Research Projects

Force mediated Neurophotonics

Understanding the mechanisms of mechano-transduction in neurons is critical both for basic science but also for translational medical research. Such research is aimed at trying to understand not only the mechanisms which underlie cellular communication but also the mechanical cues and which lead to the formation and regulation of neural networks. Recently optically based techniques such as optogenetics and laser based methods such as optical tweezers and laser induced shockwave have proven successful in in elucidating some of the mechanisms of neuronal repair and mechanosensing. However more work in needed particularly on signal transduction mechanisms associated with mechanical stimuli and a damage responses. For this purpose, it is important to develop new tools to study mechano-transduction at the cellular level.

Representation of neurons stimulated by a beam of light.

Vectorial nanoparticle manipulation

A new generation of optical technologies is becoming available which leverage a better understanding and control of polarization in tightly focused laser beams. One area of interest is in the manipulation nanoparticles below the diffraction limit. By controlling the polarization of light significant control over the dynamics of submicron scale particles can be achieved. We are working towards new systems which could enable new experiments at the nanoscale and would likely allow new access to previously “untrappable” bio materials.

The complex behaviour of optical forces created in a beam of structured light.