The choroid plexus: a “tone setter” for the brain?

We seek to understand how cerebrospinal fluid (CSF) and the choroid plexus mediate body-brain communication and shape the brain microenvironment in brain aging and neurodegenerative disorders like Alzheimer’s disease.

Key Research Areas

Immunofluorescent image of a mouse ChP showing macrophages (CX3CR1, green) and epithelial tight junctions (Occludin, magenta).

Epithelial-immune synergy in the health of blood-CSF barrier

How does the ChP maintain the health of its barrier in the face of many challenges inside and outside the brain?

Trichrome staining of a human ChP showing deep blue fibrotic patches.

The causes and consequences of a fibrotic ChP

Why are the ChP fibrotic and what does it mean to the brain?

Electron microscopy of a mouse ChP epithelial cell showing the formation of an apocrine "bleb"

ChP-brain crosstalk through the brain’s fluids

What language does the ChP speak to the brain, and how is the message delivered?

News

Welcome to our lab!
Xu lab officially opens on April 1, 2026. We are recruiting! We are looking for enthusiastic students and researchers to join this brand-new team! Comfort with animal handling and tissue microscopy is strongly preferred. Any bioinformatics skills are greatly appreciated!