If you want to know more about chemoresistance to gemcitabine in pancreatic cancer, look no further. You will also find some great figures to use for your future talk needs here: https://journals.physiology.org/doi/full/10.1152/ajpcell.00331.2022?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
News
Our Nature Cancer metabolic heterogeneity paper is (finally!) out
We show that (1) metabolic subtypes exist within pancreatic tumors, (2) these populations exchange nutrients to support each other, (3) among these, asparagine can support mitochondrial metabolism, (4) degradation of asparagine enhances mitochondrial targeting, and (5) the differences in metabolism between clones are due to a constitutive vs. inducible stress response. Check it all out here: https://www.nature.com/articles/s43018-022-00463-1
Alica gave a fantastic short talk at the AACR Special Conference on Pancreatic Cancer
Alica gave a great talk on chemoresistance at the AACR Special Conference on Pancreatic Cancer
We have received a UCI Anti-Cancer Challenge Pilot Grant
This funding will allow us to build out our investigation of the primary vs. metastatic niche in pancreatic cancer.