UCI MIND awarded $18 million, five-year grant to lead landmark dementia study focused on LATE. More details here.

Members of our lab (S. Ahmad Sajjadi, Davis Woodworth, Pooyan Mobtahej, Ghasem Farahmand, Lorena Sordo) presented 10 poster presentations at the Alzheimer’s Association International Conference (AAIC) 2024, which took place from July 28th to August 1st. The following posters were presented (presenters are bolded):

• Contribution of neuropathological changes to cognitive decline in late life; The 90+ Study
  • Authors: Jiaxin Yu MS, Davis Woodworth PhD , Syed Bukhari MS , Ali Ezzati MD , Tom Montine MD, PhD , Claudia Kawas MD , Maria Corrada ScD , Tianchen Qian PhD, S. Ahmad Sajjadi MD, PhD (1) University of California, Irvine, Irvine, CA, USA (2) Stanford University, Stanford, USA

• Detection of Cognitive Impairment through Spontaneous Speech Acoustic Markers Using Transformer-based Machine Learning Approach
  • Authors: Pooyan Mobtahej, EngD, Sam Gouron, BS, Annelisse El-Khoury, BS, Anne-Marie C. Leiby, BS, BA, Claudia H. Kawas, MD, Maria M. Corrada, ScM, ScD, and S. Ahmad Sajjadi, MD, PhD (1) School of Medicine, University of California, Irvine, CA, USA

• Asymmetrical hippocampal atrophy: an arrow in the quiver of imaging markers for LATE-NC
  • Authors: Davis C. Woodworth, PhD; Dana E. Greenia, RN, MS; Syed A. Bukhari, MS; Thomas J. Montine, MD, PhD; Ali Ezzati, MD; Claudia H. Kawas, MD; María M. M. Corrada, ScM, ScD and S. Ahmad Sajjadi, MD, PhD (1)University of California, Irvine, Irvine, CA, USA, (2) Stanford University, Stanford, CA, USA

• Evaluating updated LATE-NC staging criteria using National Alzheimer’s Coordinating Center data: stage 1 subtypes matter
  • Authors: Davis C. Woodworth, PhD; Katelynn M. Nguyen, BS, BA; Lorena Sordo, PhD; Kiana A. Scambray, MA; Elizabeth Head, PhD; Claudia H. Kawas, MD; María M. M. Corrada, ScM, ScD; Peter T Nelson, MD, PhD4 and S. Ahmad Sajjadi, MD, PhD, (1) University of California, Irvine, Irvine, CA, USA, (2) The UC Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, CA, USA, (3) University of Michigan, Ann Arbor, MI, USA, (4) College of Medicine, University of Kentucky, Lexington, KY, USA

• Serological inflammation markers and their association with cognition in the oldest old; The 90+ Study
  • Authors: Anne-Marie C Leiby, BS, BA; Ghasem Farahmand, MD; Aanan Ramanathan, BS; Davis C. Woodworth, PhD; Luohua Jiang, MD, PhD; Jiaxin Yu, MS; Tianchen Qian, PhD; María M. M. Corrada, SCM, ScD; Claudia H. Kawas, MD and S. Ahmad Sajjadi, MD, PhD, (1)University of California, Irvine, CA, USA, (2) University of California, Irvine, Irvine, CA, USA, (3) University of California Irvine, Irvine, CA, USA

• The potential of plasma TDP-43 as a biomarker for limbic predominant age related TDP-43 Encephalopathy
  • Authors: Lorena Sordo, PhD; Anne-Marie C Leiby, BS, BA; Rond Malhas, BS; James Barlow4; Robert A. Rissman, PhD5; Claudia H. Kawas, MD; María M. M. Corrada, ScM, ScD; Elizabeth Head, PhD and S. Ahmad Sajjadi, MD, PhD, (2) University of California, Irvine, CA, USA, (3) University of California, Irvine, Irvine, CA, USA, (4) University of California San Diego, La Jolla, CA, USA, (5) University of California, San Diego, La Jolla, CA, USA

• Transformer-based Deep Learning Architecture Improves Detection of Associations between Spontaneous Speech Language Markers and Cognition
  • Authors: Pooyan Mobtahej, EngD; Sam Gouron, BS; Rojan Javaheri, BS; Annelisse El-Khoury, BS; Anne-Marie C Leiby, BS, BA; David L Sultzer, MD and S. Ahmad Sajjadi, MD, PhD, (1) University of California, Irvine, Irvine, CA, USA, (2) University of California, Irvine, CA, USA, (3) The UC Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, CA, USA, (4) Institute for Memory Impairments and Neurological Disorders (UCI-MIND), University of California, Irvine, Irvine, CA, USA

• Associations of cerebral amyloid and tau with neurocognitive performance: Findings from the 90+ Study
  • Authors: Evan Fletcher, Ph.D.; Shraddha Sapkota, PhD; Oliver Martinez, BS; María M. M. Corrada, ScM, ScD; Davis C. Woodworth, PhD; S. Ahmad Sajjadi, MD, PhD and Charles Decarli, MD, (1)UC Davis, Davis, CA, USA, (2)University of California, Davis, Davis, CA, USA, (3) University of California, Irvine, Irvine, CA

• A weakly-supervised, MRI-guided clustering of cognitive decline: A post-hoc analysis of the EXPEDITION-3 clinical trial
  • Authors: Bhargav Teja Nallapu, PhD; Kellen K. Petersen, PhD; Idris Demirsoy, PhD; Richard B. Lipton, MD; Christos Davatzikos, PhD; Laura Rabin, PhD4; S. Ahmad Sajjadi, MD, PhD5 and Ali Ezzati, MD6 (1) Albert Einstein College of Medicine, Bronx, NY, USA, (2) University of California, Irvine, Irvine, CA, USA, (3) Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, (4) Brooklyn College of the City University of New York, Brooklyn, NY, USA, (5) Institute for Memory Impairments and Neurological Disorders (UCI-MIND), University of California, Irvine, Irvine, CA, USA, (6) University of California Irvine, Irvine, CA, USA

• Utility of recruitment incentives in early Alzheimer’s disease clinical trials
  • Authors: Marina Ritchie, MS; Megan G. Witbracht, PhD; Eunji Russ, MA; S. Ahmad Sajjadi, MD, PhD; Gaby Thai, MD; Steven Tam, MD; Daniel L Gillen, PhD and Joshua D Grill, PhD, University of California, Irvine, Irvine, CA, USA

NBCLA NEWS

Dr. Sajjadi appears on NBCLA news to discuss dementia risks and outcomes, in light of missing former LA County Sheriff Lee Baca being found.

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NEW PUBLICATION

Our lab published a paper titled “Associations of Amyloid Burden, White Matter Hyperintensities, and Hippocampal Volume With Cognitive Trajectories in the 90+ Study.” in the journal Neurology (Volume 103, Number 3) on July 15, 2024.

Our lab published a paper titled “Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database.” in the journal Acta Neuropathologica on June 19th.