We study genetic epilepsy in a parallel approach with three complementary systems: Drosophila, mice and human iPSC-derived neurons.
Our goal is to understand the underlying cellular mechanisms of the disease and identify targets for development of novel patient-specific therapies in order to reduce and/or eliminate seizures in humans with genetic epilepsy.
GABAergic neurons in a fly brain
An EEG trace during a seizure episode
iPSC-derived neurons atop of astrocyte feeder layers
GABAergic neurons from a control individual