Lawson KA, Ruiz CM, Mahler SV. A head-to-head comparison of two DREADD agonists for suppressing operant behavior in rats via VTA dopamine neuron inhibition. Psychopharmacology (Berl). (2023)

Lim J, Lee HL, Nguyen J, Shin J, Getze S, Quach C, Squire E, Jung KM, Mahler SV, Mackie K, Piomelli D, Luderer U. Adolescent exposure to low-dose Δ9-tetrahydrocannabinol depletes the ovarian reserve in female mice. Toxicol Sci. 2023

Halbout B, Hutson C, Hua L, Inshishian V, Mahler SV, Ostlund SB. Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats. Psychopharmacology (Berl). 2023

Birnie MT, Short AK, de Carvalho GB, Taniguchi L, Gunn BG, Pham AL, Itoga CA, Xu X, Chen LY, Mahler SV, Chen Y, Baram TZ. Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice. Nat Commun. (2023)

Martinez, M.X., Farrell, M.R., Mahler, S.V. (2023). Pathway-Specific Chemogenetic Manipulation by Applying Ligand to Axonally Expressed DREADDs. In: Eldridge, M.A., Galvan, A. (eds) Vectorology for Optogenetics and Chemogenetics. Neuromethods, vol 195. Humana, New York, NY.

Torrens A, Ruiz CM, Martinez MX, Tagne AM, Roy P, Grimes D, Ahmed F, Lallai V, Inshishian V, Bautista M, Chen YC, Huestis MA, Das A, Fowler CD, Mahler SV, Piomelli D. Nasal accumulation and metabolism of Δ⁹-tetrahydrocannabinol following aerosol (‘vaping’) administration in an adolescent rat model. Pharmacol Res. 2023

Torrens A, Roy P, Lin L, Vu C, Grimes D, Inshishian VC, Montesinos JS, Ahmed F, Mahler SV, Huestis MA, Das A, Piomelli D. Comparative Pharmacokinetics of Δ⁹-Tetrahydrocannabinol in Adolescent and Adult Male and Female Rats. Cannabis Cannabinoid Res. 2022

Ahmed F, Torrens A, Mahler SV, Ferlenghi F, Huestis MA, Piomelli D. A Sensitive Ultrahigh-Performance Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Analysis of Phytocannabinoids and Endocannabinoids in Plasma and Brain. Cannabis Cannabinoid Res. 2022

Birnie MT, Levis SC, Mahler SV, Baram TZ. Developmental Trajectories of Anhedonia in Preclinical Models. Curr Top, Behav Neurosci. (2022)

Farrell, M.R., Ye, Q.,  Xie, Y.,  Esteban, J.S.D., Mahler, S.V. (2022) Ventral pallidum GABA neurons bidirectionally control opioid relapse across rat behavioral models,
Addiction Neuroscience

Levis, S.C., Birnie, M.T., Bolton, J.L. et al. Enduring disruption of reward and stress circuit activities by early-life adversity in male rats. Transl Psychiatry 12, 251 (2022)

Levis, SC, Baram, TZ, Mahler SV. (2022). Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction. European Journal of Neuroscience.

Lawson, KA, Flores, AY, Hokenson, RE, Ruiz, CM, Mahler, SV. (2021). Nucleus accumbens chemogenetic inhibition suppresses amphetamine-induced ultrasonic vocalizations in male and female rats. Brain Sciences.

Ruiz, CM, Torrens, A, Lallai, V, Castillo, E, Manca, L, Martinez, MX, Justeson, DN, Fowler, CD, Piomelli, D, Mahler, SV. (2021). Pharmacokinetic and pharmacodynamic properties of aerosolized (“vaped”) THC in adolescent male and female rats. Psychopharmacology

Levis, SC, Mahler, SV & Baram, TZ (2021). The Developmental Origins of Opioid Use Disorder and Its Comorbidities. Frontiers in Human Neuroscience

Farrell, MR, Esteban, JSD, Faget, L, Floresco, SB, Hnasko, TS, & Mahler, SV. (2021) Ventral Pallidum GABA Neurons Mediate Motivation Underlying Risky Choice. J Neurosci, 41(20), 4500-4513

Quintanilla, J, Cox, BM, Gall, CM, Mahler, SV, Lynch, G. (in press). Retrograde Enhancement of Episodic Learning by a Post-Learning Stimulus. Learning & Memory

Brodnik, ZD, Xu, W, Batra, A, Lewandowski, SI, Ruiz, CM, Mortensen, OV, Kortaggere, S, Mahler, SV, Espana, RA (2020). Chemogenetic Manipulations of Dopamine Neurons Dictates Cocaine Potency at Distal Dopamine Transporters. Journal of Neuroscience, 40(44) 8767-8779

Ruiz, CM, Torrens, A, Castillo, E, Perrone, CR, Cevallos, J, Inshishian, V, Harder, E, Justeson, D, Huestis, MA, Swarup, V, Piomelli, D, Mahler, SV. (2020). Pharmacokinetic, behavioral, and brain activity impacts of Δ9-tetrahydrocannabinol in adolescent male and female rats. Neuropsychopharmacology.

Torrens, A, Vozella, V, Huff, H, McNeil, B, Ahmed, F, Ghidini, A, Mahler, SV, Huestis, MA, Das, A, Piomelli, D. (2020). Comparative Pharmacokinetics of Delta9-Tetrahydrocannabinol in Adolescent and Adult Male Mice, Journal of Pharmacology & Experimental Therepeutics

James, MH & Mahler, SV (2020). Do striatal push/pull circuits hold the key to relapsing heroin addiction? Neuropsychopharmacology.

Levis, SC, Bentzley, BS, Molet, J, Bolton, JL, Perrone, CR, Baram, TZ, & Mahler, SV. (in press). On the early life origins of vulnerability to opioid addiction. Molecular Psychiatry.

Farrell, MR, Ruiz, CM, Castillo, E, Faget, L, Khanbijian, C, Liu, S, Schoch, H, Rojas, G, Hnasko, TS, & Mahler, SV. (in press). Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats. Neuropsychopharmacology.

*Featured in “Research Highlight” article: Ventral pallidum: a promising target for addiction intervention. McGovern, DJ & Root, DH, Neuropsychopharmacology *Neuropsychopharmacology Cover Image (December 2019)

Bonaventura, J, Eldridge, MA, Hu, F, Gomez, JL, Sanchez-Soto, M, Abramyan, AM, Lam, S, Boehm, M, Ruiz, CM, Farrell, MR, Moreno, A, Faress, IMG, Andersen, N, Lin, JY, Moaddel, R, Morris, P, Shi, L, Sibley, DR, Mahler, SV, Nabavi, S, Pomper, MG, Bonci, A, Horti, AG, Richmond, BJ & Michaelides, M. (in press). High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nature Communications.

Jayachandran, M, Linley, S, Schlecht, M, Mahler, SV, Vertes, RP, Allen, TA. (in press). Prefrontal pathways provide top down control of memory for sequences of events. Cell Reports.

Halbout, B, Marshall, AT, Azimi, A, Liljeholm, M, Mahler, SV, & Ostlund, SB. (in press). Chemogenetic inhibition of ventral tegmental area dopamine neurons or their inputs to the nucleus accumbens disrupts cue-triggered reward seeking but not reward taking. eLife.

Mahler, SV, Brodnik, ZD, Cox, BM, Buchta, WC, Bentzley, BS, Quintanilla, J, Cope, ZA, Lin, EC, Riedy, MD, Scofield, MD, Messinger, J, Ruiz, CM, Riegel, AC, España, RA & Aston-Jones, G. (2019). Chemogenetic manipulations of ventral tegmental area dopamine neurons reveal multifaceted roles in cocaine abuse. Journal of Neuroscience, 39(3), 503-518.

Mitchell, MR, Berridge, KC, & Mahler, SV. (2018). Endocannabinoid-enhanced “liking” in nucleus accumbens shell hedonic hotspot requires endogenous opioid signals. Cannabis & Cannabinoid Research, 3(1), 166-170. doi: 10.1089/can.2018.0021

Bolton, JL, Ruiz, CM, Rismanchi, N, Sanchez, GA, Castillo, E, Huang, J, Cross, C, Baram, TZ & Mahler, SV (2018). Early-Life Adversity Facilitates Acquisition of Cocaine Self-Administration and Induces Persistent Anhedonia. Neurobiology of Stress.

Farrell, MR, Schoch, H, & Mahler, SV. (2018). Modeling Cocaine Relapse in Rodents: Behavioral Considerations and Circuit Mechanisms. Progress in Neuropsychopharmacology & Biological Psychiatry.

Mahler, SV & Aston-Jones, G. (2018). CNO evil? Considerations for the use of DREADDs in behavioral neuroscience. Neuropsychopharmacology.

Mahler, SV. (2018). Stay alert: don’t get hurt. Nature Neuroscience, 21(1), 3-5..

James, MH, McGlinchey, EM, Vattikonda, A, Mahler, SV & Aston-Jones, G. (2018). Cued reinstatement of cocaine- but not sucrose-seeking is dependent upon dopamine signaling in prelimbic cortex and is associated with recruitment of prelimbic neurons that project to contralateral nucleus accumbens core. International Journal of Neuropsychopharmacology, 21(1): 89–94

Schoch, H, Huerta, MY, Ruiz, CM, Farrell, MR, Jung, KM, Huang, JJ, Campbell, RR, Piomelli, D & Mahler, SV. (2018). Adolescent cannabinoid exposure increases natural reward seeking and alters learning. Psychopharmacology

Buchta, WC, Mahler, SV, Harlan, B, Aston-Jones, G, Riegel, AC. (2017). Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex. Physiological Reports, 5(6), e13198

James, MH, Mahler, SV, Moorman, DE, & Aston-Jones, G. (2018). A decade of orexin/hypocretin in addiction: Where are we now? Current Topics in Behavioral Neuroscience.

McGlinchy, EM, James, MH, Mahler, SV, Pantazis, C & Aston-Jones (2016). Prelimbic to accumbens core pathway is recruited in a dopamine-dependent manner to drive cued reinstatement of cocaine seeking. Journal of Neuroscience, 36(33), 8700-11.

Smith, KS, Bucci, DJ, Luikart, BW, Mahler, SV (2016). DREADDs: Use and Application in Behavioral Neuroscience. Behavioral Neuroscience, PMID: 26913540

Mahler, SV, Moorman, DE, Smith, RJ, James, MH & Aston-Jones, G. (2014). Motivational activation: A unifying hypothesis of orexin/hypocretin function. Nature Neuroscience, 17(10), 1298-1303.

Mahler, SV, Vazey, EM, Beckley, JT, Keistler, CR, McGlinchy, EM, Kaufling, J, Wilson, SP, Deisseroth, K, Woodward, JJ, Aston-Jones, G (2014). Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking. Nature Neuroscience, 17, 577-585.

Mahler, SV, Hensley-Simon, M, Tahsili-Fahadan, P, LaLumiere, RT, Thomas, C, Fallon, RV, Kalivas, PW & Aston-Jones, G. (2014). Modafinil attenuates reinstatement of cocaine seeking: Role for cystine-glutamate exchange and metabotropic glutamate receptors. Addiction Biology, 19(1), 49-60.

Mahler, SV, Smith, RJ & Aston-Jones, G. (2013). Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology, 226, 687-698.

Mahler, SV, Moorman, DE, Feltenstein, ME, Cox, BM, Ogburn, KB, Bachar, M, McGonigal, JT, Ghee, SM & See, RA (2013). A rodent “self- report” measure of methamphetamine craving? Rat ultrasonic vocalizations during methamphetamine self-administration, extinction, and reinstatement. Behavioural Brain Research, 236, 78-89.

Mahler, SV,& Aston-Jones, GS. (2012). Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats. Journal of Neuroscience, 32(38), 13309-13325.

*Featured in “Journal Club” article: Cole, S, Furlong, TM & Perry CJ. (2013). “Recruitment of multiple pathways to ventral tegmental area during cocaine-seeking behavior” Journal of Neuroscience, 33(6), 2239-41.

Mahler, SV, Smith, RJ, Moorman, DE, Sartor, GC & Aston-Jones, G. (2012). Multiple roles for orexin/hypocretin in addiction. Progress in Brain Research, 198, 79-121.

Mahler, SV & Berridge, KC. (2012). What and when to ‘want?’ Amygdala opioid focusing of incentive salience on cues for sugar and sex. Psychopharmacology. 221, 407-26.

Mahler, SV & de Wit, H (2010). Cue reactors: Individual differences in cue-induced craving after food or smoking abstinence. PLoS One 5(11): w15475. Doi:10.1371/journal.pone.0015475

Smith, KS, Mahler, SV, Peciña, S & Berridge, KC (2010). Hedonic hotspots: Generating sensory pleasure in the brain. In: ML Kringelbach & KC Berridge (Eds.). Pleasures of the Brain. Oxford University Press: Oxford UK.

Mahler, SV & Berridge, KC. (2009). Which cue to ‘want?’ Central amygdala opioid activation enhances and targets incentive salience on a prepotent reward cue. Journal of Neuroscience, 29(20), 6500-13.

Mahler, SV, Smith, KS & Berridge, KC. (2007). Endocannabinoid hedonic hotspot for sensory pleasure: Anandamide in nucleus accumbens shell enhances ‘liking’ of a sweet reward. Neuropsychopharmacology, 32(11), 2267-78.

Acheson, A, Mahler, SV, Chi, H & de Wit, H. (2006) Differential effects of nicotine on alcohol consumption in men and women. Psychopharmacology, 186(1), 54-63.

Mahler, SV & de Wit, H. (2005). Effects of haloperidol on reactions to smoking cues in humans. Behavioural Pharmacology, 16(2), 123-6.

Alsene, KA, Mahler, SV, & de Wit, H. (2005). Effects of d-amphetamine and smoking abstinence on cue-induced cigarette craving. Experimental and Clinical Psychopharmacology, 13(3), 209-18.

Young, EM, Mahler, S, Chi, H, & de Wit, H. (2005). Mecamylamine and ethanol preference in healthy volunteers. Alcoholism: Clinical & ExperimentalResearch. 29(1), 58-65.

Roney, JR, Mahler, SV & Maestripieri, D. (2003). Behavioral and hormonal responses of men to brief interactions with women. Evolution and Human Behavior, 24, 365-375.