May 2024 Bren Events Center, Symposium presenters Allyson Ngo, Nori Gonzaga, Fariha Karim, Harman Bath, Shamiha Ahmed

UROP May 2023 Symposium Presenters at the Brent Event Center UCI:

Senior Students, Yasmin, Jasmine, Brooke, Roz, Lusine and Michael!!

The Lab presented several projects at the NEURORECEPTOR MAPPING MEETING, 2021

https://www.nrm2021.org/

[125I]IAZA: A New Imaging Agent for Human Alzheimer’s Disease Brain

Presented by Thisha Reddy

Poster Session 1: Neuroscience Probes & Targets

Following Meeting abstracts will be presented at the meeting:

• [¹⁸F]Fluoroethylharmol: Improved Radiosynthesis and Evaluation of Monoamine Oxidase-A inAlzheimer’s and Parkinson’s Disease

  Amina Syed, Christopher Liang and Jogeshwar Mukherjee

  Journal of Nuclear Medicine May 1, 2021, 62 (supplement 1) 1628;

  …[ 18 F]Fluoroethylharmol: Improved Radiosynthesis and Evaluation of Monoamine Oxidase-A inAlzheimers and Parkinsons Disease Amina Syed 1 , Christopher Liang 1 and Jogeshwar Mukherjee 1 1 Radiological Sciences University of California Irvine CA United States View larger version: In this window …
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  [¹⁸F]FDG PET/CT Studies in Parkinson’s Disease Mouse Model of α-Syncleinopathy

  Anthony Campoy, Rommani Mondal, Christopher Liang and Jogeshwar Mukherjee

  Journal of Nuclear Medicine May 1, 2021, 62 (supplement 1) 1613;

  …[ 18 F]FDG PET/CT Studies in Parkinsons Disease Mouse Model of -Syncleinopathy Anthony Campoy 1 , Rommani Mondal 1 , Christopher Liang 1 and Jogeshwar Mukherjee 1 1 University of California Irvine CA United States View larger version: In this window In a new window View larger version …
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  [¹⁸F]Nifene PET/CT Studies in Parkinson’s Disease A53T Mouse Model of a-Syncleinopathy

  Christopher Liang, Anthony Campoy, Rommani Mondal and Jogeshwar Mukherjee

  Journal of Nuclear Medicine May 1, 2021, 62 (supplement 1) 1615;

  …[ 18 F]Nifene PET/CT Studies in Parkinsons Disease A53T Mouse Model of a-Syncleinopathy Christopher Liang 1 , Anthony Campoy 1 , Rommani Mondal 1 and Jogeshwar Mukherjee 1 1 Radiological Sciences, University of California Irvine CA United States View larger version: In this window In a new window …
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  Monoamine Oxidase-A is Upregulated in Post-Mortem Human Alzheimer’s Disease and Parkinson’s Disease Brain

  Jogeshwar Mukherjee, Christopher Liang, Amina Syed, Phuc Lam, Rommani Mondal, Tonya Mukherjee and Krystal Patel

  Journal of Nuclear Medicine May 1, 2021, 62 (supplement 1) 1609;

  …Monoamine Oxidase-A is Upregulated in Post-Mortem Human Alzheimers Disease and Parkinsons Disease Brain Jogeshwar Mukherjee 1 , Christopher Liang 1 , Amina Syed 1 , Phuc Lam 1 , Rommani Mondal 1 , Tonya Mukherjee 1 and Krystal Patel 1 1 Radiological Sciences University of California-Irvine Irvine …
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  Evaluation of [¹⁸F]Flotaza, a newβ-amyloid PET imaging agent in post-mortem human Alzheimer’s disease brain and 5XFAD transgenic mice

  Harsimran Kaur, Megan Felix, An Nguyen, Amina Syed, Christopher Liang and Jogeshwar Mukherjee

  Journal of Nuclear Medicine May 1, 2021, 62 (supplement 1) 1627;

  …Evaluation of [ 18 F]Flotaza, a new-amyloid PET imaging agent in post-mortem human Alzheimers disease brain and 5XFAD transgenic mice Harsimran Kaur 1 , Megan Felix 1 , An Nguyen 1 , Amina Syed 1 , Christopher Liang 1 and Jogeshwar Mukherjee 1 1 University of California Irvine CA United States …
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  Human hippocampal [¹⁸F]nifene binding to nicotinic acetylcholinergic α4β2* receptors is reduced in postmortem Alzheimer’s disease brains

  Jogeshwar Mukherjee, Christopher Liang, Anthony Campoy, Harsimran Kaur, Amina Syed and Tram Danh

  Journal of Nuclear Medicine May 1, 2021, 62 (supplement 1) 121;

  …2* receptors is reduced in postmortem Alzheimers disease brains 1 Radiological Sciences University of California-Irvine Irvine CA United States 2 Radiological Sciences Univ of Calfornia – Irvine Irvine CA United States Mukherjee Jogeshwar 1 Liang Christopher 1 Campoy Anthony 1 Kaur Harsimran 1 Syed …

Following Student Researchers presented their work at this years symposium:

Phuc Lam

Megan R. Felix

Anthony Campoy

Harsimran Kaur

Tram Danh

Rommani Mondal

Amina U. Syed

https://ovptl.uci.edu/urop-corporate/symposium/

PET radiotracer tweaked for greater precision in AD detection

By Will Morton, AuntMinnie.com staff writer

June 9, 2021 — A new PET radiotracer based on previously studied radiopharmaceuticals may improve the detection of beta amyloid plaques seen in Alzheimer’s disease, according to a study published in the August (in progress) issue of Bioorganic & Medicinal Chemistry Letters.

https://www.auntminnie.com/index.aspx?sec=ser&sub=def&pag=dis&ItemID=132627

NEW GE TracerLab FXN installed in our radiochemistry labs for carrying automated synthesis of fluorine-18 labeled novel PET radiopharmaceuticals! 12/01/2020

FOLLOWING FOUR PRESENTATIONS BY OUR LAB MEMBERS AT THIS MEETING:

Christopher Liang, Phuc Lam, Rommani Mondal, Anthony Campoy, Tram Danh,  Stephanie Martinez, Jogeshwar Mukherjee.

[¹⁸F]FAZIN3: Novel Monoamine Oxidase-A PET Reversible Radiotracer shows Upregulation in Post-Mortem Human Alzheimer’s and Parkinson’s Disease.

Rommani Mondal, Christopher Liang, Anthony Campoy, Phuc Lam, Tram Danh, Jogeshwar Mukherjee.

PET Studies in Transgenic Hualpha-Syn(A53T) Parkinson’s Disease Mouse Model of a-Syncleinopathy.

Harsimran Kaur, Megan Rose Felix, Christopher Liang, Jogeshwar Mukherjee.

[¹⁸F]Flotaza: A New b-Amyloid PET Imaging Agent in Post-Mortem Human Alzheimer’s Disease Brain.

Jogeshwar Mukherjee, Christopher Liang, Krystal Patel, Phuc Lam, Rommani Mondal.

[¹²⁵I]IPPI for tau imaging in post-mortem human Alzheimer’s disease brain.

Annual Meeting of Society of Nuclear Medicine and Molecular Imaging, July 11-14, 2020 (Virtual Meeting).

THE FOLLOWING 3 PRESENTATIONS WERE MADE BY THE LAB RESERACHERS:

Liang, C., Lam, P.Q., Martinez, S., Mukherjee J.

Development of [¹⁸F]FAZIN3 for PET imaging of neurofibrillary tangles in Alzheimer’s disease. Journal of Nuclear Medicine, Vol. 61, Supplement 1, 1032, 2020.

Lam, P.Q., Martinez, S., Liang, C., Patel, K.K., Mukherjee J.

[¹⁸F]FAZIN3: A novel PET imaging agent for Parkinson’s disease. Journal of Nuclear Medicine, Vol. 61, Supplement 1, 148, 2020.

Campoy, A., Danh, T., Patel, K.K., Kaur, H., Liang, C., Mukherjee J.

[¹⁸F]Nifene binding to Nicotinic a4b2* receptors in anterior cingulate of postmortem human Alzheimer’s disease brain. Journal of Nuclear Medicine, Vol. 61, Supplement 1, 1537, 2020.