Our group studies the dysfunction of immune cells driven by inborn or acquired genetic mutations. We use various cutting-edge genetic and immunological tools and experimental model systems such as human pluripotent stem cell-derived immune cells to address our questions.
Research Areas
Somatic mutations in epigenetic modifiers and immune cell dysfunction
Somatic mutations of epigenetic modifiers are remarkably common in aged blood stem cells. How do they affect the function of immune cells and modulate disease outcomes?
Germline mutations in epigenetic modifiers and congenital growth syndrome
The same gene mutations that cause immune cell dysfunction cause birth defects and growth syndrome when they occur in germ cells. Could we identify a therapeutic target?
Gene expression regulation by DNA methylation and other epigenetic marks
DNA methylation and other epigenetic marks underlie cell type-specific gene expression and behavior. Can we predict the behavior of immune cells based on epigenetic marks?