Migraine and cognitive function: a prospective cohort
Cognitive difficulties, such as memory problems and trouble thinking clearly, are a common and disabling part of migraines, often reported by patients during different stages of a migraine attack, including before, during, and after the headache. However, studies that use formal tests to measure cognitive performance have shown mixed results due to differences in study methods and timing. In this study, we plan to track cognitive function on a daily basis using reliable, web-based tests. Our goal is to measure how cognitive abilities change during different stages of a migraine—before, during, after, and between attacks—while also considering other factors like sleep, mood, and medications. By doing this daily, we aim to minimize memory-related errors in reporting and get a clearer understanding of how migraines affect cognitive function.
Headache Assessment via Digital Platform in United States (HeAD-US)
Migraines significantly impact many lives, affecting daily activities and well-being. Our project aims to analyze data collected from a large population through a phone application. This dataset covers various aspects of patient’s life including demographics (age, sex, marital status, income, education, employment, ethnicity, and race), migraine severity and nature of migraine symptoms (pain intensity and frequency), migraine Disability (impact on daily activities, work, and social life), neuropsychological Symptoms (stress, anxiety, and depression, sleep Patterns, and effectiveness of migraine medications. Our specific goals are: 1. Finding common triggers and patterns among different groups, 2. Using machine learning to predict migraine severity and frequency, 3. Improving treatment strategies by developing personalized and effective treatment plans, 4. Enhancing quality of life of patients by improving management strategies for better living.
Real world Migraine Studies using EHR data
Migraine projects using All of US database
The All of Us Research Program is a major initiative led by the National Institutes of Health (NIH) aimed at gathering health data from one million or more people across the United States. Its goal is to accelerate medical research and enable more precise and individualized health care by studying how individual differences in lifestyle, environment, and biology impact health outcomes. As of summer 2024, All of Us database has data from more than 800,000 people. Our group uses data from this valuable database to study the impact of genomics as well as social determinant of health on different health outcomes among patients with Migraine.
Migraine projects using Veteran’s Affair EHR database
This cohort study aims to address the cardiovascular risks associated with migraine, including cerebrovascular events, myocardial infarction (MI), and cardiovascular mortality, using 10-year data from 241,711 veterans with migraine and 483,422 matched controls from the VHA. The study will evaluate whether migraine (especially with aura) increases the risk of cardiovascular events, examine factors such as age, race, BMI, and medications that may influence this association, and assess whether including migraine improves the predictive accuracy of the Framingham Cardiac and Stroke Risk Scores.