging and Biology, 7, 14-21, 2005 (Epub 12-30, 2004).
Polley, D.B., Kvasnak, E. and Frostig, R.D. Naturalistic experience transforms sensory maps in the adult cortex of caged animals. Nature, 429, 67-71, 2004. (Chosen for evaluation by the “Faculty of 1000”)
Prakash, N., Cohen-Cory, S., Penschuck, S. and Frostig, R.D. The basal forebrain cholinergic system is involved in rapid nerve growth factor (NGF)-induced plasticity in the barrel cortex of adult rats. Journal of Neurophysiology, 91, 424-437, 2004.
2002
Penschuck, S., Chen-Bee, C., Prakash, N., and Frostig, R.D. In vivo modulation of a cortical functional sensory representation shortly after topical cholinergic agent application. Journal of Comparative Neurology, 452, 38-50, 2002.
2001
Brett-Green, B., Chen-Bee, C.H., and Frostig, R.D. Comparing the functional representations of central and border whiskers in the rat primary somatosensory cortex. Journal of Neuroscience, 15: 9944-9954, 2001.
2000
Prakash, N., Vanderhaeghen, P., Cohen-Cory, S., Frisén., J., Flanagan, J.G., and Frostig, R.D. Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knockout mice revealed by in vivo functional imaging. Journal of Neuroscience, 20:5841-5847, 2000.
Vanderhaeghen, P., Lu, Q., Prakash, N., Frisen, J., Walsh, C.A., Frostig, R.D., and Flanagan, J.G. A mapping label required for normal scale of body representation in the cortex. Nature Neuroscience, 3:358-365, 2000.
Chen-Bee, C., Polley, D.B., Brett-Green, B., Prakash, N., Kwon, M.C. and Frostig, R.D. Visualizing and quantifying evoked cortical activity assessed with intrinsic signal imaging. Journal of Neuroscience Methods, 97:157-173, 2000.
1999
Polley, D.B., Chen-Bee, C., and Frostig, R.D. Two directions of plasticity in the sensory-deprived adult cortex. Neuron, 24:623-637, 1999. (Cover story, subject to preview).
Chen, Z., Zhao, Y., Srinivas, S., Nelson, J.S., Prakash, N., and Frostig, R.D. Optical Doppler Tomography. IEEE Journal of Selected Topics in Quantum Electronics, 1134-1142, 1999.
Polley, D.B., Chen-Bee, C. and Frostig, R.D. Varying the degree of single whisker stimulation differentially affects phases of intrinsic signals in rat barrel cortex. Journal of Neurophysiology, 81:692-701,1999.
1996
Prakash, N., Cohen-Cory, S. and Frostig, R.D. Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo. Nature, 381: 702-706, 1996.
Chen-Bee, C.H. and Frostig, R.D. Variability and interhemispheric asymmetry of the single-whisker functional representations in rat barrel cortex. Journal of Neurophysiology, 76:884-894, 1996.
Chen-Bee, C.H., Kwon, M., Masino, S.A. and Frostig, R.D. Areal extent quantification of functional representations using intrinsic signal optical imaging. Journal of Neuroscience Methods, 68:27-37, 1996
Masino, S.A. and Frostig, R.D. Quantitative long-term imaging of the functional representation of a whisker in rat barrel cortex. Proceedings of the National Academy of Science USA, 93, 4942-4947, 1996.
Bakin, J.S., Kwon, M.C., Masino, S.A., Weinberger, N.M. and Frostig, R.D. Suprathreshold auditory cortex activation visualized by intrinsic signal optical imaging. Cerebral Cortex, 6:120-130, 1996.
1995
Frostig, R.D., Masino, S.A., Kwon, M.C. and Chen. C.H. Using light to probe the brain: intrinsic signal optical imaging. International Journal of imaging systems and technology 6:216-224, 1995.
Carmona, R.A., Hwang, W, L. and Frostig R.D. Wavelet analysis for brain function imaging. IEEE Transactions on Medical Imaging, 14:556-564, 1995.
1994
Grinvald, A., Lieke, E.E., Frostig, R.D., Hildesheim, R. Cortical point-spread function and long-range lateral interactions revealed by real-time optical imaging of macaque monkey primary visual cortex. Journal of Neuroscience, 14, 2545- 2568, 1994
1993
Masino, S., Kwon, M.C., Dory, Y. and Frostig, R.D. Characterization of functional organization within rat barrel cortex using intrinsic signal optical imaging through a thinned skull. Proceedings of the National Academy of Science USA, 90, 9998-10002,1993.
1991
Grinvald, A., Frostig, R.D., Siegel, R.M. and Bartfeld, E. High resolution optical imaging of functional brain architecture in the awake monkey. Proceedings of the National Academy of Science USA, 88, 11559-11563, 1991.
1990
Frostig, R.D., Lieke, E.E., Ts’o, D.Y. and Grinvald, A. Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals. Proceedings of the National Academy of Science USA, 87, 6082-6086, 1990.
Ts’o, D.Y., Frostig, R.D., Lieke, E.E. and Grinvald, A. Functional organization of the primate visual cortex revealed by high-resolution optical imaging of intrinsic signals. Science, 249, 417-420, 1990.
Frostig, R.D. Codes embedded in neuronal activity. Notes on Theoretical Biology, 1: 57-74, 1990.
Frostig, R.D., Frysinger, R.C. and Harper, R.M. Recurring discharge patterns in multiple spike trains. II. Application in forebrain areas related to cardiac and respiratory control during different sleep waking states. Biological Cybernetics, 62:495-502, 1990.
Frostig, R.D., Frostig, Z. and Harper, R.M. Recurring discharge patterns in multiple spike trains. I. Detection. Biological Cybernetics, 62:487-493, 1990.
1987
Frostig, Z., Frostig, R.D. Analysis of frequency components in time series data. Journal of Neuroscience Methods, 22:79-87, 1987.
1986
Grinvald, A., Lieke, E., Frostig, R.D., Gilbert, C.D. and Wiesel, T.N. Functional architecture of the cortex revealed by optical imaging of intrinsic signals. Nature, 324:361-364, 1986.
1984
Frostig, R.D., Frostig, Z. and Harper, R.M. Information Trains. The technique and its uses in spike train and network analysis, with examples taken from the nucleus parabrachialis medialis during sleep-waking states. Brain Research, 322:67-74, 1984.
1983
Frostig, R.D., Gottlieb, Y., Vaadia, E. and Abeles, M. The effect of stimuli on the activity and functional connectivity of local neuronal groups in the cat auditory cortex. Brain Research, 272:211-221, 1983.
1982
Devor, M., Carmon, A. and Frostig, R.D. Primary afferents and spinal sensory neurons that respond to brief pulses of intense infrared laser radiation: a preliminary survey in rats. Experimental Neurology, 76:483-494, 1982.
1981
Carmon, A. and Frostig, R.D. Noxious stimulation of animals by brief intense laser induced heat: advantage to pharmacological testing of analgesics. Life Science, 29:11-16, 1981.
Book Chapters/Reviews
Frostig, R.D. Intrinsic signal optical imaging (ISOI): state-of-the-art with emphasis on pre-clinical and clinical studies. In: Tsytsarev, Vassiliy, Vicky Yamamoto, Ning Zhong (Eds.), Functional Brain Mapping: Methods and Aims, Springer, 2020.
Frostig, R.D. and Chen-Bee, C.H. The use of intrinsic signal optical imaging for mapping cortical function. In: Romain Brette, Alain Destexhe (Eds.) Handbook of Neuronal Activity Measurements. Cambridge University Press, 2012.
Frostig, R.D. and Chen-Bee, C.H. Visualizing Adult Cortical Plasticity Using Intrinsic Signal Optical Imaging. In Frostig, R.D. (Ed.) In vivo optical imaging of brain function (second edition), CRC Press, 2009.
Cuccia, D.J., Abookasis, D., Frostig, R.D., Tromberg. B.J. Quantitative In Vivo Imaging of Tissue Absorption, Scattering, and Hemoglobin Concentration in Rat Cortex Using Spatially Modulated Structured Light. In Frostig, R.D. (Ed.) In vivo optical imaging of brain function (second edition), CRC Press, 2009.
Frostig, R.D. C. In Rectore M. and George D.J. (Eds.) Light Scattering imaging of neuronal tissue function, Humana Press, 2004.
Frostig, R.D., Chen-Bee, C. and Polley, D.B. Visualizing adult cortical plasticity using intrinsic signal optical imaging. In: Frostig R.D. (Ed.) In vivo optical imaging of brain function, CRC Press, 2002.
Frostig, R.D. The use of in vivo intrinsic signal imaging for visualization of the functional organization of the brain. Neuroprotocols, 5, 35-41, 1994.
Frostig, R.D. What does in vivo optical imaging tell us about the primary visual cortex in primates? In: A. Petres and K.S. Rockland (Eds.) Primary Visual Cortex in Primates. Cerebral Cortex vol: 10, pp: 331-358, Plenum, 1994.
Frostig, R.D., Optical measurements of brain oxygenation: coupling with high resolution imaging of brain function. Functional MRI of the brain. The Society of Magnetic Resonance in Medicine, pp: 89 – 94, Berkeley, CA, 1993.
Frostig, R.D., Lieke, E.E., Arieli, A, Ts’o D.Y., Hildesheim, R. and Grinvald, A. Optical imaging of neuronal activity in the living brain. In: J. Kruger (Ed.) Neuronal Cooperativity, Springer-Verlag, Berlin, 1991, pp. 30-51.
Grinvald, A, Ts’o D.Y., Frostig, R.D., Lieke, E.E., Arieli, A. and Hildeshiem, R. Optical imaging of neuronal activity in the brain. Proceedings of the retina research foundation symposium, 117-136, 1989.
Lieke, E.E., Frostig, R.D., Arieli, A, Ts’o, D.Y., Hildesheim, R. and Grinvald, A. Optical Imaging of Cortical Activity. Annual Review of Physiology, 51:543-559, 1989
Grinvald, A., Frostig, R.D., Lieke, E.E., and Hildesheim, R. Optical Imaging of Neuronal Activity. Physiological Reviews, 68:1285-1366, 1988.
Harper, R.M., Frysinger, R.C., Marks, J.D. Zhang, J.X. and Frostig, R.D. Forebrain control of the respiratory rhythm. In: A.L. Bianchi and M. Saubie (Eds.), Neurogenesis of the respiratory Rhythm, MTP Press Ltd., Boston, 1985, pp. 91-98.