1. Patil SV, Kaipa BR, Ranshing S, Sundaresan Y, Millar JC, Nagarajan B, Kiehlbauch C, Zhang Q, Jain A, Searby CC, Scheetz TE, Clark AF, Sheffield VC, Zode GS. Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma. Sci Rep. 2024 Mar 23;14(1):6958. doi: 10.1038/s41598-024-57286-6. PubMed PMID: 38521856; PubMed Central PMCID: PMC10960846.

2. Patel PD, Chen YL, Kasetti RB, Maddineni P, Mayhew W, Millar JC, Ellis DZ, Sonkusare SK, Zode GS*. Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16). doi: 10.1073/pnas.2022461118. PubMed PMID: 33853948; PubMed Central PMCID: PMC8072326.

3. Kasetti RB, Maddineni P, Kiehlbauch C, Patil S, Searby CC, Levine B, Sheffield VC, Zode GS*. Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin. JCI Insight. 2021 Mar 8;6(5). doi: 10.1172/jci.insight.143359. PubMed PMID: 33539326; PubMed Central PMCID: PMC8021112.

4. Maddineni P, Kasetti RB, Patel PD, Millar JC, Kiehlbauch C, Clark AF, Zode GS*. CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma. Mol Neurodegener. 2020;15(1):48. Epub 2020/08/29. doi: 10.1186/s13024-020-00400-9. PMC7457267

5. Kasetti RB, Maddineni P,Patel P, Millar JC, Searby CC, Sheffield VC and Zode GS*. ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load.  In press; Nature Communications 2020. doi:10.1038/s41467-020-19352-1.

6.  Kasetti RB, Maddineni P, Patel P, Millar JC, Phan TP, Searby CC, Clark AF, Sheffield VC and Zode GS*, TGFβ2 signaling regulates glucocorticoid-induced ocular hypertension via induction of abnormal ECM accumulation and ER stress in the trabecular meshwork. J Biol Chem. 2018 Jun 22;293(25):9854-9868. doi: 10.1074/jbc.RA118.002540. Epub 2018 May 9.PMID:29743238

7. Jain A, Zode G*, Kasetti RB, Ran FA, Yan W, Sharma TP, Bugge K, Searby CC, Fingert JH, Zhang F, Clark AF, Sheffield VC*. CRISPR-Cas9-based treatment of myocilin-associated glaucoma. Proc Natl Acad Sci U S A. 2017. doi: 10.1073/pnas.1706193114. PubMed PMID: 28973933.

8.  Patel GC, Phan TN, Maddineni P, Kasetti RB, Millar JC, Clark AF*, and Zode GS,*  Dexamethasone-induced ocular hypertension in mice: Effects of myocilin and route of administration,  Am J Pathol. 2017 Apr;187(4):713-723. doi: 10.1016/j.ajpath.2016.12.003. Epub 2017 Feb 4.

9. Peters JC, Bhattacharya S, Clark AF, Zode GS. Increased Endoplasmic Reticulum Stress in Human Glaucomatous Trabecular Meshwork Cells and Tissues. Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3860-8. doi: 10.1167/iovs.14-16220. PubMed PMID: 26066753; PubMed Central PMCID: PMC4468426.

10. Zode GS*, Sharma AB, Nishimura DY, Searby CC, Stone, E.M., and Sheffield, V.C*.  Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma. J Clin Invest. 2014 May;124(5):1956-65. Epub 2014 Apr 1.

11.  Zode, G.S., Bugge, K.E., Mohan, K., Grozdanic, S.D., Peters, J.C., Koehn, D.R., Anderson, M.G., Kardon, R.H., Stone, E.M., and Sheffield, V.C. Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open angle glaucoma. Invest Ophthalmol Vis Sci. 2012.

12. Zode GS, Kuehn MH, Nishimura DY, Searby CC, Mohan K, Grozdanic SD, et al. Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma. J Clin Invest.121(9):3542-53. PMCID: 3163970.