The choroid plexus: a “tone setter” for the brain?
We aim to tackle brain disorders from the “outside” by modulating the environment all brain cells reside in. The choroid plexus is a secretory epithelium located within each brain ventricles. It not only produces the majority of cerebrospinal fluid (CSF), water and all, that bathes the entire central nervous system, but also serves as the main blood-CSF barrier that selectively allows entry of blood-borne molecules and immune cells. We seek to understand how CSF and the choroid plexus mediate body-brain communication and shape the brain microenvironment in brain aging and neurodegenerative disorders like Alzheimer’s disease.
Key Research Areas
Epithelial-immune synergy in the health of blood-CSF barrier
How does the ChP maintain the health of its barrier in the face of many challenges inside and outside the brain?
The causes and consequences of a fibrotic ChP
Why are the ChP fibrotic and what does it mean to the brain?
ChP-brain crosstalk through the brain’s fluids
What language does the ChP speak to the brain, and how is the message delivered?