News

The Inlay lab is happy to announce a new publication from our lab in EMBO Molecular Medicine. The title of the article is, “Graft conditioning with fluticasone propionate reduces graft-versus-host disease upon allogeneic hematopoietic cell transplantation in mice“. In this article, we show that culturing donor graft cells in the glucocorticoid fluticasone propionate has two important effects that can improve bone marrow transplantation. First, the hematopoietic stem cells (HSCs) in the graft have increased engraftment potential upon transplantation. Second, if the graft is mismatched from the host, there is a reduction in Graft-versus-Host Disease (GvHD), a complication whereby immune cells in the graft can attack the patient after transplantation. The project was spearheaded by Erika Varady, a former Ph.D. student in the lab, and Angel Ayala, a current Ph.D. student. Erika and Angel share co-first authorship of this manuscript. Additional co-authors include collaborators Professor Craig Walsh and his former Ph.D. student Scott Greilach, who assisted with the design and implementation of many of the experiments and provided critical insight on T cell biology. Vanessa Scarfone and Pauline Nguyen from the Stem Cell Research Center’s Flow Cytometry Core were also essential for the completion of the project. Additional collaborators include Cuiwen Zhou, an undergraduate researcher in the lab and the lab manager, Alborz Karimzadeh, a former Ph.D. student that trained Erika and helped with the early HSC experiments, and Xiyu Chen, a former masters student who assisted with the GvHD projects. Much of the funding for this project was provided by a generous gift from the Oxnard Foundation. A link to the original publication can be found here:

https://doi.org/10.15252/emmm.202317748