2023
HMGB2 regulates the differentiation and stemness of exhausted CD8+ T cells during chronic viral infection and cancer. Neubert EN, DeRogatis JM, Lewis SA, Viramontes KM, Ortega P, Henriquez ML, Buisson R, Messaoudi I, Tinoco R. Nat Commun. 2023 Sep 13;14(1):5631. doi: 10.1038/s41467-023-41352-0. PMID: 37704621; PMCID: PMC10499904.
Cell-Intrinsic CD38 Expression Sustains Exhausted CD8+ T Cells by Regulating Their Survival and Metabolism during Chronic Viral Infection. DeRogatis JM, Neubert EN, Viramontes KM, Henriquez ML, Nicholas DA, Tinoco R. J Virol. 2023 Apr 11:e0022523. doi: 10.1128/jvi.00225-23. Epub ahead of print. PMID: 37039663.
2022
PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells. Viramontes KM, Neubert EN, DeRogatis JM, Tinoco R. Front Immunol. 2022 Jun 14;13:869768. doi: 10.3389/fimmu.2022.869768. PMID: 35774790; PMCID: PMC9237324.
Targeting the PSGL-1 Immune Checkpoint Promotes Immunity to PD-1-Resistant Melanoma. DeRogatis JM, Viramontes KM, Neubert EN, Henriquez ML, Guerrero-Juarez CF, Tinoco R. Cancer Immunol Res. 2022 May 3;10(5):612-625. doi: 10.1158/2326-6066.CIR-21-0690. PMID: 35303066; PMCID: PMC9064985.
The cure from within? a review of the microbiome and diet in melanoma. Kumar P, Brazel D, DeRogatis J, Valerin JBG, Whiteson K, Chow WA, Tinoco R, Moyers JT. Cancer Metastasis Rev. 2022 Apr 27:1–20. doi: 10.1007/s10555-022-10029-3. Epub ahead of print. PMID: 35474500; PMCID: PMC9042647.
2021
PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection. Tinoco R, Neubert EN, Stairiker CJ, Henriquez ML, Bradley LM. Front Immunol. 2021 Jul 13;12:677824. doi: 10.3389/fimmu.2021.677824.
PSGL-1 Immune Checkpoint Inhibition for CD4+ T Cell Cancer Immunotherapy. DeRogatis JM, Viramontes KM, Neubert EN, Tinoco R. Front Immunol. 2021 Feb 23;12:636238. doi: 10.3389/fimmu.2021.636238.
2020
Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth. Li Y, Elmén L, Segota I, Xian Y, Tinoco R, et al. Cell Rep. 2020;30(6):1753‐1766.e6. doi:10.1016/j.celrep.2020.01.035
Siah2 control of T-regulatory cells limits anti-tumor immunity. Scortegagna M, Hockemeyer K, Dolgalev I, Poźniak J, Rambow F, Li Y, Feng Y, Tinoco R, Otero DC, Zhang T, Brown K, Bosenberg M, Bradley LM, Marine JC, Aifantis I, Ronai ZA. Nat Commun. 2020;11(1):99. Published 2020 Jan 7. doi:10.1038/s41467-019-13826-7
2019
Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice. Li Y, Tinoco R, Elmén L, et al. Nat Commun. 2019;10(1):1492. Published 2019 Apr 2. doi:10.1038/s41467-019-09525-y
Ubiquitin Ligases in Cancer Immunotherapy – Balancing Antitumor and Autoimmunity. Fujita Y, Tinoco R, Li Y, Senft D, Ronai ZA. Trends Mol Med. 2019;25(5):428‐443. doi:10.1016/j.molmed.2019.02.002
2018
Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis. Fujita Y, Khateb A, Li Y, Tinoco R, et al.Cell Rep. 2018;24(12):3296‐3311.e6. doi:10.1016/j.celrep.2018.08.057
Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. Borlido J, Sakuma S, Raices M, Carrette F, Tinoco R, Bradley LM, D’Angelo MA. Nat Immunol. 2018;19(6):594‐605. doi:10.1038/s41590-018-0103-5
Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells. Tinoco R, Carrette F, Henriquez ML, Fujita Y, Bradley LM. J Immunol. 2018;200(8):2690‐2702. doi:10.4049/jimmunol.1701251
2017
Targeting the PSGL-1 pathway for immune modulation. Tinoco R, Bradley LM. Immunotherapy. 2017;9(10):785‐788. doi:10.2217/imt-2017-0078
PSGL-1: A New Player in the Immune Checkpoint Landscape. Tinoco R, Otero DC, Takahashi AA, Bradley LM. Trends Immunol. 2017;38(5):323‐335. doi:10.1016/j.it.2017.02.002
2016
PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion. Tinoco R, Carrette F, Barraza ML, et al. Immunity. 2016;44(5):1190‐1203. doi:10.1016/j.immuni.2016.04.015
2012
Regulation of Antigen-Experienced T Cells: Lessons from the Quintessential Memory Marker CD44. Baaten BJ, Tinoco R, Chen AT, Bradley LM. Front Immunol. 2012;3:23. Published 2012 Feb 27. doi:10.3389/fimmu.2012.00023
2009
Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI. Immunity. 2009;31(1):145‐157. doi:10.1016/j.immuni.2009.06.015
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Kerdiles YM, Beisner DR, Tinoco R, et al. Nat Immunol. 2009;10(2):176‐184. doi:10.1038/ni.1689