Novel Chimeric Rodent Model Yields Vital Information about Alzheimer’s
Scientists at the University of California, Irvine, report that they used a chimeric model to learn how key human brain immune cells respond to Alzheimer’s. By developing a way for these microglia to grow and function in mice, the team says researchers now have an unprecedented view of crucial mechanisms contributing to the disease.
The scientists, led by Mathew Blurton-Jones, PhD, associate professor of neurobiology & behavior, believe their findings also hold promise for investigating many other neurological conditions such as Parkinson’s, traumatic brain injury, and stroke. Their study (“Development of a Chimeric Model to Study and Manipulate Human Microglia in vivo”) appears in Neuron.
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