Publications

2024

  • Atcha, H., Kulkarni, D., Meli, V.S., Veerasubramanian, P.K., Wang, Y., Cahalan, M.D., Pathak, M.M., Liu, W.F. (2024) Piezo1-mediated mechanotransduction enhances macrophage oxLDL uptake and atherogenesis. PNAS Nexus, vol. 3, no. 11, Oct. 2024, doi: 10.1093/pnasnexus/pgae436.
  • Butenko, S., Nagalla, R.R., Guerro-Juarez, C.F., Palomba, F., David, L., Nguyen, R.Q., Gay, D., Almet, A.A., Digman, M.A., Nie, Q., Scumpia, P.O., Plikus, M.V., Liu, W.F. (2024) Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing.  Nature Communications, vol. 15, no. 1, Aug. 2024, doi: https://doi.org/10.1038/s41467-024-50072-y.

2023

  • Hsu, S.J., Luu, T.U., Smith, T.D., Liu, W.F. (2023) Macro‐ and micro‐scale culture environment differentially regulate the effects of crowding on macrophage function. Biotechnology and Bioengineering, vol. 121, no. 1, pp. 306–316. doi: https://doi.org/10.1002/bit.28554. 

2022

  • Zhou, J., Meli, V.S., Chen, E., Kapre, R., Nagalla, R.R., Xiao, W., Borowsky, A.D., Lam, K.S., Liu, W.F., Louie, A.Y. (2022) Magnetic resonance imaging of tumor-associated-macrophages (TAMs) with a nanoparticle contrast agent. RSC Advances, vol. 12, no. 13, pp. 7742–7756. doi: https://doi.org/10.1039/d1ra08061j.
  • Butenko, S., Miwa, H., Liu, Y., Plikus, M.V., Scumpia, P.O., Liu, W.F. (2022) Engineering Immunomodulatory Biomaterials to Drive Skin Wounds toward Regenerative Healing. Cold Spring Harbor Perspectives in Biology, vol. 15, no. 5, pp. a041242–a041242. doi: https://doi.org/10.1101/cshperspect.a041242.
  • Du, H., Barleson, J.M., Butenko, S., Alonso, V., Liu, W.F. (2022) Tuning immunity through tissue mechanotransduction.  Nature Reviews Immunology. doi: https://doi.org/10.1038/s41577-022-00761-w.
  • Donahue, R., Link, J.M., Meli, V.S., Hu, J.C., Liu, W.F., Athanasiou, K.A. (2022) Stiffness and bioactive factor-mediated protection of self-assembled cartilage against macrophage challenge in a novel co-culture system. Cartilage, vol. 13, no. 1, p. 194760352210814-194760352210814. doi: https://doi.org/10.1177/19476035221081466.

2021

  • Atcha, H., Jairaman, A., Evans, E. L., Pathak, M. M., Cahalan, M. D., Liu, W. F. (2021) Ion channel mediated mechanotransduction in immune cells. Current Opinion in Solid State and Materials Science, 25(6), 100951. https://doi.org/10.1016/j.cossms.2021.100951
  • Meli, V. S., Donahue, R. P., Link, J. M., Hu, J. C., Athanasiou, K. A., Liu, W. F. (2021) Isolation and characterization of porcine macrophages and their inflammatory and fusion responses in different stiffness environments. Biomaterials Science, 9(23), 7851–7861. https://doi.org/10.1039/d1bm00746g
  • Atcha, H., Jairaman, A., Holt, J. R., Meli, V. S., Nagalla, R. R., Veerasubramanian, P. K., Brumm, K. T., Lim, H. E., Othy, S., Cahalan, M. D., Pathak, M. M., & Liu, W. F. (2021) Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nature Communications 2021 12:1, 12(1), 1–14. https://doi.org/10.1038/s41467-021-23482-5
  • Veerasubramanian, P. K., Shao, H., Meli, V. S., Phan, T. A. Q., Luu, T. U., Liu, W. F., Downing, T. L. (2021) A Src-H3 acetylation signaling axis integrates macrophage mechanosensation with inflammatory response. Biomaterials, 279, 121236. https://doi.org/10.1016/j.biomaterials.2021.121236
  • Veerasubramanian, P. K., Joe, V. C., Liu, W. F., Downing, T. L. (2021) Characterization of Macrophage and Cytokine Interactions with Biomaterials Used in Negative-Pressure Wound Therapy. Bioengineering 2022, Vol. 9, Page 2, 9(1), 2. https://doi.org/10.3390/BIOENGINEERING9010002
  • Atcha, H., Meli, V. S., Davis, C. T., Brumm, K. T., Anis, S., Chin, J., Jiang, K., Pathak, M. M., Liu, W. F. (2021) Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to Mechanical Cues. Frontiers in Immunology, 12(September), 1–14. https://doi.org/10.3389/fimmu.2021.689397

2020

  • Liu, Q., Chiu, A., Wang, L., An, D., Li, W., Chen, E. Y., Zhang, Y., Pardo, Y., McDonough, S. P., Liu, L., Liu, W. F., Chen, J., Ma, M. (2020) Developing mechanically robust, triazole-zwitterionic hydrogels to mitigate foreign body response (FBR) for islet encapsulation. Biomaterials, 230, 119640. https://doi.org/10.1016/J.BIOMATERIALS.2019.119640
  • Rowley, A. T., Meli, V. S., Wu-Woods, N. J., Chen, E. Y., Liu, W. F., Wang, S. W. (2020) Effects of Surface-Bound Collagen-Mimetic Peptides on Macrophage Uptake and Immunomodulation. Frontiers in Bioengineering and Biotechnology, 8, 747. https://doi.org/10.3389/FBIOE.2020.00747/BIBT
  • Meli, V. S., Atcha, H., Veerasubramanian, P. K., Nagalla, R. R., Luu, T. U., Chen, E. Y., Guerrero-Juarez, C. F., Yamaga, K., Pandori, W., Hsieh, J. Y., Downing, T. L., Fruman, D. A., Lodoen, M. B., Plikus, M. V., Wang, W., Liu, W. F. (2020) YAP-mediated mechanotransduction tunes the macrophage inflammatory response. Science Advances, 6(49). https://doi.org/10.1126/SCIADV.ABB8471/SUPPL_FILE/ABB8471_SM.PDF

2019

  • Herrera, V., Hsu, S. C. J., Rahim, M. K., Chen, C., Nguyen, L., Liu, W. F., Haun, J. B. (2019) Pushing the limits of detection for proteins secreted from single cells using quantum dots. Analyst, 144(3), 980–989. https://doi.org/10.1039/C8AN01083H
  • Atcha, H., & Liu, W. F. (2019). Immunological considerations for heart valve replacements. Principles of Heart Valve Engineering, 321–342. https://doi.org/10.1016/B978-0-12-814661-3.00012-5
  • Hsieh, J. Y., Keating, M. T., Smith, T. D., Meli, V. S., Botvinick, E. L., & Liu, W. F. (2019) Matrix crosslinking enhances macrophage adhesion, migration, and inflammatory activation. APL Bioengineering, 3(1), 016103. https://doi.org/10.1063/1.5067301
  • Rowley, A. T., Nagalla, R. R., Wang, S. W., Liu, W. F. (2019) Extracellular Matrix-Based Strategies for Immunomodulatory Biomaterials Engineering. Advanced Healthcare Materials, 8(8), 1801578. https://doi.org/10.1002/ADHM.201801578
  • Meli, V. S., Veerasubramanian, P. K., Atcha, H., Reitz, Z., Downing, T. L., Liu, W. F. (2019) Biophysical regulation of macrophages in health and disease. Journal of Leukocyte Biology, 106(2), 283–299. https://doi.org/10.1002/JLB.MR0318-126R
  • Liu, Q., Chiu, A., Wang, L. H., An, D., Zhong, M., Smink, A. M., de Haan, B. J., de Vos, P., Keane, K., Vegge, A., Chen, E. Y., Song, W., Liu, W. F., Flanders, J., Rescan, C., Grunnet, L. G., Wang, X., Ma, M. (2019) Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation. Nature Communications 2019 10:1, 10(1), 1–14. https://doi.org/10.1038/s41467-019-13238-7

2018

  • Jansen, L. E., Amer, L. D., Chen, E. Y. T., Nguyen, T. V., Saleh, L. S., Emrick, T., Liu, W. F., Bryant, S. J., & Peyton, S. R. (2018) Zwitterionic PEG-PC Hydrogels Modulate the Foreign Body Response in a Modulus-Dependent Manner. Biomacromolecules, 19(7), 2880–2888. https://doi.org/10.1021/ACS.BIOMAC.8B00444/SUPPL_FILE/BM8B00444_SI_002.PDF
  • Atcha, H., Davis, C. T., Sullivan, N. R., Smith, T. D., Anis, S., Dahbour, W. Z., Robinson, Z. R., Grosberg, A., Liu, W. F. (2018) A Low-Cost Mechanical Stretching Device for Uniaxial Strain of Cells: A Platform for Pedagogy in Mechanobiology. Journal of Biomechanical Engineering, 140(8), 81005–81006. https://doi.org/10.1115/1.4039949/424475
  • Luu, T. U., Liu, W. F. (2018) Regulation of Macrophages by Extracellular Matrix Composition and Adhesion Geometry. Regenerative Engineering and Translational Medicine, 4(4), 238–246. https://doi.org/10.1007/S40883-018-0065-Z/FIGURES/3
  • Liu, W. F. (2018) Control by cell size. Nature Materials 2018 17:12, 17(12), 1055–1056. https://doi.org/10.1038/s41563-018-0225-z

2017

  • Smith, T. D., Nagalla, R. R., Chen, E. Y., & Liu, W. F. (2017) Harnessing macrophage plasticity for tissue regeneration. Advanced Drug Delivery Reviews, 114, 193–205. https://doi.org/10.1016/j.addr.2017.04.012
  • Kim, Y. K., Chu, S. H., Hsieh, J. Y., Kamoku, C. M., Tenner, A. J., Liu, W. F., Wang, S. W. (2017) Incorporation of a Ligand Peptide for Immune Inhibitory Receptor LAIR-1 on Biomaterial Surfaces Inhibits Macrophage Inflammatory Responses. Advanced Healthcare Materials, 6(24), 1700707. https://doi.org/10.1002/ADHM.201700707
  • Hsieh, J. Y., Smith, T. D., Meli, V. S., Tran, T. N., Botvinick, E. L., Liu, W. F. (2017) Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen. Acta Biomaterialia, 47, 14–24. https://doi.org/10.1016/j.actbio.2016.09.024
  • Chen, E. Y., Chu, S. H., Gov, L., Kim, Y. K., Lodoen, M. B., Tenner, A. J., Liu, W. F. (2017) CD200 modulates macrophage cytokine secretion and phagocytosis in response to poly(lactic- co -glycolic acid) microparticles and films. Journal of Materials Chemistry B, 5(8), 1574–1584. https://doi.org/10.1039/C6TB02269C
  • Krishnan, R., Ko, D., Foster, C. E., Liu, W.F., Smink, A. M., de Haan, B., De Vos, P., Lakey, J. R. T. (2017) Immunological Challenges Facing Translation of Alginate Encapsulated Porcine Islet Xenotransplantation to Human Clinical Trials. Methods in Molecular Biology, 1479, 305–333. https://doi.org/10.1007/978-1-4939-6364-5_24

2016

  • Smith, T. D., Tse, M. J., Read, E. L., Liu, W. F. (2016) Regulation of macrophage polarization and plasticity by complex activation signals. Integrative Biology, 8(9), 946–955. https://doi.org/10.1039/C6IB00105J
  • Alfonso García A., Smith T.D., Datta R., Luu T.U., Gratton E., Potma E.O., Liu W.F. (2016) Label-free identification of macrophage phenotype by fluorescence lifetime imaging microscopy. Journal of Biomedical Optics. 21(4):46007. doi:10.1117/1.JBO.21.4.046005
  • Kim, Y. K., Chen, E. Y., Liu, W. F. (2016) Biomolecular strategies to modulate the macrophage response to implanted materials. Journal of Materials Chemistry B, 4(9), 1600–1609. https://doi.org/10.1039/C5TB01605C
  • Wang, T., Luu, T.U., Chen, A., Khine, M., Liu, W.F. (2016) Topographical modulation of macrophage phenotype by shrink film multi-scale wrinkles. Biomaterials Science. 4:948-52. doi:10.1039/C6BM00224B
  • McWhorter, F.Y., Smith, T.D., Luu, T.U., Rahim, M.K., Haun, J.B., Liu, W.F. (2016) Macrophage secretion heterogeneity in engineered microenvironments revealed using a microwell platform. Integrative Biology. Advance article. doi:10.1039/C6IB00053

2015

  • Luu, T.U., Gott, S.C., Woo, B.W.K., Rao, M.P., Liu, W.F. (2015) Micro and nano-patterned topographical cues for regulating macrophage cell shape and phenotype. ACS Applied Materials and Interfaces. 7(51):28665-72. doi:10.1021/acsami.5b10589
  • Kim, Y.K., Chen, E.Y., Liu, W.F. (2015) Biomolecular strategies to modulate the macrophage response to implanted materials. J. Mater. Chem. B. doi:10.1039/c5tb01605c
  • McWhorter, F.Y., Davis, C.T., Liu, W.F. (2015) Physical and mechanical regulation of macrophage phenotype and function. Cell Mol. Life Sci. 72(7):1303-16. doi:10.1007/s00018-014-1796-8

2014

  • Harker, K.S., Jivan, E., McWhorter, F.Y., Liu, W.F., Lodoen, M.B. (2014) Shear Forces Enhance Toxoplasma gondii Tachyzoite Motility on Vascular Endothelium.  MBio. 5(2):01111-13. doi:10.1128/mBio.01111-13
  • Kim YK, Que R, Wang SW, Liu WF. (2014) Modification of Biomaterials with a Self-Protein Inhibits the Macrophage Response. Adv. Healthcare Mat. doi:10.1002/adhm.201300532

2013

  • Ueno, N., Harker, K.S., Clarke, E.V., McWhorter, F.Y., Liu, W.F., Tenner, A.J., Lodoen M.B. (2013) Real-time imaging of infected human monocytes under fluidic shear stress reveals rapid translocation of intracellular parasites across endothelial barriers. Cell Microbiol. doi:10.1111/cmi.12239
  • McWhorter, F.Y.*, Wang, T.*, Nguyen, P., Chung, T., Liu, W.F. (2013) Modulation of macrophage phenotype by cell shape. Proc Nat Acad Sci USA. doi:10.1073/pnas.1308887110.
  • Harker, K.S., Ueno, N., Wang, T., Bonhomme, C., Liu, W.F., Lodoen, M.B. (2013) Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress. J Leukoc Biol. 93(5)789-800.
  • Dheda, S.S., Kim, Y.K., Melnyk, C., Liu, W.F., Mohamed, F.A. (2013) Corrosion and in vitro biocompatibility properties of cryomilled-spark plasma sintered commercially pure titanium. J Mater Sci Mater Med. 24(5):1239-49.
  • Alavi, S.H., Liu, W.F., Kheradvar, A. (2013) Inflammatory Response Assessment of a Hybrid Tissue-Engineered Heart Valve Leaflet. Ann Biomed Eng. 42(2):316-26.

2012

  • Leight, J.L., Liu, W.F., Chaturvedi, R.R., Chen, S., Yang, M.T., Raghavan, S., Chen, C.S. (2012) Manipulation of 3D Cluster Size and Geometry by Release from 2D Micropatterns. Cell and Mol Bioengineering. 5(3):299-306.
  • Liu WF. (2012) Mechanical regulation of cellular phenotype: implications for vascular tissue regeneration. Cardiovasc Res. 95(2)251-22.