A Productive 2018 So Far!

We have finally begun to see the fruits of our hard work over the last 2.9 years here at UCI.

Here are several new papers, congrats to all the authors!!

Jessica Bolton & Christina Ruiz et al show effects of early life adversity on cocaine seeking

Mitch Farrell et al review how we model cocaine relapse in rats

I talk about a new Nature Neuroscience paper on orexin in nucleus accumbens

Aston-Jones and I discuss the use of CNO as a DREADD agonist

Morgan James et al show prefontal cortex dopamine regulates accumbens projections in relapse

…and there is still plenty more to do in 2018! 😉

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New Nature Neuroscience Commentary on Accumbens Orexin

Blomeley, Garau, and Burdakov describe a new role for orexin recruitment of nucleus accumbens D2 dopamine neurons in avoiding risk. I had something to say about this cool paper!

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New collaborative paper with Aston-Jones Lab is online!

Check it out

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New Paper on Adolescent Cannabinoid Exposure

The Mahler Lab’s first research paper is out!!

We are currently following up on this project by determining how adolescent cannabinoid receptor stimulation with drugs including THC affects development of brain reward circuits.

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Opportunity to Join the Mahler Lab Summer 2017!

Are you an undergraduate from an underrepresented background that is interested in learning more about neural circuits underlying effects of cocaine or cannabis?  If so, apply for a prestigious, completely funded internship in Southern California for summer 2017!

NIDA Summer Research Internship Program

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Two New Papers in Collaboration with Aston-Jones Lab

Check them out!

(Another) review on orexin: James, MH, Mahler, SV, Moorman, DE, & Aston-Jones, G. (in press). A decade of orexin/hypocretin in addiction: Where are we now? Current Topics in Behavioral Neuroscience.

A role for dopamine in prefrontal-accumbens pathway mediation of cocaine relapse: McGlinchy, EM, James, MH, Mahler, SV, Pantazis, C & Aston-Jones (2016). Prelimbic to accumbens core pathway is recruited in a dopamine-dependent manner to drive cued reinstatement of cocaine seeking. Journal of Neuroscience, 36(33), 8700-11.

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New Paper on DREADD Methods in Behavioral Neuroscience

Check out our new paper on how to use DREADDs for behavioral neuroscience experiments, spearheaded by Berridge Lab alum Kyle Smith, and colleagues at Dartmouth

Smith et al Behav Neurosci 2016 DREADD review

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Technician Job Available!

The Mahler Lab is growing, and we are looking for a new key member–a full time technician.

Ideal candidates will have experience with rodent (preferably rat) behavioral testing, stereotaxic or other rodent surgery, systemic and/or intracranial injections, immunohistochemistry, microscopy, and general lab skills.

Candidates must be organized and ambitious.  Attaining authorship on major papers is a possibility if you are motivated, making this an excellent opportunity for those looking at grad or med school in the next couple of years.

One year+ commitment required.

Apply here!

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Graduate Student Needed!

The Mahler Lab is missing an important person–You!

We are looking for 1-2 graduate students in 2016.  Interested parties can apply to the Interdepartmental Neuroscience Program at UCI.  In addition to soaking in the lovely Southern California Climate on UCI’s beautiful campus, you will take classes and rotate in 2-3 labs during your first year.

Join our happy family of anteaters!

Cox,Gall,Peter,Lynch

 

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Looking for Undergraduate Volunteers!

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The Mahler lab has come to life!

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We are rocking 16 shiny operant boxes and numerous other behavioral apparatuses, immnohistochemistry, and fluorescent/brightfield microscopy setups.

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We are just getting down to science, and we have lots to do–viral vectors to validate, tissue to process, animals to be behaviorally test, programs to write, and video to analyze. Are you interested in neuroscience and looking to contribute to the field?

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If you are a current UCI undergraduate who is willing to volunteer 10 hours a week (especially in 3 hour blocks at the same time each day; weekend availability desired; course credit considered), and are interested in the behavioral neuroscience of addition and reward–contact Dr. Mahler: mahlers at uci.edu

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Desired skills for applicants: experience with animal training, programming ability, data processing and management, fixing and building instrumentation. Please send a list of relevant courses and experiences, and why you want to volunteer in your initial email.

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