Our research focuses on understanding the mechanisms that allow for the generation of alternative splicing patterns. Our long-term goals are to understand how these processes are regulated, to relate the basic mechanisms of splice-site recognition to biological processes and to identify strategies to manipulate the expression of splicing isoforms in disease genes. To achieve these goals, we use a wide variety of approaches that include biochemistry, genetics, deep sequencing and bioinformatics.
We are an interdisciplinary team with expertise in molecular biology, computational biology and physical chemistry. We welcome questions and inquiries about our work.