57. Kaipa BR, Kasetti R, Sundaresan Y, Li L, Yacoub S, Millar C, Cho W, Skowronska-Krawczyk D, Maddineni P, Palczewski K, Zode G. (2025) Impaired axonal transport at the optic nerve head contributes to neurodegeneration in a novel Cre-inducible mouse model of myocilin glaucoma. JCI Insight (accepted)
56. Narasimhan A, Min SH, Johnson LL, Roehrich H, Cho W, Her TK, Windschitl C, O’Kelly RD, Angelini L, Yousefzadeh MJ, McLoon LK, Hauswirth WW, Robbins PD, Skowronska-Krawczyk D*, Niedernhofer LJ*. (2024) The Ercc1-/Δ mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration. Aging Cell *co-corresponding author
Featured in several scientific news outlets:
- National Eye Institute Research News https://www.nei.nih.gov/about/news-and-events/news/uc-irvine-co-led-study-finds-dna-damage-key-factor-age-related-macular-degeneration
- Science Daily DNA damage is key factor in age-related macular degeneration, study finds
- EurekaAlert! AAAS UC Irvine-co-led study finds DNA damage is key factor in age-related macular degeneration
- Futurity DNA damage is key to age-related macular degeneration
- Sciencenewsnet UC Irvine-co-led study finds DNA damage is key factor in age-related macular degeneration
- Medical Express DNA damage is key factor in age-related macular degeneration, study finds
55. Montaser AB, Gao F, Peters D, Vainionpää K, Zhibin N, Skowronska-Krawczyk D, Figeys D, Palczewski K, Leinonen H. (2024) Retinal Proteome Profiling of Inherited Retinal Degeneration Across Three Different Mouse Models Suggests Common Drug Targets in Retinitis Pigmentosa. Mol Cell Proteomics
54. Bastola T, Perkins GA, Huu VAN, Ju S, Kim KY, Shen Z, Skowronska-Krawczyk D, Weinreb RN, Ju WK. (2024) Administration of Bicarbonate Protects Mitochondria, Rescues Retinal Ganglion Cells, and Ameliorates Visual Dysfunction Caused by Oxidative Stress. Antioxidants
53. Lewandowski D, Gao F, Imanishi S, Tworak A, Bassetto M, Dong Z, Pinto AFM, Tabaka M, Kiser PD, Imanishi Y, Skowronska-Krawczyk D, Palczewski K. (2024) Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice.J Biol Chem
52. Wallis M, Xu Q, Krawczyk M, Skowronska-Krawczyk D*. (2024)Evolution of the enhancer-rich regulatory region of the gene for the cell-type specific transcription factor POU1F1. Heliyon *corresponding author
51. Zhang W, Li Y, Fung AA, Li Z, Jang H, Zha H, Chen X, Gao F, Wu JY, Sheng H, Yao J, Skowronska-Krawczyk D, Jain S, Shi L. (2024)Multi-molecular hyperspectral PRM-SRS microscopy. Nat Commun.
50. Gao F, Tom E, Lieffrig SA, Finnemann SC, Skowronska-Krawczyk D.* (2023) A novel quantification method for retinal pigment epithelium phagocytosis using a very-long-chain polyunsaturated fatty acids-based strategy. Front Mol Neurosci *corresponding author
49. Skowronska-Krawczyk, D. * (2023) Hallmarks of Aging – Causes and Consequences. Aging Biology *corresponding author
48. Jang H, Li Y, Fung AA, Bagheri P, Hoang K, Skowronska-Krawczyk D, Chen X, Wu JY, Bintu B, Shi L. (2023) Nature Methods Super-resolution SRS microscopy with A-PoD. 11/2022
47. Xu Q, Rydz C, Nguyen Huu VA, Rocha L, Palomino La Torre C, Lee I, Cho W, Jabari M, Donello J, Lyon DC, Brooke R, Horvath S, Weinreb RN, Ju WK, Foik A, Skowronska-Krawczyk D*; (2022) Aging Cell https://doi.org/10.1111/acel.13737; *corresponding author
- Featured in >35 news outlets, including:
National Eye Institute Research News https://www.nei.nih.gov/about/news-and-events/news/new-uc-irvine-led-study-shows-repeated-stress-accelerates-aging-eye
EyeNet journal – American Association of Ophthalmology news, article about our published work in Aging Cell 2022 https://www.aao.org/eyenet/article/stress-induced-aging-in-eye-and-glaucoma,
porquoi docteur https://www.pourquoidocteur.fr/Articles/Question-d-actu/41816-Le-stress-pourrait-accelerer-perte-vision,
healthview https://www.healthview.gr/agchos-pos-mporei-na-katastrepsei-tin-orasi/,
AlJazeera https://www.aljazeera.net/health/2022/11/29/دراسة-حديثة-تفسر-السبب-ارتفاع-ضغط,
green Me https://www.greenme.it/salute-e-alimentazione/salute/stress-invecchiamento-oculare/,
Esculap, ophthalmology news – https://okulistyka.esculap.com/news/164367/pod-wpywem-stresu-oczy-szybciej-si-starzej ,
GEN Genetic Engineering & Biotechnology News https://www.genengnews.com/news/retinal-aging-accelerated-by-stress/,
Medical Express https://medicalxpress.com/news/2022-11-stress-aging-eye.html , and others.
46. Jones MK, Agarwal D, Mazo KW, Chopra M, Jurlina SL, Dash N, Xu Q, Ogata AR, Chow M, Hill AD, Kambli NK, Xu G, Sasik R, Birmingham A, Fisch KM, Weinreb RN, Enke RA, Skowronska-Krawczyk D, Wahlin KJ (2022) Chromatin Accessibility and Transcriptional Differences in Human Stem Cell-Derived Early-Stage Retinal Organoids; Cells 2022
Cover story of the November issue of Cells
45. Malek G, Campisi J, Kitazawa K, Webster C, Lakkaraju A, Skowronska-Krawczyk D. (2022) Does senescence play a role in age-related macular degeneration? Exp Eye Res. 2022
44. Skowronska-Krawczyk D*, Priyanka Narayan, Peter Tessarz (2022) Editorial, Research Topic: Molecular Role of Lipids in Aging; Front. Aging (2022); *corresponding author
43. Gao F, Tom E, Skowronska-Krawczyk D*, (2022) Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions; Front. Aging (2022); *corresponding author
42. Rho C.R., Kim S.W., Lane S., Gao F., Kim J., Xie Y., Brown, D.J., Skowronska-Krawczyk, D., and J.V. Jester, Expression of Acyl-CoA wax-alcohol acyltransferase 2 (AWAT2) by human and rabbit meibomian glands and meibocytes. Ocul Surf 23 (2022) 60-70.
41. Lewandowski D., Foik A.T., Smidak R., Choi E.H., Zhang J., Hoang T., Tworak A., Suh S., Leinonen H., Dong Z., Pinto A.F., Tom E., Luu J., Lee J., Ma X., Bieberich E., Blackshaw S., Saghatelian A., Lyon D.C., Skowronska-Krawczyk D., Tabaka M., and Palczewski K., (2022) Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. JCI Insight 7 (2022).
- Featured in several news outlets including:
MedicalExpress https://medicalxpress.com/news/2022-01-pharmacological-treatment-retinitis-pigmentosa-vision.html ,
ScienceDaily https://www.sciencedaily.com/releases/2022/01/220127104205.htm ,
Mirage https://www.miragenews.com/cause-develop-pharmacological-treatment-for-714092/,
NewsMedical https://www.news-medical.net/news/20220128/Desipramine-and-L-cycloserine-together-reduce-ceramide-levels-in-the-retina-and-enhance-vision.aspx and more.
40. Lewandowski, D., X Sander, C.L., A. Tworak, Gao, F., Xu, Q., Skowronska-Krawczyk, D.*, (2021) Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life. Prog Retin Eye Res (2021) 101037 *corresponding author
39. Roa JN, Ma Y, Mikulski Z, Xu Q, Ilouz R, Taylor SS*, Skowronska-Krawczyk D* (2021) Protein Kinase A in Human Retina: Differential Localization of Cβ, Cα, RIIα, and RIIβ in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits. Frontiers in Mol Neuro, November 18; *corresponding authors
38. Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D*, Kiser PD*, Palczewski K*. (2021) Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol.Aug 2;220(8) *corresponding authors
37. Bohaczuk SC, Thackray VG, Shen J, Skowronska-Krawczyk D, Mellon PL. (2020) FSHB Transcription is Regulated by a Novel 5′ Distal Enhancer with a Fertility-Associated Single Nucleotide Polymorphism. Endocrinology. Oct 3:bqaa181.
36. Skowronska-Krawczyk, D*, Budin, I*. (2020) Review Aging Membranes: Unexplored Functions for Lipids in the Lifespan of the Central Nervous System Exp. Gerontol. (2020) Mar;131:110817; *corresponding authors
35. Rocha LR, Nguyen Huu VA, Palomino La Torre C, Xu Q, Jabari M, Krawczyk M, Weinreb RN, Skowronska-Krawczyk D*, (2019) Removal of early senescent cells protects retinal ganglion cells loss in experimental ocular hypertension. Aging Cell 2020 Feb;19(2):e13089. *corresponding author
- Featured in several news outlets including:
Saltman Quarterly Insider Volume 13, Spring 2020 as a selected topic by students. https://issuu.com/sqonline/docs/spring_insider_2020_06.03.20 ,
Fight Aging! https://www.fightaging.org/archives/2020/01/senolytic-therapies-as-preventative-medicine-for-glaucoma/?alm_mvr=0
34. Pandolfi, E.C., Breuer, J.A., Nguyen Huu, V.A., Talluri, T., Nguyen, D., Lee, J.S., Hu, R., Bharti, K., Skowronska-Krawczyk, D., Gorman, M.R., Mellon P.L., Hoffmann H.M. (2019) The Homeodomain Transcription Factors Vax1 and Six6 are Required for SCN Development and Function Mol Neuro. PMID: 31705443 DOI: 10.1007/s12035-019-01781-9
33. Moore SM, Skowronska-Krawczyk D, Chao DL. (2020) Review Targeting of the NRL Pathway as a Therapeutic Strategy to Treat Retinitis Pigmentosa J. Clin. Med. 2020, 9(7), 2224;
32. Lee EJ, Chiang WJ, Kroeger H, Bi CX, Chao DL, Skowronska-Krawczyk D, Mastey RR, Tsang SH, Chea L, Kim K, Lambert SR, Grandjean JM, Baumann B, Audo I, Kohl S, Moore AT, Wiseman RL, Carroll J, Lin JH. (2020) Multiexon deletion alleles of ATF6 linked to achromatopsia. JCI Insight. Apr 9;5(7):e136041
31. Gao, MH, Giamouridis, D, Lai, NC, Guo, T, Xia, B, Kim, YC, Nguyen Huu, VA, Skowronska-Krawczyk, D, Lantier, L, Bhargava, R, Hammond, HK (2019) Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency. Mol Ther Meth & Clin Dev Epub December 14; https://doi.org/10.1016/j.omtm.2019.12.002
30. El-Nimri NW, Moore SM, Zangwill LM, Proudfoot JA, Weinreb RN, Skowronska-Krawczyk D*, Baxter SL* . (2020) Evaluating the neuroprotective impact of senolytic drugs on human vision. Sci Rep. Dec 10;10(1):21752. *corresponding authors
- Featured in:
29. Edwards G, Perkins GA, Kim KY, Kong Y, Lee Y, Choi SH, Skowronska-Krawczyk D, Weinreb RN, Zangwill L, Strack S, Ju WK (2020) Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fragmentation and loss in retinal ganglion cells. Cell Death Dis, 11, 254, doi:10.1038/s41419-020-2456-6
28. Dasyani M, Gao F, Xu Q, Van Fossan D, Zhang E, F M Pinto A, Saghatelian A, Skowronska-Krawczyk D*, Chao DL*. (2020) Elovl2 Is Required for Robust Visual Function in Zebrafish. Cells. Dec 2;9(12):2583 *corresponding author
27. Choi SH, Kim KY, Perkins GA, Phan S, Edwards G, Xia Y, Kim J, Skowronska-Krawczyk D, Weinreb RN, Ellisman MH, Miller YI, Ju WK. (2020) AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration. Redox Biol. Aug 27;37:101703
26. Chen D, Chao DL, Rocha L, Kolar M, Nguyen Huu VA, Krawczyk M, Dasyani M, Wang T, Jabari M, Jafari M, Ross KD, Saghatelian A, Hamilton BA, Zhang K, Skowronska-Krawczyk D. (2020) The Lipid Elongation Enzyme ELOVL2 is a molecular regulator of aging in the retina. Aging Cell Feb;19(2):e13100
- Featured in several news outlets including:
Eureka Alert! (AAAS) https://www.eurekalert.org/news-releases/836926
MedicalXpress and
Genetic Engineering and Biotechnology News (GEN) https://www.genengnews.com/news/elovl2-gene-found-to-play-critical-role-in-aging-of-the-eye/
Science Daily https://www.sciencedaily.com/releases/2020/01/200115140506.htm
Technology Networks https://www.technologynetworks.com/tn/news/geneticists-take-a-closer-look-at-the-aging-eye-329436
Spektrum.de https://www.spektrum.de/alias/bilder-der-woche/leuchtende-netzhaut/1700236
25. Chao DL., Skowronska-Krawczyk D (2020) Review ELOVL2: Not just a biomarker of aging Trans Med Aging Volume 4, 2020, Pages 78-80 *co-corresponding authors
24. Skowronska-Krawczyk D*, Chao DL. Review Long-Chain Polyunsaturated Fatty Acids and Age-Related Macular Degeneration. Adv Exp Med Biol (2019). 1185:39-43 * corresponding author
23. Moore S, Skowronska-Krawczyk D, Chao DL. Review RNA Therapeutics for Inherited Retinal Diseases. Adv Exp Med Biol (2019) 1185:85-89.
22. Han J, Lando L, Skowronska-Krawczyk D, Chao DL. Review Genetics of Diabetic Retinopathy. Curr Diab Rep. 2019 Jul 29;19(9):67.
21. Skowronska-Krawczyk, D. (2018) Marking cell-type-restricted enhancers before their activation. Cell Cycle. 2018 Jun 21. doi: 10.1080/15384101.2018.1491459.
20. Kim, HS., Tan, Y., Ma, W., Merkurjev, D., Destici, E., Ma, Q., Suter, T., Ohgi, K., Friedman, M., Skowronska-Krawczyk, D., Rosenfeld, MG. (2018). Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells. Nature 556 (7702):510-514. doi: 10.1038/s41586-018-0048-8. Epub Apr 18.
19. Friedman, D.A., Pilko, A., Skowronska-Krawczyk, D., Krasinska, K., Parker, J.W., Hirsh, J., Gordon D.M. (2018) The Role of Dopamine in the Collective Regulation of Foraging in Harvester Ants. iScience. Sept 27; 10.1016/j.isci.2018.09.001
18. Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y. (2017) Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function. Nature 541, 558, doi:10.1038/nature19831 (2017).
17. Scully KM, Skowronska-Krawczyk D, Krawczyk M, Merkurjev D, Taylor H, Livolsi A, Tollkuhn J, Stan RV, Rosenfeld MG. (2016). Epithelial cell integrin β1 is required for developmental angiogenesis in the pituitary gland. PNAS doi: 10.1073/pnas.1614970113
16. Rodrigues T, Krawczyk M, Skowronska-Krawczyk D, Matter-Sadzinski L, Matter JM. (2016) Delayed neurogenesis with respect to eye growth shapes the pigeon retina for high visual acuity. Development 143: 4701-4712; doi: 10.1242/dev.138719
15. Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y. (2016). Lens Regeneration using endogenous stem cells with gain of visual function. Nature Mar 16
14. Zhang, F., Tanasa, B., Merkurjev, D., Lin, C., Song, X., Li, W., Tan, Y., Zhang, Ohgi, K.A., Krones, A., Skowronska-Krawczyk, D., Rosenfeld, M.G. (2015) Enhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program. PNAS
13. Skowronska-Krawczyk D*, Zhao L*, Zhu J, Weinreb R, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Cao G, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zheng L, Krawczyk M, Chen D, Shi C, Zin C, Zhu J, Mellon P, Gao W, Zhang L, Sun X, Zhong S, Zhuo Y, Rosenfeld M, Liu Y, Zhang K. (2015). P16/INK4A up-regulation mediated by Six6 defines retinal ganglion cell pathogenesis in glaucoma. Mol Cell. Sept 10. doi: 10.1016/j.molcel.2015.07.027 *equally contributed
Featured in “Assassins of eyesight” (2015) Nature, News and Views; Huberman A.D., El-Danaf R.N.
12. Skowronska-Krawczyk, D.*, Rosenfeld, M.G. (2015) Nuclear Matrix Revisited? Cell Cycle 14(10) doi: 10.1080/15384101.2015.1032643 * corresponding author
11. Skowronska-Krawczyk, D.*, Ma, Q., Schwartz, M., Scully, K., Taylor, H., Li, W., Tollkuhn, J., Liu, Z., Ohgi, K., Notani, D., Rosenfeld, M.G*. (2014). Required enhancer-matrin-3 network interactions for a homeodomain transcription program. Nature 514, 257-261, doi:10.1038/nature13573 *corresponding author
Featured in “Homeodomain proteins in action: similar DNA binding preferences, highly variable connectivity” (2017) Curr Opinion in Gen & Dev; Bobola N., Merabet S.
Featured in “Matrin3: connecting gene expression with the nuclear matrix” (2016) Wiley Interdiscip Rev RNA; Coehlo M.B., Attig J., Ule J., Smith C.W.
10. Telese, F.*, Gamliel, A.*, Skowronska-Krawczyk, D.*, Garcia-Bassets, I.*, and Rosenfeld, M.G. (2013). “Seq-ing” insights into the epigenetics of neuronal gene regulation. Neuron 77, 606-623. *equally contributed
9. Chiodini, F.*, Matter-Sadzinski, L.*, Rodrigues, T.*, Skowronska-Krawczyk, D.*, Brodier, L., Schaad, O., Bauer, C., Ballivet, M., and Matter, J.M. (2013). A positive feedback loop between ATOH7 and a Notch effector regulates cell-cycle progression and neurogenesis in the retina. Cell Rep 3, 796-807. *equally contributed
8. Skowronska-Krawczyk, D.*, Chiodini, F., Ebeling, M., Alliod, C., Kundzewicz, A., Castro, D., Ballivet, M., Guillemot, F., Matter-Sadzinski, L., and Matter, J.M.* (2009). Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis. Development 136, 3767-3777. * corresponding author
7. Heng, J.I., Nguyen, L., Castro, D.S., Zimmer, C., Wildner, H., Armant, O., Skowronska-Krawczyk, D., Bedogni, F., Matter, J.M., Hevner, R., et al. (2008). Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature 455, 114-118.
6. Hernandez, J., Matter-Sadzinski, L., Skowronska-Krawczyk, D., Chiodini, F., Alliod, C., Ballivet, M., and Matter, J.M. (2007). Highly conserved sequences mediate the dynamic interplay of basic helix-loop-helix proteins regulating retinogenesis. J Biol Chem 282, 37894-37905.
5. Del Bene, F., Ettwiller, L., Skowronska-Krawczyk, D., Baier, H., Matter, J.M., Birney, E., and Wittbrodt, J. (2007). In vivo validation of a computationally predicted conserved Ath5 target gene set. PLoS Genet 3, 1661-1671.
4. Castro, D.S., Skowronska-Krawczyk, D., Armant, O., Donaldson, I.J., Parras, C., Hunt, C., Critchley, J.A., Nguyen, L., Gossler, A., Gottgens, B., et al. (2006). Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev Cell 11, 831-844.
3. Skowronska-Krawczyk, D.*, Matter-Sadzinski, L., Ballivet, M., and Matter, J.M.* (2005). The basic domain of ATH5 mediates neuron-specific promoter activity during retina development. Mol Cell Biol 25, 10029-10039. *corresponding author
2. Skowronska-Krawczyk, D.*, Ballivet, M., Dynlacht, B.D., and Matter, J.M.* (2004). Highly specific interactions between bHLH transcription factors and chromatin during retina development. Development 131, 4447-4454. *corresponding author
1. Bind, E., Kleyner, Y., Skowronska-Krawczyk, D., Bien, E., Dynlacht, B.D., and Sanchez, I. (2004). A novel mechanism for mitogen-activated protein kinase localization. Mol Biol Cell 15, 4457-4466.