Publications

FOR LIST OF PUBLICATIONS SEE: https://www.ncbi.nlm.nih.gov/myncbi/

 

 

 

Liang C, Nguyen GA, Danh TB, Sandhu AK, Melkonyan LL, Syed AU, Mukherjee J. Abnormal [¹⁸ F]NIFENE binding in transgenic 5xFAD mouse model of Alzheimer’s disease: In vivo PET/CT imaging studies of α4β2* nicotinic acetylcholinergic receptors and in vitro correlations with Aβ plaques. Synapse. 2023 May;77(3):e22265. doi: 10.1002/syn.22265. Epub 2023 Feb 23. PubMed PMID: 36749986; PubMed Central PMCID: PMC10148164.

Nguyen, G.A.H., Liang, C., Mukherjee, J. [¹²⁴I]IBETA, a new Ab amyloid plaque PET imaging agent for Alzheimer’s disease. MOLECULES, 27(14): 4552, 2022. https://www.mdpi.com/1420-3049/27/14/4552

Buchsbaum, M.S., Mitelman, S.A., Christian, B.T., Merrill, B.M., Buchsbaum, B.R., Mitelman, D., Mukherjee, J., Lehrer, D.S. Four-modality imaging of never-medicated subjects with schizophrenia: 18F-fluorodeoxyglucose and ¹⁸F-fallypride PET, diffusion tensor imaging, and MRI. Psychiatry Research: Neuroimaging, 320, 111428, 2022; doi.org/10.1016/j.pscychresns.2021.111428. https://pubmed.ncbi.nlm.nih.gov/34954446/

Campoy, A-D.T., Liang, C., Ladwa, R.M., Patel, K.K., Patel, I.H., Mukherjee, J. [¹⁸F]Nifene PET/CT imaging in mice models: Improved methods and preliminary studies of a4b2* nicotinic acetylcholinergic receptors in transgenic A53T mouse model of a-synucleinopathy and post-mortem human Parkinson’s disease. MOLECULES, 26(23):7360, 2021. https://www.mdpi.com/1420-3049/26/23/7360

Kaur, H., Felix, M.R., Liang, C., Mukherjee J. Development and evaluation [¹⁸F]Flotaza for Ab plaque imaging in post-mortem Alzheimer’s disease brain. Bioorg. Med. Chem. Lett., 46: 128164, 2021.

Mondal, R., Campoy, A-D.T., Liang, C., Mukherjee, J. [¹⁸F]FDG PET/CT Studies in Transgenic Hualpha-Syn(A53T) Parkinson’s Disease Mouse Model of a-Syncleinopathy. Frontiers Neuroscience (Neurodegeneration Section), Vol. 15, Article 676257, 2021. Doi:10.3389/fnins.2021.676257. https://www.frontiersin.org/articles/10.3389/fnins.2021.676257/full

Mukherjee, J., Liang, C., Patel, K.K., Lam, P.Q., Mondal, R. Development and evaluation [¹²⁵I]IPPI for tau imaging in post-mortem human Alzheimer’s disease brain. Synapse, 75: e22183, 2021.

                 

 

Rommani Mondal

 

Lau, W.L., Liang, C., Liu, H., Singh, K., Mukherjee, J. Development of Zirconium-89 PET for in vivo imaging of alpha-Klotho. American Journal of Nuclear Medicine and Molecular Imaging, 10 (2): 95-105, 2020.

 

Mitelman, S.A., Buchsbaum, M.S., Christian, B.T., Merrill, B.M., Buchsbaum, B.R., Mukherjee, J., Lehrer, D.S. Positive association between cerebral gray matter metabolism and dopamine D2/D3 density in healthy and schizophrenia subjects: a dual-tracer ¹⁸F-fluorodeoxyglucose and ¹⁸F-fallypride positron emission tomography study. World Journal of Biological Psychiatry 21(5): 368-382, 2020. Online, September 2019. https://doi.org/10.1080/15622975.2019.1671609

 

Mitelman, S.A., Buchsbaum, M.S., Christian, B.T., Merrill, B.M., Buchsbaum, B.R., Mukherjee, J., Lehrer, D.S. Dopamine receptor density and white matter integrity: ¹⁸F-Fallypride positron emission tomography and diffusion tensor imaging study in healthy and schizophrenia subjects. Brain Imaging and Behavior, 14(3): 736-752, 2020. online doi.org/10.1007/s11682-018-0012-0, 2019.

 

Samra, G.K., Dang K., Ho, H., Baranwal, A., Mukherjee J. Dual targeting agents for Aβ plaque/P-glycoprotein and Aβ plaque/nicotinic acetylcholine α4β2* receptors – Potential approaches to facilitate Aβ Plaque removal in Alzheimer’s disease brain Medicinal Chemistry Research, 27(6): 1634-1646, 2018.(DOI: 10.1007/s00044-018-2178-9).

Samra, G.K., Intskirveli, I., Govind, A.P., Liang, C., Lazar, R., Green, W.N., Metherate, R., Mukherjee, J.: Development of fluorescent probes for imaging α4β2* nicotinic acetylcholine receptors. Bioorganic Medicinal Chemistry Letters, 28(3): 371-377, 2018.

 

Mukherjee, J., Lao, P., Betthauser, T., Samra, G.K., Pan, M-L., Patel, I.H., Liang, C., Metherate, R., Christian, B.T.: Human brain imaging of nicotinic acetylcholine α4β2* receptors using [18F]Nifene: selectivity, functional activity, toxicity, aging effects, gender effects and extrathalamic pathways. J. Comparative Neurology, 526(1): 80-95, 2018.

Vyas, N.S., Buchsbaum, M.S., Lehrer, D.S., Merrill, B., DeCastro A, Doninger, N.A., Christian, B.T., Mukherjee, J.: D2/D3 dopamine receptor binding with [F-18]fallypride correlates of executive function in medication-naïve patients with schizophenia.  Schizophrenia Research, 192: 442-456, 2018.

Betthauser, T.J., Hillmer, A.T., Lao, P., Ehlerding, E., Mukherjee, J., Stone, C.K., Christian, B.T.:  Human biodistribution and dosimetry of ¹⁸F-Nifene, an α4β2* nicotinic acetylcholine receptor PET tracer.  Nuclear Medicine Biology, 55: 7-11, 2017.

Lao, P., Betthauser, T.J., Tudorascu, D.L., Hillmer, A.T., Barnhart, T.E., Stone, C.K., Mukherjee, J., Christian, B.T.:  ¹⁸F-Nifene test-retest reproducibility in first-in-human investigations of α4β2* nicotinic acetylcholine receptor.  Synapse, 71: e21981, 2017. [Cover image in the issue is from the paper].

Coleman, R.A., Liang, C., Patel, R., Ali, S., Mukherjee, J.: Brain and brown adipose tissue metabolism in Tg 2576 transgenic mice models of Alzheimer’s disease assessed using ¹⁸F-FDG PET.  Molecular Imaging, 16: 1-9, 2017.

Mukherjee, J., Majji, D., Kaur, J., Constantinescu, C.C., Narayanan, T.K., Shi, B., Nour, M.T., Pan, M-L.: PET radiotracer development for imaging high-affinity state of dopamine D2 and D3 receptors: Binding studies of fluorine-18 labeled aminotetralins in rodents.  Synapse, 71: e21950, 2017. [Cover image in the issue is from the paper].

Mukherjee, J., Baranwal, A., Schade, K.N.: Classification of therapeutic and experimental drugs for brown adipose tissue activation: Potential treatment strategies for diabetes and obesity. Current Diabetes Reviews, 12: 414-428, 2016.

Pithia, N.K., Liang, C., Pan, X-Z., Pan, M-L., Mukherjee, J.: Synthesis and evaluation of (S)-[¹⁸F]Fesetron in the rat brain as a potential PET imaging agent for serotonin 5-HT3 receptors. Bioorg. Med. Chem. Lett., 26 (8): 1919-1924, 2016 (published online March 2016).

Pan, M.L., Mukherjee, M.T., Patel, H.H., Patel, B., Constantinescu, C.C., Mirbolooki, M.R., Liang, C., Mukherjee, J.: Evaluation of [¹¹C]TAZA for amyloid Ab plaque imaging in postmortem Alzheimer’s disease brain region and whole body distribution in rodent PET/CT. Synapse, 70: 163-176, 2016 (published online January 2016; Editor’s Choice Paper).

Mukherjee, J., Bajwa, A.K., Wooten, D.W., Hillmer, A.T., Pan, M-L., Pandey, S.K., Saigal, N., Christian, B.T.: Comparative assessment of ¹⁸F-Mefway as a serotonin 5-HT1A receptor PET imaging agent across species-rodents, nonhuman primates and humans. J. Comparative Neurology, 524(7): 1457-1471, 2016 (published online October 2015).

Baranwal, A., Mirbolooki, M.R., Mukherjee, J.: Initial assessment of β3-adrenoceptor activated brown adipose tissue in streptozotocin-induced diabetic rodent model using ¹⁸F-FDG PET/CT Molecular Imaging, 14: 561-566, 2015.

Mukherjee, J., Constantinescu, C.C., Hoang, A.T., Jerjian, T., Majji D., Pan, M-L.:  Evaluation of ¹⁸F-fallypride binding to dopamine D3 receptor subtype using in vitro and in vivo imaging in the rodent brain. Synapse, 69 (12): 577-591, 2015 (published online September 2015) [Cover image in the issue is from the paper]

Baranwal, A., Mukherjee, J.:  ¹⁸F-Fluorodeoxyglucamines: Reductive amination of hydrophilic ¹⁸F-fluoro-2-deoxyglucose with lipophilic amines for the development of potential PET imaging agents. Bioorganic Medicinal Chemistry Letter, 25 (15): 2902-2906, 2015 (published online May 2015).

Schade, K.N., Baranwal, A., Liang, C., Mirbolooki, M.R., Mukherjee, J.:  Preliminary Evaluation of β3 Adrenoceptor Agonist-Induced ¹⁸F-FDG Metabolic Activity in Brown Adipose Tissue of Obese Zucker Rat. Nuclear Medicine & Biology, 42(8):691-694, 2015 (published online April 2015).

Thio, J.P., Liang, C., Bajwa, A.K., Wooten, D.W., Christian, B.T., Mukherjee, J.:  Synthesis and evaluation of mefway analogs as ligands for serotonin 5HT1A receptors. Med. Chem. Res., 24(4): 1480-1486, 2015 (published online September 2014).

Mirbolooki, M.R., Schade, K.N., Constantinescu, C.C., Pan, M-L., Mukherjee, J.: Enhancement of ¹⁸F-fluorodeoxyglucose metabolism in rat brain frontal cortex using a β3 adrenoceptor agonist. Synapse, 69 (2): 96-98, 2015 (published online November 2014).

Hillmer, A.T, Wooten, D.W., Bajwa, A.K., Higgins, A.T., Lao, P.J., Bettehauser, T.J., Barnhart, T.E., Rowley, H.A., Stone, C.K., Sterling, J.C., Mukherjee, J., Christian, B.T.: First in Human Evaluation of [¹⁸F]Mefway, a PET Radioligand Specific to Serotonin-1A Receptors. J. Nucl. Med., 55(12): 1973-1979, 2014. [Cover image in the issue is from the paper]

Wooten, D., Hillmer, A., Murali, D., Barnhart, T., Bonab, A., Normandin, M., Schneider, M.L., Thio, J.P., Bajwa, A.K., Mukherjee, J., Christian, B.T.:  An in vivo comparison of 3- and 4-trans-[¹⁸F]Mefway in the nonhuman primate. Amer. J. Nucl. Med. Mol. Imag., 4(5): 483-489, 2014. [Cover image online in the issue is from the paper]

Kaur, J., Khararjian, A., Coleman, R.A., Constantinescu, C.C., Pan, M-L., Mukherjee, J.:  Spinal cord dopamine D2/D3 receptors: In vivo and ex vivo imaging in the rat using ¹⁸F/¹¹C-Fallypride. Nucl. Med. Biol., 41: 841-847, 2014 (published online August 2014).

Kuruvilla, S.A., Hillmer, A., Wooten, D.W., Patel, A., Christian, B.T., Mukherjee, J.:  Synthesis and evaluation of 2-¹⁸F-fluoro-5-iodo-3-[2-(S)-3,4-dehydropyrrolinylmethoxy]pyridine (¹⁸F-niofene) as a potential imaging agent for nicotinic α4β2 receptors. Amer. J. Nucl. Med. Mol. Imaging, 4(4): 354-364, 2014.

Garcia, A., Venugopal, A., Pan, M-L., Mukherjee, J.: Imaging pancreas in healthy and diabetic rodent model using ¹⁸F-fallypride PET/CT. Diabetes Technology. & Therapeutics Development., 16(10): 640-643, 2014 (published online May 2014).

Tang, W., Kuruvilla, S.A., Galitovskiy, V., Pan, M-L., Grando, S.A., Mukherjee, J.: Targeting histone deacetylase in lung cancer for early diagnosis: ¹⁸F-FAHA PET/CT imaging of NNK-treated A/J mice model. Amer. J. Nucl. Med. Mol. Imaging, 4(4): 324-332, 2014.

Pandey, S.K., Kaur, J., Easwaramoorthy, B., Shah A., Coleman, R.A., Mukherjee, J.: Multimodality imaging probe for PET and fluorescence imaging. Molecular Imaging, 13(3): 1-7, 2014 (published online March 2014).

Pandey, S.K., Venugopal, A., Kant, R., Coleman, R.A., Mukherjee, J.: ¹²⁴I-Epidepride: A high affinity and selective PET radiotracer with potential for extended imaging of dopamine D2/D3 receptors. Nucl. Med. Biol.,41(5): 426-431, 2014 (published online January 2014).

Tahara, N., Mukherjee, J., de Haas, H.J., Petrov, A.D., Tawakol, A., Haider, N., Tahara, A., Constantinescu, C.C., Zhou J., Boersma, H.H., Imaizumi, T., Nakano, M., Finn, A., Fayad, Z., Virmani, R. Fuster, F., Bosca, L. and  Narula, J.: 2-Deoxy-[2-¹⁸F]fluoro-D-mannose positron emission tomography imaging in atherosclerosis. Nature Medicine, 20(2): 215-219, 2014 (online, January 12, 2014).

Baranwal, A., Patel, H.H., Mukherjee, J.: ¹⁸F-Fluorodeoxyglycosylamines: Maillard reaction of ¹⁸F-FDG with biological amines. J. Label. Compds. Radiopharm., 57(2): 86-91, 2014 (published online, early view, December 2013).

Mirbolooki, M.R., Upadhyay, S.K., Constantinescu, C., Pan, M.L., Mukherjee, J. Adrenergic pathway activation enhances brown adipose tissue metabolism: A ¹⁸F-FDG PET/CT study in mice.  Nucl Med Biol., 41:10-16, 2014 (published on line October 2013).

Hillmer, A., Wooten, D., Farhoud, M., Higgins, A., Lao, P., Barnhart, T., Mukherjee, J., Christian, B. PET imaging of acetylcholinesterase inhibitor induced effects on a4b2 nicotinic acetylcholine receptor binding.  Synapse, 67: 882-886, 2013 (published on line August 2013).

Potkin, S.G., Keator, D.B., Kesler-West, M.L., Nguyen, D.D., van Erp, T.G.M., Mukherjee, J., Shah, N., Preda, A. D2 receptor occupancy following lurasidone treatment in patients with schizophrenia or schizophrenia disorder. CNS Spectrums, doi:10.1017/S109285291300059X, 2013 (published on line October 2013).

Hillmer, A., Wooten, W.D., Slesarev, M.S., Ahlers, E.O., Barnhart, T.E., Schneider, M.L., Mukherjee, J., Christian, B.T. Measuring a4b2 nicotinic acetylcholine receptor density in vivo ¹⁸F-nifene PET in the nonhuman primate. . J. Cereb. Blood Flow Metab., 33: 1806-1814, 2013 (published on line August 2013).

Wooten, D.W., Hillmer, A.T., Moirano, J.M., Tudorascu, D.L., Ahlers, E.O., Slesarev, M.S., Barnhart, T.E., Mukherjee, J., Schneider, M.L., Christian, B.T.: 5-HT1A sex based differences in Bmax, in vivo KD, and BPND in the nonhuman primate. Neuroimage, 77: 125-132, 2013 (published online, March 2013).

Pithia, N., Gulati, N., Pandey, S., Coleman, R., Kant, R. Mukherjee, J. Synthesis and Biological Evaluation of ¹⁸F-Norfallypride in the rodent brain using PET imaging. Nucl. Med. Biol., 40: 697-704, 2013 (published on line, April 2013).

Hillmer, A.T., Wooten, D.W., Farhoud, M., Barnhart, T.E., Mukherjee, J., Christian, B.: The effects of lobeline on a4b2 nicotinic acetylcholine receptor binding and uptake of ¹⁸F-nifene in rats. J. Neurosci. Methods, 214: 163-169, 2013 (published online Feb 2013).

Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Upadhyay SK, Eckel-Mahan KL, Mirbolooki MR, Tjong I, Griffey SM, Schmunk G, Koehne A, Halbout B, Iadonato S, Pedersen B, Borrelli E, Wang PH, Mukherjee J, Sassone-Corsi P, Chandy KG. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2239-48. doi: 10.1073/pnas.1221206110. Epub 2013 May 31. PMID: 23729813

Synthesis and biological evaluation of 18F-Norfallypride in the rodent brain using PET imaging.Pithia N, Gulati N, Pandey S, Coleman R, Kant R, Mukherjee J. Nucl Med Biol. 2013 Jul;40(5):697-704. doi: 10.1016/j.nucmedbio.2013.02.011. Epub 2013 Apr 4. PMID: 23562464

5-HT1A sex based differences in Bmax, in vivo K_D, and BP_ND in the nonhuman primate. Wooten DW, Hillmer AT, Moirano JM, Tudorascu DL, Ahlers EO, Slesarev MS, Barnhart TE, Mukherjee J, Schneider ML, Christian BT. Neuroimage. 2013 Aug 15;77:125-32. doi: 10.1016/j.neuroimage.2013.03.027. Epub 2013 Mar 26. PMID: 23537936

Evaluation of serotonin 5-HT1A receptors in rodent models using [¹⁸F]mefway PET. Saigal N, Bajwa AK, Faheem SS, Coleman RA, Pandey SK, Constantinescu CC, Fong V, Mukherjee J. Synapse. 2013 Mar 18. doi: 10.1002/syn.21665. [Epub ahead of print] PMID: 23504990. [Cover image in the issue is from the paper]

The effects of lobeline on α4β2* nicotinic acetylcholine receptor binding and uptake of [¹⁸F]nifene in rats. Hillmer AT, Wooten DW, Farhoud M, Barnhart TE, Mukherjee J, Christian BT. J Neurosci Methods. 2013 Apr 15;214(2):163-9. doi: 10.1016/j.jneumeth.2013.01.018. Epub 2013 Jan 28. PMID: 23370310

Evaluation of [¹⁸F]Nifene biodistribution and dosimetry based on whole-body PET imaging of mice. Constantinescu CC, Garcia A, Mirbolooki MR, Pan ML, Mukherjee J. Nucl Med Biol. 2013 Feb;40(2):289-94. doi: 10.1016/j.nucmedbio.2012.11.004. Epub 2012 Dec 21. PMID: 23265670

A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse. Nalbandian A, Llewellyn KJ, Badadani M, Yin HZ, Nguyen C, Katheria V, Watts G, Mukherjee J, Vesa J, Caiozzo V, Mozaffar T, Weiss JH, Kimonis VE. Muscle Nerve. 2013 Feb;47(2):260-70. doi: 10.1002/mus.23522. Epub 2012 Nov 21.

Nicotinic α4β2 receptor imaging agents. Part IV. Synthesis and biological evaluation of 3-(2-(S)-3,4-dehydropyrrolinyl methoxy)-5-(3′-¹⁸F-fluoropropyl)pyridine (¹⁸F-Nifrolene) using PET. Pichika R, Kuruvilla SA, Patel N, Vu K, Sinha S, Easwaramoorthy B, Narayanan TK, Shi B, Christian B, Mukherjee J. Nucl Med Biol. 2013 Jan;40(1):117-25. doi: 10.1016/j.nucmedbio.2012.09.009. Epub 2012 Nov 7. PMID: 23141552

Synthesis and evaluation of 3-¹²³I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic α4β2 receptor imaging agent. Pandey SK, Pan S, Kant R, Kuruvilla SA, Pan ML, Mukherjee J. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7610-4. doi: 10.1016/j.bmcl.2012.10.012. Epub 2012 Oct 10. PMID: 23116890

Targeting presynaptic norepinephrine transporter in brown adipose tissue: a novel imaging approach and potential treatment for diabetes and obesity. Mirbolooki MR, Constantinescu CC, Pan ML, Mukherjee J. Synapse. 2013 Feb;67(2):79-93. doi: 10.1002/syn.21617. Epub 2012 Nov 8. PMID: 23080264

Galitovskiy, V., Kuruvilla, S.A., Sevrioukov, E., Corches, A., Pan, M.L., Kalantri-Dehaghi, M., Mukherjee, J., Grando, S. Development of novel approach to diagnostic imaging of lung cancer with ¹⁸F-nifene PET/CT using A/J mice treated with NNK. J. Cancer Res & Therapy, 1: 128-137, 2013.

The homozygote VCP(R¹⁵⁵H/R¹⁵⁵H) mouse model exhibits accelerated human VCP-associated disease pathology. Nalbandian A, Llewellyn KJ, Kitazawa M, Yin HZ, Badadani M, Khanlou N, Edwards R, Nguyen C, Mukherjee J, Mozaffar T, Watts G, Weiss J, Kimonis VE. PLoS One. 2012;7(9):e46308. doi: 10.1371/journal.pone.0046308. Epub 2012 Sep 28. PMID: 23029473

PET imaging of α4β2* nicotinic acetylcholine receptors: quantitative analysis of ¹⁸F-nifene kinetics in the nonhuman primate. Hillmer AT, Wooten DW, Slesarev MS, Ahlers EO, Barnhart TE, Murali D, Schneider ML, Mukherjee J, Christian BT. J Nucl Med. 2012 Sep;53(9):1471-80. doi: 10.2967/jnumed.112.103846. Epub 2012 Jul 31. PMID: 22851633

Measurement of 5-HT_1A receptor density and in-vivo binding parameters of [¹⁸F]mefway in the nonhuman primate. Wooten DW, Hillmer AT, Moirano JM, Ahlers EO, Slesarev M, Barnhart TE, Mukherjee J, Schneider ML, Christian BT. J Cereb Blood Flow Metab. 2012 Aug;32(8):1546-58. doi: 10.1038/jcbfm.2012.43. Epub 2012 Apr 4. PMID: 22472611

Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F-nifene: relating PET imaging, autoradiography, and behavior. Bieszczad KM, Kant R, Constantinescu CC, Pandey SK, Kawai HD, Metherate R, Weinberger NM, Mukherjee J. Synapse. 2012 May;66(5):418-34. doi: 10.1002/syn.21530. Epub 2012 Feb 15. PMID: 22213342

Reist, C., Mukherjee, J., Wu, J; Modulating blood-brain barrier permeability and treatment-resistant psychiatric illness: Is pituitary neuroimaging a new frontier? Curr. Pharmacogenomics Personalized Med., 10, 182-184, 2012.

Ketoconazole-associated preferential increase in dopamine D2 receptor occupancy in striatum compared to pituitary in vivo: role for drug transporters? Reist C, Wu JC, Lilja Y, Mukherjee J, Gripeos D, Constantinescu C, Raggi MA, Mercolini L, Ozdemir V. J Clin Psychopharmacol. 2012 Feb;32(1):110-3. doi: 10.1097/JCP.0b013e3182408fc8. PMID: 22198458

Evaluation of [¹⁸F]Mefway biodistribution and dosimetry based on whole-body PET imaging of mice. Constantinescu CC, Sevrioukov E, Garcia A, Pan ML, Mukherjee J. Mol Imaging Biol. 2013 Apr;15(2):222-9. doi: 10.1007/s11307-012-0582-y. PMID: 22833323

Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation. Mirbolooki MR, Constantinescu CC, Pan ML, Mukherjee J. EJNMMI Res. 2011 Dec 1;1(1):30. doi: 10.1186/2191-219X-1-30. PMID: 22214183

The multiple faces of valosin-containing protein-associated diseases: inclusion body myopathy with Paget’s disease of bone, frontotemporal dementia, and amyotrophic lateral sclerosis. Nalbandian A, Donkervoort S, Dec E, Badadani M, Katheria V, Rana P, Nguyen C, Mukherjee J, Caiozzo V, Martin B, Watts GD, Vesa J, Smith C, Kimonis VE. J Mol Neurosci. 2011 Nov;45(3):522-31. doi: 10.1007/s12031-011-9627-y. Epub 2011 Sep 3. Review. PMID: 21892620

Striatal and extrastriatal microPET imaging of D2/D3 dopamine receptors in rat brain with [¹⁸F]fallypride and [¹⁸F]desmethoxyfallypride. Constantinescu CC, Coleman RA, Pan ML, Mukherjee J. Synapse. 2011 Aug;65(8):778-87. doi: 10.1002/syn.20904. Epub 2011 Mar 21. PMID: 21218455

¹⁸F-Fallypride PET of pancreatic islets: in vitro and in vivo rodent studies. Garcia A, Mirbolooki MR, Constantinescu C, Pan ML, Sevrioukov E, Milne N, Wang PH, Lakey J, Chandy KG, Mukherjee J. J Nucl Med. 2011 Jul;52(7):1125-32. doi: 10.2967/jnumed.111.088583. Epub 2011 Jun 16. PMID: 21680697

Evaluation of F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging. Kant R, Constantinescu CC, Parekh P, Pandey SK, Pan ML, Easwaramoorthy B, Mukherjee J. EJNMMI Res. 2011 Jun 1;1. doi:pii: 6. PMID: 22039577

Nicotinic α4β2 receptor imaging agents. Part III. Synthesis and biological evaluation of 3-(2-(S)-azetidinylmethoxy)-5-(3′-¹⁸F-fluoropropyl)pyridine (¹⁸F-nifzetidine). Pichika R, Easwaramoorthy B, Christian BT, Shi B, Narayanan TK, Collins D, Mukherjee J. Nucl Med Biol. 2011 Nov;38(8):1183-92. doi: 10.1016/j.nucmedbio.2011.05.005. Epub 2011 Aug 9. PMID: 21831652

An in vivo comparison of cis- and trans-[¹⁸F]mefway in the nonhuman primate. Wooten D, Hillmer A, Murali D, Barnhart T, Schneider ML, Mukherjee J, Christian BT. Nucl Med Biol. 2011 Oct;38(7):925-32. doi: 10.1016/j.nucmedbio.2011.04.001. Epub 2011 Jul 7. PMID: 21741252

Specific α4β2 nicotinic acetylcholine receptor binding of [F-18]nifene in the rhesus monkey. Hillmer AT, Wooten DW, Moirano JM, Slesarev M, Barnhart TE, Engle JW, Nickles RJ, Murali D, Schneider ML, Mukherjee J, Christian BT. Synapse. 2011 Dec;65(12):1309-18. doi: 10.1002/syn.20965. Epub 2011 Aug 31. PMID: 21674627

In vivo kinetics of [F-18]MEFWAY: a comparison with [C-11]WAY100635 and [F-18]MPPF in the nonhuman primate. Wooten DW, Moraino JD, Hillmer AT, Engle JW, Dejesus OJ, Murali D, Barnhart TE, Nickles RJ, Davidson RJ, Schneider ML, Mukherjee J, Christian BT. Synapse. 2011 Jul;65(7):592-600. doi: 10.1002/syn.20878. Epub 2010 Dec 8. PMID: 21484878

Exercise elevates dopamine D2 receptor in a mouse model of Parkinson’s disease: in vivo imaging with [¹⁸F]fallypride. Vučković MG, Li Q, Fisher B, Nacca A, Leahy RM, Walsh JP, Mukherjee J, Williams C, Jakowec MW, Petzinger GM. Mov Disord. 2010 Dec 15;25(16):2777-84. doi: 10.1002/mds.23407. PMID: 20960487 (Cover image in the issue from this paper)

VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. Badadani M, Nalbandian A, Watts GD, Vesa J, Kitazawa M, Su H, Tanaja J, Dec E, Wallace DC, Mukherjee J, Caiozzo V, Warman M, Kimonis VE. PLoS One. 2010 Oct 5;5(10). doi:pii: e13183. 10.1371/journal.pone.0013183. PMID: 20957154

(R)-N-Methyl-3-(3′-[F]fluoropropyl)phenoxy)-3-phenylpropanamine (F-MFP3) as a potential PET imaging agent for norepinephrine transporter. Nguyen VL, Pichika R, Bhakta PH, Kant R, Mukherjee J. J Labelled Comp Radiopharm. 2010 Feb 9;53(4):172-177. PMID: 20495670

High-affinity dopamine D2/D3 PET radioligands 18F-fallypride and 11C-FLB457: a comparison of kinetics in extrastriatal regions using a multiple-injection protocol. Vandehey NT, Moirano JM, Converse AK, Holden JE, Mukherjee J, Murali D, Nickles RJ, Davidson RJ, Schneider ML, Christian BT. J Cereb Blood Flow Metab. 2010 May;30(5):994-1007. doi: 10.1038/jcbfm.2009.270. Epub 2009 Dec 30. PMID: 20040928

Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity. Lee B, London ED, Poldrack RA, Farahi J, Nacca A, Monterosso JR, Mumford JA, Bokarius AV, Dahlbom M, Mukherjee J, Bilder RM, Brody AL, Mandelkern MA. J Neurosci. 2009 Nov 25;29(47):14734-40. doi: 10.1523/JNEUROSCI.3765-09.2009. PMID: 19940168

Performance evaluation of an Inveon PET preclinical scanner. Constantinescu CC, Mukherjee J. Phys Med Biol. 2009 May 7;54(9):2885-99. doi: 10.1088/0031-9155/54/9/020. Epub 2009 Apr 21. PMID: 19384008

[¹¹C]cyclopropyl-FLB 457: a PET radioligand for low densities of dopamine D2 receptors. Airaksinen AJ, Nag S, Finnema SJ, Mukherjee J, Chattopadhyay S, Gulyás B, Farde L, Halldin C. Bioorg Med Chem. 2008 Jul 1;16(13):6467-73. doi: 10.1016/j.bmc.2008.05.039. Epub 2008 May 20. PMID: 18534857

¹¹C-L-methionine positron emission tomography in the clinical management of cerebral gliomas. Singhal T, Narayanan TK, Jain V, Mukherjee J, Mantil J. Mol Imaging Biol. 2008 Jan-Feb;10(1):1-18. Epub 2007 Oct 24. Review. PMID: 17957408

Effect of acetylcholinesterase inhibitors on the binding of nicotinic α4β2 receptor PET radiotracer, ¹⁸F-nifene: A measure of acetylcholine competition. Easwaramoorthy B, Pichika R, Collins D, Potkin SG, Leslie FM, Mukherjee J. Synapse. 2007 Jan;61(1):29-36. PMID: 17068780

Synthesis and biologic evaluation of a novel serotonin 5-HT_1A receptor radioligand, ¹⁸F-labeled mefway, in rodents and imaging by PET in a nonhuman primate. Saigal N, Pichika R, Easwaramoorthy B, Collins D, Christian BT, Shi B, Narayanan TK, Potkin SG, Mukherjee J. J Nucl Med. 2006 Oct;47(10):1697-706. PMID: 17015907

D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia. Buchsbaum MS, Christian BT, Lehrer DS, Narayanan TK, Shi B, Mantil J, Kemether E, Oakes TR, Mukherjee J. Schizophr Res. 2006 Jul;85(1-3):232-44. Epub 2006 May 19. PMID: 16713185

Nicotinic α4β2 receptor imaging agents: part II. Synthesis and biological evaluation of 2-[¹⁸F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine (¹⁸F-nifene) in rodents and imaging by PET in nonhuman primate. Pichika R, Easwaramoorthy B, Collins D, Christian BT, Shi B, Narayanan TK, Potkin SG, Mukherjee J. Nucl Med Biol. 2006 Apr;33(3):295-304. PMID: 16631077

Positron autoradiography for intravascular imaging: feasibility evaluation. Shikhaliev PM, Xu T, Ducote JL, Easwaramoorthy B, Mukherjee J, Molloi S. Phys Med Biol. 2006 Feb 21;51(4):963-79. Epub 2006 Feb 1. PMID: 16467590

Moderate-level prenatal alcohol exposure alters striatal dopamine system function in rhesus monkeys. Schneider ML, Moore CF, Barnhart TE, Larson JA, DeJesus OT, Mukherjee J, Nickles RJ, Converse AK, Roberts AD, Kraemer GW. Alcohol Clin Exp Res. 2005 Sep;29(9):1685-97. PMID: 16205369

Measurement of d-amphetamine-induced effects on the binding of dopamine D-2/D-3 receptor radioligand, ¹⁸F-fallypride in extrastriatal brain regions in non-human primates using PET. Mukherjee J, Christian BT, Narayanan TK, Shi B, Collins D. Brain Res. 2005 Jan 25;1032(1-2):77-84. PMID: 15680944

Synthesis and evaluation of nicotine alpha4beta2 receptor radioligand, 5-(3′-¹⁸F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine, in rodents and PET in nonhuman primate. Chattopadhyay S, Xue B, Collins D, Pichika R, Bagnera R, Leslie FM, Christian BT, Shi B, Narayanan TK, Potkin SG, Mukherjee J. J Nucl Med. 2005 Jan;46(1):130-40. PMID: 15632043

Clinical utility of ¹¹C-flumazenil positron emission tomography in intractable temporal lobe epilepsy. Padma MV, Simkins R, White P, Satter M, Christian BT, Dunigan K, Lee C, Jacobs M, Mukherjee J, Mantil JC. Neurol India. 2004 Dec;52(4):457-62. PMID: 15626833

Binding characteristics of high-affinity dopamine D2/D3 receptor agonists, ¹¹C-PPHT and ¹¹C-ZYY-339 in rodents and imaging in non-human primates by PET. Mukherjee J, Narayanan TK, Christian BT, Shi B, Yang ZY. Synapse. 2004 Nov;54(2):83-91. PMID: 15352133

Measuring the in vivo binding parameters of [¹⁸F]-fallypride in monkeys using a PET multiple-injection protocol. Christian BT, Narayanan T, Shi B, Morris ED, Mantil J, Mukherjee J. J Cereb Blood Flow Metab. 2004 Mar;24(3):309-22. PMID: 15091112

Synthesis and biological evaluation of the binding of dopamine D2/D3 receptor agonist, (R,S)-5-hydroxy-2-(N-propyl-N-(5′-¹⁸F-fluoropentyl)aminotetralin (¹⁸F-5-OH-FPPAT) in rodents and nonhuman primates. Shi B, Narayanan TK, Christian BT, Chattopadhyay S, Mukherjee J. Nucl Med Biol. 2004 Apr;31(3):303-11. PMID: 15028242 (Cover image in the Journal issue is from this paper).

Prenatal stress, moderate fetal alcohol, and dopamine system function in rhesus monkeys. Roberts AD, Moore CF, DeJesus OT, Barnhart TE, Larson JA, Mukherjee J, Nickles RJ, Schueller MJ, Shelton SE, Schneider ML. Neurotoxicol Teratol. 2004 Mar-Apr;26(2):169-78. PMID: 15019951

¹¹C-Fallypride: radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain. Mukherjee J, Shi B, Christian BT, Chattopadhyay S, Narayanan TK. Bioorg Med Chem. 2004 Jan 2;12(1):95-102. PMID: 14697774

A comparative study on the uptake and incorporation of radiolabeled methionine, choline and fluorodeoxyglucose in human astrocytoma. Narayanan TK, Said S, Mukherjee J, Christian B, Satter M, Dunigan K, Shi B, Jacobs M, Bernstein T, Padma M, Mantil J. Mol Imaging Biol. 2002 Mar;4(2):147-56. PMID: 14537137

Brain imaging of ¹⁸F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors. Mukherjee J, Christian BT, Dunigan KA, Shi B, Narayanan TK, Satter M, Mantil J. Synapse. 2002 Dec 1;46(3):170-88. PMID: 12325044

Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18F-fallypride. Mukherjee J, Christian BT, Narayanan TK, Shi B, Mantil J. Neuropsychopharmacology. 2001 Oct;25(4):476-88. PMID: 11557161

Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [¹⁸F]fallypride in nonhuman primates. Christian BT, Narayanan TK, Shi B, Mukherjee J. Synapse. 2000 Oct;38(1):71-9. PMID: 10941142

In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist ¹¹C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate. Mukherjee J, Narayanan TK, Christian BT, Shi B, Dunigan KA, Mantil J. Synapse. 2000 Jul;37(1):64-70. PMID: 10842352

Shi, B., Narayanan, T.K., Yang, Z.Y., Christian, B.T. and Mukherjee, J.:  Radiosynthesis and in vitro     evaluation of 2-(N-alkyl-N-1-¹¹C-propyl)-aminotetralin analogs as high affinity dopamine D-2 receptor agonists for use as potential PET radiotracers. Nucl. Med. Biol., 26 (7): 725-735, 1999.

Mukherjee, J., Yang, Z.Y., Brown, T., Wernick, M., Yasillo, N.J., Ouyang, X., Chen, C-T., Mintzer, R. and Cooper, M.: Preliminary assessment of extrastriatal dopamine D-2 receptor binding in the rodent and non-human primate brains using the high affinity radioligand, [F-18]fallypride. Nucl. Med. Biol., 26 (5): 519-527, 1999.

Yang, Z-Y. and Mukherjee, J.: N-[1-Cyclopropylmethyl-2-pyrrolidinyl)methyl] substituted benzamides:   Synthesis and dopamine D-2 and D-3 receptor binding affinities. Med. Chem. Res., 9: 1-8, 1999.

Mukherjee, J. and Yang, Z.Y.: Development of N-[3-(2’,4’-dichlorophenoxy)-2-¹⁸F-fluoropropyl]-N-methylpropargylamine (¹⁸F-fluoroclorgyline) as a potential PET raditracer for monoamine oxidase.  Nucl.   Med. Biol., 26 (6): 619-625, 1999.

Mukherjee, J., Yang, Z.Y. and Lew, R.: N-(6-[F-18]Fluorohexyl)-N-methylpropargylamine: A fluorine-   18 labeled monoamine oxidase B inhibitor for potential use in PET studies. Nucl. Med. Biol., 26: 111-116, 1999.

Mukherjee, J. and Yang, Z-Y.: Monoamine oxidase A inhibition by fluoxetine (Prozac): An in vitro and in vivo study. Synapse, 31: 285-289, 1999.

Mukherjee, J., Das, M.K., Yang, Z-Y. and Lew, R.: Evaluation of the binding of the radiolabeled antidepressant drug, ¹⁸F-fluoxetine (¹⁸F-Prozac) in the rodent brain: An in vitro and in vivo study. Nucl. Med. Biol., 25: 605-610, 1998.

Mukherjee, J. and Yang, Z-Y.: Evaluation of monoamine oxidase B inhibition by fluoxetine (Prozac):     An in vitro and in vivo study. Eur. J. Pharmacol., 337: 111-114, 1997.

Kao, C-M., Yap, J.T., Mukherjee, J. and Wernick, M.N.:   Image reconstruction for dynamic PET based on low-order approximation and restoration of the sinogram. IEEE Transactions in Medical Imaging, 16: 738-749, 1997.

Mukherjee, J., Yang, Z.Y., Lew, R., Brown, T., Kronmal, S., Cooper, M. and Seiden, L.S.: Evaluation   of d-amphetamine effects on the binding of dopamine D-2 receptor radioligand, [F-18]fallypride in non- human primates using positron emission tomography. Synapse, 27: 1-13, 1997.

Yang, Z.Y., Perry, B.D. and Mukherjee, J.:  Fluorinated Benzazepines 1.  Syntheses, radiosyntheses and biological evaluation of a series of substituted benzazepines as selective and high affinity radiotracers for positron emission tomographic studies of dopamine D-1 receptors. Nucl. Med. Biol., 23: 793-805, 1996.

Mukherjee, J., Yang, Z.Y., Brown, T., Roemer, J. and Cooper, M.: ¹⁸F-Desmethoxyfallypride:  A fluorine-18 radiotracer with properties similar to carbon-11 raclopride for PET studies of dopamine D-2 receptors. Life Sciences, 59: 669-678, 1996.

Ouyang, X-H., Mukherjee, J. and Yang, Z.Y.:  Syntheses, radiosyntheses and biological evaluation of thienylcyclohexyl piperidine derivatives as potential radiotracers for the N-methyl-D-aspartate receptor- linked calcium ionophore. Nucl. Med. Biol., 23: 315-324, 1996.

Mukherjee, J., Yang, Z.Y., Brown, T., Jiang, M., Kapp, O., Chen, C-T. and Cooper, M.: Potential anomalies of dopamine D-2 receptor : Challenges for non-invasive imaging studies by positron emission tomography. Med. Chem. Res., 5: 174-192, 1995.

Mukherjee, J., Yang, Z.Y., Das, M.K. and Brown, T.: Fluorinated benzamide neuroleptics 3. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3[F-18]-fluoropropyl)-2,3-dimethoxy-benzamide as an improved dopamine D-2 receptor tracer. Nucl. Med. Biol., 22: 283-296, 1995 [Cover image in the issue is from the paper].

Chen, C-T., Aarsvold, J.N., Block, T.A., Matthews, K.L., Mintzer, R.A., Mukherjee, J., Yasillo, N.J.,     River, L.P., Cooper, M. and Lee, R.C.:  Radionuclide probes for tissue damage. Ann. N. Y. Acad. Sci., 720: 181-191, 1994.

Cooper, M., Metz, J., de Wit, H. and Mukherjee, J.:  From the cradle to the grave: Alcohol and its effects upon the brain. J. Nucl. Med., 34: 798-803, 1993.

Das, M.K. and Mukherjee, J.:  Radiosynthesis of [F-18]fluoxetine as a potential radiotracer of serotonin reuptake-sites. Int. J. Appl. Radiat. Isotopes, 44: 835-842, 1993.

Mukherjee, J., Yang, Z.Y. and Perry, B.D.: Fluorine-18 labeled substituted benzazepines as potential radiotracers for imaging dopamine D-1 receptors by PET. Eur. J. Pharmacol., 243: 287-290, 1993.

Mukherjee, J.: Fluorinated benzamide neuroleptics 2. Synthesis and radiosynthesis of (S)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-5-(3[F-18]-fluoropropyl)-3-substituted-2-methoxybenzamide.  Int. J. Appl. Radiat. Isotopes, 42: 713-721, 1991.

Mukherjee, J.: Use of diethylaminosulfur trifluoride in an efficient synthesis of  (S)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-5-(3-fluoropropyl)-2-methoxybenzamide. J. Fluorine Chem., 49: 151-154, 1990.

DeJesus, O.T., Sunderland, J.J., Nickles, R.J., Mukherjee, J. and Appelman, E.H.: Synthesis of radiofluorinated analogs of m-tyrosine as potential L-DOPA tracers via direct reaction of acetylhypofluorite. Int. J. Appl. Radiat. Isotopes, 41: 433-437, 1990.

Mukherjee, J., Perry, B.D. and  Cooper, M.:  Fluorinated benzamide neuroleptics 1. Radiosynthesis of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(2[F-18]-fluoroethyl)-2-methoxybenzamide: A potential fluorine-18 labeled PET radiotracer for dopamine D-2 receptors. J. Label. Compounds Radiopharm., 28: 609-616, 1990.

Mukherjee, J., Luh, K.E., Yasillo, N., Perry, B.D., Levy, D., Chen, C-T., Ortega, C., Beck, R.N. and      Cooper, M.:  Dopamine D-2 receptors imaged by PET in cebus apella using [F-18]benzamide   neuroleptic.  Eur. J. Pharmacol., 175: 363-364, 1990.

DeJesus, O.T., Mukherjee, J. and Khalifah, R.G.: Synthesis of a radiobrominated m-tyrosine analog.  J. Label. Compounds Radiopharm., 27: 189-194, 1989.

DeJesus, O.T. and Mukherjee, J.:  Radiobrominated m-tyrosine analog as a potential CNS L-Dopa PET tracer. Biochem. Biophys. Res. Commun., 150: 1027-1031, 1988.

Mukherjee, J., Rogers, J.I., Khalifah, R.G. and Everett, Jr. G.W.:  N-15 NMR studies of the complex of carbonic anhydrase with the novel carbonyl hydration substrate, pyruvamide.  Evidence for the coordination of the deprotonated amide group to the active-site zinc. J. Amer. Chem. Soc., 109: 7232-7233, 1987.

Rogers, J.I., Mukherjee, J. and Khalifah, R.G.:  Interaction of amide inhibitors with the active site of carbonic anhydrase.  Metal-induced deprotonation of the bound amide group is indicated by slow binding kinetics, by visible spectra of complexes with cobalt enzyme, and by pH effects on binding affinity.       Biochemistry, 26: 5672-5679, 1987.

Khalifah, R.G., Rogers, J.I. and Mukherjee, J.:  Interaction of the unique competitive inhibitor imidazole and related compounds with the active site metal of carbonic anhydrase.  Linkage between pH effects  on the inhibitor binding affinity and pH effects on the visible spectra of inhibitor complexes with the cobalt enzyme. Biochemistry, 26: 7057-7063, 1987.

Khalifah, R.G., Rogers, J.I., Mukherjee, J. and Morley, P.J.:  Molecular basis for catalytic activity changes in active-site-modified carbonic anhydrases: A C-13 magnetic resonance view.  Ann. N. Y. Acad.   Sci., 429: 114-128, 1984.

Mukherjee, J. and Banerji, K.K.: Kinetics and mechanism of the oxidation of primary alcohols by sodium N-chlorobenzenesulfonamide.  Indian J. Chem. Sect. A, 20: 394-395, 1981.

Mukherjee, J. and Banerji, K.K.: Kinetics and mechanism of the oxidation of primary alcohols by N-bromoacetamide. J. Org. Chem., 46: 2323-2326, 1981.

Mukherjee, J. and Banerji, K.K.: Kinetics and mechanism of the oxidation of substituted benzyl alcohols. J. Chem. Soc. Perkin Trans. II, 676-678, 1980.