Publications

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Journal Articles

  1. Coulis, G., Jaime, D., Guerrero-Juarez, C., Kastenschmidt, J.M., Farahat, P.K., Nguyen, Q., Pervolarakis, N., McLinden, K., Thurlow, L., Movahedi, S., Hughes, B.S., Duarte, J., Sorn, A., Montoya, E., Mozaffar, I., Dragan, M., Othy, S., Joshi, T., Hans, C.P., Kimonis, V., MacLean, A.L., Nie, Q., Wallace, L.M., Harper, S.Q., Mozaffar, T., Hogarth, M.W., Bhattacharya, S., Jaiswal, J.K., Golann, D.R., Su, Q., Kessenbrock, K., Stec, M., Spencer, M.J., Zamudio, J.R. & Villalta, S.A. 2023. Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis. Sci Adv 9, eadd9984. https://pubmed.ncbi.nlm.nih.gov/37418531/
  2. Bolton, J. L.,Short, A.K.#, Othy, S.#, Kooiker, C.L., Shao, M., Gunn, B.C., Beck J., Bai, X., Law S.M., Savage J.C., Lambert J.L., Belelli D., Tremblay M., Cahalan, M. D., & Baram, T. Z. 2022. Impaired developmental microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons exacerbates stress responses throughout life. Cell Reports, Mar 29;38(13):110600. [#Equal contribution]. https://pubmed.ncbi.nlm.nih.gov/35354026/
  3. Jairaman A., McQuade A., Granzotto A., Kang Y.J., Chadarevian J.P., Gandhi S., Parker I., Smith I., Cho H., Sensi SL., Othy S., Blurton-Jones M., and Cahalan M.D. 2022.TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia. Elife, Feb 22;11:e73021. https://pubmed.ncbi.nlm.nih.gov/35191835/
  4. Jairaman A.*, Othy S*., Nourse J., Dong T.X, Zavala A., Chen F., Parker I., Pathak M.M., and Cahalan M.D. 2021. Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses. Sci Adv, Jul 7;7(28): :eabg5859 [*co-first author]. https://pubmed.ncbi.nlm.nih.gov/34233878/
  5. Marangoni, F., Zhakyp, A., Corsini M., Geels, S.N., Carrizosa, E., Thelen, M., Mani, V., Prüßmann, J., Warner, R.D., Ozga, A.J., Di Pilato, M., Othy, S., Mempel, T.R. 2021. Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop. Cell, Jul 22;184(15): :3998-4015. https://pubmed.ncbi.nlm.nih.gov/34157302/  
  6. Atcha  H., Jairaman A., Holt J.R., Meli V.S., Nagalla R.R., Veerasubramanian P.K.,Brumm K.T., Lim H.E., Othy S., Cahalan M.D., Pathak M.M., and Liu W.F. 2021. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun, May 31; 12(1):3256. https://pubmed.ncbi.nlm.nih.gov/34059671/
  7. Othy S*#., Jairaman A*., Dynes J.L., Dong T.X, Tune C, Yeromin A.V., Zavala A., Akunwafo C., Chen F., Parker I., and Cahalan M.D#. 2020. Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation., Proc Natl Acad Sci USA, Jul 30;202006895[*co-first authors; # corresponding authors]. https://pubmed.ncbi.nlm.nih.gov/32732436/ Commentary by Prof. Stefan Feske.
  8. Wakida N.M., Gomez-Godinez V., Li H., Nguyen J., Kim E.K., Dynes J.L, Othy S., Lau A.L., Ding P., Shi L.Z., Carmona C., Thompson L.M., Cahalan M.D., and Berns M.W. 2020. “Calcium dynamics in astrocytes during phagocytosis”. Front Bioeng Biotechnol, Aug 27; 8:912. https://pubmed.ncbi.nlm.nih.gov/32984268/
  9. McIntyre L.L., Greilach S.A., Othy S., Sears-Kraxberger I., Wi B., Ayala-Angulo J., Vu E., Pham Q., Silva J., Dang K., Rezk F., Steward O., Cahalan M.D., Lane T.E and Walsh C.M. 2020. Regulatory T cells promote remyelination in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis following human neural stem cell transplant. Neurobiol Dis.Jul; 140:104868. https://pubmed.ncbi.nlm.nih.gov/32276110/
  10. Hernández-Ruiz M*., Othy S*., Herrera C., Nguyen HT., Arrevillaga-Boni G., Catalan-Dibene J., Cahalan M.D., and Zlotnik A. 2019. Cxcl17-/- mice develop exacerbated disease in a T cell-dependent autoimmune model. J Leukoc Biol. May; 105(5):1027-1039. [*co-first author] https://pubmed.ncbi.nlm.nih.gov/30860634/
  11. Dong T.X*., Othy S*., Greenberg M.L., Jairaman A., Akunwafo C., Leverrier S., Yu Y., Parker I., Dynes J.L., and Cahalan M.D. 2017. Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility. Elife, Dec 14; 6:e32417[*co-first author] Faculty of 1000 recommended article,  Featured in eLife digest. https://pubmed.ncbi.nlm.nih.gov/29239723/
  12. Dong T.X*., Othy S*., Jairaman A., Skupsky J., Zavala A., Parker I., Dynes J.L., and Cahalan M.D. 2017. T Cell Calcium Dynamics Visualized in a Ratiometric tdTomato-GCaMP6f Transgenic Reporter Mouse. Elife, Dec 14; 6:e27827. [*co-first author]. Featured in eLife digest https://pubmed.ncbi.nlm.nih.gov/29239725/
  13. Matheu M.P*., Othy S*., Greenberg M.L., Dong T.X., Schuijs M., Deswarte K., Hammad H., Lambrecht B.N., Parker I., and Cahalan M.D. 2015. Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming. Nat Commun Feb 5; 6:6219, [*co-first author] https://pubmed.ncbi.nlm.nih.gov/25653051/
  14. Othy, S., Topcu, S., Saha, C., Kothapalli, P., Lacroix-Desmazes, S., Kasermann, F., Miescher, S., Bayry, J., and Kaveri, S.V. 2014. Sialylation may be dispensable for reciprocal modulation of helper T cells by intravenous immunoglobulin. Eur J Immunol. Jul; 44(7):2059-63. https://pubmed.ncbi.nlm.nih.gov/24700174/
  15. Othy, S., Hegde, P., Topcu, S., Sharma, M., Maddur, M.S., Lacroix-Desmazes, S., Bayry, J., and Kaveri, S.V. 2013. IVIg inhibits encephalitogenic potential of pathogenic T cells and interferes with their trafficking to the central nervous system implicating ing sphingosine-1 phosphate receptor 1-mTOR axis. J Immunol May 1;190(9):4535-41. https://pubmed.ncbi.nlm.nih.gov/23526819/
  16. Othy, S., Topcu, S., Kaveri, S., and Bayry, J. 2012. Effect of CC chemokine receptor 4 antagonism in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA Sep 11;109(37):E2412-3. https://pubmed.ncbi.nlm.nih.gov/22864916/
  17. Othy, S., Bruneval, P., Topcu, S., Dugail, I., Delers, F., Lacroix-Desmazes, S., Bayry, J., and Kaveri, S. 2012. Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: role of lipid accumulation. J Autoimmun Sep;39(3):168-72. https://pubmed.ncbi.nlm.nih.gov/22704540/
  18. Maddur, M.S., Othy, S., Hegde, P., Vani, J., Desmazes, SL., Bayry, J., and Kaveri, S.V. 2010. Immunomodulation by intravenous immunoglobulin: Role of regulatory T cells. J Clin Immunol May, 30, Suppl 1, S4-8. https://pubmed.ncbi.nlm.nih.gov/20405183/