Clinical Findings
Individuals with LATE typically experience gradual, progressive memory loss (amnestic cognitive impairment), not unlike early stages of AD. LATE may also affect other cognitive functions such as…

• Difficulties with planning, problem-solving, and organizing tasks.
• Challenges in finding words or understanding complex language.
• Trouble navigating familiar environments or recognizing objects and faces.

These symptoms can impact daily activities and reduce independence over time.

Imaging Findings
Brain imaging studies, such as MRI and PET scans, may show…

• Atrophy (shrinkage) of brain areas, particularly in the medial temporal lobe regions. This includes the hippocampus, which is crucial for memory.
• Changes in area of the limbic system that are involved in emotion and memory processing.

However, distinguishing LATE from AD based on imaging alone is challenging. Specialized imaging techniques and biomarkers are being researched to improve diagnostic accuracy.

Inconclusive Genetic Findings
Currently, there is no strong evidence linking LATE to specific genetic factors. Unlike some other forms of dementia, such as familial AD or frontotemporal dementia (FTD), LATE does not appear to have a significant inherited component. Most cases occur sporadically without a clear genetic predisposition.

(Source: ALZFORUM)