For a complete list of publications, click Here.
2023 Articles:
Engineering an inhibitor-resistant human CSF1R variant for microglia replacement.
J Exp Med. 2023 Mar 6;220(3):e20220857. doi: 10.1084/jem.20220857. Epub 2022 Dec 30.PMID: 36584406
2022 Articles:
Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits.
iScience. 2022 Dec 6;26(1):105732. doi: 10.1016/j.isci.2022.105732. eCollection 2023 Jan 20.PMID: 36590162
Using Advanced Diffusion-Weighted Imaging to Predict Cell Counts in Gray Matter: Potential and Pitfalls.
Front Neurosci. 2022 Jun 3;16:881713. doi: 10.3389/fnins.2022.881713. eCollection 2022.PMID: 35720733
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice.
Cell Rep. 2022 Jun 14;39(11):110961. doi: 10.1016/j.celrep.2022.110961.PMID: 35705056
Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein.
Int J Mol Sci. 2022 May 29;23(11):6080. doi: 10.3390/ijms23116080.PMID: 35682759
A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling.
Development. 2022 Apr 15;149(8):dev200237. doi: 10.1242/dev.200237. Epub 2022 Mar 25.PMID: 35333324
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.
Elife. 2022 Feb 22;11:e73021. doi: 10.7554/eLife.73021.
PMID: 35191835
The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer’s disease mouse model.
Alzheimers Dement. 2022 Feb 9. doi: 10.1002/alz.12577.
PMID: 35142046
Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer’s disease brain.
J Extracell Vesicles. 2022 Jan;11(1):e12183. doi: 10.1002/jev2.12183.
PMID: 35029059
Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies.
NPJ Vaccines. 2022 Jan 10;7(1):1. doi: 10.1038/s41541-021-00424-2.
PMID: 35013319
The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C.
Sci Transl Med. 2021 Dec;13(622):eabg2919. doi: 10.1126/scitranslmed.abg2919. Epub 2021 Dec 1. PMID: 34851695
2021 Articles:
Human Induced Pluripotent Stem Cell-Derived Microglia (hiPSC-Microglia).
Methods Mol Biol. 2021 Nov 13. doi: 10.1007/7651_2021_429. Online ahead of print.
PMID: 34773245
Modeling Sporadic Alzheimer’s Disease in Human Brain Organoids under Serum Exposure
Chen X, Sun G, Tian E, Zhang M, Davtyan H, Beach TG, Reiman EM, Blurton-Jones M, Holtzman DM, Shi Y. Adv Sci (Weinh). 2021 Aug 2:e2101462. doi: 10.1002/advs.202101462.
PMID: 34337898
Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease
Mol Neurodegener. 2021 Jul 23;16(1):50. doi: 10.1186/s13024-021-00473-0.
PMID: 34301296
C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.
Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, Vazquez M, Kim J, Ghaffari L, O’Rourke JG, Geschwind DH, Blurton-Jones M, Holtzman DM, Sattler R, Baloh RH..
Neuron. 2021 Jun 5;S0896-6273(21)00373-1. doi: 10.1016/j.neuron.2021.05.020. Epub 2021 Jun 15.
PMID:34133945
PapRIV, a BV-2 microglial cell activating quorum sensing peptide.
Janssens Y, Debunne N, De Spiegeleer A, Wynendaele E, Planas M, Feliu L, Quarta A, Claes C, Van Dam D, De Deyn PP, Ponsaerts P, Blurton-Jones M, De Spiegeleer B.Sci Rep. 2021 May 21;11(1):10723. doi: 10.1038/s41598-021-90030-y.
PMID: 34021199
2020 Articles:
A Bump-Hole Strategy for Increased Stringency of Cell-Specific Metabolic Labeling of RNA.
Nguyen K, Kuubota M, Arco JD, Feng C, Singha M, Beasley S, Sakr J, Gandhi SP, Blurton-Jones M, Fernández Lucas J, Spitale RC.ACS Chem Biol. 2020 Dec 18;15(12):3099-3105. doi: 10.1021/acschembio.0c00755. Epub 2020 Nov 21.
PMID: 33222436
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease.
McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. Nat Commun. 2020 Oct 23;11(1):5370. doi: 10.1038/s41467-020-19227-5.
PMID: 33097708
Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials.
Petrushina I, Hovakimyan A, Harahap-Carrillo IS, Davtyan H, Antonyan T, Chailyan G, Kazarian K, Antonenko M, Jullienne A, Hamer MM, Obenaus A, King O, Zagorski K, Blurton-Jones M, Cribbs DH, Lander H, Ghochikyan A, Agadjanyan MG.Neurobiol Dis. 2020 Jun;139:104823. doi: 10.1016/j.nbd.2020.104823. Epub 2020 Feb 28. Review.
PMID:32119976
Human iPSC-derived microglia: A growing toolset to study the brain’s innate immune cells.
Hasselmann J, Blurton-Jones M.Glia. 2020 Apr;68(4):721-739. doi: 10.1002/glia.23781. Epub 2020 Jan 11
PMID:31926038
2019 Articles:
Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice.
Davtyan H, Hovakimyan A, Kiani Shabestari S, Antonyan T, Coburn MA, Zagorski K, Chailyan G, Petrushina I, Svystun O, Danhash E, Petrovsky N, Cribbs DH, Agadjanyan MG, Blurton-Jones M, Ghochikyan A.Alzheimers Res Ther. 2019 Dec 17;11(1):107. doi: 10.1186/s13195-019-0556-2.
PMID:31847886
Amyloid-beta impairs TOM1-mediated IL-1R1 signaling.
Martini AC, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, Blurton-Jones M, Gutierrez A, Baglietto-Vargas D, Medeiros R, LaFerla FM.Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21198-21206. doi: 10.1073/pnas.1914088116. Epub 2019 Sep 30.
PMID:31570577
Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.
Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M.Neuron. 2019 Sep 25;103(6):1016-1033.e10. doi: 10.1016/j.neuron.2019.07.002. Epub 2019 Jul 30.
PMID:31375314
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham GE, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C.Nat Commun. 2019 Jul 19;10(1):3215. doi: 10.1038/s41467-019-11053-8.
PMID:31324781
Hippocampal BDNF regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence.
Harvey E, Blurton-Jones M, Kennedy PJ.Hippocampus. 2019 Nov;29(11):1101-1113. doi: 10.1002/hipo.23127. Epub 2019 Jun 17.PMID:31206907
Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions.
Faal T, Phan DTT, Davtyan H, Scarfone VM, Varady E, Blurton-Jones M, Hughes CCW, Inlay MA.Stem Cell Reports. 2019 Mar 5;12(3):451-460. doi: 10.1016/j.stemcr.2019.01.005. Epub 2019 Feb 7.
PMID:30745035
Microglia in Alzheimer’s Disease: Exploring How Genetics and Phenotype Influence Risk.
McQuade A, Blurton-Jones M.J Mol Biol. 2019 Apr 19;431(9):1805-1817. doi: 10.1016/j.jmb.2019.01.045. Epub 2019 Feb 7. Review.
PMID:30738892
CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer’s disease.
Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CM, Lodoen MB, Blurton-Jones M, Inlay MA.Glia. 2019 May;67(5):844-856. doi: 10.1002/glia.23575. Epub 2018 Dec 26.
PMID:30588668
2018 Articles:
Development and validation of a simplified method to generate human microglia from pluripotent stem cells.
McQuade A, Coburn M, Tu CH, Hasselmann J, Davtyan H, Blurton-Jones M.Mol Neurodegener. 2018 Dec 22;13(1):67. doi: 10.1186/s13024-018-0297-x.
PMID:30577865
Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia.
Nakazono T, Jun H, Blurton-Jones M, Green KN, Igarashi KM.Neurosci Res. 2018 Apr;129:40-46. doi: 10.1016/j.neures.2018.02.002. Epub 2018 Feb 10. Review.
PMID:29438778
Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation.
Mathur V, Burai R, Vest RT, Bonanno LN, Lehallier B, Zardeneta ME, Mistry KN, Do D, Marsh SE, Abud EM, Blurton-Jones M, Li L, Lashuel HA, Wyss-Coray T.Neuron. 2017 Dec 20;96(6):1290-1302.e6. doi: 10.1016/j.neuron.2017.11.032.
PMID:29268096
Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington’s Disease Mice.
Reidling JC, Relaño-Ginés A, Holley SM, Ochaba J, Moore C, Fury B, Lau A, Tran AH, Yeung S, Salamati D, Zhu C, Hatami A, Cepeda C, Barry JA, Kamdjou T, King A, Coleal-Bergum D, Franich NR, LaFerla FM, Steffan JS, Blurton-Jones M, Meshul CK, Bauer G, Levine MS, Chesselet MF, Thompson LM.Stem Cell Reports. 2018 Jan 9;10(1):58-72. doi: 10.1016/j.stemcr.2017.11.005. Epub 2017 Dec 7.
PMID:29233555
2017 Articles:
MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency.
Davtyan H, Zagorski K, Petrushina I, Kazarian K, Goldberg NRS, Petrosyan J, Blurton-Jones M, Masliah E, Cribbs DH, Agadjanyan MG, Ghochikyan A.Neurobiol Aging. 2017 Nov;59:156-170. doi: 10.1016/j.neurobiolaging.2017.08.006. Epub 2017 Aug 10.
PMID:28870518
Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency.
Agadjanyan MG, Zagorski K, Petrushina I, Davtyan H, Kazarian K, Antonenko M, Davis J, Bon C, Blurton-Jones M, Cribbs DH, Ghochikyan A.Mol Neurodegener. 2017 May 5;12(1):33. doi: 10.1186/s13024-017-0172-1.
PMID:28472993
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.
Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, Gylys KH, Cahalan MD, Cummings BJ, Antel JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M.Neuron. 2017 Apr 19;94(2):278-293.e9. doi: 10.1016/j.neuron.2017.03.042.
PMID:28426964
MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice.
Davtyan H, Chen WW, Zagorski K, Davis J, Petrushina I, Kazarian K, Cribbs DH, Agadjanyan MG, Blurton-Jones M, Ghochikyan A.Vaccine. 2017 Apr 11;35(16):2015-2024. doi: 10.1016/j.vaccine.2017.03.020. Epub 2017 Mar 18.
PMID:28320590
Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice.
Lakatos A, Goldberg NR, Blurton-Jones M.Acta Neuropathol Commun. 2017 Mar 10;5(1):21. doi: 10.1186/s40478-017-0421-0.
PMID:28283027
Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies.
Goldberg NRS, Marsh SE, Ochaba J, Shelley BC, Davtyan H, Thompson LM, Steffan JS, Svendsen CN, Blurton-Jones M.Stem Cells Transl Med. 2017 Jun;6(6):1477-1490. doi: 10.1002/sctm.16-0362. Epub 2017 Feb 22.
PMID:28225193
Neural stem cell therapy for neurodegenerative disorders: The role of neurotrophic support.
Marsh SE, Blurton-Jones M.
Neurochem Int. 2017 Jun;106:94-100. doi: 10.1016/j.neuint.2017.02.006. Epub 2017 Feb 20.
PMID: 28219641
HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer’s Disease.
Marsh SE, Yeung ST, Torres M, Lau L, Davis JL, Monuki ES, Poon WW, Blurton-Jones M.
Stem Cell Reports. 2017 Feb 14;8(2):235-248. doi: 10.1016/j.stemcr.2016.12.019.
PMID: 28199828
Response to StemCells Inc.
Monuki ES, Anderson AJ, Blurton-Jones M, Cummings BJ.Stem Cell Reports. 2017 Feb 14;8(2):195-197. doi: 10.1016/j.stemcr.2017.02.002.
PMID: 28199827
2016 Articles:
Increased tauopathy drives microglia-mediated clearance of beta-amyloid.
Chen W, Abud EA, Yeung ST, Lakatos A, Nassi T, Wang J, Blum D, Buée L, Poon WW, Blurton-Jones M.Acta Neuropathol Commun. 2016 Jun 23;4(1):63. doi: 10.1186/s40478-016-0336-1.
PMID:27339073
BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens.
White AO, Kramár EA, López AJ, Kwapis JL, Doan J, Saldana D, Davatolhagh MF, Alaghband Y, Blurton-Jones M, Matheos DP, Wood MA.Nat Commun. 2016 May 26;7:11725. doi: 10.1038/ncomms11725.
PMID:27226355
Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology.
Spangenberg EE, Lee RJ, Najafi AR, Rice RA, Elmore MR, Blurton-Jones M, West BL, Green KN.Brain. 2016 Apr;139(Pt 4):1265-81. doi: 10.1093/brain/aww016. Epub 2016 Feb 26.
PMID:26921617
The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function.
Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW, Blurton-Jones M.Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1316-25. doi: 10.1073/pnas.1525466113. Epub 2016 Feb 16.
PMID:26884167
2015 Articles:
Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism.
Goldberg NRS, Caesar J, Park A, Sedgh S, Finogenov G, Masliah E, Davis J, Blurton-Jones M.Stem Cell Reports. 2015 Nov 10;5(5):791-804. doi: 10.1016/j.stemcr.2015.09.008. Epub 2015 Oct 17.
PMID:26489892
Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer’s disease and neuronal loss.
Ager RR, Davis JL, Agazaryan A, Benavente F, Poon WW, LaFerla FM, Blurton-Jones M.Hippocampus. 2015 Jul;25(7):813-26. doi: 10.1002/hipo.22405. Epub 2015 Jan 8.
PMID:25530343
2014 Articles:
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models.
Blurton-Jones M, Spencer B, Michael S, Castello NA, Agazaryan AA, Davis JL, Müller FJ, Loring JF, Masliah E, LaFerla FM.Stem Cell Res Ther. 2014 Apr 16;5(2):46. doi: 10.1186/scrt440.
PMID:25022790
2013 Articles:
Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.
Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, LaFerla FM, Kitazawa M.Am J Pathol. 2013 Aug;183(2):504-15. doi: 10.1016/j.ajpath.2013.04.014. Epub 2013 Jun 5.
PMID:23747512
2012 Articles:
Soluble aβ promotes wild-type tau pathology in vivo.
Chabrier MA, Blurton-Jones M, Agazaryan AA, Nerhus JL, Martinez-Coria H, LaFerla FM.J Neurosci. 2012 Nov 28;32(48):17345-50. doi: 10.1523/JNEUROSCI.0172-12.2012.
PMID:23197725
Concise review: Can stem cells be used to treat or model Alzheimer’s disease?
Chen WW, Blurton-Jones M.Stem Cells. 2012 Dec;30(12):2612-8. doi: 10.1002/stem.1240. Review.
PMID:22997040
Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid.
Walls KC, Coskun P, Gallegos-Perez JL, Zadourian N, Freude K, Rasool S, Blurton-Jones M, Green KN, LaFerla FM.J Biol Chem. 2012 Aug 31;287(36):30317-27. doi: 10.1074/jbc.M112.365890. Epub 2012 Jun 29.
PMID:22753410
Examining the mechanisms that link β-amyloid and α-synuclein pathologies.
Marsh SE, Blurton-Jones M.Alzheimers Res Ther. 2012 Apr 30;4(2):11. doi: 10.1186/alzrt109. eCollection 2012. Review.
PMID:22546279
2011 Articles:
Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.
Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M.J Biol Chem. 2011 Jul 8;286(27):24264-74. doi: 10.1074/jbc.M111.227421. Epub 2011 May 23.
PMID:21606494
2010 Articles:
Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.
Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM.J Neurosci. 2010 May 26;30(21):7281-9. doi: 10.1523/JNEUROSCI.0490-10.2010.
PMID:20505094
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
Koike MA, Green KN, Blurton-Jones M, Laferla FM.Am J Pathol. 2010 Jul;177(1):300-10. doi: 10.2353/ajpath.2010.090750. Epub 2010 May 14.
PMID:20472896
2009 Articles:
Nueral stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.
Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM.Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13594-9. doi: 10.1073/pnas.0901402106. Epub 2009 Jul 24.
PMID:19633196
β-Amyloid impairs axonal BDNF retrograde trafficking.
Poon WW, Blurton-Jones M, Tu CH, Feinberg LM, Chabrier MA, Harris JW, Jeon NL, Cotman CW.Neurobiol Aging. 2011 May;32(5):821-33. doi: 10.1016/j.neurobiolaging.2009.05.012. Epub 2009 Jun 21.
PMID:19540623