Publications

2019
Watanabe M, Haney JR, Vishlagi N, Turcios F, Buth JE, Gu W, Collier AJ, Miranda OA, Chen D, Sabri S, Clark AT, Plath K, Christofk HR, Gandal MJ, Novitch BG.TGFβ superfamily signaling regulates the state of human stem cell pluripotency and competency to create telencephalic organoids. bioRxiv. 2019 December 13. doi: https://doi.org/10.1101/2019.12.13.875773.

Samarasinghe RA, Miranda OA, Mitchell S, Fernando I, Watanabe M, Buth JE, Kurdian A, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, Novitch BG. Identification of neural oscillations and epileptiform changes in human brain organoids. bioRxiv. 2019 October 28. doi: https://doi.org/10.1101/82 0183. 

2017
Li C, Deng YQ, Wang S, Ma F, Aliyari R, Huang XY, Zhang NN, Watanabe M, Dong HL, Liu P, Li XF, Ye Q, Tian M, Hong S, Fan J, Zhao H, Li L, Vishlagi N, Buth JE, Au C, Liu Y, Lu N, Du P, Qin XF, Zhang B, Gong D, Dai X, Sun R, Novitch BG, Xu Z, Qin CF, Cheng G. 25-Hydroxycholesterol protects host against Zika virus infection and its associated microcephaly in a mouse model. Immunity. 2017 March 21;46(3):446-456. doi: https://doi.org/10.1016/ j.immuni.2017.02.012.

Watanabe M, Buth JE, Vishlagi N, Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Novitch BG. Self-organized cerebral organoids with human-specific features predict effective drugs to combat Zika virus infection. Cell Reports. 2017 October 10;21(2):517-532. doi: https://doi.org/10.1016/j.celrep.2017.09.047.                  

2016
Watanabe M.Fung ES, Chan FB, Wong JS, Coutts M, Monuki ES. BMP4 acts as a dorsal telencephalic morphogen in a mouse embryonic stem cell culture system. Biology Open. 2016;5:1834-1843. doi: 10.1242/bio.012021.

2015
Lun MP, Johnson MB, Broadbelt KG, Watanabe M, Kang YJ, Chau KF, Springel MW, Malesz A, Sousa AMM, Pletikos M, Adelita T, Calicchio ML, Zhang Y, Holtzman MJ, Lidov HGW, Sestan N, Steen H, Monuki ES, Lehtinen MK. Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. Journal of Neuroscience. 25 March 2015;35(12):4903-4916. doi:10.1523/JNEUROSCI. 3081-14.2015.

2014
Watanabe M, Monuki ES. (2014). Generation of Choroid Plexus Epithelial Cells from Human Embryonic Stem Cells. US Patent No. 8,748,176B2. Oakland, CA. The Regents of the University of California.                               

2013
Watanabe M. Bmp4 as a Classic Morphogen for Deriving Dorsal Telencephalic Midline Fates from Embryonic Stem Cells. 2013.

2012
Watanabe M, Kang YJ, Davies LM, Meghpara S, Lau K, Chung CY, Kathiriya J, Hadjantonakis AK, Monuki ES. BMP4 sufficiency to induce choroid plexus epithelial fate from embryonic stem cell-derived neuroepithelial progenitors. Journal of Neuroscience. 7 November 2012;32(45):5934-15945. doi: https://doi.org/10.1523/JNEUROSCI.3227-12.2012.

2011
Biswas M, Phan D, Watanabe M, and Chan JY. The Fbw7 Tumor Suppressor Regulates Nuclear Factor E2-related Factor 1 Transcription Factor Turnover through Proteasome-mediated Proteolysis. Journal of Biological Chemistry. 11 November 2011;286:39282-39289. doi:10.1074/jbc.M111.253807

Nakano I, Joshi K, Visnyei K, Hu B, Watanabe M, Lam D, Wexler E, Saigusa K, Nakamura Y, Laks DR, Mischel PS, Viapiano M, Kornblum HI. Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. Neuro-Oncology. June 2011;13(6):622–634. doi: https://doi.org/10.1093/ neuonc/nor023

Watanabe M, Monuki ES. Embryonic Stem Cell-Derived Choroid Plexus Epithelial Cells: A Potential Therapy for Alzheimer’s Disease. Journal of Neuropathology and Experimental Neurology.2011;70(6):517.