2023
Ruiz BI, Xazmin LH, Yang Y, Fan Q, Wang T, Wu H, Hanse EA, Kong M. Alpha-ketoglutarate regulates Tnfrsf12a/Fn14 expression via histone modification and prevents cancer-induced cachexia. Genes 2023, 14(9), 1818; https://doi.org/10.3390/genes14091818
Franco C., Seabrook LJ, Nguyen ST, Yang Y, Campos M, Fan Q, Cicchetto A, Kong M, Christofk, HR, & Albrecht, LV. Vitamin B6 is governed by the local compartmentalization of metabolic enzymes during growth. Science Advances 2023, 8 Sep 2023 Vol 9, Issue 36 DOI: 10.1126/sciadv.adi2232
Hanse EA, Wang T, Tifrea D, Senthil M, Kim AC, Kong M, Eng OS. A Novel Assessment of Metabolic Pathways in Peritoneal Metastases from Low-Grade Appendiceal Mucinous Neoplasms. Ann Surg Oncol. 2023 Aug;30(8):5132-5141. doi: 10.1245/s10434-023-13587-0. Epub 2023 May 6. PMID: 37149550
Yang Y, Reid MA, Hanse EA, Li H, Li Y, Ruiz BI, Fan Q, Kong M. SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice. Nat Commun. 2023 Mar 13;14(1):1368. doi: 10.1038/s41467-023-36809-1. PMID: 36914647, PMCID: PMC10011557
2022
Hanse EA, Kong M. A happy cell stays home: When metabolic stress creates epigenetic advantages in the tumor microenvironment. Front Oncol. 2022 Aug 26;12:962928. doi: 10.3389/fonc.2022.962928. eCollection 2022. PMID: 36091163
2021
Hanse EA, Pan M, Liu W, Yang Y, Ishak Gabra MB, Tran TQ, Lowman XH, Ruiz B, Wang QA, Kong M. The B56a subunit of PP2A is necessary for mesenchymal stem cell commitment to adipocyte. EMBO Rep. 2021 Jul 7:e51910. doi: 10.15252/embr.202051910. PMID: 34232566
Tong X, Kong M, Thurmond DC. Connecting the Dots Between Obesity, Diabetes and Cancer. Front Endocrinol (Lausanne). 2020 Nov 19;11:583456. doi: 10.3389/fendo.2020.583456. eCollection 2020. PMID: 33329390
2020
Ishak Gabra MB, Yang Y, Li H, Senapati P, Hanse EA, Lowman XH, Tran TQ, Zhang L, Doan LT, Xu X, Schones DE, Fruman DA, Kong M. Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth. Nat Commun. 2020 Jul 3; 11(1):3326. doi: 10.1038/s41467-020-17181-w. PMID: 32620791
Tran TQ, Hanse EA, Habowski AN, Li H, Ishak Gabra MB, Yang Y, Lowman XH, Ooi AM, Liao SY, Edwards RA, Waterman ML, Kong M. α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer. Nature Cancer. 2020 1(3):345-58. doi: 10.1038/s43018-020-0035-5.
Davis RT, Blake K, Ma D, Ishak Gabra MB, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre A, Alshetaiwi H, Xiao Z, Liu J, Locasale JW, Digman MA, Mjolsness E, Kong M, Werb Z and Lawson DA. Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing. Nat Cell Biol. 2020 Mar;22(3):310-320. doi: 10.1038/s41556-020-0477-0. Epub 2020 Mar 6. PMID: 32144411
2019
Lowman XH, Hanse EA, Yang Y, Ishak Gabra MB, Tran TQ, Li H, Kong M. p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake. Cell Rep. 2019 Mar 12; 26(11):3051-3060.e4. PMID: 30865893.
Yang Y, Ishak Gabra MB, Hanse EA, Lowman XH, Tran TQ, Li H, Milman N, Liu J, Reid MA, Locasale JW, Gil Z, Kong M. MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1. Nat Commun. 2019 Feb 18;10(1):809.
Bian C, Zhang C, Luo T, Vyas A, Chen SH, Liu C, Kassab MA, Yang Y, Kong M, Yu X. NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression. Nat Commun. 2019 Feb 11;10(1):693
2018
Ishak Gabra MB, Yang Y, Lowman XH, Reid MA, Tran TQ, Kong M. IKKß activates p53 to promote cancer cell adaptation to glutamine deprivation. Oncogenesis. 2018 Nov 26;7(11):93.
Abeywardana T, Oh M, Jiang L, Yang Y, Kong M, Song J, Yang Y. (2018) CARM1 suppresses de novo serine synthesis by promoting PKM2 activity. J Biol Chem. 2018 Sep 28;293(39):15290-15303. doi: 10.1074/jbc.RA118.004512. Epub 2018 Aug 21.
2017
Tran TQ, Ishak Gabra MB, Lowman XH, Yang Y, Reid MA, Pan M, O’Connor TR, Kong M. (2017). Glutamine deficiency induced DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes. PLoS Biol. Nov 6;15(11):e2002810. doi: 10.1371/journal.pbio.2002810. 2017 Nov. PMID: 29107960
2016
Pan M., Reid M.A., Lowman X.H., Kulkarni R.P., Tran T.Q., Liu X., Yang Y., Hernandez-Davies J.E., Rosales K.K., Li H., Hugo W., Song C., Xu X., Schones D.E., Ann D.K., Gradinaru V., Lo R.S., Locasale J.W., Kong M. (2016). Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. Nat Cell Biol. Oct;18(10):1090-101. PMID: 276179322.
Reid M.A., Lowman X.H., Pan M., Tran T.Q., Warmoes M.O., Ishak Gabra M.B., Yang Y., Locasale J.W., Kong M. (2016). IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes & Development. Aug 15;30(16):1837-51. PMID: 27585591; PMCID: PMC5024682
Tran T.Q., Lowman X.H., Reid M.A., Mendez-Dorantes C., Pan M., Yang Y., Kong M. (2016). Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction. Oncogene. Oct 10. PMID: 27721412
2015
Rosales K.R., Reid M.A., Yang Y., Tran T.Q., Wang W.I., Lowman X., Pan M. and Kong M. (2015). TIPRL inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response. PLoS One. 2015 Dec 30.
Fong M.Y., Zhou W., Liu L., Alontaga A.Y., Chandra M., Ashby J., Chow A., O’Connor S.T., Li S., Chin A.R., Somlo G., Palomares M., Li Z., Tremblay J.R., Tsuyada A., Sun G., Reid M.A., Wu X., Swiderski P., Ren X., Shi Y., Kong M., Zhong W., Chen Y., Wang S.E. (2015). Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nature Cell Biology.Jan 26. doi: 10.1038/ncb3094.
Hernandez-Davies JE, Tran TQ, Reid MA, Rosales KR, Lowman XH, Pan M, Moriceau G, Yang Y, Wu J, Lo RS, Kong M. (2015). Vemurafenib resistance reprograms melanoma cells towards glutamine dependence. J Transl Med. Jul 3;13(1):210. doi: 10.1186/s12967-015-0581-2. PMID: 26139106
2013
Reid M.A., Wang W.I., Rosales K.R., Welliver M.X., Pan M., and Kong M. (2013). The B55ɑ subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation. Molecular Cell. 50(2):200-211.
Jiang L., Stanevich V., Satyshur K.A., Kong M., Watkins G.R., Wadzinski B.E., Sengupta R., and Xing Y. (2013). Structural basis of protein phosphatase 2A stable latency. Nat Commun. Apr 16;4:1699. doi: 10.1038/ncomms2663
Lin T.C., Chen Y.R., Kensicki E., Li A.Y., Kong M., Li Y., Mohney R.P., Shen H.M., Stiles B., Mizushima N., Lin L.I., & Ann D.K. (2012). Autophagy: Resetting glutamine-dependent metabolism and oxygen consumption. Autophagy. 8(10): 1477-1493
2004-2010
Gruber J., Yong J., Zatechka D.S., Sabin L., Zhang Z., Lum J.J., Kong M., Zong W.X., Lau C.K., Cherry S., Ihle J., Dreyfuss G., and Thompson C.B. (2009). Ars2 links the nuclear cap binding complex to RNA interference and cell proliferation. Cell 138:328-39
Kong M., Ditsworth D., Lindsten T., and Thompson C.B. (2009). alpha4 is an essential regulator of PP2A phosphatase activity. Molecular Cell. 36:51-60
Kong M., Bui .TV., Ditsworth D., Gruber J.J., Goncharov D., Krymskaya V.P., Lindsten T., and Thompson C.B. (2007). The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration. J. Biol. Chem. 282, 29712-20
Lum J.J., Bauer D.E., Kong M., Harris M.H., Li C., Lindsten T., Thompson C.B. (2005). Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237-48
Kong M., Fox C.J., Mu J., Solt L., Xu A., Cinalli R.M., Birnbaum M.J., Lindsten T., Thompson C.B. (2004). The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science 306, 695-8