Filtrated common functional principal component analysis of multigroup functional data

Shuhao Jiao. Ron Frostig. Hernando Ombao. “Filtrated common functional principal component analysis of multigroup functional data.” Ann. Appl. Stat. 18 (2) 1160 – 1177, June 2024. https://doi.org/10.1214/23-AOAS1827

Astrocyte-neuron lactate shuttle plays a pivotal role in sensory-based neuroprotection in a rat model of permanent middle cerebral artery occlusion

Bhatti, M. S. Frostig R.D. Astrocyte-neuron lactate shuttle plays a pivotal role in sensory-based neuroprotection in a rat model of permanent middle cerebral artery occlusion. In press, Scientific Reports 2023

Development of highly sensitive, flexible dual L-glutamate and GABA microsensors for in vivo brain sensing

Chu, S.S., Nguyen, H.A., Lin, D., Bhatti, M. Jones-Tinsley, C.E., Do, A.H., Frostig, R.D.,Nenadic, Z., Xu, X., Lim, M.M., Cao H. Development of highly sensitive, flexible dual L-glutamate and GABA microsensors for in vivo brain sensing. Biosensors and Bioelectronics, doi.org/10.1016/j.bios.2022.11494

Variation pattern classification of functional data

Jiao, S. Frostig R.D. and Ombao, H. Variation pattern classification of functional data. Canadian Journal of Statistics, doi.org/10.1002/cjs.11738

Head implant for the neuroimaging of awake, head-fixed rats

Bhatti, M.S., Malone., H., Hui, G., and Frostig, R.D. Head implant for the neuroimaging of awake, head-fixed rats. Journal of Visual Experiment (JOVE), doi: 10.3791/64324

Break point detection for functional covariance

Jiao, S. Frostig R.D., Ombao, H. Break point detection for functional covariance.Scandinavian Journal of Statistics, 1-36

Sensory stimulation-based protection from impending stroke following MCA occlusion is correlated with desynchronization of widespread spontaneous local field potentials

Rasheed, W., Wodeyar, A., Srinivasan, R. and Frostig, R.D. Sensory stimulation-based protection from impending stroke following MCA occlusion is correlated with desynchronization of widespread spontaneous local field potentials. Scientific Reports doi.org/10.1038/s41598-022-05604-112:1744

Intrinsic signal optical imaging (ISOI): state-of-the-art with emphasis on pre-clinical and clinical studies

Frostig, R.D. Intrinsic signal optical imaging (ISOI): state-of-the-art with emphasis on pre-clinical and clinical studies. In: Tsytsarev, Vassiliy (Ed.), Functional Brain Mapping: Methods and Aims, Springer, 2020

Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia

Wann, E.G., Wodeyar, A., Srinivasan, R. and Frostig, R.D. Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia. Scientific Reports, DOI: 10.1038/s41598-020-78179-4

Modeling Spectral Properties in Stationary Processes of Varying Dimensions with Applications to Brain Local Field Potential Signals

Sundararajan, R.R., Frostig, R.D. and Ombao, H. Modeling Spectral Properties in Stationary Processes of Varying Dimensions with Applications to Brain Local Field Potential Signals. Entropy, 22, 1375; doi:10.3390/e22121375

Regularized matrix data clustering and its application to image analysis

Gao, X., Shen, W., Zhang, L., Hu, J., Fortin, N.J., Frostig, R.D. and Ombao, H. Regularized matrix data clustering and its application to image analysis. Biometrics, 1-13

Spatiotemporal dynamics of pial collateral blood flow following permanent middle cerebral artery occlusion in a rat model of sensory-based protection: a Doppler optical coherence tomography study

Zhu, J., Hancock, A.M., Qi. L., Telkmann, K., Shahbaba, B., Chen , Z. and Frostig, R.D. Spatiotemporal dynamics of pial collateral blood flow following permanent middle cerebral artery occlusion in a rat model of sensory-based protection: a Doppler optical coherence tomography study. Neurophotonics 6(4), 045012 (2019), doi: 10.1117/1. NPh.6.4.045012

Modeling non-linear spectral domain dependence using copulas with applications to rat local field potentials

Fontaine, C., Frostig, R.D. and Ombao, H. Modeling non-linear spectral domain dependence using copulas with applications to rat local field potentials. Econometrics and Statistics, https://doi.org/10.1016/j.ecosta.2019.06.003

Long-Range, Border-Crossing, Horizontal Axon Radiations Are a Common Feature of Rat Neocortical Regions That Differ in Cytoarchitecture

Johnson, B.A. and Frostig, R.D. Long-Range, Border-Crossing, Horizontal Axon Radiations Are a Common Feature of Rat Neocortical Regions That Differ in Cytoarchitecture. Frontiers in Neuroanatomy 12:50. doi: 10.3389/fnana.2018.00050, 2018

Testing the effects of sensory stimulation as a collateral-based therapeutic for ischemic stroke in C57BL/6J and CD1 mouse strains

Hancock, A.M. and Frostig, R.D. Testing the effects of sensory stimulation as a collateral-based therapeutic for ischemic stroke in C57BL/6J and CD1 mouse strains. PLoS ONE 12(9):e0183909. https://doi.org/10.1371/journal. pone.0183909. 2017

Imaging Cajal’s neuronal avalanche: how wide-field imaging of the point-spread advanced the understanding of neocortical structure-function relationship

Frostig, R.D., Chen-Bee, C.H., Johnson, B.A. and Jacobs, N.S. Imaging Cajal’s neuronal avalanche: how wide-field imaging of the point-spread advanced the understanding of neocortical structure-function relationship. Neurophotonics, DOI: 10.1117/1.NPh.4.3.031217, 2017

Prominent lateral spread of imaged evoked activity beyond cortical columns in barrel cortex provides foundation for coding whisker identity

Jacobs, N.S. and Frostig, R.D. Prominent lateral spread of imaged evoked activity beyond cortical columns in barrel cortex provides foundation for coding whisker identity. Neurophotonics, DOI: 10.1117/1.NPh.4.3.031218, 2017

Fully distributed blood flow velocity for middle cerebral arteries using Doppler optical coherence tomography

Qi, L., Zhu, J., Hancock, A.M., Dai, C., Zhang, X, Frostig, R.D. and Chen, Z. Fully distributed blood flow velocity for middle cerebral arteries using Doppler optical coherence tomography. Biomedical Optics Express, DOI: 10.1364/BOE.7.000601, 2016

Hyperspectral optical tomography of intrinsic signals in the rat cortex

Konecky, S.D., Wilson, R.H., Hagen, N., Mazhar, A., Tkaczyk, T.S., Frostig, R.D. and Tromberg, B.J. Hyperspectral optical tomography of intrinsic signals in the rat cortex. Neurophotonics, DOI: 10.1117/1.NPh.2.4.045003, 2015

Long, intrinsic horizontal axons radiating through and beyond rat barrel cortex have spatial distributions similar to horizontal spreads of activity evoked by whisker stimulation​

Johnson, B.A. and Frostig, R.D. Long, intrinsic horizontal axons radiating through and beyond rat barrel cortex have spatial distributions similar to horizontal spreads of activity evoked by whisker stimulation, Brain Structure Function DOI 10.1007/s00429-015-1123-7, 2015

Photonics meets connectomics: case of diffuse, long horizontal projections in rat cortex​

Johnson, B.A. and Frostig R.D. Photonics meets connectomics: case of diffuse, long horizontal projections in rat cortex. Neurophotonics, doi:10.3389/fncir.2015.00034. eCollection 2015

Emergence of spatiotemporal invariance in large neuronal ensembles in rat barrel cortex

Jacobs, N.S., Chen-Bee, C.H. and Frostig R.D. Emergence of spatiotemporal invariance in large neuronal ensembles in rat barrel cortex. Frontiers in Neural Circuits, 9:34. doi: 10.3389/fncir.2015.00034. eCollection 2015

Complete protection from impending stroke following permanent middle cerebral artery occlusion in awake, behaving rats

Lay, C. C. and Frostig, R.D. Complete protection from impending stroke following permanent middle cerebral artery occlusion in awake, behaving rats. European Journal of Neuroscience, doi:10.1111/ejn.12723, 2014

Unimodal primary sensory cortices are directly connected by long-range horizontal projections in the rat sensory cortex

Stehberg, J. Dang, P.T. and Frostig, R.D.Unimodal primary sensory cortices are directly connected by long-range horizontal projections in the rat sensory cortex. Frontiers in Neuroantomy, doi:10.3389/fnana, 2014

Sensory stimulation-based complete protection from ischemic stroke remains stable at 4 months post-occlusion of MCA

Hancock, A.M., Lay, C.C., Davis, M.F. and Frostig, R.D. Sensory stimulation-based complete protection from ischemic stroke remains stable at 4 months post-occlusion of MCA. Journal of Neurological Disorders, 1: 135. doi:10.4172/2329-6895.1000135, 2013

Complete sensory-induced protection from ischemic stroke under isoflurane anesthesia

Lay, C.C., Jacobs, N., Hancock, A.M., Zhou, Y. and Frostig, R.D. Complete sensory-induced protection from ischemic stroke under isoflurane anesthesia. doi: 10.1111/ejn.12217. European Journal of Neuroscience, 2013

Permanent Cerebral Vessel Occlusion Via Double Ligature and Transection

Davis, M.F., Lay, C., and Frostig, R.D. Permanent Cerebral Vessel Occlusion Via Double Ligature and Transection. Journal of Visualized Experiments, e50418, doi:10.3791/50418, 2013

Whisker array functional representation in the rat barrel cortex: transcendence of one-to-one topography and its underlying mechanism

Chen-Bee, C.H., Zhou, Y, Jacobs, N., Lim, B. and Frostig, R.D. Whisker array functional representation in the rat barrel cortex: transcendence of one-to-one topography and its underlying mechanism. Frontiers in Neural Circuits, doi: 10.3389/fncir, 2012

A rat’s whiskers point the way towards a novel stimulus-dependent, protective stroke therapy

Frostig, R.D. Lay, C., and Davis, M.F. A rat’s whiskers point the way towards a novel stimulus-dependent, protective stroke therapy. The Neuroscientist, DOI: 10.1177/1073858412462607, 2012

The use of intrinsic signal optical imaging for mapping cortical function

Frostig, R.D. and Chen-Bee, C.H. The use of intrinsic signal optical imaging for mapping cortical function. In: Romain Brette, Alain Destexhe (Eds.) Handbook of Neuronal Activity Measurements. Cambridge University Press, 2012

Mild sensory stimulation protects the aged rodent from cortical ischemic stroke after permanent middle cerebral artery occlusion

Christopher C. Lay, Melissa F. Davis, Cynthia H. Chen-Bee and Ron D. Frostig. Mild sensory stimulation protects the aged rodent from cortical ischemic stroke after permanent middle cerebral artery occlusion. Journal of the American Heart Association (JAHA), doi: 10.1161/JAHA.112.001255; 2012

Mild sensory stimulation reestablishes cortical function during the acute phase of ischemia​

Christopher C. Lay, Melissa F. Davis, Cynthia H. Chen-Bee and Ron D. Frostig. Mild sensory stimulation reestablishes cortical function during the acute phase of ischemia. Journal of Neuroscience, 31(32):11495–11504; 2011

The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: Effects of whisker use

Gomez-Pinilla Fernando, Ying Zhe. Agoncilloa Teodora and Ron D Frostig. The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: Effects of whisker use. Brain Research, 1388 39-47; 2011

Amount but not pattern of protective sensory stimulation alters recovery after permanent middle cerebral artery occlusion

Melissa F. Davis, Christopher C. Lay, Cynthia H. Chen-Bee and Ron D. Frostig. Amount but not pattern of protective sensory atimulation alters recovery after permanent middle cerebral artery occlusion. Stroke. 42;792-798; 2011

Intrinsic signal optical imaging of brain function using short stimulus delivery intervals

Chen-Bee, C.H., Agoncillo, T., Layc C.C., Frostig, R.D. Intrinsic signal optical imaging of brain function using short stimulus delivery intervals. Journal of Neuroscience Methods, 01(009), 2010

Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination

Abookasis D, Lay CC, Mathews MS, Linskey ME, Frostig RD, Tromberg BJ. Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination. Journal of Biomedical Optics, 14 (2): 024033, 2009

Large-scale organization of rat sensorimotor cortex based on a motif of large activation spreads

Frostig RD, Xiong Y, Chen-Bee CH, Kvasnák E, Stehberg J. Large-scale organization of rat sensorimotor cortex based on a motif of large activation spreads. Journal of Neuroscience, 28 (49): 13274-84, 2008

The tri-phasic intrinsic signal: implications for functional imaging

Chen-Bee, C.H., Agoncillo, T., Xiong, Y., Frostig, R.D. The tri-phasic intrinsic signal: implications for functional imaging. Journal of Neuroscience, 27 (17): 4572 – 4586, 2007

Functional organization and plasticity in the adult rat barrel cortex: moving out-of-the-box

Frostig, R.D., Functional organization and plasticity in the adult rat barrel cortex: moving out-of-the-box. Current Opinion in Neurobiology, 16:1-6, 2006

Whisker-based discrimination of object orientation determined with a rapid training paradigm

Polley, D.B., Rickert, J., and Frostig, R.D. Whisker-based discrimination of object orientation determined with a rapid training paradigm. Neurobiology of Learning and Memory, 83, 134-142, 2005

What has intrinsic signal optical imaging taught us about NGF-induced rapid plasticity in adult cortex and its relationship to the cholinergic system?

Prakash, N. and Frostig, R.D. What has intrinsic signal optical imaging taught us about NGF-induced rapid plasticity in adult cortex and its relationship to the cholinergic system? Molecular Imaging and Biology, 7, 14-21, 2005 (Epub 12-30, 2004)

Naturalisitic experience transforms sensory maps in the adult cortex of caged animals

Polley, D. B., Kvasnak, E. and Frostig, R.D. Naturalisitic experience transforms sensory maps in the adult cortex of caged animals. Nature, 429, 67-71, 2004

The basal forebrain cholinergic system is involved in rapid nerve growth factor (NGF)-induced plasticity in the barrel cortex of adult rats

Prakash, N., Cohen-Cory, S., Penschuck, S. and Frostig, R.D. The basal forebrain cholinergic system is involved in rapid nerve growth factor (NGF)-induced plasticity in the barrel cortex of adult rats. Journal of Neurophysiology, 91, 424-437, 2004. (Epub 09-24, 2003).

In vivo modulation of a cortical functional sensory representation shortly after topical cholinergic agent application

Penschuck, S., Chen-Bee, C., Prakash, N., and Frostig, R.D. In vivo modulation of a cortical functional sensory representation shortly after topical cholinergic agent application. Journal of Comparative Neurology , 452, 38-50, 2002

Comparing the functional representations of central and border whiskers in the rat primary somatosensory cortex

Brett-Green, B., Chen-Bee, C.H., and Frostig, R.D. Comparing the functional representations of central and border whiskers in the rat primary somatosensory cortex. Journal of Neuroscience, 15: 9944-9954, 2001

Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knockout mice revealed by in vivo functional imaging

Prakash, N., Vanderhaeghen, P., Cohen-Cory, S., Frisén., J., Flanagan, J.G., and Frostig, R.D. Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knockout mice revealed by in vivo functional imaging. Journal of Neuroscience, 20:5841-5847, 2000

A mapping label required for normal scale of body representation in the cortex

Vanderhaeghen, P., Lu, Q., Prakash, N., Frisen, J., Walsh , C.A. , Frostig, R.D., and Flanagan, J.G. A mapping label required for normal scale of body representation in the cortex. Nature Neuroscience, 3:358-365, 2000

Visualizing and quantifying evoked cortical activity assessed with intrinsic signal imaging

Chen-Bee, C., Polley, D.B., Brett-Green, B., Prakash, N., Kwon, M.C. and Frostig, R.D. Visualizing and quantifying evoked cortical activity assessed with intrinsic signal imaging. Journal of Neuroscience Methods, 97:157-173, 2000

Two directions of plasticity in the sensory-deprived adult cortex

Polley, D.B., Chen-Bee, C., and Frostig, R.D. Two directions of plasticity in the sensory-deprived adult cortex.Neuron, 24:623-637, 1999

Optical Doppler Tomography

Chen, Z., Zhao, Y., Srinivas, S., Nelson, J.S., Prakash, N., and Frostig, R.D. Optical Doppler Tomography. IEEE Journal of Selected Topics in Quantum Electronics, 1134-1142, 1999

Varying the degree of single whisker stimulation differentially affects phases of intrinsic signals in rat barrel cortex

Polley, D.B., Chen-Bee, C. and Frostig, R.D. Varying the degree of single whisker stimulation differentially affects phases of intrinsic signals in rat barrel cortex. Journal of Neurophysiology, 81:692-701,1999

Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo

Prakash, N., Cohen-Cory, S. and Frostig, R.D. Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo. Nature, 381: 702-706, 1996

Variability and interhemispheric asymmetry of the single-whisker functional representations in rat barrel cortex

Chen-Bee, C.H. and Frostig, R.D. Variability and interhemispheric asymmetry of the single-whisker functional representations in rat barrel cortex. Journal of Neurophysiology, 76:884-894, 1996

Areal extent quantification of functional representations using intrinsic signal optical imaging

Chen-Bee, C.H., Kwon, M., Masino , S.A. and Frostig, R.D. Areal extent quantification of functional representations using intrinsic signal optical imaging. Journal of Neuroscience Methods, 68:27-37, 1996

Quantitative long-term imaging of the functional representation of a whisker in rat barrel cortex

Masino , S.A. and Frostig, R.D. Quantitative long-term imaging of the functional representation of a whisker in rat barrel cortex. Proceedings of the National Academy of Science USA , 93, 4942-4947, 1996

Suprathreshold auditory cortex activation visualized by intrinsic signal optical imaging

Bakin, J.S., Kwon, M.C., Masino , S.A. , Weinberger , N.M. and Frostig, R.D. Suprathreshold auditory cortex activation visualized by intrinsic signal optical imaging. Cerebral Cortex, 6:120-130, 1996

Wavelet analysis for brain function imaging

Carmona, R.A., Hwang, W, L. and Frostig R.D. Wavelet analysis for brain function imaging. IEEE Transactions on Medical Imaging, 14:556-564, 1995

Using Light to Probe the Brain: Intrinsic Signal Optical Imaging

Frostig review 1995 Int J Imaging Syst Tech – Summer ‐ Autumn Fall 1995 – Frostig – Using light to probe the brain Intrinsic signal optical

Cortical point-spread function and long-range lateral interactions revealed by real-time optical imaging of macaque monkey primary visual cortex

Grinvald, A., Lieke, E.E., Frostig, R.D., Hildesheim, R. Cortical point-spread function and long-range lateral interactions revealed by real-time optical imaging of macaque monkey primary visual cortex. Journal of Neuroscience, 14, 2545- 2568, 1994

Characterization of functional organization within rat barrel cortex using intrinsic signal optical imaging through a thinned skull

Masino, S., Kwon, M.C., Dory, Y. and Frostig, R.D. Characterization of functional organization within rat barrel cortex using intrinsic signal optical imaging through a thinned skull. Proceedings of the National Academy of Science USA , 90, 9998-10002,1993

High resolution optical imaging of functional brain architecture in the awake monkey

Grinvald, A., Frostig, R.D., Siegel, R.M. and Bartfeld, E. High resolution optical imaging of functional brain architecture in the awake monkey. Proceedings of the National Academy of Science USA , 88, 11559-11563, 1991

Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high resolution optical imaging of intrinsic signals

Frostig, R.D., Lieke, E.E., Ts’o, D.Y. and Grinvald, A. Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high resolution optical imaging of intrinsic signals. Proceedings of the National Academy of Science USA , 87, 6082-6086, 1990

Functional organization of the primate visual cortex revealed by high-resolution optical imaging of intrinsic signals

Ts’o, D.Y., Frostig, R.D., Lieke, E.E. and Grinvald, A. Functional organization of the primate visual cortex revealed by high-resolution optical imaging of intrinsic signals. Science, 249, 417-420, 1990

Codes embedded in neuronal activity

Frostig, R.D. Codes embedded in neuronal activity. Notes on Theoretical Biology, 1: 57-74

Recurring discharge patterns in multiple spike trains. II. Application in forebrain areas related to cardiac and respiratory control during different sleep waking states

Frostig, R.D., Frysinger, R.C. and Harper, R.M. Recurring discharge patterns in multiple spike trains.    II. Application in forebrain areas related to cardiac and respiratory control during different sleep waking states. Biological Cybernetics, 62:495-502

Recurring discharge patterns in multiple spike trains. I. Detection

Frostig, R.D., Frostig, Z. and Harper, R.M. Recurring discharge patterns in multiple spike trains. I.   Detection. Biological Cybernetics, 62:487-493

Analysis of frequency components in time series data

Frostig, Z, Frostig, R.D.   Analysis of frequency components in time series data. Journal of Neuroscience Methods, 22:79-87

Functional architecture of the cortex revealed by optical imaging of intrinsic signals

Grinvald, A., Lieke, E., Frostig, R.D., Gilbert, C.D. and Wiesel, T.N. Functional architecture of the cortex revealed by optical imaging of intrinsic signals. Nature, 324:361-364, 1986

Information Trains. The technique and its uses in spike train and network analysis, with examples taken from the nucleus parabrachialis medialis during sleep-waking states

Frostig, R.D., Frostig, Z. and Harper, R.M. Information Trains. The technique and its uses in spike train and network analysis, with examples taken from the nucleus parabrachialis medialis during sleep-waking states. Brain Research, 322:67-74

The effect of stimuli on the activity and functional connectivity of local neuronal groups in the cat auditory cortex

Frostig, R.D., Gottlieb, Y., Vaadia, E. and Abeles, M. The effect of stimuli on the activity and functional connectivity of local neuronal groups in the cat auditory cortex. Brain Research, 272:211-221

Primary afferents and spinal sensory neurons that respond to brief pulses of intense infrared laser radiation: a preliminary survey in rats

Devor, M., Carmon, A. and Frostig, R.D. Primary afferents and spinal sensory neurons that respond to brief pulses of intense infrared laser radiation: a preliminary survey in rats. Experimental Neurology, 76:483-494,

Noxious stimulation of animals by brief intense laser induced heat: advantage to pharmacological testing of analgetics

Carmon, A. and Frostig, R.D. Noxious stimulation of animals by brief intense laser induced heat: advantage to pharmacological testing of analgetics. Life Science, 29:11-16