Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE) is a form of dementia that affects memory and thinking abilities, similar to Alzheimer’s disease (AD). LATE is characterized by the accumulation of a protein called TDP-43 in the brain’s limbic system, which includes regions critical for memory and emotion.

How Common is LATE?
LATE becomes increasingly common with advanced age. Research suggests that LATE neuropathologic changes (LATE-NC) may be present in approximately 20-50% of individuals over the age of 80. Despite its prevalence, LATE is often underrecognized because its symptoms closely resemble those of Alzheimer’s disease.

Who is Affected by LATE?
LATE primarily affects older adults, particularly those over the age of 80. It is less common in younger seniors. The condition is associated with age-related changes, with the risk increasing as people live longer.