2019
314. “Ferrocene-based metal–organic framework nanosheets loaded with palladium as a super-high active hydrogenation catalyst.” Zheng Deng, Haojie Yu, Li Wang, Jiyang Liua and Kenneth J. Shea, J. Mater. Chem. A, 2019, 7, 15975-15980.
313. “Dyeing and Functionalization of Wearable Silk Fibroin/Cellulose Composite by Nanocolloidal Array” Dan Yan, Lili Qiu, Kenneth J. Shea, Zihui Meng† and Min Xue, ACS Appl. Mater. Interfaces, 2019,11, 42, 39163-39170.
312. “Engineering the binding kinetics of synthetic polymer nanoparticles for siRNA delivery” Hiroyuki Koide, Tatsuya Fukuta, Anna Okishima, Saki Ariizumi, Chiaki Kiyokawa, Hiroki Tsuchida, Masahiko Nakamoto, Keiichi Yoshimatsu, Hidenori Ando, Takehisa Dewa, Tomohiro Asai, Naoto Oku, Yu Hoshino, and Kenneth J. Shea, Biomacromolecules, 2019, 20, 3648-3657.
- “A Metabolite Responsive Nanoparticle-Protein Complex.” Krista Fruehauf, Tae Il Kim, Edward Nelson, Joseph P. Patterson, Szu-Wen Wang and Kenneth J. Shea, Biomacromolecules, 2019, 20, 2703-2712.
- “Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle” Hiroyuki Koide†, Keiichi Yoshimatsu, Yu Hoshino, Saki Ariizumi, Anna Okishima, Takafumi Ide, Hiromichi Egami, Yoshitaka Hamashima, Yuri Nishimura, Yoshiko Miura, Tomohiro Asai, Naoto Oku, and Kenneth J. Shea, Journal of Controlled Release, 2019, 295, 13-20.
2018
- Redox/temperature responsive nonionic nanogel and photonic crystal hydrogel: Comparison between N, N’-Bis(acryloyl)cystamine and N, N’-methylenebisacrylamide, Li, Xueting; Yuan, Shuchang; Shea, Kenneth J.; Qiu, Gao; Lu, Xihua; Zhang, Ruiyun, Polymer, 2018, 137, 112-121.
Redox/temperature responsive poly(N-isopropylacrylamide/N-hydroxyethylacrylamide) (P(NIPA/HEAA)) nonionic nanogels (NP-BAC) crosslinked with N,N′-Bis(acryloyl)cystamine (BAC) have been prepared. An analogous nanogel incorporating N,N′-methylenebisacrylamine (BIS), a reduction-insensitive nanogel (NP-BIS), was chosen as a control nanogel. Compared to the nondegradable NP-BIS nanogel, NP-BAC nanogel particles were found to swell and become less dense due to cleavage of disulfide bonds in BAC. Interestingly, the NP-BAC nanogels preserved their spherical shape after reduction. When loaded with the drug propranolol, NP-BAC nanogels showed accelerated drug release in the presence of 1,4-dithiothreitol (DTT), with rate of release controlled by the DTT concentration. Furthermore, the liquid-crystal-glass
- Self-assembly of a nano hydrogel colloidal array for the sensing of humidity, Wang, Zhe; Xue, Min; Zhang, Herong; Meng, Zihui; Shea, Kenneth J.; Qiu, Lili; Ji, Tiantian; Xie, Tengsheng, RSC Advances, 2018, 8, 9963-9969.
- “Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis.” Jeffrey O’Brien, Shih-Hui Lee, José María Gutiérrez*, Kenneth J. Shea*, PLOS Neglected Tropical Diseases, 2018, 12, e0006736. https://doi.org/10.1371/journal. pntd.0006736.
- “A synthetic polymer affinity ligand for Bacillus thuringiensis (Bt) Cry1Ab/Ac protein. The use of biomimicry based on Bt protein-insect receptor binding mechanism.” Mingming Liu*, Rong Huang, Adam Weisman, Xiaoyang Yu, Shih-Hui Lee, Yalu Chen, Chao Huang, Senhua Hu, Xiuhua Chen, Wenfeng Tan, Fan Liu. Hao Chen, Kenneth J. Shea,, Journal of the American Chemical Society, 2018, 140, 6853−6864. Read the paper here.
- “Preparation of redox- and photo-responsive ferrocene- and azobenzene-based polymer films and their properties.” Xia Xia, HaojieYu, Li Wang, Zheng Deng, Kenneth J.Shea, Zain-ul-Abdin, European Polymer Journal, 2018, 100, 103-110.
Polymer films made by ferrocene- and azobenzene-based polymers are redox- and photo-responsive. These films have broad application prospects in the future for high density information storage.
2017
304. “Efficient capture, rapid killing and ultrasensitive detection of bacteria by a nano-decorated multi-functional electrode sensor”, Runrun Wu, Yue Maa, Jianming Pan, Shih-Hui Lee, Jinxin Liu, Hengjia Zhu, Runxin Gu, Kenneth J. Shea and Guoqing Pan, Biosensors and Bioelectronics, 2017,101, 52–59.
Fig. 1. Schematic illustration of the one-pot fabrication procedure of prickly Zn-CuO@GO nano-decorated porous Ni electrode via facile green sonochemical method.
303. “”Synthesis of poly(methylene-b-ε-caprolactone) and poly(ε-caprolactone) with linear alkyl end groups. Synthesis, characterization, phase behavior and compatibilization efficacy.” José E. Báez, Ruobing Zhao, Kenneth J. Shea, Industrial & Engineering Chemistry Research, 2017, 56, 10366- 10386.
- “Self assembly of the polymer brush-grafted silica colloidal for the recognition of proteins” Zihui Meng Analytical and Bioanalytical Chemistry, 2017, 409, 5319-5326.
Colloidal array self-assembled by polymer brush-grafted silica for proteins detection
301. “Synthetic Polymer Protein Affinity Reagents. A Polymer Nanoparticle with Engineered Affinity for a Vascular Endothelial Growth Factor (VEGF165), Hiroyuki Koide, Keiichi Yoshimatsu, Yu Hoshino, Shih-Hui Lee, Ai Okajima, Saki Ariizumi, Yudai Narita, Yusuke Yonamine, Adam C. Weisman, Yuri Nishimura, Naoto Oku1, Yoshiko Miura, and Kenneth J. Shea, Nature Chemistry, 2017, 9, 715 –722.
2016
300. “Coordination-bond-driven fabrication of crack-free photonic crystals”. Shi, X. D.; Liu, W. Y.; Zhao,D.; Li, X. T.; Dou, R. M.; Shea, K. J.; Lu, X. H. J. Mater. Chem. C, 2016, 4, 7208-7214, DOI: https://doi.org/10.1039/C6TC01792D
299, Synthesis of surfactant-free hydroxypropyl methylcellulose nanogels for controlled release of insulin, Zhao, Di; Shi, Xiaodi; Liu, Tianqun; Lu, Xihua; Qiu, Gao; Shea, Kenneth J. Carbohydrate Polymers, 2016, 151, 1006-1011.
298, “Preparation of high encapsulation efficiency fragrance microcapsules and their application in textiles” Zhao, Di; Jiao, Xin; Zhang, Miaomiao; Ye, Kai; Shi, Xiaodi; Lu, Xihua; Qiu, Gao; Shea, Kenneth J. RSC Advances, 2016, 6, 80924-80933.
297. “Molecular imprinted photonic crystal for sensing of biomolecules” Chen, Wei; Meng, Zihui; Xue, Min; Shea, Kenneth, J. Molecular Imprinting, 2016, 4, 1-12.
296. “Engineering the Protein Corona of a synthetic polymer nanoparticle for Broad-Spectrum Sequestration and Neutralization of Venomous Biomacromolecules,” Jeffrey O’Brien, Shih-Hui Lee, Shunsuke Onogi, Kenneth J. Shea, Journal of the American Chemical Society, 2016, 138 16604-16607.
295. “Biomimetic Design of Mussel-Derived Bioactive Peptides for Dual-functionalization of Titanium-Based Biomaterials.” Guoqing Pan*, Shujin Sun, Wen Zhang, Ruobing Zhao, Wenguo Cui, Fan He, Lixin Huang, Shih-Hui, Lee, Kenneth J. Shea, Huilin Yang* and Qin Shi.* Journal of the American Chemical Society, 2016, 138, 15078−15086.
294. “Measuring Protein Binding to Individual Hydrogel Nanoparticles with Single Nanoparticle SPRI Microscopy,” Adam M. Maley, Yuhei Terada, Shunsuke Onogi, Kenneth J. Shea, Yoshiko Miura and Robert M. Corn, The Journal of Physical Chemistry. Part C, 2016, 120, 16843 – 16849.
293. “A Convenient Controlled Aqueous C1 Synthesis of Long-chain Aliphatic AB, AA and BB Macromers for the Synthesis of Polyesters with Tunable Hydrocarbon Chain Segments.” Ruobing Zhao, Yan Zhang, Jaeyoon Chung and Kenneth J. Shea, ACS Macro Letters, 2016, 5, 1200–1210.
292. “A sol-gel derived pH-responsive bovine serum albumin molecularly imprinted poly(ionic liquids) on the surface of multiwall carbon nanotubes,” Mingming Liu, Jiangyan Pi, Xiaojie Wang, Rong Huang, Yamei Du, Xiaoyang Yu, Wenfeng Tan, Fan Liu, Kenneth J. Shea, Analytica Chimica Acta, 2016, 932, 29-40.
291. “Tuning the Protein Corona of Hydrogel Nanoparticles. The Synthesis of Abiotic Biomacromolecule Affinity Reagents.” Jeffrey O’Brien, Kenneth J. Shea, Accounts of Chemical Research, 2016, 49, 1200−1210.
290. “Tuning Hydrophobicity in an Abiotic Affinity Reagent. Polymer Hydrogel Affinity Reagents for Molecules with Lipid-like Domains.” Beverly Chou, Peter Mirau, Tian Jian, Szu-Wen Wang, and Kenneth J. Shea, Biomacromolecules, 2016, 17, 1860–1868.
289. “Design of Synthetic Polymer Nanoparticles that Facilitate Resolubilization and Refolding of Aggregated Proteins”, Masahiko Nakamoto, Tadashi Nonaka, Kenneth J. Shea, Yoshiko Miura, and Yu Hoshino, Journal of the American Chemical Society, 2016, 136, 4282–4285.
2015
288. “Polymerization mechanism of poly(ethylene glycol dimethacrylate) fragrance nanocapsules”, Di Zhao, Xin Jiao, Yao Zhang, Dong An, Xiaodi Shia, Xihua Lu, Gao Qiu and Kenneth J. Shea, RSC Adv., 2015, 5, 96067-96073.
287. “Preparation, properties and supercooling prevention of phase change material n-octadecane microcapsules with peppermint fragrance scent” Qian Wu, Di Zhao, Xin Jiao, Yao Zhang, Kenneth J. Shea, Xihua Lu, and , Gao Qiu, Ind. Eng. Chem. Res. 2015, 54, 8130−8136.
286. “Preparation, properties and supercooling prevention of phase change material n-octadecane microcapsules with peppermint fragrance scent” Qian Wu, Di Zhao, Xin Jiao, Yao Zhang, Kenneth J. Shea, Xihua Lu, and , Gao Qiu, Ind. Eng. Chem. Res. 2015, 54, 8130−8136.
285. “Bioinspired Lotus-like Self-Illuminous Coating”, Xiaodi Shi, Renmei Dou, Tianze Ma, Weiyi Liu, Xihua Lu, Kenneth J. Shea, Yanlin Song and Lei Jiang, ACS Appl. Mater. Interfaces 2015, 7, 18424−18428.
284. “Synthesis of surfactant-free hydroxypropylcellulose nanogel and its dual-responsive properties” Dong Ana, Di Zhaoa, Xueting Lia, Xihua Lua,b, Gao Qiub, Kenneth J. Shea, Carbohydrate Polymers, 2015, 134, 385–389.
283. “Chiral Polymers of Intrinsic Microporosity. The Selective Membrane Transport of Enantiomers Xilun Weng, José E. Baez, Mariya Khiterer, Madelene Y. Hoe, Zongbi Bao, Kenneth J. Shea, Angewandte Chemie, 2015, 54, in press.
282. “Polymeric antidotes for toxin sequestration” Adam Weisman, Beverly Chou, Jeffrey O’Brien, Kenneth J. Shea, Advanced Drug Delivery Reviews, 2015, 85, in press.
281. “A Gradient Methylidene-Ethylidene Copolymer via C1 Polymerization: an Ersatz Gradient Ethylene-Propylene Co-polymer,” Ruobing Zhao and Kenneth J. Shea, ACS Macro Letters, 2015, 4, 584 – 587.
280. “Monitoring Peptide Uptake in Single Hydrogel Nanoparticles with Near Infrared Surface Plasmon Resonance Microscopy,” Kyunghee Cho, Jennifer B. Wood, Keiichi Yoshimatsu, Kenneth J. Shea and Robert M. Corn*, Analytical Chemistry, 2015, 87, 4973–4979.
279. “Molecularly Imprinted Hollow Spheres for the Solid Phase Extraction of Estrogens”, Wei Chen, Min Xue, Fei Xue, Xiangrong Mu, Zhibin Xu, Zihui Meng, Xianxian Zhu, Kenneth J. Shea, Talanta, 2015, 140, 68-72.
278. “Design of Multi-functional Linear Polymers that Capture and Neutralize a Toxic Peptide: A Comparison with Cross-linked Nano-gel Particles”, Yusuke Wada, Haejoo Lee, Yu Hoshino, Shunsuke Kotani, Kenneth J. Shea, Yoshiko Miura, Journal of Materials Chemistry B, 2015, DOI: 10.1039/C4TB01967A.
277. “Studies Toward the Synthesis of (–)-Stenine. Leah Cleary, Victor W. Mak, Monica E. McCallum, Mandy M. Loo, Kenneth J. Shea, Tetrahedron Letters, 2015, 56, 3497-3499.
276. “Preparation and evaluation protocol for abiotic polymer nanoparticles for sequestration and neutralization of a target peptide toxin” Keiichi Yoshimatsu, Hiroyuki Koide , Yu Hoshino & Kenneth J. Shea, Nature Protocols, 2015, 10, 595–604. doi:10.1038/nprot.2015.032.
275. “Preparation of Nanogel-immobilized Porous Gel Beads for Affinity Separation of Proteins: Fusion of Nano and Micro Gel Materials”, Yu Hoshino, Yuka Arata, Yusuke Yonamine, Shih-Hui Lee, Aki Yamasaki, Ryousuke Tsuhara, Katsuhiko Yano, Kenneth J. Shea, Yoshiko Miura, Polymer Journal, 2015, 47, 220–225.
2014
274. ” Protein Recognition by a Surface Imprinted Colloidal Array”, Wei Chen, Wen Lei, Min Xue, Fei Xue, Zi-hui Meng, Wei-bing Zhang, Feng Quc and Kenneth J. Shea, J. Mater. Chem. A, 2014, 2, 7165-7169.
273. “Progress Toward the Total Synthesis of epi–N-Methyl Welwitindolinone B Isothiocyanate”, Leah Cleary, Jennifer Pitzen, John A. Brailsford, Kenneth J. Shea. Organic Letters, 2014, 16, 4460-4463.
272. “Synthesis of High Molecular Weight Polymethylene via C1 Polymerization. The Role of Oxygenated Impurities and Their Influence on Polydispersity”, Jun Luo, Ruobing Zhao and Kenneth J. Shea, Macromolecules, 2014, 47, 5484-5491.
271. “Engineering Nanoparticle Anti-toxins Utilizing Aromatic Interactions” Adam Weisman, Yingyao Allie Chen, Yu Hoshino and Kenneth Shea, Biomacromolecules, 2014, 15, 3290-3295.
270. “Polymer Nanoparticle Hydrogels with Autonomous Affinity Switching for Protection of Proteins from Thermal Stress” John M. Beierle, Keiichi Yoshimatsu, Beverly Chou, Benjamin K. Lesel, Kenneth J. Shea, Angewandte Chemie, 2014, 53, 9275-9279.
269. “Dynamic Introduction of Cell Adhesive Factor via Reversible Multi-CovalentPhenylboronic Acid/Cis-Diol Polymeric Complexes” Guoqing Pan, Bingbing Guo, Yue Ma, Wenguo Cui, Fan He, Bin Li,Huilin Yang and Kenneth J. Shea, Journal of the American Chemical Society, 2014, 36, 6203 – 6206.
268. “Methylene-Bridged Polysilsesquioxanes: Substitution of a Methylene Spacer within a Silicate Matrix” Joseph A. Tran, Kenneth J. Shea and Douglas A. Loy, J. of Materials Science, 2014, 49, 5006-5016.
267. “Epitope Discovery for a Synthetic Polymer Nanoparticle: A New Strategy for Developing a Peptide Tag” Keiichi Yoshimatsu, Tomohiko Yamazaki, Yu Hoshino, Paul E. Rose, Linda F. Epstein, Les P. Miranda, Philip Tagari, John M. Beierle, Yusuke Yonamine, and Kenneth J. Shea, Journal of the American Chemical Society, 2014, 136, 1194 – 1197.
2013
264. “Particle deformation and concentration polarization in electroosmotic transport of hydrogels through pores.” Pevarnik, M., Schiel, M.,Yoshimatsu, K., Vlassiouk, I. V., Kwon, J. S., Shea, K. J., Siwy, Z. S. ACS Nano. 2013. 7(4) 3720-8.
263. “Origins of regio- and stereochemistry in type 2 intramolecular N-acylnitroso Diels-Alder reactions: a computational study of tether length and substituent effects.” Cleary, L., Mak, V. W., Rychnovsy, S. D., Shea, K. J., Sizemore, N. J. Org. Chem. 2013. 78 (8), 4090 – 8.
262. “Polymer nanoparticle-protein interface. Evaluation of the contribution of positively charged functional groups to protein affinity.” Yonamine, Y., Yoshimatsu, K., Lee, S. H., Hoshino, Y., Okahata, Y., Shea, K. J. ACS Appl. Mater. Interfaces. 2013, 5(2), 374 – 9.
2012
261. “Engineered Synthetic Polymer Nanoparticles as IgG Affinity Ligands”. Shih-Hui Lee, Yu Hoshino, Arlo Randall, Zhiyang Zeng, Pierre Baldi, Ruey-an Doong and Kenneth. J. Shea, Journal of the American Chemical Society, 2012, 134, ASAP.
260. “An ELISA-mimic screen for synthetic polymer nanoparticles with high affinity to target proteins” Yusuke Yonamine, Yu Hoshino and Kenneth J. Shea. Biomacromolecules, 2012, 13, ASAP.
259. “Light-triggered Charge Reversal of Organic-Silica Hybrid Nanoparticles” Li-Chih Hu, Yusuke Yonamine, Shih-Hui Lee, Wytze E. van der Veer, Kenneth J. Shea, Journal of the American Chemical Society, 2012, 134, ASAP.
258. “Hydrocarbon Polymers from a Salt in Water. The Synthesis of Polymethylene Waxes from Trimethylsulfoxonium Salts Catalyzed by Trialkyl Boranes.” Jun Luo, Fangfang Lu and Kenneth J. Shea, ACS MacroLetters, 2012, 1, 560 – 563.
257. “Synthetic Polymer Nanoparticle-Polysaccharide Interactions: A Systematic Study” Zhiyang Zeng, Jiten Patel, Shih-Hui Le1, Monica McCallum, Anu Tyagi, Mingdi Yan, Kenneth J. Shea, Journal of the American Chemical Society, 2012, 134, 2681 – 2690.
256. “Temperature-Responsive “Catch-and-Release” of Proteins using Multifunctional Polymer Nanoparticles”, Keiichi Yoshimatsu, Benjamin K. Lesel, Yusuke Yonamine, John M. Beierle, Yu Hoshino and Kenneth J. Shea, Angewandte Chemie, 2012, 51, 2405–2408.
255. “Learning and Discrimination of Cuticular Hydrocarbons in the Argentine Ant Linepithema Humile” Ellen Van Wilgenburg, Antoine Felden, Dong-Hwan Choe, Robert Sulc, Kenneth J. Shea, Mark A. Elgar1, Neil D. Tsutsui, Biology Letters, 2012, 8, 17-20. doi: 10.1098/rsbl.2011.0643.
254. “The Rational Design of a Plastic Antidote: Synthetic Polymer Nanoparticles that Neutralize Toxic Peptides in Vivo” Yu Hoshino, Hiroyuki Koide, Keiichi Furuya, Walter W. III Haberaecker, Shih-Hui Lee, Takashi Kodama, Hiroaki Kanawaza, Naoto Oku, and Kenneth J. Shea, Proceedings of the National Academy of Science (PNAS), 2012, 109,33-38; published ahead of print December 22, 2011, doi:10.1073/pnas.1112828109.
2011
253. “Electric-Field-Induced Wetting and Dewetting in Single Hydrophobic Nanopores” Matthew R. Powell, Leah Cleary, Matthew Davenport, Kenneth J. Shea, Zuzanna S. Siwy. Nature Nanotechnology, 2011, 6, 798-802, Highlight “Water flow at the flip of a switch. Artificial nanopores with hydrophobic surface patches can be reversibly filled with water by applying electric fields.” Ulrich Rant, Nature Nanotechnology, 2011, 6, 759-760.
252. “Rectangular Chain Packing of Methyl-Branched Paraffins – Persistence of an Inter-chain Interaction and Forms of Disorder.” Douglas L. Dorset, Lisa S. Baugh, Jun Luo and Kenneth J. Shea. Journal of Physical Chemistry B, 2011, 115, 8858-8863.
251. “Copper(II)-Catalyzed RT Aerobic Oxidation of Hydroxamic Acids and Hydrazides to Acyl-Nitroso and Azo Intermediates, and their Diels¬Alder Trapping”, Duangduan Chaiyaveij, Leah Cleary, Andrei S. Batsanov, Todd B. Marder, Kenneth J. Shea, and Andrew Whiting, Organic Letters, 2011, 13, 3442– 3445.
250. “Microwave Assisted Synthesis of Bridgehead Alkenes” Leah Cleary, Hoseong Yoo, Kenneth J. Shea, Organic Letters, 2011, 13, 1781-1783.
249. “Organo-Silica Hybrid Functional Nanomaterials: How do Organic Bridging Groups and Silsesquioxane Moieties Work Hand-in-hand?”, Li-Chih Hu, Kenneth J. Shea, Chemical Society Reviews. 2011, 40, 688-695.
248. “Recent Progress In Hybrid Materials Science” Sanchez C, Shea K. J. , Kitagawa S. Chemical Society Reviews, 2011, 40, 471-472.
247. “The Evolution of Plastic Antibodies.” Yu Hoshino and Kenneth J. Shea, Journal of Materials Chemistry, 2011, 20, 3517-3521.
2010
246. “Affinity Selection of Plastic Nanoparticles with Thermo-responsive Peptide Recognition Sites”, Yu Hoshino, Walter W. Haberaecker III, Takashi Kodama, Zhiyang Zeng, Yoshio Okahata, Kenneth J. Shea, J. Am. Chem. Soc. 2010, 132, 13648 – 13650.
245. “Uniform, Spherical Bridged Polysilsesquioxane Nano- and Microparticles”, Li-Chih Hu, Mariya Khiterer, Shing-Jong Huang, Jerry Chun Chung Chan, Joe Davey, and Kenneth J. Shea, Chemistry of Materials, 2010, 22, 244-5250.
244. “Polyhomologation; A Living C1 Polymerization.” Jun Luo and Kenneth J. Shea, Accounts of Chemical Research, 2010, 43, 1420-1433.
243. “Deciphering the Chemical Basis of Nestmate Recognition.” Ellen van Wilgenburg, Robert Sulc, Kenneth J. Shea, Miriam Brandt, and Neil D.Tsutsui. Journal of Chemical Ecology, 2010, 36, 751-758.
242. “The Living Polymerization of Ylides.” a Chapter in “Complex Macromolecular Architectures: Synthesis, Characterization, and Self-Assembly”, Jun Luo and Kenneth J. Shea, John Wiley & Sons., 2010.
241. “As Synthesized” Nanoparticles Recognize, Neutralize and Remove a Toxic Peptide in vivo” Yu Hoshino, Hiroyuki Koide, Takeo Urakami, Hiroaki Kanawaza, Takashi Kodama, Zhiyang Zeng, Naoto Oku, and Kenneth J. Shea, J. Am. Chem. Soc. 2010, 132, 6644-6645.
240. “Synthetic Polymer Nanoparticles with Antibody-Like Affinity for a Hydrophilic Peptide” Zhiyang Zeng, Yu Hoshino, Andy Rodriguez, Hoseong Yoo, and Kenneth J. Shea, ACS Nano, 2010, 4, 199-204.