PUBLICATIONS

UC Irvine

Seo G, Mckinley J, Wang W. MAP4K2 connects the Hippo pathway to autophagy in response to energy stress. Autophagy. 2023 Nov 8:1-3. doi: 10.1080/15548627.2023.2280876. PMID: 37937799

Seo G, Yu C, Han H, Xing L, Kattan RE, An J, Kizhedathu A, Yang B, Luo A, Buckle AL, Tifrea D, Edwards R, Huang L, Ju HQ#, Wang W#. The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress. Molecular Cell. 2023 Aug 17:S1097-2765(23)00562-2. doi: 10.1016/j.molcel.2023.07.019. PMID: 37595580. (# co-corresponding authors)

Pham PD, Lu H, Han H, Zhou JJ, Madan A, Wang W, Murre C, Cho KWY. Transcriptional network governing extraembryonic endoderm cell fate choice. Developmental Biology. 2023 Jul 7;502:20-37. doi: 10.1016/j.ydbio.2023.07.002. Online ahead of print.PMID: 37423592

Meli VS, Veerasubramanian PK, Downing TL, Wang W, Liu WF. Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells. Science Signaling. 2023 May 2;16(783):eadc9656. doi: 10.1126/scisignal.adc9656. Epub 2023 May 2.PMID: 37130167

He XY, Fan X, Qu L, Wang X, Jiang L, Sang LJ, Shi CY, Lin S, Yang JC, Yang ZZ, Lei K, Li JH, Ju HQ, Yan Q, Liu J, Wang F, Shao J, Xiong Y, Wang W#, Lin A#.LncRNA modulates Hippo-YAP signaling to reprogram iron metabolism. Nature Communications. 2023 Apr 20;14(1):2253. doi: 10.1038/s41467-023-37871-5. PubMed PMID: 37080959; PubMed Central PMCID: PMC10119135. (# co-corresponding authors)

Han H, Wang W. A tale of two Hippo pathway modules. EMBO Journal. 2023 Apr 19:e113970. doi: 10.15252/embj.2023113970. PMID: 37073568

Zhou JJ, Cho JS, Han H, Blitz IL, Wang W, Cho KWY. Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis. Elife. 2023 Mar 27;12:e79380. doi: 10.7554/eLife.79380. PMID: 36971347

Zhang Z, Lu YX, Liu F, Sang L, Shi C, Xie S, Bian W, Yang JC, Yang Z, Qu L, Chen SY, Li J, Yang L, Yan Q, Wang W, Fu P, Shao J, Li X, Lin A. lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1. Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2206694120. doi: 10.1073/pnas.2206694120. Epub 2023 Feb 16. PMID: 36795754

Kattan RE, Ayesh D, Wang W. Analysis of affinity purification-related proteomic data for studying protein-protein interaction networks in cells. Briefings in Bioinformatics. 2023 Mar 19;24(2):bbad010. doi: 10.1093/bib/bbad010.PMID: 36682002

Shi C, Wang Y, Wu M, Chen Y, Liu F, Shen Z, Wang Y, Xie S, Shen Y, Sang L, Zhang Z, Gao Z, Yang L, Qu L, Yang Z, He X, Guo Y, Pan C, Che J, Ju H, Liu J, Cai Z, Yan Q, Yu L, Wang L, Dong X, Xu P, Shao J, Liu Y, Li X#, Wang W#, Zhou R#, Zhou T#, Lin A#. Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation. Nat Communications. 2022 Nov 14;13(1):6951. doi: 10.1038/s41467-022-34346-x.PMID: 36376293. (# co-corresponding authors)

Jia Z, Yang S, Li M, Lei Z, Ding X, Fan M, Wang D, Xie D, Zhou H, Qiu Y, Zhuang Q, Li D, Yang W, Qi X, Cang X, Zhao JW, Wang W, Lin A, Yan Q. A novel NF2 splicing mutant causes neurofibromatosis type 2 via liquid-liquid phase separation with large tumor suppressor and Hippo pathway. iScience. 2022 Oct 4;25(11):105275. doi: 10.1016/j.isci.2022.105275. eCollection 2022 Nov 18.PMID: 36300003

Nabti I, Reddy BJN, Rezgui R, Wang W, Gross SP, Shubeita GT. The ubiquitous microtubule-associated protein 4 (MAP4) controls organelle distribution by regulating the activity of the kinesin motor. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2206677119. doi: 10.1073/pnas.2206677119. Epub 2022 Oct 3.PMID: 36191197

Jiang H, Bian W, Sui Y, Li H, Zhao H, Wang W, Li X. FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ. Science Advances. 2022 Sep 23;8(38):eabq4831. doi: 10.1126/sciadv.abq4831. Epub 2022 Sep 21.PMID: 36129980

Liu F, Tian T, Zhang Z, Xie S, Yang J, Zhu L, Wang W, Shi C, Sang L, Guo K, Yang Z, Qu L, Liu X, Liu J, Yan Q, Ju HQ, Wang W, Piao HL, Shao J, Zhou T, Lin A. Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma. Nature Metabolism. 2022 Aug;4(8):1022-1040. doi: 10.1038/s42255-022-00616-7. Epub 2022 Aug 22.PMID: 35995997

Zhou JJ, Pham PD, Han H, Wang W, Cho KWY. Engagement of Foxh1 in chromatin regulation revealed by protein interactome analyses. Dev Growth Differ. 2022 Aug; 64 (6) 297-305. doi: 10.1111/dgd.12799. PMID: 35848281

Bian W, Jiang H, Feng S, Chen J#, Wang W#, Li X#. Protocol for establishing a protein-protein interaction network using tandem affinity purification followed by mass spectrometry in mammalian cells. STAR Protoc. 2022 Jul 19;3(3):101569. doi: 10.1016/j.xpro.2022.101569. eCollection 2022 Sep 16.PMID: 35874475 (# co-corresponding authors)

Zhou JJ, Pham PD, Han H, Wang W, Cho KWY. Foxh1 engages in chromatin regulation revealed by protein interactome analyses. Dev Growth Differ. 2022 Jul 18. doi: 10.1111/dgd.12799. Online ahead of print.PMID: 35848281

Seo G, Wang W. Putting a leash on Hippo. Nature Chemical Biology. 2022 Jul 4. doi: 10.1038/s41589-022-01066-8. PMID: 35788179

Han H, Mahieu A, de Paula LD, Wang W. Functional interplay between the Hippo pathway and heavy metals. Mol Cell Oncol. 2022 Apr 9;9(1):2061297. doi: 10.1080/23723556.2022.2061297. eCollection 2022.PMID: 35434269

Han H, Nakaoka HJ, Hofmann L, Zhou JJ, Yu C, Zeng L, Nan J, Seo G, Vargas RE, Yang B, Qi R, Bardwell L, Fishman DA, Cho KWY, Huang L, Luo R, Warrior R, Wang W. The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1. Nature Cell Biology. 2022 Jan 13. doi: 10.1038/s41556-021-00813-8. PMID: 35027733

Kattan RE, Han H, Seo G, Yang B, Lin Y, Dotson M, Pham S, Menely Y, Wang W. Interactome analysis of human phospholipase D and phosphatidic acid-associated protein network. Mol Cell Proteomics. 2022 Jan 7:100195. doi: 10.1016/j.mcpro.2022.100195. PMID: 35007762 

Bian W, Tang M, Jiang H, Xu W, Hao W, Sui Y, Hou Y, Nie L, Zhang H, Wang C, Li N, Wang J, Qin J, Wu L, Ma X#, Chen J#, Wang W#, Li X#. Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation. Developmental Cell. 2021 Oct 1:S1534-5807(21)00733-4. doi: 10.1016/j.devcel.2021.09.015. Online ahead of print. PMID: 34626540. (# co-corresponding authors)

Zhou Z, Yuan Z, Hong W, Wang W. Editorial: A Hippo’s View: From Molecular Basis to Translational Medicine. Front Cell Dev Biol. 2021 Jul 23;9:729155. doi: 10.3389/fcell.2021.729155. eCollection 2021. PMID: 34368170

Li RH, Tian T, Ge QW, He XY, Shi CY, Li JH, Zhang Z, Liu FZ, Sang LJ, Yang ZZ, Liu YZ, Xiong Y, Yan Q, Li X, Ju HQ, Liu J, Wang LJ, Shao JZ, Wang W, Zhou T, Lin A. A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling. Cell Research. 2021 Jul 15. doi: 10.1038/s41422-021-00530-9. PMID: 34267352

Kim MJ, Cervantes C, Jung YS, Zhang X, Zhang J, Lee SH, Jun S, Litovchick L, Wang W, Chen J, Fang B, Park JI.  PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis. Molecular Cell. 2021 Apr 15;81(8):1698-1714.e6. doi: 10.1016/j.molcel.2021.02.001. Epub 2021 Feb 23.PMID: 33626321

Sang L, Ju HQ, Yang Z, Ge Q, Zhang Z, Liu F, Yang L, Gong H, Shi C, Qu L, Chen H, Wu M, Chen H, Li R, Zhuang Q, Piao H, Yan Q, Yu W, Wang L, Shao J, Liu J, Wang W, Zhou T, Lin A. Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress. Nature Metabolism. 2021 Jan;3(1):90-106. doi: 10.1038/s42255-020-00325-z. Epub 2021 Jan 4.PMID: 33398195

Meli VS, Atcha H, Veerasubramanian PK, Nagalla RR, Luu TU, Chen EY, Guerrero-Juarez CF, Yamaga K, Pandori W, Hsieh JY, Downing TL, Fruman DA, Lodoen MB, Plikus MV, Wang W, Liu WF. YAP-mediated mechanotransduction tunes the macrophage inflammatory response. Science Advances. 2020 Dec 4;6(49):eabb8471. doi: 10.1126/sciadv.abb8471. PMID: 33277245

Seo G, Han H, Vargas RE, Yang B, Li X, Wang W. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. Cell Reports. 2020 Jul 7;32(1):107860. doi: 10.1016/j.celrep.2020.107860.PMID: 32640226

Vargas RE, Wang W. Significance of long non-coding RNA AGPG for the metabolism of esophageal cancer. Cancer Commun (Lond). 2020 May 25. doi: 10.1002/cac2.12035. PMID: 32449319

Chen Y, Han H, Seo G, Vargas RE, Yang B, Chuc K, Zhao H, Wang W. Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution. Scientific Reports. 2020 Feb 21. DOI: 10.1038/s41598-020-60120-4. PMID: 32081887.

Vargas RE, Duong VT, Han H, Ta AP, Chen Y, Zhao S, Yang B, Seo G, Chuc K, Oh S, El Ali A, Razorenova OV, Chen J#, Luo R#, Li X#, Wang W#. Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor. EMBO Journal. 2019 Nov 29:e102406. doi: 10.15252/embj.2019102406. PMID:31782549. (# co-corresponding authors)

Chapman DE, Reddy BJN, Huy B, Bovyn MJ, Cruz SJS, Al-Shammari ZM, Han H, Wang W, Smith DS, Gross SP. Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528. Nat Communications. 2019 Jan 16;10(1):228. doi: 10.1038/s41467-018-08110-z. PMID: 30651536

Han H, Vargas R, Seo G, Wang W. Phosphatidic acid: a lipid regulator of the Hippo pathway. Molecular & Cellular Oncology. 2018 Dec 30. https://doi.org/10.1080/23723556.2018.1558683

Jung YS, Jun S, Kim MJ, Lee SH, Suh HN, Lien EM, Jung HY, Lee S, Zhang J, Yang JI, Ji H, Wu JY, Wang W, Miller RK, Chen J, McCrea PD, Kopetz S, Park JI. TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling. Nature Cell Biology. 2018 Oct 29. doi: 10.1038/s41556-018-0219-8. [Epub ahead of print] PMID: 30374053

Jung YS, Wang W, Jun S, Zhang J, Srivastava M, Kim MJ, Lien EM, Shang J, Chen J, McCrea PD, Zhang S, Park JI. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. Nature Cell Biology. 2018 Nov;20(11):1303-1314. doi: 10.1038/s41556-018-0215-z. Epub 2018 Oct 22. PMID: 30361697

Han H, Qi R, Zhou JJ, Ta AP, Yang B, Nakaoka HJ, Seo G, Guan KL, Luo R, Wang WRegulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Molecular Cell. 2018 Sep 13. pii: S1097-2765(18)30698-1. doi: 10.1016/j.molcel.2018.08.038. PMID: 30293781

Sang LJ, Ju HQ, Liu GP, Tian T, Ma GL, Lu YX, Liu ZX, Pan RL, Li RH, Piao HL, Marks JR, Yang LJ, Yan Q, Wang W, Shao J, Zhou Y, Zhou T, Lin A. LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling. Molecular Cell. 2018 Oct 4;72(1):71-83.e7. doi: 10.1016/j.molcel.2018.08.014. Epub 2018 Sep 13.

Han H, Yang B, Nakaoka HJ, Yang J, Zhao Y, Le Nguyen K, Bishara AT, Mandalia TK, Wang WHippo signaling dysfunction induces cancer cell addiction to YAP. Oncogene. 2018 Aug 1. doi: 10.1038/s41388-018-0419-5.

Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton BN, Chang L, Liu N, Zeng L, Wang W, Wang Y, Zhang P, Hu X, Su X, Liang H, Sun Y, Ma L. SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Nat Communications. 2018 Jun 11;9(1):2269. doi: 10.1038/s41467-018-04620-y.

Zheng X, Han H, Liu GP, Ma YX, Pan RL, Sang LJ, Li RH, Yang LJ, Marks JR, Wang W#, Lin A#. LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. EMBO Journal. 2017; 36(22):3325-3335. (# co-corresponding authors)

Li X, Wang W, Chen J. Recent progress in mass spectrometry proteomics for biomedical research. Science China. Life sciences. 2017; 60(10):1093-1113.

Han H, Yang B, Wang W. Angiomotin-like 2 interacts with and negatively regulates AKT. Oncogene. 2017; 36(32):4662-4669.

Li X, Han H, Zhou MT, Yang B, Ta AP, Li N, Chen J#, Wang W#. Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy. Cell Reports. 2017; 20(3):737-749. (# co-corresponding authors)

Li X, Gao M, Choi JM, Kim BJ, Zhou MT, Chen Z, Jain AN, Jung SY, Yuan J, Wang W#, Wang Y#, Chen J#. Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling. Mol Cell Proteomics. MCP. 2017; 16(4):594-607. (# co-corresponding authors)

Li X, Tran KM, Aziz KE, Sorokin AV, Chen J#, Wang W#. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. MCP. 2016; 15(9):3030-44. (# co-corresponding authors)

MDACC & SIBCB

Yi J, Lu L, Yanger K, Wang W, Sohn BH, Stanger BZ, Zhang M, Martin JF, Ajani JA, Chen J, Lee JS, Song S, Johnson RL. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology. 2016; 64(5):1757-1772.

Li X*, Wang W*, Xi Y, Gao M, Tran M, Aziz KE, Qin J, Li W, Chen J. FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis. Cell Reports. 2016; 16(2):487-497. (* co-first authors)

Chen Z, Tran M, Tang M, Wang W, Gong Z, Chen J. Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway. Molecular & Cellular Proteomics : MCP. 2016; 15(4):1299-308.

Liu X, Xiao ZD, Han L, Zhang J, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, Wang J, Liang H, Gan B. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nature Cell Biology. 2016; 18(4):431-42.

Jun S, Jung YS, Suh HN, Wang W, Kim MJ, Oh YS, Lien EM, Shen X, Matsumoto Y, McCrea PD, Li L, Chen J, Park JI. LIG4 mediates Wnt signalling-induced radioresistance. Nature Communications. 2016; 7:10994.

Wang X, Jung YS, Jun S, Lee S, Wang W, Schneider A, Sun Oh Y, Lin SH, Park BJ, Chen J, Keyomarsi K, Park JI. PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness. Nature Communications. 2016; 7:10633.

Wang W, Li N, Li X, Tran MK, Han X, Chen J. Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins. Cell Reports. 2015; 13(3):524-532.

Wang W, Xiao ZD, Li X, Aziz KE, Gan B, Johnson RL, Chen J. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nature Cell Biology. 2015; 17(4):490-9.

Wang W*, Li X*, Lee M, Jun S, Aziz KE, Feng L, Tran MK, Li N, McCrea PD, Park JI, Chen J. FOXKs promote Wnt/β-catenin signaling by translocating DVL into the nucleus. Developmental Cell. 2015; 32(6):707-18. (* co-first authors)

Li X*, Wang W*, Wang J, Malovannaya A, Xi Y, Li W, Guerra R, Hawke DH, Qin J, Chen J. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Molecular Systems Biology. 2015; 11(1):775. (* co-first authors)

Li N, Zhang Y, Han X, Liang K, Wang J, Feng L, Wang W, Songyang Z, Lin C, Yang L, Yu Y, Chen J. Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth. Genes and Development. 2015; 29(2):157-70.

Li X, Wang W, Chen J. From pathways to networks: connecting dots by establishing protein-protein interaction networks in signaling pathways using affinity purification and mass spectrometry. Proteomics. 2015; 15(2-3):188-202. NIHMSID: NIHMS700523

Feng L, Li N, Li Y, Wang J, Gao M, Wang W, Chen J.Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1. Cell Discovery. 2015; 1:15019.

Wang W, Li X, Chen J. Energy crisis and the Hippo pathway. Cell Cycle. 2015; 14(13):1995-6.

Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J. Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. Mol Cell Proteomics. MCP. 2014; 13(11):2986-3000.

Wang W*, Li X*, Huang J, Feng L, Dolinta KG, Chen J. Defining the protein-protein interaction network of the human hippo pathway. Mol Cell Proteomics. MCP. 2014; 13(1):119-31. (* co-first authors)

Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nature Cell Biology. 2013; 15(12):1486-1494.

Fong KW, Li Y, Wang W, Ma W, Li K, Qi RZ, Liu D, Songyang Z, Chen J. Whole-genome screening identifies proteins localized to distinct nuclear bodies. Journal of Cell Biology. 2013; 203(1):149-64

Feng L, Fong KW, Wang J, Wang W, Chen J. RIF1 counteracts BRCA1-mediated end resection during DNA repair. Journal of Biological Chemistry. 2013; 288(16):11135-43.

Leung JW, Ghosal G, Wang W, Shen X, Wang J, Li L, Chen J. Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. Journal of Biological Chemistry. 2013; 288(9):6342-50.

Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Journal of Cell Science. 2013; 126(Pt 3):825-37.

Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J. PTPN14 is required for the density-dependent control of YAP1. Genes & Development. 2012; 26(17):1959-71.

Wang W, Liu Y, Liao K. Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility. BMC Cell Biology. 2011; 12:49.

Wang W, Huang J, Chen J. Angiomotin-like proteins associate with and negatively regulate YAP1. Journal of Biological Chemistry. 2011; 286(6):4364-70.

Wang W, Chen L, Ding Y, Jin J, Liao K. Centrosome separation driven by actin-microfilaments during mitosis is mediated by centrosome-associated tyrosine-phosphorylated cortactin. Journal of Cell Science. 2008; 121(Pt 8):1334-43.