CV

Xing Dai, Ph. D.
D250 Med Sci I, Department of Biological Chemistry
School of Medicine, University of California
Irvine, CA 92697-1700
Tel: 949-824-3101
Fax: 949-824-2688
E-mail: xdai@uci.edu

EDUCATION:

1995 Ph. D. in Biochemistry and Molecular Biology
University of Chicago, Chicago, Illinois
1989 M. S. in Biochemistry and Biophysics
University of Hawaii at Monoa, Honolulu, Hawaii
1985 B. S. in Biology
East China Normal University, Shanghai, P. R. of China

EMPLOYMENT:

1995-1999 Postdoctoral Fellow, University of Chicago, IL, Dept. of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute
1999-2006 Assistant Professor, University of California, Irvine, Dept. of Biological Chemistry
2006-Present Associate Professor, University of California, Irvine, Dept. of Biological Chemistry

HONORS AND AWARDS:

1995 Howard Hughes Medical Institute Postdoctoral Fellowship
1996 NIH Individual National Research Service Postdoctoral Fellowship Award
2001 March of Dimes Basil O’Connor Award
2004 NIAMS/NIH Independent Scientist Award
2006, 2007, 2008
UCI School of Medicine Excellence in Teaching Award

PUBLICATIONS:

Research articles:
1. Ogata, K., Dai, X., and Volini, M. (1989). ” Bovine mitochondrial rhodanese is a phosphoprotein”. J. Biol. Chem. 264, 2718-2725.

2. Glucksmann-Kuis, M. A.,  Dai, X., Markiewicz, P., and Rothman-Denes, L. B. (1996). “E. coli SSB activation of N4 virion RNA polymerase: specific activation of an essential DNA hairpin required for promoter recognition”.  Cell 84, 147-154.

3. Dai, X., Greizerstein, M., Nadas-Chinni, K., and Rothman-Denes, L. B. (1997). “Supercoil-induced extrusion of a regulatory DNA hairpin”.  Proc. Natl. Acad. Sci. USA 94, 2174-2179.

4. Dai, X. and Rothman-Denes, L. B. (1998). “Sequence and DNA strucutral determinants of N4 virion RNA polymerase-promoter recognition”.  Genes & Development 12, 2782-2790.

5. Dai, X., Kloster, M., and Rothman-Denes, L. B. (1998). “Sequence-dependent extrusion of a small DNA hairpin at the N4 virion RNA polymerase promotes”.  J. Mol. Biol.283, 43-58.

6. Dai, X., Schonbaum, C., Degenstein, L., Bai, W., Mahowald, A., Fuchs, E. (1998). “The ovo gene required for cutcle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice”. Genes & Development 12, 3452-3463.

7. Li, B., Mackay, D. R., Dai, Q., Li, T. W. H., Nair, M., Fallahi, M., Schonbaum, C., Fantes, J., Mahowald, A., Waterman, M. L., Fuchs, E., and Dai, X. (2002).  The LEF1/-catenin complex activates movo1, a mouse homolog of Drosophila ovo gene required for epidermal appendage differentiation.  Proc. Natl. Acad. Sci. USA 99, 6064-6069.

8. Li, B., Dai, Q., Li, L., Nair, M., Mackay, D. R., and Dai, X. (2002).  ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice.  Genomics 80, 319-325.

9. Kaufman, C. K., Zhou, P., Pasolli, H. A., Rendl, M., Bolotin, D., Lim, K. C., Dai, X., Alegre, M. L., and Fuchs, E.  (2003).  GATA-3: an unexpected regulator of cell lineage determination in skin.  Genes & Development 17, 2108-2122.

10. Li, B. Mackay, D. R., Ma, J., and Dai, X. (2004).  Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component. Genomics 84, 398-405.

11. Li, B., Nair, M., Mackay, D. R., Bilanchone, V., Hu, M., Fallahi, M., Song, H., Dai, Q., Cohen, P. E. and Dai, X.  (2005).  Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression.  Development 132, 1463-1473.

12. Mackay, D. R., Hu, M., Li, B., Rhéaume, C., and Dai, X.  (2006). The mouse Ovol2 gene is required for cranial neural tube development.  Developmental Biology 291, 38-52.

13. Nair, M., Teng, A., Bilanchone, V., Agrawal, A., Li, B. and Dai, X.  (2006). Ovol1 controls the growth arrest of embryonic epidermal progenitor cells and represses c-Myc transcription. J. Cell Biology 173, 253-264.

14.  Teng, A., Nair, M., Wells, J., Segre, J. A., and Dai, X.  (2007). Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis.  BBA 1772, 89-95.

15.  Nair, M. Bilanchone, V., Ortt, K., Sinha, S., and Dai, X. (2007). Ovol1 represses transcription by competing for DNA binding with the c-Myb activator and by recruiting histone deacetylases.  Nucleic Acids Research 35, 1687-1697.

16. Qian, D., Jones, C., Rzadzinska, A., Mark, S., Zhang, X., Steel, K.P., Dai, X., and Chen, P. (2007).  Wnt5a functions in planar cell polarity regulation in mouse.  Developmental Biology 306, 121-133.

17.  Li, B., Rhéaume, C., Teng, A.., Bilanchone, V., Munguia, J. E., Hu, M., Jessen, S., Piccolo, S., Waterman, M.L., and Dai, X. (2007). Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2.  Genesis 45, 318-325.

18. Jonckheere, N., Mayes, E.; Shih, H. P.; Li, B., Lioubinski, O., Dai., X., and Sander, M. (2008). Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Developmental Biology, 318(2):224-35.

19. Nair M., Nagamori, I., Sun, P., Mishra, D., Rhéaume, C., Li, B., Sassoni-Corssi P., Dai, X. (2008). Nuclear regulator PYGO2 controls spermiogenesis and chromatin modification.  Developmental Biology 320(2):446-55.

20. Gu, B., Sun, P., Yuan, Y., Moraes, R., Li, A., Teng A., Agrawal, A., Rhéaume, C., Bilanchone, B., Veltmaat J. M, Takemaru, K., Millar, S. Lee, E. Y-H. P., Lewis, M. T., Li, B., and Dai, X. (2009). Pygo2 expands mammary progenitor cells by regulating histone H3 K4 methylation.  J. Cell Biology 185:811-26. (With news and commentary).

21. Cai, A. Q., Peng, Y., Wells, J. and Dai, X., Nie, Q. Multi-scale modelling for threshold dependent differentiation. Mathematical Modeling of Natural Phenomena 4(4): 103-117.

22. Wells, J., Lee, B., Cai, A. Q., Karapetyan, A., Lee, W. J., Rugg, E., Sinha, S., Nie, Q., Dai, X. Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1. J. of Biological Chemistry 284(42):29125-35.

23. Vetere, A., Li, W-C., Paroni, F., Juhl, K., Guo, L., Nishimura, W., Dai, X., Bonner-Weir, S., Sharma, A.  OVO Homolog-like 1 (OVOl1) Transcription Factor: a Novel Target of Neurogenin-3 in Pancreas. In press for Diabetologia.

Reviews:
1. Miller, A., Dai, X., Choi, M., Glucksmann-Kuis, M. A., and Rothman-Denes, L. B. (1996). “Role of single-stranded DNA binding proteins in transcriptional activation”.  Methods in Enzymology 274, 9-20.

2. Rothman-Denes, L. B., Dai, X., Davydova, E., Carter, R., Kazmierczak, K. (1998). “Transcriptional regulation by DNA structural transtions and single-stranded DNA binding proteins”. Cold Spring Harbor Symposium on Quantitative Biology LXIII, 63-73.

3. Dai, X. and Rothman-Denes, L. B. (1999). “DNA structure and transcription”. Current Opinion in Microbiology 2, 126-130.

4. Dai, X. and Segre J. (2004).  Transcriptional regulation of epidermal specification and differentiation.  Current Opinion in Genetics & Development 14, 485-491.  (Section Editors: Christopher K Glass and Michael G Rosenfeld).

5. Jessen, S. Gu, B. and Dai, X. (2008)  Pygopus and the Wnt signaling pathway­ – a diverse set of connections. Bioessays 30(5):448-56.

Book chapter:
Wells, J. and Dai, X. (2009). Using siRNA knock-down in HaCaT cells to study transcriptional control of epidermal proliferation potential. Epidermal Cells – Methods and Protocols, 2nd Edition (editor: Kursad Turksen). Epidermal Cells – Methods and Protocols, 2nd Edition (editor: Kursad Turksen), Springer.

Books and essays (literature, in Chinese):
1. Dai, X. (1997).  A song from heart, p.353-359.  In Zhong, J.W. and Gao (ed.), In memory of a great writer – Dai Houying.  Hainan International Publishing House, P. R. China.  (Short assay).

2.  Dai, H. Y. and Dai, X. (1998).  Like mother, like daughter.  Jinan University Publishing House, P. R. China.  (Book).

3. Dai, X. (1999).  From the eyes of a child, p. 1-5.  In Li, X. P. (ed.), The way of life – a spiritual journey (collection of short assays).  Shanghai People Publishing House. P. R. China.

4. Dai, X. (2006). The phone is no longer ringing on the other end (short assay series; total of 4).  Xin Min Newspaper. P.R. China.

 

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