2022
Daruwalla A, Sui X, Kiser PD. Preparation of carotenoid cleavage dioxygenases for X-ray crystallography. Methods Enzymol. 2022;671:243-71. doi: 10.1016/bs.mie.2021.10.020.
Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure. 2022;30(2):263-77 e5. doi: 10.1016/j.str.2021.10.002.
2021
Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021;6(9). doi: 10.1172/jci.insight.146604.
Kiser PD. Retinal Pigment Epithelium 65 kDa Protein (RPE65): An Update. Prog Retin Eye Res. 2021:101013. doi: 10.1016/j.preteyeres.2021.101013.
Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA, Consortium L, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, Vincent A, Mahroo OA, Kiser PD, Petersen-Jones SM. A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Hum Mol Genet. 2021. doi: 10.1093/hmg/ddab316.
Kiser PD, Palczewski K. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. J Biol Chem. 2021;296:100072. doi: 10.1074/jbc.REV120.014405.
Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. Function of mammalian M-cones depends on the level of CRALBP in Muller cells. J Gen Physiol. 2021;153(1). doi: 10.1085/jgp.202012675.
York NJ, Lockart MM, Sardar S, Khadka N, Shi W, Stenkamp RE, Zhang J, Kiser PD, Pierce BS. Structure of 3-mercaptopropionic acid dioxygenase with a substrate analog reveals bidentate substrate binding at the iron center. J Biol Chem. 2021:100492. doi: 10.1016/j.jbc.2021.100492.
Bandara S, Thomas LD, Ramkumar S, Khadka N, Kiser PD, Golczak M, von Lintig J. The Structural and Biochemical Basis of Apocarotenoid Processing by beta-Carotene Oxygenase-2. ACS Chem Biol. 2021;16(3):480-90. doi: 10.1021/acschembio.0c00832.
Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, Palczewski K. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol. 2021;220(8). doi: 10.1083/jcb.202101063.
Blum E, Zhang J, Zaluski J, Einstein DE, Korshin E, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. Rational alteration of pharmacokinetics of chiral fluorinated and deuterated derivatives of emixustat for retina therapies. J Med Chem. 2021;64(12):8287-302. doi: doi/10.1021/acs.jmedchem.1c00279.
Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021;5(2):169-78. doi: 10.1038/s41551-020-00632-6.
2020
Daruwalla A, Zhang J, Lee HJ, Khadka N, Farquhar ER, Shi W, von Lintig J, Kiser PD. Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase. Proc Natl Acad Sci U S A. 2020;117(33):19914-25. doi: 10.1073/pnas.2004116117.
Thomas LD, Bandara S, Parmar VM, Srinivasagan R, Khadka N, Golczak M, Kiser PD, von Lintig J. The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids. J Biol Chem. 2020;295(46):15553-65. doi: 10.1074/jbc.RA120.015515.
Gazda MA, Toomey MB, Araujo PM, Lopes RJ, Afonso S, Myers CA, Serres K, Kiser PD, Hill GE, Corbo JC, Carneiro M. Genetic Basis of De Novo Appearance of Carotenoid Ornamentation in Bare-Parts of Canaries. Mol Biol Evol. 2020;37(5):1317-28. doi: 10.1093/molbev/msaa006.
Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. FASEB J. 2020;34(10):13918-34. doi: 10.1096/fj.202000796RR.
Palczewski K, Kiser PD. Shedding new light on the generation of the visual chromophore. Proc Natl Acad Sci U S A. 2020;117(33):19629-38. doi: 10.1073/pnas.2008211117.
2019
Khadka N, Farquhar ER, Hill HE, Shi W, von Lintig J, Kiser PD. Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J Biol Chem. 2019;294(27):10596-606. doi: 10.1074/jbc.RA119.007535.
Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019;33(4):fj201802493R. doi: 10.1096/fj.201802493R.
Silvaroli JA, Widjaja-Adhi MAK, Trischman T, Chelstowska S, Horwitz S, Banerjee S, Kiser PD, Blaner WS, Golczak M. Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1. ACS Chem Biol. 2019;14(3):434-48. doi: 10.1021/acschembio.8b01070.
Daruwalla A, Kiser PD. Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs). Biochim Biophys Acta Mol Cell Biol Lipids. 2019:158590. doi: 10.1016/j.bbalip.2019.158590.
Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019;294(50):19137-54. doi: 10.1074/jbc.RA119.011169.
Montano MM, Yeh IJ, Chen Y, Hernandez C, Kiselar JG, de la Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, Lawes MC. Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. Breast Cancer Res. 2019;21(1):138. doi: 10.1186/s13058-019-1228-7.
Kiser PD. Alkene-cleaving carotenoid cleavage dioxygenases. In: Scott RA, editor. Encyclopedia of Inorganic and Bioinorganic Chemistry: John Wiley & Sons, Ltd; 2019. p. 1-13. doi: 10.1002/9781119951438.eibc2702
2018
Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018;475(20):3171-88. doi: 10.1042/BCJ20180193.
Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018;150(4):571-90. doi: 10.1085/jgp.201711815.
Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018;9(1):1996. doi: 10.1038/s41467-018-04432-0.
Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018;27(13):2225-43. doi: 10.1093/hmg/ddy128.
Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018;364(2):207-20. doi: 10.1124/jpet.117.245167.
Kelly ME, Ramkumar S, Sun W, Colon Ortiz C, Kiser PD, Golczak M, von Lintig J. The Biochemical Basis of Vitamin A Production from the Asymmetric Carotenoid beta-Cryptoxanthin. ACS Chem Biol. 2018;13(8):2121-9. doi: 10.1021/acschembio.8b00290.
Sui X, Farquhar ER, Hill HE, von Lintig J, Shi W, Kiser PD. Preparation and characterization of metal-substituted carotenoid cleavage oxygenases. J Biol Inorg Chem. 2018;23(6):887-901. doi: 10.1007/s00775-018-1586-0.
