Liz’s study shows that chronic elimination of microglia from AD models does not affect plaques or amyloid, showing that microglia are not key clearance mechanisms, but that their elimination improves cognition, reduces neuroinflammation, restores dendritic spine densities, and fully prevents neurons dying as a result of the amyloid pathology.
Chronic elimination of microglia in the 5xfAD mouse model of Alzheimer’s disease attenuates dendritic spine loss and cognitive impairments without modulating amyloid pathology.
Spangenberg EE, Rice RA, Elmore MRP, Blurton-Jones M, West BL, Green KN. Brain. In Press Click Here to Download