Emerging Smart NanoBioSensing Technologies & Internet of Things to Realize Precision Medicine
At Integrated Nano Bio Electronics Innovation Lab, in close collaboration with Stanford University, we apply innovative engineering solutions to address major challenges in modern life science and medicine with the three main aims of prevention, early diagnosis, and effective treatments of the diseases. Our efforts are highly multidisciplinary and combine expertise from nearly every traditional and emerging field of technical studies such as micro/nanotechnology, micro/nanoelectronics, micro/nanofabrication, micro/nanoelectromechanical systems (N/MEMS), micro/nanofluidics, nanomaterials, 3D bioprinting, flexible & wearable electronics, and microelectronic circuits & systems design.
In our lab, we develop (design, micro/nanofabrication, validation) innovative, state-of-the-art, low cost and novel -omics, and multi-level smart wearable and portable N/MEMS-based sensing devices, along with (artificial intelligence-based) computing systems with the aim of achieving continuous health monitoring and instant data analysis via interactive real-time feedback. The smart sensing technology effort is mostly focused on disease-related -omics, and the development of multi-level sensing technologies. The design, implementation, and testing of novel-sensing technologies that are tailored to the essential requirements of the disease, such as the ability to reliably extract massive important health information with a variety of sensors constraints, are the critical competencies of this effort. We develop these sensing devices as fully integrated and easy-to-use molecular detection platforms that can rapidly perform minimally invasive analyses of multiplex informative biomolecules (i.e. electrolytes, metabolites, proteins, genes) in highly complex body fluids such as blood, sweat, saliva and urine. We integrate these devices into handheld and portable electronic platforms with system-level functionalities to enable translational applications. Such systems will help to achieve early “personalized/precision medicine” to customize healthcare delivery for each individual and maximize the effectiveness of treatment interventions. Additionally, we develop microfluidics-based lab-on-a-chip (LOC) devices for a variety of biomedical applications such as point of care (POC) testing, organ on a chip (OC), organ printing (3D), single cell manipulation and analysis, and drug testing. We also work on bio-MEMS micro robotic platforms (nanosensors & actuators) for high-throughput genomic analysis/editing, perturbation, and manipulation of (single) rare cells to accelerate the study of (tumour) cells heterogeneity.