Publications

BIBLIOGRAPHY: PUBLISHED AND IN PRESS:

  1. David Salom, D., K. Palczewski.Structure and self-association of Arrestin-1. J Struct Biol. 2025 Jan 27:108173. doi: 10.1016/j.jsb.2025.108173. Online ahead of print.PMID: 39880147 
  2. Tomczewski S., A. Curatolo, A. Foik, P. Węgrzyn, B. Bałamut, M. Wielgo, W. Kulesza, A. Galińska, K. Kordecka, S. Gulati, H. Fernandes, K. Palczewski, M. Wojtkowski (2025) Photopic flicker optoretinography (f-org) captures the light-driven length modulation of photoreceptors during phototransduction. Proc. Natl. Acad. Sci USA (in press)
  3. Lindfors S, Schmotz C, Lewandowski D, Hau A, Saikko L, Lehtonen E, Majaniemi V, Karhe M, Naams JB, Nisen H, Tienari J, Saleem MA, Pfeil K, Bugger H, Pietiläinen KH, Mirtti T, Palczewski K, Lehtonen S. Integrin Trafficking, Fibronectin Architecture, and Glomerular Injury upon AdipoR1 Depletion. J Am Soc Nephrol. 2025 Jan 28. doi: 10.1681/ASN.0000000611. Online ahead of print.PMID: 3987409
  4. Kaipa BR, Kasetti R, Sundaresan Y, Li L, Yacoub S, Millar JC, Cho W, Skowronska-Krawczyk D, Maddineni P, Palczewski K, Zode GS. Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma. JCI Insight. 2025 Jan 21:e188710. doi: 10.1172/jci.insight.188710. Online ahead of print.PMID: 39836483
  5. Kaushik V, Gessa L, Kumar N, Pinkas M, Czarnocki-Cieciura M, Palczewski K, Nováček J, Fernandes H. CryoEM structure and small-angle X-ray scattering analyses of porcine retinol-binding protein 3. Open Biol. 2025 Jan;15(1):240180. doi: 10.1098/rsob.240180. Epub 2025 Jan 22. PMID: 39837501
  6. Salom, D., P. D. Kiser,and K. Palczewski. Insights into the Activation and Self-Association of Arrestin-1. (2024) Biochemistry. 2025 Jan 21;64(2):364-376. doi: 10.1021/acs.biochem.4c00632. Epub 2024 Dec 20.PMID: 39704710
  7. Hołubowicz R, Du SW, Felgner J, Smidak R, Choi EH, Palczewska G, Menezes CR, Dong Z, Gao F, Medani O, Yan AL, Hołubowicz MW, Chen PZ, Bassetto M, Risaliti E, Salom D, Workman JN, Kiser PD, Foik AT, Lyon DC, Newby GA, Liu DR, Felgner PL, Palczewski K. Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations. Nat Biomed Eng. 2025 Jan;9(1):57-78. doi: 10.1038/s41551-024-01296-2. Epub 2024 Nov 28.PMID: 39609561
  8. Montaser AB, Gao F, Peters D, Vainionpää K, Zhibin N, Skowronska-Krawczyk D, Figeys D, Palczewski K, Leinonen H. Retinal proteome profiling of inherited retinal degeneration across three different mouse models suggests common drug targets in retinitis pigmentosa. Mol Cell Proteomics. 2024 Nov;23(11):100855. doi: 10.1016/j.mcpro.2024.100855. Epub 2024 Oct 9.PMID: 39389360
  9. Engfer ZJ, Palczewski K. The multifaceted roles of retinoids in eye development, vision, and retinal degenerative diseases. Curr Top Dev Biol. 2025;161:235-296. doi: 10.1016/bs.ctdb.2024.10.003. Epub 2024 Oct 23.PMID: 39870435 Review.
  10. Du SW, Newby GA, Salom D, Gao F, Menezes CR, Suh S, Choi EH, Chen PZ, Liu DR, Palczewski K. In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice. Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2416827121. doi: 10.1073/pnas.2416827121. Epub 2024 Nov 18.PMID: 39556729 
  11. Krishnamoorthi A, Salom D, Wu A, Palczewski K, Rentzepis PM. Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature. Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2414037121. doi: 10.1073/pnas.2414037121. Epub 2024 Oct 2.PMID: 39356673
  12. Weir K, Vega N, Busa VF, Sajdak B, Kallestad L, Merriman D, Palczewski K, Carroll J, Blackshaw S. Identification of shared gene expression programs activated in multiple modes of torpor across vertebrate clades. Sci Rep. 2024 Oct 17;14(1):24360. doi: 10.1038/s41598-024-74324-5.PMID: 39420030
  13. Salom D, Wu A, Liu CC, Palczewski K. The Impact of Nanobodies on G Protein-Coupled Receptor Structural Biology and Their Potential as Therapeutic Agents. Mol Pharmacol. 2024 Sep 17;106(4):155-163. doi: 10.1124/molpharm.124.000974.PMID: 39107078 Review.
  14. Leinonen H, Zhang J, Occelli LM, Seemab U, Choi EH, L P Marinho LF, Querubin J, Kolesnikov AV, Galinska A, Kordecka K, Hoang T, Lewandowski D, Lee TT, Einstein EE, Einstein DE, Dong Z, Kiser PD, Blackshaw S, Kefalov VJ, Tabaka M, Foik A, Petersen-Jones SM, Palczewski K. A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models. Nat Commun. 2024 Jul 15;15(1):5943. doi: 10.1038/s41467-024-50033-5.PMID: 39009597 
  15. Du SW, Komirisetty R, Lewandowski D, Choi EH, Panas D, Suh S, Tabaka M, Radu RA, Palczewski K. (2024) Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degeneration. J Biol Chem. 2024 May 3:107344. doi: 10.1016/j.jbc.2024.107344. PMID: 38705389.
  16. Lewandowski D, Gao F, Imanishi S, Tworak A, Bassetto M, Dong Z, Pinto AFM, Tabaka M, Kiser PD, Imanishi Y, Skowronska-Krawczyk D, Palczewski K. Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1 deficient mice. J Biol Chem. 2024 Apr 16:107291. doi: 10.1016/j.jbc.2024.107291. PMID: 38636661
  17. Bassetto M, Kolesnikov AV, Lewandowski D, Kiser JZ, Halabi M, Einstein DE, Choi EH, Palczewski K, Kefalov VJ, Kiser PD. Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors. Cell Rep. 2024 Apr 25;43(5):114143. doi: 10.1016/j.celrep.2024.114143. PMID: 38676924
  18. Hong JD, Salom D, Choi EH, Du SW, Tworak A, Smidak R, Gao F, Solano YJ, Zhang J, Kiser PD, Palczewski K. Retinylidene Chromophore Hydrolysis from Mammalian Visual and Non-Visual Opsins. J Biol Chem. 2024 Jan 23:105678. doi: 10.1016/j.jbc.2024.105678. PMID: 38272218
  19. An M, Raguram A, Du SW, Banskota S, Davis JR, Newby GA, Chen PZ, Palczewski K, Liu DR. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nat Biotechnol. 2024 Jan 8. doi: 10.1038/s41587-023-02078-y. PMID: 38191664
  20. Engfer ZJ, Lewandowski D, Dong Z, Palczewska G, Zhang J, Kordecka K, Płaczkiewicz J, Panas D, Foik AT, Tabaka M, Palczewski K. Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2314698120. doi: 10.1073/pnas.2314698120. Epub 2023 Dec 8.PMID: 38064509
  21. Gao J, Leinonen H, Wang EJ, Ding M, Perry G, Palczewski K, Wang X. Sex-Specific Early Retinal Dysfunction in Mutant TDP-43 Transgenic Mice. J Alzheimers Dis. 2023 Dec 18. doi: 10.3233/JAD-231102
  22. Wu A, Salom D, Hong JD, Tworak A, Watanabe K, Pardon E, Steyaert J, Kandori H, Katayama K, Kiser PD, Palczewski K. Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun. 2023 Aug 25;14(1):5209. doi: 10.1038/s41467-023-40911-9.
  23. Tworak A, Kolesnikov AV, Hong JD, Choi EH, Luu JC, Palczewska G, Dong Z, Lewandowski D, Brooks MJ, Campello L, Swaroop A, Kiser PD, Kefalov VJ, Palczewski K. Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia. Cell Rep. 2023 Aug 15;42(8):112982. doi: 10.1016/j.celrep.2023.112982.
  24. Choi EH, Suh S, Sears AE, Hołubowicz R, Kedhar SR, Browne AW, Palczewski K. Genome editing in the treatment of ocular diseases.Exp Mol Med. 2023 Aug 1. doi: 10.1038/s12276-023-01057-2.
  25. Hong JD, Palczewski K. A short story on how chromophore is hydrolyzed from rhodopsin for recycling. Bioessays. 2023 Jul 16:e2300068.
  26. Gulati, S., K. Palczewski, Rhodopsin dimers in the Retinal Rod Outer Segment. In “Cryo-electron microscopy in structural biology” 2023 (Editor Krishnarao Appasani). Taylor & Francis Group., CRC Press, Inc. Boca Raton, Florida, USA (in press).
  27. Hołubowicz R, Palczewski K. Saving eyesight, one gene at a time. Trends Mol Med. 2023 May 9:S1471-4914(23)00090-4. doi: 10.1016/j.molmed.2023.04.008
  28. Luu, J. C., A. Saadane, H. Leinonen, E. H. Choi, F. Gao, D. Lewandowski, M. Halabi, C. L. Sander, A. Wu, J. M. Wang, R. Singh, S. Gao, E. M. Lessieur, Z. Dong, G. Palczewska, R. F. Mullins, N. S. Peachey, P.D. Kiser, M. Tabaka, T. S. Kern, and K. Palczewski. Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2221045120. doi: 10.1073/pnas.2221045120. Epub 2023 May 1.PMID: 37126699
  29. Bogusławski J, Tomczewski S, Dąbrowski M, Komar K, Milkiewicz J, Palczewska G, Palczewski K, Wojtkowski M. In vivo imaging of the human retina using a two-photon excited fluorescence ophthalmoscope. STAR Protoc. 2023 Apr 13;4(2):102225. doi: 10.1016/j.xpro.2023.102225. 
  30. Du, S. W., K. Palczewski. Eye on genome editing. J Exp Med. 2023 May 1;220(5):e20230146. doi: 10.1084/jem.20230146.
  31. Poria, D., A. V. Kolesnikov, T. J. Lee, D. Salom, K. Palczewski, V. J. Kefalov. Investigating the role of rhodopsin F45L mutation in mouse rod photoreceptor signaling and survival. eNeuro. 2023 Feb 21:ENEURO.0330-22.2023. doi: 10.1523/ENEURO.0330-22.2023.
  32. Yan, A. L.; S. W. Du, and K. Palczewski. Genome editing, a superior therapy for inherited retinal diseases. Vision Research. 2023 Feb 15;206:108192. doi: 10.1016/j.visres.2023.108192. PMID: 36804635
  33. Palczewska, G., M. Wojtkowski, K. Palczewski. From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation. Prog Retin Eye Res. 2023 Feb 12;93:101170. doi: 10.1016/j.preteyeres.2023.101170. PMID: 36787681
  34. Dhankhar, D., D. Salom, K. Palczewski, P. M. Rentzepis. Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature. Proc Natl Acad Sci U S A. 2023; 120(1):e2214276120
  35. Chromophore hydrolysis and release from photoactivated rhodopsin in native membranes. Hong JD, Salom D, Kochman MA, Kubas A, Kiser PD, Palczewski K.Proc Natl Acad Sci U S A. 2022; 119(45):e2213911119. And Profile of Krzysztof Palczewski. Ravindran S.Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2215599119.
  36. Huh C.Y. L., H. Leinonen, J. Zhang, J. Zeitoun, T. Nakayama, J. P. Peach, J. Z. Kiser, K. Palczewski, P. D. Kiser, S. P. Gandhi. Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration. Curr Biol. 2022 Sep 16:S0960-9822(22)01449-X
  37. Gulati S. and K. Palczewski. Structural view of G protein-coupled receptor signaling in the retinal rod outer segment. (2022) Trends Biochem Sci. 2022 Sep 23:S0968-0004(22)00235-3. doi: 10.1016/j.tibs.2022.08.010
  38. Sun D., W. Sun, S-Q. Gao, J. Lehrer, A. Naderi, S. Lee, C. Wei, A. L. Schilb, J. Scheidt, R. C. Hall, E. I. Traboulsi, K. Palczewski, Z-R. Lu. Effective gene therapy of Stargardt disease with PEG-ECO/pGRK1-ABCA4-S/MAR nanoparticles. Mol Ther Nucleic Acids. 2022 Aug 24;29:823-835. doi: 10.1016/j.omtn.2022.08.026
  39. Susie Suh, E. H. Choi, A. Raguram, D. R. Liu, K. Palczewski. Precision genome editing in the eye. 2022 Proc. Natl. Acad. Sci. ;119(39):e2210104119
  40. Kolesnikov, A.V. J. Luu, H. Jin, K. Palczewski, V. J. Kefalov. Deletion of Protein Phosphatase 2A Accelerates Retinal Degeneration in GRK1- and Arr1-Deficient Mice. Invest Ophthalmol Vis Sci. 2022 Jul 8;63(8):18. doi: 10.1167/iovs.63.8.18
  41. Leinonen H, Lyon DC, Palczewski K, Foik AT. Visual System Hyperexcitability and Compromised V1 Receptive Field Properties in Early-Stage Retinitis Pigmentosa in Mice. eNeuro. 2022 27;9(3):ENEURO.0107-22.2022. doi: 10.1523/ENEURO.0107-22.2022. Print 2022 May-Jun.PMID: 35701168 
  42. Tarban N, Halász H, Gogolák P, Garabuczi É, Moise AR, Palczewski K, Sarang Z, Szondy Z. Regenerating Skeletal Muscle Compensates for the Impaired Macrophage Functions Leading to Normal Muscle Repair in Retinol Saturase Null Mice. Cells. 2022 Apr 13;11(8):1333. doi: 10.3390/cells11081333.PMID: 35456012 
  43. Chen S, Getter T, Salom D, Wu D, Quetschlich D, Chorev DS, Palczewski K, Robinson CV. Capturing a rhodopsin receptor signalling cascade across a native membrane. Nature. 2022 Apr;604(7905):384-390. doi: 10.1038/s41586-022-04547-x. Epub 2022 Apr 6.PMID: 35388214 
  44. Choi EH, Suh S, Foik AT, Leinonen H, Newby GA, Gao XD, Banskota S, Hoang T, Du SW, Dong Z, Raguram A, Kohli S, Blackshaw S, Lyon DC, Liu DR, Palczewski K. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nat Commun. 2022 Apr 5;13(1):1830. doi: 10.1038/s41467-022-29490-3.PMID: 35383196 
  45. Banskota S, Raguram A, Suh S, Du SW, Davis JR, Choi EH, Wang X, Nielsen SC, Newby GA, Randolph PB, Osborn MJ, Musunuru K, Palczewski K, Liu DR. Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Cell. 2022 Jan 20;185(2):250-265.e16. doi: 10.1016/j.cell.2021.12.021. Epub 2022 Jan 11.PMID: 35021064 
  46. Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu J, Lee J, Ma X, Bieberich E, Blackshaw S, Saghatelian A, Lyon DC, Skowronska-Krawczyk D, Tabaka M, Palczewski K. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. JCI Insight. 2022 Feb 22;7(4):e156301. doi: 10.1172/jci.insight.156301.PMID: 35015730 
  47. Cheng C, Weiss L, Leinonen H, Shmara A, Yin HZ, Ton T, Do A, Lee J, Ta L, Mohanty E, Vargas J, Weiss J, Palczewski K, Kimonis V. VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy. J Transl Med. 2022 Jan 8;20(1):21. doi: 10.1186/s12967-021-03186-6.PMID: 34998409 
  48. Pöge M, Mahamid J, Imanishi SS, Plitzko JM, Palczewski K, Baumeister W. Determinants shaping the nanoscale architecture of the mouse rod outer segment. Elife. 2021 Dec 21;10:e72817. doi: 10.7554/eLife.72817.PMID: 34931611 
  49. Boguslawski J, Palczewska G, Tomczewski S, Milkiewicz J, Kasprzycki P, Stachowiak D, Komar K, Marzejon MJ, Sikorski BL, Hudzikowski A, Głuszek A, Łaszczych Z, Karnowski K, Soboń G, Palczewski K, Wojtkowski M. In vivo imaging of the human eye using a 2-photon-exd fluorescence scanning laser ophthalmoscope. J Clin Invest. 2022 Jan 18;132(2):e154218. doi: 10.1172/JCI154218.PMID: 34847075 
  50. Getter T, Kemp A, Vinberg F, Palczewski K. Identification of small-molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization. J Biol Chem. 2021 Dec;297(6):101401. doi: 10.1016/j.jbc.2021.101401. Epub 2021 Nov 11.PMID: 34774799 
  51. Du SW, Palczewski K. MicroRNA regulation of critical retinal pigment epithelial functions. Trends Neurosci. 2022 Jan;45(1):78-90. doi: 10.1016/j.tins.2021.10.008. Epub 2021 Nov 6.PMID: 34753606 Review.
  52. Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA; 99 Lives Consortium, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, Vincent A, Mahroo OA, Kiser PD, Petersen-Jones SM. A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Hum Mol Genet. 2022 Apr 22;31(8):1263-1277. doi: 10.1093/hmg/ddab316.PMID: 34726233
  53. Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure. 2022 Feb 3;30(2):263-277.e5. doi: 10.1016/j.str.2021.10.002. Epub 2021 Oct 21.PMID: 34678158
  54. Kochman MA, Palczewski K, Kubas A. Theoretical Study of the Photoisomerization Mechanism of All-Trans-Retinyl Acetate. J Phys Chem A. 2021 Sep 30;125(38):8358-8372. doi: 10.1021/acs.jpca.1c05533. Epub 2021 Sep 21.PMID: 34546761 
  55. Kern TS, Du Y, Tang J, Lee CA, Liu H, Dreffs A, Leinonen H, Antonetti DA, Palczewski K. Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies. Mol Pharmacol. 2021 Nov;100(5):470-479. doi: 10.1124/molpharm.121.000278. Epub 2021 Aug 15.PMID: 34393108 
  56. Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, Palczewski K. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol. 2021 Aug 2;220(8):e202101063. doi: 10.1083/jcb.202101063. Epub 2021 Jun 16.PMID: 34132745 
  57. Blum E, Zhang J, Zaluski J, Einstein DE, Korshin EE, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J Med Chem. 2021 Jun 24;64(12):8287-8302. doi: 10.1021/acs.jmedchem.1c00279. Epub 2021 Jun 3.PMID: 34081480 
  58. Gulati S, Palczewski K. New focus on regulation of the rod photoreceptor phosphodiesterase. Curr Opin Struct Biol. 2021 Aug;69:99-107. doi: 10.1016/j.sbi.2021.03.016. Epub 2021 May 1.PMID: 33945959 Review.
  59. Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6. J Pharmacol Exp Ther. 2021 Jul;378(1):31-41. doi: 10.1124/jpet.120.000486. Epub 2021 Apr 30.PMID: 33931547 
  60. Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021 May 10;6(9):e146604. doi: 10.1172/jci.insight.146604.PMID: 33784255 
  61. Yu G, Gao SQ, Dong Z, Sheng L, Sun D, Zhang N, Zhang J, Margeivicus S, Fu P, Golczak M, Maeda A, Palczewski K, Lu ZR. Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice. Bioconjug Chem. 2021 Mar 17;32(3):572-583. doi: 10.1021/acs.bioconjchem.1c00043. Epub 2021 Mar 7.PMID: 33677964 
  62. Marzejon MJ, Kornaszewski Ł, Bogusławski J, Ciąćka P, Martynow M, Palczewska G, Maćkowski S, Palczewski K, Wojtkowski M, Komar K. Two-photon microperimetry with picosecond pulses. Biomed Opt Express. 2020 Dec 17;12(1):462-479. doi: 10.1364/BOE.411168. eCollection 2021 Jan 1.PMID: 33659083 
  63. Sun D, Sun W, Gao SQ, Wei C, Naderi A, Schilb AL, Scheidt J, Lee S, Kern TS, Palczewski K, Lu ZR. Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model. J Control Release. 2021 Feb 10;330:329-340. doi: 10.1016/j.jconrel.2020.12.010. Epub 2020 Dec 21.PMID: 33358976 
  64. Łabuz G, Rayamajhi A, Khoramnia R, Palczewska G, Palczewski K, Holschbach A, Auffarth GU. THE LOSS OF INFRARED LIGHT SENSITIVITY OF PHOTORECEPTOR CELLS MEASURED WITH TWO-PHOTON EXCITATION AS AN INDICATOR OF DIABETIC RETINOPATHY: A Pilot Study. Retina. 2021 Jun 1;41(6):1302-1308. doi: 10.1097/IAE.0000000000003032.PMID: 33323904 
  65. Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. Function of mammalian M-cones depends on the level of CRALBP in Müller cells. J Gen Physiol. 2021 Jan 4;153(1):e202012675. doi: 10.1085/jgp.202012675.PMID: 33216847 
  66. Kiser PD, Palczewski K. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. J Biol Chem. 2021 Jan-Jun;296:100072. doi: 10.1074/jbc.REV120.014405. Epub 2020 Nov 23.PMID: 33187985
  67. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021 Feb;5(2):169-178. doi: 10.1038/s41551-020-00632-6. Epub 2020 Oct 19.PMID: 33077938 
  68. Leinonen H, Pham NC, Boyd T, Santoso J, Palczewski K, Vinberg F. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. Elife. 2020 Sep 22;9:e59422. doi: 10.7554/eLife.59422.PMID: 32960171 
  69. Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. FASEB J. 2020 Oct;34(10):13918-13934. doi: 10.1096/fj.202000796RR. Epub 2020 Aug 28.PMID: 32860273 
  70. Łabuz G, Rayamajhi A, Usinger J, Komar K, Merz P, Khoramnia R, Palczewska G, Palczewski K, Auffarth GU. Clinical Application of Infrared-Light Microperimetry in the Assessment of Scotopic-Eye Sensitivity. Transl Vis Sci Technol. 2020 Jul 7;9(8):7. doi: 10.1167/tvst.9.8.7. eCollection 2020 Jul.PMID: 32855854 
  71. Palczewska G, Boguslawski J, Stremplewski P, Kornaszewski L, Zhang J, Dong Z, Liang XX, Gratton E, Vogel A, Wojtkowski M, Palczewski K. Noninvasive two-photon optical biopsy of retinal fluorophores. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22532-22543. doi: 10.1073/pnas.2007527117. Epub 2020 Aug 26.PMID: 32848058 
  72. Palczewski K, Kiser PD. Shedding new light on the generation of the visual chromophore. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):19629-19638. doi: 10.1073/pnas.2008211117. Epub 2020 Aug 5.PMID: 32759209 Review.
  73. Blum E, Zhang J, Korshin E, Palczewski K, Gruzman A. Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases. Bioorg Med Chem Lett. 2020 Sep 15;30(18):127421. doi: 10.1016/j.bmcl.2020.127421. Epub 2020 Jul 18.PMID: 32717613 
  74. Luu J, Kallestad L, Hoang T, Lewandowski D, Dong Z, Blackshaw S, Palczewski K. Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model. Hum Mol Genet. 2020 Aug 29;29(15):2611-2624. doi: 10.1093/hmg/ddaa158.PMID: 32691052 
  75. Han X, Hofmann L, de la Fuente M, Alexander N, Palczewski K; INVENT Consortium, Nieman MT. PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153. Blood. 2020 Nov 5;136(19):2217-2228. doi: 10.1182/blood.2019004634.PMID: 32575122 
  76. Choi EH, Daruwalla A, Suh S, Leinonen H, Palczewski K. Retinoids in the visual cycle: role of the retinal G protein-coupled receptor. J Lipid Res. 2021;62:100040. doi: 10.1194/jlr.TR120000850. Epub 2021 Feb 6.PMID: 32493732 Review.
  77. Sun D, Schur RM, Sears AE, Gao SQ, Sun W, Naderi A, Kern T, Palczewski K, Lu ZR. Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium. ACS Appl Bio Mater. 2020 May 18;3(5):3078-3086. doi: 10.1021/acsabm.0c00130. Epub 2020 Apr 3.PMID: 34327311
  78. Corral-Serrano JC, Lamers IJC, van Reeuwijk J, Duijkers L, Hoogendoorn ADM, Yildirim A, Argyrou N, Ruigrok RAA, Letteboer SJF, Butcher R, van Essen MD, Sakami S, van Beersum SEC, Palczewski K, Cheetham ME, Liu Q, Boldt K, Wolfrum U, Ueffing M, Garanto A, Roepman R, Collin RWJ. PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Proc Natl Acad Sci U S A. 2020 May 5;117(18):9922-9931. doi: 10.1073/pnas.1903125117. Epub 2020 Apr 20.PMID: 32312818 
  79. Valdez-Lopez JC, Gulati S, Ortiz EA, Palczewski K, Robinson PR. Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation. PLoS One. 2020 Apr 1;15(4):e0228121. doi: 10.1371/journal.pone.0228121. eCollection 2020.PMID: 32236094 
  80. Sarang Z, Sághy T, Budai Z, Ujlaky-Nagy L, Bedekovics J, Beke L, Méhes G, Nagy G, Rühl R, Moise AR, Palczewski K, Szondy Z. Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity. Biomolecules. 2019 Nov 13;9(11):737. doi: 10.3390/biom9110737.PMID: 31766264 
  81. Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019 Dec 13;294(50):19137-19154. doi: 10.1074/jbc.RA119.011169. Epub 2019 Nov 6.PMID: 31694912 
  82. Kallestad L, Blackshaw S, Khalil AM, Palczewski K. Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium. Sci Rep. 2019 Oct 15;9(1):14821. doi: 10.1038/s41598-019-51379-3.PMID: 31616038 
  83. Sun D, Schur RM, Sears AE, Gao SQ, Vaidya A, Sun W, Maeda A, Kern T, Palczewski K, Lu ZR. Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles. Mol Ther. 2020 Jan 8;28(1):293-303. doi: 10.1016/j.ymthe.2019.09.010. Epub 2019 Sep 12.PMID: 31611143 
  84. Ruminski D, Palczewska G, Nowakowski M, Zielińska A, Kefalov VJ, Komar K, Palczewski K, Wojtkowski M. Two-photon microperimetry: sensitivity of human photoreceptors to infrared light. Biomed Opt Express. 2019 Aug 9;10(9):4551-4567. doi: 10.1364/BOE.10.004551. eCollection 2019 Sep 1.PMID: 31565509 
  85. Kahremany S, Sander CL, Tochtrop GP, Kubas A, Palczewski K. Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis. Org Biomol Chem. 2019 Sep 21;17(35):8125-8139. doi: 10.1039/c9ob01645g. Epub 2019 Aug 28.PMID: 31455964 
  86. Vinberg F, Palczewska G, Zhang J, Komar K, Wojtkowski M, Kefalov VJ, Palczewski K. Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience. 2019 Sep 15;416:100-108. doi: 10.1016/j.neuroscience.2019.07.047. Epub 2019 Aug 7.PMID: 31400484 
  87. Zhao DY, Pöge M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K. Cryo-EM structure of the native rhodopsin dimer in nanodiscs. J Biol Chem. 2019 Sep 27;294(39):14215-14230. doi: 10.1074/jbc.RA119.010089. Epub 2019 Aug 9.PMID: 31399513 
  88. Kahremany S, Kubas A, Tochtrop GP, Palczewski K. Catalytic synthesis of 9-cis-retinoids: mechanistic insights. Dalton Trans. 2019 Jul 16;48(28):10581-10595. doi: 10.1039/c9dt02189b.PMID: 31218312 
  89. Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. Stereospecific modulation of dimeric rhodopsin. FASEB J. 2019 Aug;33(8):9526-9539. doi: 10.1096/fj.201900443RR. Epub 2019 May 23.PMID: 31121099 
  90. Mustafi D, Arbabi A, Ameri H, Palczewski K. Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention. Pharmaceuticals (Basel). 2019 May 17;12(2):74. doi: 10.3390/ph12020074.PMID: 31108889 
  91. Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. J Biol Chem. 2019 Jun 14;294(24):9461-9475. doi: 10.1074/jbc.RA119.008697. Epub 2019 May 9.PMID: 31073029 
  92. Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS. Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1538-1546. doi: 10.1167/iovs.18-26433.PMID: 30994864 
  93. Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K. Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates. J Biol Chem. 2019 May 17;294(20):8123-8133. doi: 10.1074/jbc.RA118.006835. Epub 2019 Apr 4.PMID: 30948514 
  94. Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K. A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1442-1453. doi: 10.1167/iovs.19-26560.PMID: 30947334 
  95. Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L. Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Sci Adv. 2019 Feb 27;5(2):eaav4322. doi: 10.1126/sciadv.aav4322. eCollection 2019 Feb.PMID: 30820458 
  96. Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. Specificity of the chromophore-binding site in human cone opsins. J Biol Chem. 2019 Apr 12;294(15):6082-6093. doi: 10.1074/jbc.RA119.007587. Epub 2019 Feb 15.PMID: 30770468 
  97. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 Apr;33(4):5782-5792. doi: 10.1096/fj.201802493R. Epub 2019 Jan 15.PMID: 30645148 
  98. Sakami S, Imanishi Y, Palczewski K. Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. FASEB J. 2019 Mar;33(3):3680-3692. doi: 10.1096/fj.201801662R. Epub 2018 Nov 21.PMID: 30462532 
  99. Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State. J Neurosci. 2019 Jan 9;39(2):212-223. doi: 10.1523/JNEUROSCI.1980-18.2018. Epub 2018 Nov 20.PMID: 30459230 
  100. Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 Oct 22;475(20):3171-3188. doi: 10.1042/BCJ20180193.PMID: 30352831 Review.
  101. Palczewska G, Kern TS, Palczewski K. Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. Methods Mol Biol. 2019;1834:333-343. doi: 10.1007/978-1-4939-8669-9_21.PMID: 30324453 
  102. Sakami S, Palczewski K. Immuno-TEM/STEM in Retinal Research. Methods Mol Biol. 2019;1834:311-332. doi: 10.1007/978-1-4939-8669-9_20.PMID: 30324452 
  103. Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. Exploring a new ligand binding site of G protein-coupled receptors. Chem Sci. 2018 Jul 13;9(31):6480-6489. doi: 10.1039/c8sc01680a. eCollection 2018 Aug 21.PMID: 30310578 
  104. Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F. A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness. iScience. 2018 Jun 29;4:1-19. doi: 10.1016/j.isci.2018.05.001. Epub 2018 May 5.PMID: 30240733 
  105. Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. JCI Insight. 2018 Sep 6;3(17):e121555. doi: 10.1172/jci.insight.121555. eCollection 2018 Sep 6.PMID: 30185665 
  106. Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration. Mol Pharmacol. 2018 Oct;94(4):1132-1144. doi: 10.1124/mol.118.112581. Epub 2018 Jul 17.PMID: 30018116 
  107. Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 May 18;9(1):1996. doi: 10.1038/s41467-018-04432-0.PMID: 29777099 
  108. Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun. 2018 May 17;9(1):1976. doi: 10.1038/s41467-018-04261-1.PMID: 29773803 
  109. Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 Jul 1;27(13):2225-2243. doi: 10.1093/hmg/ddy128.PMID: 29659842 
  110. Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A. An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. Med Chem. 2018;14(7):688-694. doi: 10.2174/1573406414666180412154952.PMID: 29651942 
  111. Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018 Apr 2;150(4):571-590. doi: 10.1085/jgp.201711815. Epub 2018 Mar 2.PMID: 29500274 
  112. Luu J, Palczewski K. Human aging and disease: Lessons from age-related macular degeneration. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):2866-2872. doi: 10.1073/pnas.1721033115. Epub 2018 Feb 26.PMID: 29483257 
  113. Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K. Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs. Mol Pharmacol. 2018 May;93(5):438-452. doi: 10.1124/mol.117.111294. Epub 2018 Feb 16.PMID: 29453250 
  114. Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models. FASEB J. 2018 Jun;32(6):3289-3300. doi: 10.1096/fj.201701250R. Epub 2018 Jan 24.PMID: 29401616 
  115. Owen TS, Salom D, Sun W, Palczewski K. Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry. 2018 Feb 13;57(6):1022-1030. doi: 10.1021/acs.biochem.7b01118. Epub 2018 Jan 29.PMID: 29320632 
  116. Murashova GA, Mancuso CA, Canfield JL, Sakami S, Palczewski K, Palczewska G, Dantus M. Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser. Biomed Opt Express. 2017 Oct 26;8(11):5228-5242. doi: 10.1364/BOE.8.005228. eCollection 2017 Nov 1.PMID: 29188116 
  117. Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21.PMID: 29162627 
  118. Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. Context-dependent compensation among phosphatidylserine-recognition receptors. Sci Rep. 2017 Nov 7;7(1):14623. doi: 10.1038/s41598-017-15191-1.PMID: 29116131 
  119. Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9675-E9684. doi: 10.1073/pnas.1712405114. Epub 2017 Oct 23.PMID: 29078372 
  120. Murashova GA, Mancuso CA, Sakami S, Palczewski K, Palczewska G, Dantus M. Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser. Proc SPIE Int Soc Opt Eng. 2017 Mar;10069:100692K. doi: 10.1117/12.2252457.PMID: 28989217 
  121. Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K. Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. J Biol Chem. 2017 Dec 1;292(48):19826-19839. doi: 10.1074/jbc.M117.812677. Epub 2017 Oct 4.PMID: 28978645 
  122. Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S. Designing Safer Analgesics via μ-Opioid Receptor Pathways. Trends Pharmacol Sci. 2017 Nov;38(11):1016-1037. doi: 10.1016/j.tips.2017.08.004. Epub 2017 Sep 19.PMID: 28935293 Review.
  123. Sears AE, Bernstein PS, Cideciyan AV, Hoyng C, Charbel Issa P, Palczewski K, Rosenfeld PJ, Sadda S, Schraermeyer U, Sparrow JR, Washington I, Scholl HPN. Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness. Transl Vis Sci Technol. 2017 Sep 14;6(5):6. doi: 10.1167/tvst.6.5.6. eCollection 2017 Sep.PMID: 28920007 Review.
  124. Alexander NS, Palczewski K. Crowd sourcing difficult problems in protein science. Protein Sci. 2017 Nov;26(11):2118-2125. doi: 10.1002/pro.3247. Epub 2017 Aug 29.PMID: 28762619 Review.
  125. Tonade D, Liu H, Palczewski K, Kern TS. Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. 2017 Oct;60(10):2111-2120. doi: 10.1007/s00125-017-4381-5. Epub 2017 Jul 28.PMID: 28755268 
  126. Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber’s Congenital Amaurosis. Mol Ther Nucleic Acids. 2017 Jun 16;7:42-52. doi: 10.1016/j.omtn.2017.02.005. Epub 2017 Feb 28.PMID: 28624218 
  127. Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ. The role of retinol dehydrogenase 10 in the cone visual cycle. Sci Rep. 2017 May 24;7(1):2390. doi: 10.1038/s41598-017-02549-8.PMID: 28539612 
  128. Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017 Jun 6;56(22):2836-2852. doi: 10.1021/acs.biochem.7b00251. Epub 2017 May 19.PMID: 28493664 
  129. Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. J Biol Chem. 2017 Jun 30;292(26):10983-10997. doi: 10.1074/jbc.M117.780478. Epub 2017 May 9.PMID: 28487362 
  130. Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther. 2017 Jul;362(1):131-145. doi: 10.1124/jpet.117.240721. Epub 2017 May 5.PMID: 28476927 
  131. Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K. Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry. 2017 May 2;56(17):2338-2348. doi: 10.1021/acs.biochem.7b00165. Epub 2017 Apr 21.PMID: 28402104 
  132. Palczewski K. Skunkworks project for Big Pharma. Pharmacol Res. 2017 Oct;124:167-168. doi: 10.1016/j.phrs.2017.03.022. Epub 2017 Mar 28.PMID: 28363722
  133. Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2608-E2615. doi: 10.1073/pnas.1617446114. Epub 2017 Mar 13.PMID: 28289214 
  134. Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Hum Mol Genet. 2016 Oct 15;25(20):4376-4388. doi: 10.1093/hmg/ddw268.PMID: 28172828 
  135. Sharma R, Schwarz C, Hunter JJ, Palczewska G, Palczewski K, Williams DR. Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):604-613. doi: 10.1167/iovs.16-20061.PMID: 28129424 
  136. Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K. MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. J Biol Chem. 2017 Feb 24;292(8):3366-3378. doi: 10.1074/jbc.M116.770024. Epub 2017 Jan 19.PMID: 28104803 
  137. Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 Jan 15;26(2):305-319. doi: 10.1093/hmg/ddw387.PMID: 28065882 
  138. Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW. A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins. Biochemistry. 2017 Jan 10;56(1):61-72. doi: 10.1021/acs.biochem.6b00877. Epub 2016 Nov 29.PMID: 28045251 
  1. Schwarz C, Sharma R, Fischer WS, Chung M, Palczewska G, Palczewski K, Williams DR, Hunter JJ. Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomed Opt Express. 2016 Nov 16;7(12):5148-5169. doi: 10.1364/BOE.7.005148. eCollection 2016 Dec 1.PMID: 28018732 
  2. Kiser PD, Palczewski K. Retinoids and Retinal Diseases. Annu Rev Vis Sci. 2016 Oct;2:197-234. doi: 10.1146/annurev-vision-111815-114407. Epub 2016 Jul 18.PMID: 27917399 Review.
  3. Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K. Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium. J Biol Chem. 2016 Dec 23;291(52):26937-26949. doi: 10.1074/jbc.M116.764563. Epub 2016 Nov 14.PMID: 27875314 
  4. Orban T., K. Palczewski, Structure and function of G protein–coupled receptor kinases 1 and 7. In “G protein receptor kinases” (Editors V. Gurevich and J. Tesmer). Springer 2016, 25–43
  5. Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa. Pharmacol Res. 2017 Jan;115:1-13. doi: 10.1016/j.phrs.2016.10.031. Epub 2016 Nov 9.PMID: 27838510 
  6. Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K. Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. Biochemistry. 2016 Nov 29;55(47):6545-6557. doi: 10.1021/acs.biochem.6b00907. Epub 2016 Nov 16.PMID: 27809489 
  7. Chen Y, Kern TS, Kiser PD, Palczewski K. Eyes on systems pharmacology. Pharmacol Res. 2016 Dec;114:39-41. doi: 10.1016/j.phrs.2016.09.026. Epub 2016 Oct 5.PMID: 27720767
  8. Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ. Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Nucleic Acids Res. 2016 Dec 1;44(21):10467-10479. doi: 10.1093/nar/gkw846. Epub 2016 Sep 20.PMID: 27655633 
  9. Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS. Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4272-81. doi: 10.1167/iovs.16-19415.PMID: 27548901 
  10. Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci Signal. 2016 Jul 26;9(438):ra74. doi: 10.1126/scisignal.aag0245.PMID: 27460988 
  11. Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. The Molecular Mechanism of P2Y1 Receptor Activation. Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10331-5. doi: 10.1002/anie.201605147. Epub 2016 Jul 27.PMID: 27460867 
  12. Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J Biol Chem. 2016 Sep 9;291(37):19401-12. doi: 10.1074/jbc.M116.744912. Epub 2016 Jul 24.PMID: 27453555 
  13. Alexander NS, Palczewska G, Stremplewski P, Wojtkowski M, Kern TS, Palczewski K. Image registration and averaging of low laser power two-photon fluorescence images of mouse retina. Biomed Opt Express. 2016 Jun 20;7(7):2671-91. doi: 10.1364/BOE.7.002671. eCollection 2016 Jul 1.PMID: 27446697 
  14. Yuan S, Peng Q, Palczewski K, Vogel H, Filipek S. Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor. Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8661-5. doi: 10.1002/anie.201603766. Epub 2016 May 31.PMID: 27244650 
  15. Sears AE, Palczewski K. Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle. Biochemistry. 2016 Jun 7;55(22):3082-91. doi: 10.1021/acs.biochem.6b00319. Epub 2016 May 23.PMID: 27183166 Review.
  16. Comitato A, Di Salvo MT, Turchiano G, Montanari M, Sakami S, Palczewski K, Marigo V. Dominant and recessive mutations in rhodopsin activate different cell death pathways. Hum Mol Genet. 2016 Jul 1;25(13):2801-2812. doi: 10.1093/hmg/ddw137. PMID: 27149983 
  17. Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage. J Biol Chem. 2016 Jun 17;291(25):12951-9. doi: 10.1074/jbc.M115.713248. Epub 2016 Apr 18.PMID: 27129240 
  18. Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, Fischer DF, Bürli RW, MacLeod AM, Harte WE, Palczewski K, Imanishi Y. A small molecule mitigates hearing loss in a mouse model of Usher syndrome III. Nat Chem Biol. 2016 Jun;12(6):444-51. doi: 10.1038/nchembio.2069. Epub 2016 Apr 25.PMID: 27110679 
  19. Sharma R, Schwarz C, Williams DR, Palczewska G, Palczewski K, Hunter JJ. In Vivo Two-Photon Fluorescence Kinetics of Primate Rods and Cones. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):647-57. doi: 10.1167/iovs.15-17946.PMID: 26903225 
  20. Sharma R, Williams DR, Palczewska G, Palczewski K, Hunter JJ. Two-Photon Autofluorescence Imaging Reveals Cellular Structures Throughout the Retina of the Living Primate Eye. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):632-46. doi: 10.1167/iovs.15-17961.PMID: 26903224 
  21. Hofmann L, Gulati S, Sears A, Stewart PL, Palczewski K. An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device. Anal Biochem. 2016 Apr 15;499:63-65. doi: 10.1016/j.ab.2016.01.016. Epub 2016 Feb 4.PMID: 26851339 
  22. Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. The Biochemical Basis of Vitamin A3 Production in Arthropod Vision. ACS Chem Biol. 2016 Apr 15;11(4):1049-57. doi: 10.1021/acschembio.5b00967. Epub 2016 Feb 2.PMID: 26811964 
  23. Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. J Biol Chem. 2015 Dec 18;290(51):30212-23. doi: 10.1074/jbc.M115.696799. Epub 2015 Oct 23.PMID: 26499794 
  24. Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J Biol Chem. 2015 Nov 27;290(48):29035-44. doi: 10.1074/jbc.M115.682310. Epub 2015 Oct 14.PMID: 26468292 
  25. Stremplewski P, Komar K, Palczewski K, Wojtkowski M, Palczewska G. Periscope for noninvasive two-photon imaging of murine retina in vivo. Biomed Opt Express. 2015 Aug 13;6(9):3352-61. doi: 10.1364/BOE.6.003352. eCollection 2015 Sep 1.PMID: 26417507 
  26. Sundermeier TR, Palczewski K. The impact of microRNA gene regulation on the survival and function of mature cell types in the eye. FASEB J. 2016 Jan;30(1):23-33. doi: 10.1096/fj.15-279745. Epub 2015 Sep 23.PMID: 26399786 Review.
  27. Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. 2015 Nov 6;290(45):27239-27247. doi: 10.1074/jbc.M115.682096. Epub 2015 Sep 21.PMID: 26391396 
  28. Kolesnikov AV, Maeda A, Tang PH, Imanishi Y, Palczewski K, Kefalov VJ. Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. J Physiol. 2015 Nov 15;593(22):4923-41. doi: 10.1113/JP271285. Epub 2015 Oct 18.PMID: 26350353 
  29. Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. J Biol Chem. 2015 Oct 16;290(42):25728-44. doi: 10.1074/jbc.M115.662684. Epub 2015 Sep 1.PMID: 26330551 
  30. Alexander NS, Palczewska G, Palczewski K. Semi-automated discrimination of retinal pigmented epithelial cells in two-photon fluorescence images of mouse retinas. Biomed Opt Express. 2015 Jul 23;6(8):3032-52. doi: 10.1364/BOE.6.003032. eCollection 2015 Aug 1.PMID: 26309765 
  31. Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski K, Lu ZR. Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells. Macromol Biosci. 2015 Dec;15(12):1663-72. doi: 10.1002/mabi.201500192. Epub 2015 Aug 13.PMID: 26271011 
  32. Jacobson SG, Cideciyan AV, Aguirre GD, Roman AJ, Sumaroka A, Hauswirth WW, Palczewski K. Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert Opin Orphan Drugs. 2015 May 4;3(5):563-575. doi: 10.1517/21678707.2015.1030393.PMID: 26246977 
  33. Schur RM, Sheng L, Sahu B, Yu G, Gao S, Yu X, Maeda A, Palczewski K, Lu ZR. Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments. Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4936-42. doi: 10.1167/iovs.15-16522.PMID: 26225634 
  34. Orban T, Johnson WM, Dong Z, Maeda T, Maeda A, Sakai T, Tsuneoka H, Mieyal JJ, Palczewski K. Serum levels of lipid metabolites in age-related macular degeneration. FASEB J. 2015 Nov;29(11):4579-88. doi: 10.1096/fj.15-275289. Epub 2015 Jul 17.PMID: 26187344 
  35. Hofmann L, Palczewski K. Advances in understanding the molecular basis of the first steps in color vision. Prog Retin Eye Res. 2015 Nov;49:46-66. doi: 10.1016/j.preteyeres.2015.07.004. Epub 2015 Jul 15.PMID: 26187035 Review.
  36. Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, von Lintig J, Palczewski K, Kern TS. Retinylamine Benefits Early Diabetic Retinopathy in Mice. J Biol Chem. 2015 Aug 28;290(35):21568-79. doi: 10.1074/jbc.M115.655555. Epub 2015 Jul 2.PMID: 26139608 
  37. Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 2015 Jul 1;125(7):2781-94. doi: 10.1172/JCI80950. Epub 2015 Jun 15.PMID: 26075817 
  38. Yuan S, Palczewski K, Peng Q, Kolinski M, Vogel H, Filipek S. The mechanism of ligand-induced activation or inhibition of μ- and κ-opioid receptors. Angew Chem Int Ed Engl. 2015 Jun 22;54(26):7560-3. doi: 10.1002/anie.201501742. Epub 2015 May 12.PMID: 25968837
  39. Baker BY, Gulati S, Shi W, Wang B, Stewart PL, Palczewski K. Crystallization of proteins from crude bovine rod outer segments. Methods Enzymol. 2015;557:439-58. doi: 10.1016/bs.mie.2014.11.045. Epub 2015 Mar 17.PMID: 25950977 
  40. Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11(6):409-15. doi: 10.1038/nchembio.1799. Epub 2015 Apr 20.PMID: 25894083 
  41. Chen Y, Palczewski K. Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders. Annu Rev Pharmacol Toxicol. 2016;56:273-98. doi: 10.1146/annurev-pharmtox-010715-103033. Epub 2015 Mar 23.PMID: 25839098 Review.
  42. Chen Y, Tang H, Seibel W, Papoian R, Li X, Lambert NA, Palczewski K. A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2553-67. doi: 10.1167/iovs.14-16298.PMID: 25783607 
  43. Zhang N, Tsybovsky Y, Kolesnikov AV, Rozanowska M, Swider M, Schwartz SB, Stone EM, Palczewska G, Maeda A, Kefalov VJ, Jacobson SG, Cideciyan AV, Palczewski K. Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations. Hum Mol Genet. 2015 Jun 1;24(11):3220-37. doi: 10.1093/hmg/ddv073. Epub 2015 Feb 24.PMID: 25712131 
  44. Hofmann L, Palczewski K. The G protein-coupled receptor rhodopsin: a historical perspective. Methods Mol Biol. 2015;1271:3-18. doi: 10.1007/978-1-4939-2330-4_1.PMID: 25697513 
  45. Du Y, Cramer M, Lee CA, Tang J, Muthusamy A, Antonetti DA, Jin H, Palczewski K, Kern TS. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May;29(5):2194-204. doi: 10.1096/fj.14-269431. Epub 2015 Feb 9.PMID: 25667222 
  46. Mustafi D, Kikano S, Palczewski K. Serial block face-scanning electron microscopy: a method to study retinal degenerative phenotypes. Curr Protoc Mouse Biol. 2014 Dec 11;4(4):197-204. doi: 10.1002/9780470942390.mo140169.PMID: 25621191 
  47. Puntel A, Maeda A, Golczak M, Gao SQ, Yu G, Palczewski K, Lu ZR. Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles. Biomaterials. 2015 Mar;44:103-10. doi: 10.1016/j.biomaterials.2014.12.019. Epub 2015 Jan 12.PMID: 25617130 
  48. Kevany BM, Zhang N, Jastrzebska B, Palczewski K. Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration. Hum Mol Genet. 2015 May 1;24(9):2627-40. doi: 10.1093/hmg/ddv025. Epub 2015 Jan 23.PMID: 25616964 
  49. Zhang J, Dong Z, Mundla SR, Hu XE, Seibel W, Papoian R, Palczewski K, Golczak M. Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration. Mol Pharmacol. 2015;87(3):477-91. doi: 10.1124/mol.114.096560. Epub 2014 Dec 23.PMID: 25538117 
  50. Salom D, Cao P, Yuan Y, Miyagi M, Feng Z, Palczewski K. Isotopic labeling of mammalian G protein-coupled receptors heterologously expressed in Caenorhabditis elegans. Anal Biochem. 2015 Mar 1;472:30-6. doi: 10.1016/j.ab.2014.11.008. Epub 2014 Nov 20.PMID: 25461480 
  51. Palczewska G, Vinberg F, Stremplewski P, Bircher MP, Salom D, Komar K, Zhang J, Cascella M, Wojtkowski M, Kefalov VJ, Palczewski K. Human infrared vision is triggered by two-photon chromophore isomerization. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5445-54. doi: 10.1073/pnas.1410162111. Epub 2014 Dec 1.PMID: 25453064 
  52. Yu G, Wu X, Ayat N, Maeda A, Gao SQ, Golczak M, Palczewski K, Lu ZR. Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice. Biomacromolecules. 2014 Dec 8;15(12):4570-8. doi: 10.1021/bm501352s. Epub 2014 Nov 20.PMID: 25390360 
  53. Golczak M, Sears AE, Kiser PD, Palczewski K. LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. Nat Chem Biol. 2015 Jan;11(1):26-32. doi: 10.1038/nchembio.1687. Epub 2014 Nov 10.PMID: 25383759 
  54. Palczewski K. Chemistry and biology of the initial steps in vision: the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2014 Oct 22;55(10):6651-72. doi: 10.1167/iovs.14-15502.PMID: 25338686 
  55. Chiang WC, Kroeger H, Sakami S, Messah C, Yasumura D, Matthes MT, Coppinger JA, Palczewski K, LaVail MM, Lin JH. Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Mol Neurobiol. 2015 Aug;52(1):679-95. doi: 10.1007/s12035-014-8881-8. Epub 2014 Oct 2.PMID: 25270370 
  56. Park S, Li C, Haeseleer F, Palczewski K, Ames JB. Structural insights into activation of the retinal L-type Ca²⁺ channel (Cav1.4) by Ca²⁺-binding protein 4 (CaBP4). J Biol Chem. 2014 Nov 7;289(45):31262-73. doi: 10.1074/jbc.M114.604439. Epub 2014 Sep 25.PMID: 25258313 
  57. Sundermeier TR, Jin H, Kleinjan ML, Mustafi D, Licatalosi DD, Palczewski K. Argonaute high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation reveals a snapshot of miRNA gene regulation in the mammalian retina. Biochemistry. 2014 Sep 23;53(37):5831-3. doi: 10.1021/bi500966b. Epub 2014 Sep 15.PMID: 25204418 
  58. Yuan S, Filipek S, Palczewski K, Vogel H. Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway. Nat Commun. 2014 Sep 9;5:4733. doi: 10.1038/ncomms5733.PMID: 25203160 
  59. Baker BY, Shi W, Wang B, Palczewski K. High-resolution crystal structures of the photoreceptor glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with three and four-bound NAD molecules. Protein Sci. 2014 Nov;23(11):1629-39. doi: 10.1002/pro.2543. Epub 2014 Sep 25.PMID: 25176140 
  60. Palczewska G, Golczak M, Williams DR, Hunter JJ, Palczewski K. Endogenous fluorophores enable two-photon imaging of the primate eye. Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4438-47. doi: 10.1167/iovs.14-14395.PMID: 24970255 
  61. Palczewska G, Dong Z, Golczak M, Hunter JJ, Williams DR, Alexander NS, Palczewski K. Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye. Nat Med. 2014 Jul;20(7):785-9. doi: 10.1038/nm.3590. Epub 2014 Jun 22.PMID: 24952647 
  62. Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Mol Pharmacol. 2014 Aug;86(2):231-42. doi: 10.1124/mol.114.093070. Epub 2014 Jun 9.PMID: 24913940 
  63. Amengual J, Zhang N, Kemerer M, Maeda T, Palczewski K, Von Lintig J. STRA6 is critical for cellular vitamin A uptake and homeostasis. Hum Mol Genet. 2014 Oct 15;23(20):5402-17. doi: 10.1093/hmg/ddu258. Epub 2014 May 22.PMID: 24852372 
  64. Comar WD, Schubert SM, Jastrzebska B, Palczewski K, Smith AW.J Time-resolved fluorescence spectroscopy measures clustering and mobility of a G protein-coupled receptor opsin in live cell membranes. Am Chem Soc. 2014 Jun 11;136(23):8342-9. doi: 10.1021/ja501948w. Epub 2014 Jun 2.PMID: 24831851 
  65. Sundermeier TR, Zhang N, Vinberg F, Mustafi D, Kohno H, Golczak M, Bai X, Maeda A, Kefalov VJ, Palczewski K. DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. FASEB J. 2014 Aug;28(8):3780-91. doi: 10.1096/fj.14-254292. Epub 2014 May 8.PMID: 24812086 
  66. Maeda A, Palczewska G, Golczak M, Kohno H, Dong Z, Maeda T, Palczewski K. Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1428-37. doi: 10.1073/pnas.1317986111. Epub 2014 Mar 24.PMID: 24706832 
  67. Orban T, Jastrzebska B, Palczewski K. Structural approaches to understanding retinal proteins needed for vision. Curr Opin Cell Biol. 2014 Apr;27:32-43. doi: 10.1016/j.ceb.2013.11.001. Epub 2013 Nov 28.PMID: 24680428 Review.
  68. Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K. Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO). J Biol Chem. 2014 May 2;289(18):12286-99. doi: 10.1074/jbc.M114.552836. Epub 2014 Mar 19.PMID: 24648526 
  69. Tsybovsky Y, Palczewski K. Expression, purification and structural properties of ABC transporter ABCA4 and its individual domains. Protein Expr Purif. 2014 May;97:50-60. doi: 10.1016/j.pep.2014.02.010. Epub 2014 Feb 28.PMID: 24583180 
  70. Wang B, Tsybovsky Y, Palczewski K, Chance MR. Reliable determination of site-specific in vivo protein N-glycosylation based on collision-induced MS/MS and chromatographic retention time. J Am Soc Mass Spectrom. 2014 May;25(5):729-41. doi: 10.1007/s13361-013-0823-6. Epub 2014 Feb 19.PMID: 24549892 
  71. Tu X, Palczewski K. The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements. J Struct Biol. 2014 Apr;186(1):86-94. doi: 10.1016/j.jsb.2014.02.001. Epub 2014 Feb 12.PMID: 24531000 
  72. Sundermeier TR, Vinberg F, Mustafi D, Bai X, Kefalov VJ, Palczewski K. R9AP overexpression alters phototransduction kinetics in iCre75 mice. Invest Ophthalmol Vis Sci. 2014 Mar 6;55(3):1339-47. doi: 10.1167/iovs.13-13564.PMID: 24526444 
  73. Palczewski K. CrossTalk: CROSSTALK: Atomic force microscopy (AFM) reveals rhodopsin organization in native disc membranes. In CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out. 2014, J. Physiology. http://jp.physoc.org/content/592/12/2443.short/reply#jphysiol_el_773
  74. Chen Y, Jastrzebska B, Cao P, Zhang J, Wang B, Sun W, Yuan Y, Feng Z, Palczewski K. Inherent instability of the retinitis pigmentosa P23H mutant opsin. J Biol Chem. 2014 Mar 28;289(13):9288-303. doi: 10.1074/jbc.M114.551713. Epub 2014 Feb 10.PMID: 24515108 
  75. Wu X, Yu G, Luo C, Maeda A, Zhang N, Sun D, Zhou Z, Puntel A, Palczewski K, Lu ZR. Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration. ACS Nano. 2014 Jan 28;8(1):153-61. doi: 10.1021/nn4054107. Epub 2013 Dec 20.PMID: 24350906 
  76. Bolze CS, Helbling RE, Owen RL, Pearson AR, Pompidor G, Dworkowski F, Fuchs MR, Furrer J, Golczak M, Palczewski K, Cascella M, Stocker A. Human cellular retinaldehyde-binding protein has secondary thermal 9-cis-retinal isomerase activity. J Am Chem Soc. 2014 Jan 8;136(1):137-46. doi: 10.1021/ja411366w. Epub 2013 Dec 20.PMID: 24328211 
  77. Chen Y, Palczewska G, Mustafi D, Golczak M, Dong Z, Sawada O, Maeda T, Maeda A, Palczewski K. Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. J Clin Invest. 2013 Dec;123(12):5119-34. doi: 10.1172/JCI69076. Epub 2013 Nov 15.PMID: 24231350 
  78. Sakami S, Kolesnikov AV, Kefalov VJ, Palczewski K. P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet. 2014 Apr 1;23(7):1723-41. doi: 10.1093/hmg/ddt561. Epub 2013 Nov 7.PMID: 24214395 
  79. Kevany BM, Tsybovsky Y, Campuzano ID, Schnier PD, Engel A, Palczewski K. Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells. J Biol Chem. 2013 Dec 20;288(51):36272-84. doi: 10.1074/jbc.M113.520700. Epub 2013 Nov 6.PMID: 24196967 
  80. Salom D, Padayatti PS, Palczewski K. Crystallization of G protein-coupled receptors. Methods Cell Biol. 2013;117:451-68. doi: 10.1016/B978-0-12-408143-7.00024-4.PMID: 24143992 
  81. Maeda T, Lee MJ, Palczewska G, Marsili S, Tesar PJ, Palczewski K, Takahashi M, Maeda A. Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo. J Biol Chem. 2013 Nov 29;288(48):34484-93. doi: 10.1074/jbc.M113.518571. Epub 2013 Oct 15.PMID: 24129572 
  82. Amengual J, Widjaja-Adhi MAK, Rodriguez-Santiago S, Hessel S, Golczak M, Palczewski K, von Lintig J. Two carotenoid oxygenases contribute to mammalian provitamin A metabolism. J Biol Chem. 2013 Nov 22;288(47):34081-34096. doi: 10.1074/jbc.M113.501049. Epub 2013 Oct 8.PMID: 24106281 
  83. Du Y, Veenstra A, Palczewski K, Kern TS. Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16586-91. doi: 10.1073/pnas.1314575110. Epub 2013 Sep 25.PMID: 24067647 
  84. Sharma R, Yin L, Geng Y, Merigan WH, Palczewska G, Palczewski K, Williams DR, Hunter JJ. In vivo two-photon imaging of the mouse retina. Biomed Opt Express. 2013 Jul 9;4(8):1285-93. doi: 10.1364/BOE.4.001285. eCollection 2013.PMID: 24009992 
  85. Helbling RE, Bolze CS, Golczak M, Palczewski K, Stocker A, Cascella M. Cellular retinaldehyde binding protein-different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates. J Phys Chem B. 2013 Sep 19;117(37):10719-29. doi: 10.1021/jp405410t. Epub 2013 Sep 10.PMID: 23964907
  86. Mustafi D, Kevany BM, Genoud C, Bai X, Palczewski K. Photoreceptor phagocytosis is mediated by phosphoinositide signaling. FASEB J. 2013 Nov;27(11):4585-95. doi: 10.1096/fj.13-237537. Epub 2013 Aug 2.PMID: 23913857 
  87. Kiser PD, Golczak M, Palczewski K. Chemistry of the retinoid (visual) cycle. Chem Rev. 2014 Jan 8;114(1):194-232. doi: 10.1021/cr400107q. Epub 2013 Jul 11.PMID: 23905688 Review. 
  88. Sui X, Kiser PD, Lintig Jv, Palczewski K. Structural basis of carotenoid cleavage: from bacteria to mammals. Arch Biochem Biophys. 2013 Nov 15;539(2):203-13. doi: 10.1016/j.abb.2013.06.012. Epub 2013 Jul 1.PMID: 23827316 Review.
  89. Kowatz T, Babino D, Kiser P, Palczewski K, von Lintig J. Characterization of human β,β-carotene-15,15′-monooxygenase (BCMO1) as a soluble monomeric enzyme. Arch Biochem Biophys. 2013 Nov 15;539(2):214-22. doi: 10.1016/j.abb.2013.05.007. Epub 2013 May 29.PMID: 23727499 
  90. Palczewski K, Orban T. From atomic structures to neuronal functions of g protein-coupled receptors. Annu Rev Neurosci. 2013 Jul 8;36:139-64. doi: 10.1146/annurev-neuro-062012-170313. Epub 2013 May 15.PMID: 23682660 Review.
  91. Palczewski K, Kiser PD. Biochemistry. As good as chocolate. Science. 2013 May 3;340(6132):562-3. doi: 10.1126/science.1238521.PMID: 23641106
  92. Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem. 2013 May 24;288(21):15326-41. doi: 10.1074/jbc.M112.448712. Epub 2013 Apr 9.PMID: 23572532 
  93. Mustafi D, Kevany BM, Bai X, Maeda T, Sears JE, Khalil AM, Palczewski K. Evolutionarily conserved long intergenic non-coding RNAs in the eye. Hum Mol Genet. 2013 Aug 1;22(15):2992-3002. doi: 10.1093/hmg/ddt156. Epub 2013 Apr 4.PMID: 23562822 
  94. Tsybovsky Y, Orban T, Molday RS, Taylor D, Palczewski K. Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. Structure. 2013 May 7;21(5):854-60. doi: 10.1016/j.str.2013.03.001. Epub 2013 Apr 4.PMID: 23562398 
  95. Tian M, Zallocchi M, Wang W, Chen CK, Palczewski K, Delimont D, Cosgrove D, Peng YW. Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors. PLoS One. 2013;8(3):e58832. doi: 10.1371/journal.pone.0058832. Epub 2013 Mar 28.PMID: 23555598 
  96. Jastrzebska B, Ringler P, Palczewski K, Engel A. The rhodopsin-transducin complex houses two distinct rhodopsin molecules. J Struct Biol. 2013 May;182(2):164-72. doi: 10.1016/j.jsb.2013.02.014. Epub 2013 Feb 28.PMID: 23458690 
  97. Yan J, Kaur S, DeLucia M, Hao C, Mehrens J, Wang C, Golczak M, Palczewski K, Gronenborn AM, Ahn J, Skowronski J. Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem. 2013 Apr 12;288(15):10406-17. doi: 10.1074/jbc.M112.443796. Epub 2013 Feb 20.PMID: 23426366 
  98. Padayatti PS, Wang L, Gupta S, Orban T, Sun W, Salom D, Jordan SR, Palczewski K, Chance MR. A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Mol Cell Proteomics. 2013 May;12(5):1259-71. doi: 10.1074/mcp.M112.025536. Epub 2013 Feb 1.PMID: 23378516 
  99. Jastrzebska B, Salom D, Jin H, Cao P, Sun W, Palczewski K, Feng Z. Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans. Methods Enzymol. 2013;520:239-56. doi: 10.1016/B978-0-12-391861-1.00011-3.PMID: 23332703 
  100. Jastrzebska B, Orban T, Golczak M, Engel A, Palczewski K. Asymmetry of the rhodopsin dimer in complex with transducin. FASEB J. 2013 Apr;27(4):1572-84. doi: 10.1096/fj.12-225383. Epub 2013 Jan 9.PMID: 23303210 
  101. Maeda A, Palczewski K. Retinal degeneration in animal models with a defective visual cycle. Drug Discov Today Dis Models. 2013 Winter;10(4):e163-e172. doi: 10.1016/j.ddmod.2014.01.001.PMID: 25210527 
  102. Vahedi-Faridi A, Jastrzebska B, Palczewski K, Engel A. 3D imaging and quantitative analysis of small solubilized membrane proteins and their complexes by transmission electron microscopy. Microscopy (Oxf). 2013 Feb;62(1):95-107. doi: 10.1093/jmicro/dfs091. Epub 2012 Dec 23.PMID: 23267047 
  103. Latek D, Modzelewska A, Trzaskowski B, Palczewski K, Filipek S. G protein-coupled receptors–recent advances. Acta Biochim Pol. 2012;59(4):515-29. Epub 2012 Dec 18.PMID: 23251911 Review.
  104. Maeda T, Dong Z, Jin H, Sawada O, Gao S, Utkhede D, Monk W, Palczewska G, Palczewski K. QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles. Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):455-66. doi: 10.1167/iovs.12-11152.PMID: 23249702 
  105. Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest. 2013 Jan;123(1):121-37. doi: 10.1172/JCI66176. Epub 2012 Dec 10.PMID: 23221340 
  106. Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2747-56. doi: 10.1073/pnas.1212025109. Epub 2012 Sep 24.PMID: 23012475 
  107. Gao SQ, Maeda T, Okano K, Palczewski K. A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids. Invest Ophthalmol Vis Sci. 2012 Sep 19;53(10):6314-23. doi: 10.1167/iovs.12-10279.PMID: 22918645 
  108. Tu X, Palczewski K. Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration. J Struct Biol. 2012 Dec;180(3):439-46. doi: 10.1016/j.jsb.2012.07.011. Epub 2012 Aug 7.PMID: 22892318 
  109. Mustafi D, Maeda T, Kohno H, Nadeau JH, Palczewski K. Inflammatory priming predisposes mice to age-related retinal degeneration. J Clin Invest. 2012 Aug;122(8):2989-3001. doi: 10.1172/JCI64427. Epub 2012 Jul 17.PMID: 22797304 
  110. Hachiya A, Marchand B, Kirby KA, Michailidis E, Tu X, Palczewski K, Ong YT, Li Z, Griffin DT, Schuckmann MM, Tanuma J, Oka S, Singh K, Kodama EN, Sarafianos SG. HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors. J Biol Chem. 2012 Aug 24;287(35):29988-99. doi: 10.1074/jbc.M112.351551. Epub 2012 Jul 2.PMID: 22761416 
  111. Amengual J, Golczak M, Palczewski K, von Lintig J.Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein. J Biol Chem. 2012 Jul 13;287(29):24216-27. doi: 10.1074/jbc.M112.353979. Epub 2012 May 27.PMID: 22637576 
  112. Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J Biol Chem. 2012 Jul 6;287(28):23790-807. doi: 10.1074/jbc.M112.361550. Epub 2012 May 17.PMID: 22605381 
  113. Orban T, Jastrzebska B, Gupta S, Wang B, Miyagi M, Chance MR, Palczewski K. Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein. Structure. 2012 May 9;20(5):826-40. doi: 10.1016/j.str.2012.03.017.PMID: 22579250 
  114. Sexton TJ, Golczak M, Palczewski K, Van Gelder RN. Melanopsin is highly resistant to light and chemical bleaching in vivo. J Biol Chem. 2012 Jun 15;287(25):20888-97. doi: 10.1074/jbc.M111.325969. Epub 2012 Apr 30.PMID: 22547062 
  115. Orban T, Huang CC, Homan KT, Jastrzebska B, Tesmer JJ, Palczewski K. Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1).Biochemistry. 2012 Apr 24;51(16):3404-11. doi: 10.1021/bi300295y. Epub 2012 Apr 11.PMID: 22480180 
  116. Sundermeier TR, Palczewski K. The physiological impact of microRNA gene regulation in the retina. Cell Mol Life Sci. 2012 Aug;69(16):2739-50. doi: 10.1007/s00018-012-0976-7. Epub 2012 Mar 30.PMID: 22460583 Review.
  117. Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. J Biol Chem. 2012 Apr 13;287(16):13356-70. doi: 10.1074/jbc.M112.347518. Epub 2012 Feb 22.PMID: 22356908 
  118. Padayatti P, Palczewska G, Sun W, Palczewski K, Salom D. Imaging of protein crystals with two-photon microscopy. Biochemistry. 2012 Feb 28;51(8):1625-37. doi: 10.1021/bi201682q. Epub 2012 Feb 16.PMID: 22324807 
  119. Okano K, Maeda A, Chen Y, Chauhan V, Tang J, Palczewska G, Sakai T, Tsuneoka H, Palczewski K, Maeda T. Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage. J Neurochem. 2012 Apr;121(1):146-56. doi: 10.1111/j.1471-4159.2012.07647.x. Epub 2012 Feb 9.PMID: 22220722 
  120. Maeda A, Golczak M, Chen Y, Okano K, Kohno H, Shiose S, Ishikawa K, Harte W, Palczewska G, Maeda T, Palczewski K. Primary amines protect against retinal degeneration in mouse models of retinopathies. Nat Chem Biol. 2011 Dec 25;8(2):170-8. doi: 10.1038/nchembio.759.PMID: 22198730 
  121. \Salom D, Palczewski K, Structural biology of membrane proteins. In “Production of membrane proteins: strategies for expression and isolation.” (ed. Anne Skaja Robinson) 2011, 9, 249–73. Wiley–VCH publisher
  122. Chen Y, Okano K, Maeda T, Chauhan V, Golczak M, Maeda A, Palczewski K. Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem. 2012 Feb 10;287(7):5059-69. doi: 10.1074/jbc.M111.315432. Epub 2011 Dec 19.PMID: 22184108 
  123. Salom D, Wang B, Dong Z, Sun W, Padayatti P, Jordan S, Salon JA, Palczewski K. Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells. Biochemistry. 2012 Jan 10;51(1):214-24. doi: 10.1021/bi201707v. Epub 2011 Dec 20.PMID: 22145929 
  124. Salom D, Cao P, Sun W, Kramp K, Jastrzebska B, Jin H, Feng Z, Palczewski K. Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans. FASEB J. 2012 Feb;26(2):492-502. doi: 10.1096/fj.11-197780. Epub 2011 Nov 16.PMID: 22090314 
  125. Cao P, Sun W, Kramp K, Zheng M, Salom D, Jastrzebska B, Jin H, Palczewski K, Feng Z. Light-sensitive coupling of rhodopsin and melanopsin to G(i/o) and G(q) signal transduction in Caenorhabditis elegans. FASEB J. 2012 Feb;26(2):480-91. doi: 10.1096/fj.11-197798. Epub 2011 Nov 16.PMID: 22090313 
  126. Palczewski K. J Chemistry and biology of vision. Biol Chem. 2012 Jan 13;287(3):1612-9. doi: 10.1074/jbc.R111.301150. Epub 2011 Nov 10.PMID: 22074921 Review.
  127. Palczewski K. Thematic minireview series on focus on vision. J Biol Chem. 2012 Jan 13;287(3):1610-1. doi: 10.1074/jbc.R111.322347. Epub 2011 Nov 10.PMID: 22074916
  128. Baker BY, Palczewski K. Detergents stabilize the conformation of phosphodiesterase 6. Biochemistry. 2011 Nov 8;50(44):9520-31. doi: 10.1021/bi2014695. Epub 2011 Oct 14.PMID: 21978030 
  129. Salon JA, Lodowski DT, Palczewski K. The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev. 2011 Dec;63(4):901-37. doi: 10.1124/pr.110.003350.PMID: 21969326 Review.
  130. Jastrzebska B, Ringler P, Lodowski DT, Moiseenkova-Bell V, Golczak M, Müller SA, Palczewski K, Engel A.Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization. J Struct Biol. 2011 Dec;176(3):387-94. doi: 10.1016/j.jsb.2011.08.016. Epub 2011 Sep 6.PMID: 21925606 
  131. Maeda T, Perusek L, Amengual J, Babino D, Palczewski K, von Lintig J. Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis. Mol Pharmacol. 2011 Nov;80(5):943-52. doi: 10.1124/mol.111.074732. Epub 2011 Aug 23.PMID: 21862692 
  132. Zhu Q, Sun W, Okano K, Chen Y, Zhang N, Maeda T, Palczewski K. Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina. J Biol Chem. 2011 Sep 9;286(36):31749-60. doi: 10.1074/jbc.M111.259028. Epub 2011 Jul 15.PMID: 21768104 
  133. Tsybovsky Y, Wang B, Quazi F, Molday RS, Palczewski K. Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4. Biochemistry. 2011 Aug 16;50(32):6855-66. doi: 10.1021/bi200774w. Epub 2011 Jul 8.PMID: 21721517 
  134. Mustafi D, Kevany BM, Genoud C, Okano K, Cideciyan AV, Sumaroka A, Roman AJ, Jacobson SG, Engel A, Adams MD, Palczewski K. Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB J. 2011 Sep;25(9):3157-76. doi: 10.1096/fj.11-186767. Epub 2011 Jun 9.PMID: 21659555 
  135. Peshenko IV, Olshevskaya EV, Savchenko AB, Karan S, Palczewski K, Baehr W, Dizhoor AM. Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. Biochemistry. 2011 Jun 28;50(25):5590-600. doi: 10.1021/bi200491b. Epub 2011 Jun 6.PMID: 21598940 
  136. Jastrzebska B, Palczewski K, Golczak M. Role of bulk water in hydrolysis of the rhodopsin chromophore. J Biol Chem. 2011 May 27;286(21):18930-7. doi: 10.1074/jbc.M111.234583. Epub 2011 Apr 1.PMID: 21460218 
  137. Orban T, Palczewska G, Palczewski K. Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues. J Biol Chem. 2011 May 13;286(19):17248-58. doi: 10.1074/jbc.M110.195198. Epub 2011 Mar 25.PMID: 21454509 
  138. Bereta G, Palczewski K. Heterogeneous N-terminal acylation of retinal proteins results from the retina’s unusual lipid metabolism. Biochemistry. 2011 May 10;50(18):3764-76. doi: 10.1021/bi200245t. Epub 2011 Apr 11.PMID: 21449552 
  139. Kiser PD, Golczak M, Maeda A, Palczewski K. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012 Jan;1821(1):137-51. doi: 10.1016/j.bbalip.2011.03.005. Epub 2011 Apr 5.PMID: 21447403 Review.
  140. Mustafi D, Avishai A, Avishai N, Engel A, Heuer A, Palczewski K. Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. J Neurosci Methods. 2011 May 15;198(1):70-6. doi: 10.1016/j.jneumeth.2011.03.013. Epub 2011 Mar 23.PMID: 21439323 
  141. Jastrzebska B, Debinski A, Filipek S, Palczewski K.Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function. Prog Lipid Res. 2011 Jul;50(3):267-77. doi: 10.1016/j.plipres.2011.03.002. Epub 2011 Mar 22.PMID: 21435354 Review.
  142. Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J Biol Chem. 2011 Apr 29;286(17):15543-55. doi: 10.1074/jbc.M111.228551. Epub 2011 Mar 7.PMID: 21383019 
  143. Hunter JJ, Masella B, Dubra A, Sharma R, Yin L, Merigan WH, Palczewska G, Palczewski K, Williams DR. Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy. Biomed Opt Express. 2010 Dec 17;2(1):139-48. doi: 10.1364/BOE.2.000139.PMID: 21326644 
  144. Palczewski K. Focus on vision: 3 decades of remarkable contributions to biology and medicine. FASEB J. 2011 Feb;25(2):439-43. doi: 10.1096/fj.11-0202ufm.PMID: 21282210 
  145. Huang CC, Orban T, Jastrzebska B, Palczewski K, Tesmer JJ. Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. Biochemistry. 2011 Mar 22;50(11):1940-9. doi: 10.1021/bi101606e. Epub 2011 Feb 22.PMID: 21265573 
  146. Sakami S, Maeda T, Bereta G, Okano K, Golczak M, Sumaroka A, Roman AJ, Cideciyan AV, Jacobson SG, Palczewski K. Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem. 2011 Mar 25;286(12):10551-67. doi: 10.1074/jbc.M110.209759. Epub 2011 Jan 11.PMID: 21224384 
  147. Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA. J Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. Biol Chem. 2011 Feb 18;286(7):5607-13. doi: 10.1074/jbc.M110.188433. Epub 2010 Dec 15.PMID: 21159775 
  148. Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J. A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J. 2011 Mar;25(3):948-59. doi: 10.1096/fj.10-173906. Epub 2010 Nov 24.PMID: 21106934 
  149. Palczewska G, Maeda T, Imanishi Y, Sun W, Chen Y, Williams DR, Piston DW, Maeda A, Palczewski K. Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Nat Med. 2010 Dec;16(12):1444-9. doi: 10.1038/nm.2260. Epub 2010 Nov 14.PMID: 21076393 
  150. Palczewski K. Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Arch Ophthalmol. 2010 Nov;128(11):1483-5. doi: 10.1001/archophthalmol.2010.245.PMID: 21060052
  151. Lodowski DT, Palczewski K, Miyagi M. Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange. Biochemistry. 2010 Nov 9;49(44):9425-7. doi: 10.1021/bi101502v. Epub 2010 Oct 15.PMID: 20939497 
  152. Li H, Palczewski K, Baehr W, Clagett-Dame M. Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. Biol Reprod. 2011 Feb;84(2):336-41. doi: 10.1095/biolreprod.110.086157. Epub 2010 Sep 29.PMID: 20881313 
  153. Huang J, Xu Z, Wang D, Ogata CM, Palczewski K, Lee X, Young NM. Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. Glycobiology. 2010 Dec;20(12):1643-53. doi: 10.1093/glycob/cwq118. Epub 2010 Sep 8.PMID: 20826825 
  154. Tsybovsky Y, Molday RS, Palczewski K. The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol. 2010;703:105-25. doi: 10.1007/978-1-4419-5635-4_8.PMID: 20711710 Review.
  155. Golczak M, Palczewski K. An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase. J Biol Chem. 2010 Sep 17;285(38):29217-22. doi: 10.1074/jbc.M110.152314. Epub 2010 Jul 12.PMID: 20628054 
  156. Pulagam LP, Palczewski K. Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane. J Biol Chem. 2010 Sep 17;285(38):29446-56. doi: 10.1074/jbc.M110.151407. Epub 2010 Jul 13.PMID: 20628051 
  157. Goc A, Chami M, Lodowski DT, Bosshart P, Moiseenkova-Bell V, Baehr W, Engel A, Palczewski K. Structural characterization of the rod cGMP phosphodiesterase 6. J Mol Biol. 2010 Aug 20;401(3):363-73. doi: 10.1016/j.jmb.2010.06.044. Epub 2010 Jul 1.PMID: 20600113 
  158. Lobo GP, Amengual J, Li HN, Golczak M, Bonet ML, Palczewski K, von Lintig J. Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner. J Biol Chem. 2010 Sep 3;285(36):27891-9. doi: 10.1074/jbc.M110.132571. Epub 2010 Jun 23.PMID: 20573961 
  159. Imanishi Y, Palczewski K. Visualization of retinoid storage and trafficking by two-photon microscopy. Methods Mol Biol. 2010;652:247-61. doi: 10.1007/978-1-60327-325-1_14.PMID: 20552433 
  160. Golczak M, Bereta G, Maeda A, Palczewski K. Molecular biology and analytical chemistry methods used to probe the retinoid cycle. Methods Mol Biol. 2010;652:229-45. doi: 10.1007/978-1-60327-325-1_13.PMID: 20552432 
  161. Palczewski K. Oligomeric forms of G protein-coupled receptors (GPCRs). Trends Biochem Sci. 2010 Nov;35(11):595-600. doi: 10.1016/j.tibs.2010.05.002. Epub 2010 Jun 9.PMID: 20538466 
  162. Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 Jul 15;26(14):1804-5. doi: 10.1093/bioinformatics/btq264. Epub 2010 May 25.PMID: 20501551 
  163. Palczewski K. Retinoids for treatment of retinal diseases. Trends Pharmacol Sci. 2010 Jun;31(6):284-95. doi: 10.1016/j.tips.2010.03.001.PMID: 20435355 Review.
  164. Jastrzebska B, Tsybovsky Y, Palczewski K. Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J. 2010 Apr 28;428(1):1-10. doi: 10.1042/BJ20100270.PMID: 20423327 Review.
  165. Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8428-33. doi: 10.1073/pnas.1000640107. Epub 2010 Apr 19.PMID: 20404157 
  166. Kiser PD, Palczewski K. Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res. 2010 Sep;29(5):428-42. doi: 10.1016/j.preteyeres.2010.03.002. Epub 2010 Mar 19.PMID: 20304090 Review.
  167. von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci. 2010 Jul;35(7):400-10. doi: 10.1016/j.tibs.2010.01.005. Epub 2010 Feb 24.PMID: 20188572 Review.
  168. Cao P, Yuan Y, Pehek EA, Moise AR, Huang Y, Palczewski K, Feng Z. Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans.
  169. PLoS One. 2010 Feb 19;5(2):e9312. doi: 10.1371/journal.pone.0009312.PMID: 20174477 
  170. Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, Palczewski K. Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure. 2010 Jan 13;18(1):116-26. doi: 10.1016/j.str.2009.11.008.PMID: 20152158 
  171. Kevany BM, Palczewski K. Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda). 2010 Feb;25(1):8-15. doi: 10.1152/physiol.00038.2009.PMID: 20134024 Review.
  172. Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010 Mar 26;285(13):9667-9682. doi: 10.1074/jbc.M109.063941. Epub 2010 Jan 25.PMID: 20100834 
  173. Lobo GP, Hessel S, Eichinger A, Noy N, Moise AR, Wyss A, Palczewski K, von Lintig J. ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production. FASEB J. 2010 Jun;24(6):1656-66. doi: 10.1096/fj.09-150995. Epub 2010 Jan 8.PMID: 20061533 
  174. Orban T, Gupta S, Palczewski K, Chance MR. Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. Biochemistry. 2010 Feb 9;49(5):827-34. doi: 10.1021/bi901889t.PMID: 20047303 Review.
  175. O’Byrne SM, Kako Y, Deckelbaum RJ, Hansen IH, Palczewski K, Goldberg IJ, Blaner WS. Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E862-70. doi: 10.1152/ajpendo.00491.2009. Epub 2009 Dec 29.PMID: 20040693 
  176. Moise AR, Lobo GP, Erokwu B, Wilson DL, Peck D, Alvarez S, Domínguez M, Alvarez R, Flask CA, de Lera AR, von Lintig J, Palczewski K. Increased adiposity in the retinol saturase-knockout mouse. FASEB J. 2010 Apr;24(4):1261-70. doi: 10.1096/fj.09-147207. Epub 2009 Nov 25.PMID: 19940255 
  177. Bereta G, Wang B, Kiser PD, Baehr W, Jang GF, Palczewski K. A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. J Biol Chem. 2010 Jan 15;285(3):1899-908. doi: 10.1074/jbc.M109.061713. Epub 2009 Nov 9.PMID: 19901021 
  178. Kiser PD, Lorimer GH, Palczewski K. Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt 10):967-71. doi: 10.1107/S1744309109032928. Epub 2009 Sep 18.PMID: 19851000 
  179. Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17325-30. doi: 10.1073/pnas.0906600106. Epub 2009 Oct 5.PMID: 19805034 
  180. Moise AR, Alvarez S, Domínguez M, Alvarez R, Golczak M, Lobo GP, von Lintig J, de Lera AR, Palczewski K. Activation of retinoic acid receptors by dihydroretinoids. Mol Pharmacol. 2009 Dec;76(6):1228-37. doi: 10.1124/mol.109.060038. Epub 2009 Sep 21.PMID: 19770350 
  181. Angel TE, Gupta S, Jastrzebska B, Palczewski K, Chance MR. Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14367-72. doi: 10.1073/pnas.0901074106. Epub 2009 Aug 13.PMID: 19706523 
  182. Maeda A, Golczak M, Maeda T, Palczewski K. Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5435-43. doi: 10.1167/iovs.09-3944. Epub 2009 Jun 24.PMID: 19553623 
  183. Mustafi D, Engel AH, Palczewski K. Structure of cone photoreceptors. Prog Retin Eye Res. 2009 Jul;28(4):289-302. doi: 10.1016/j.preteyeres.2009.05.003. Epub 2009 Jun 6.PMID: 19501669 Review.
  184. Maeda T, Maeda A, Matosky M, Okano K, Roos S, Tang J, Palczewski K. Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4917-25. doi: 10.1167/iovs.09-3581. Epub 2009 Jun 3.PMID: 19494204 
  185. Maeda A, Shiose S, Okano K, Matosky M, Maeda T, Palczewski K. WITHDRAWN: Retinol dehydrogenase RDH11 protects the mouse retina from light-induced degeneration. Invest Ophthalmol Vis Sci. 2009 Aug 13. doi: 10.1167/iovs.09-3749. PMID: 19458342
  186. Angel TE, Chance MR, Palczewski K. Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8555-60. doi: 10.1073/pnas.0903545106. Epub 2009 May 11.PMID: 19433801 
  187. Tian G, Zhou Y, Hajkova D, Miyagi M, Dinculescu A, Hauswirth WW, Palczewski K, Geng R, Alagramam KN, Isosomppi J, Sankila EM, Flannery JG, Imanishi Y. Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton. J Biol Chem. 2009 Jul 10;284(28):18980-93. doi: 10.1074/jbc.M109.003160. Epub 2009 May 7.PMID: 19423712 
  188. Geng R, Geller SF, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Jones SM, Wright CG, Melki S, Imanishi Y, Palczewski K, Alagramam KN, Flannery JG. Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Hum Mol Genet. 2009 Aug 1;18(15):2748-60. doi: 10.1093/hmg/ddp210. Epub 2009 May 3.PMID: 19414487 
  189. Jastrzebska B, Goc A, Golczak M, Palczewski K. Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex. Biochemistry. 2009 Jun 16;48(23):5159-70. doi: 10.1021/bi900284x.PMID: 19413332 
  190. Maeda T, Maeda A, Casadesus G, Palczewski K, Margaron P. Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4368-78. doi: 10.1167/iovs.09-3700. Epub 2009 Apr 30.PMID: 19407008 
  191. Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 2009 May 26;48(20):4294-304. doi: 10.1021/bi900417b.PMID: 19348429 
  192. Lodowski DT, Palczewski K. Chemokine receptors and other G protein-coupled receptors. Curr Opin HIV AIDS. 2009 Mar;4(2):88-95. doi: 10.1097/COH.0b013e3283223d8d.PMID: 19339946 Review.
  193. Maeda T, Cideciyan AV, Maeda A, Golczak M, Aleman TS, Jacobson SG, Palczewski K. Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. Hum Mol Genet. 2009 Jun 15;18(12):2277-87. doi: 10.1093/hmg/ddp163. Epub 2009 Apr 1.PMID: 19339306 
  194. Maeda A, Maeda T, Golczak M, Chou S, Desai A, Hoppel CL, Matsuyama S, Palczewski K. Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J Biol Chem. 2009 May 29;284(22):15173-83. doi: 10.1074/jbc.M900322200. Epub 2009 Mar 20.PMID: 19304658 
  195. Lodowski DT, Angel TE, Palczewski K. Comparative analysis of GPCR crystal structures. Photochem Photobiol. 2009 Mar-Apr;85(2):425-30. doi: 10.1111/j.1751-1097.2008.00516.x. Epub 2009 Jan 19.PMID: 19192200 Review.
  196. Baehr W, Palczewski K. Focus on molecules: guanylate cyclase-activating proteins (GCAPs). Exp Eye Res. 2009 Jun 15;89(1):2-3. doi: 10.1016/j.exer.2008.12.016. Epub 2009 Jan 8.PMID: 19162008
  197. Cideciyan AV, Swider M, Aleman TS, Tsybovsky Y, Schwartz SB, Windsor EA, Roman AJ, Sumaroka A, Steinberg JD, Jacobson SG, Stone EM, Palczewski K. ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet. 2009 Mar 1;18(5):931-41. doi: 10.1093/hmg/ddn421. Epub 2008 Dec 12.PMID: 19074458 
  198. Salom D, Wu N, Sun W, Dong Z, Palczewski K, Jordan S, Salon JA. Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry. 2008 Dec 16;47(50):13296-307. doi: 10.1021/bi8018527.PMID: 19053287
  199. Li C, Chan J, Haeseleer F, Mikoshiba K, Palczewski K, Ikura M, Ames JB. Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. J Biol Chem. 2009 Jan 23;284(4):2472-81. doi: 10.1074/jbc.M806513200. Epub 2008 Nov 13.PMID: 19008222 
  200. Goc A, Angel TE, Jastrzebska B, Wang B, Wintrode PL, Palczewski K. Different properties of the native and reconstituted heterotrimeric G protein transducin. Biochemistry. 2008 Nov 25;47(47):12409-19. doi: 10.1021/bi8015444.PMID: 18975915 
  201. Mustafi D, Palczewski K. Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors.Mol Pharmacol. 2009 Jan;75(1):1-12. doi: 10.1124/mol.108.051938. Epub 2008 Oct 22.PMID: 18945819 Review.
  202. Jastrzebska B, Golczak M, Fotiadis D, Engel A, Palczewski K. Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin. FASEB J. 2009 Feb;23(2):371-81. doi: 10.1096/fj.07-114835. Epub 2008 Sep 30.PMID: 18827025 
  203. Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K. Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry. 2008 Sep 16;47(37):9856-65. doi: 10.1021/bi800905v. Epub 2008 Aug 23.PMID: 18722466 
  204. Maeda T, Maeda A, Leahy P, Saperstein DA, Palczewski K. Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):322-33. doi: 10.1167/iovs.08-2301. Epub 2008 Aug 15.PMID: 18708622 
  205. Jiang L, Wheaton D, Bereta G, Zhang K, Palczewski K, Birch DG, Baehr W. A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Res. 2008 Oct;48(23-24):2425-32. doi: 10.1016/j.visres.2008.07.016. Epub 2008 Sep 16.PMID: 18706439 
  206. Maeda A, Maeda T, Golczak M, Palczewski K. Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem. 2008 Sep 26;283(39):26684-93. doi: 10.1074/jbc.M804505200. Epub 2008 Jul 25.PMID: 18658157 
  207. Imanishi Y, Sun W, Maeda T, Maeda A, Palczewski K. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem. 2008 Sep 5;283(36):25091-102. doi: 10.1074/jbc.M802981200. Epub 2008 Jul 7.PMID: 18606814 
  208. Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci. 2008 Apr 9;28(15):4008-14. doi: 10.1523/JNEUROSCI.0317-08.2008.PMID: 18400900 
  209. Wongsiriroj N, Piantedosi R, Palczewski K, Goldberg IJ, Johnston TP, Li E, Blaner WS. The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem. 2008 May 16;283(20):13510-9. doi: 10.1074/jbc.M800777200. Epub 2008 Mar 17.PMID: 18348983 
  210. Stephen R, Filipek S, Palczewski K, Sousa MC. Ca2+ -dependent regulation of phototransduction. Photochem Photobiol. 2008 Jul-Aug;84(4):903-10. doi: 10.1111/j.1751-1097.2008.00323.x. Epub 2008 Mar 12.PMID: 18346093 Review.
  211. Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ. Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem. 2008 May 16;283(20):14053-62. doi: 10.1074/jbc.M708974200. Epub 2008 Mar 13.PMID: 18339619 
  212. Müller DJ, Wu N, Palczewski K. Vertebrate membrane proteins: structure, function, and insights from biophysical approaches. Pharmacol Rev. 2008 Mar;60(1):43-78. doi: 10.1124/pr.107.07111. Epub 2008 Mar 5.PMID: 18321962 Review.
  213. Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y, Palczewski K, von Lintig J. RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metab. 2008 Mar;7(3):258-68. doi: 10.1016/j.cmet.2008.01.009.PMID: 18316031 
  214. Sapra KT, Park PS, Palczewski K, Muller DJ. Mechanical properties of bovine rhodopsin and bacteriorhodopsin: possible roles in folding and function. Langmuir. 2008 Feb 19;24(4):1330-7. doi: 10.1021/la702299z.PMID: 18266338 
  215. Golczak M, Maeda A, Bereta G, Maeda T, Kiser PD, Hunzelmann S, von Lintig J, Blaner WS, Palczewski K. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem. 2008 Apr 11;283(15):9543-54. doi: 10.1074/jbc.M708982200. Epub 2008 Jan 14.PMID: 18195010 
  216. Baehr W, Palczewski K. Guanylate cyclase-activating proteins and retina disease. Subcell Biochem. 2007;45:71-91. doi: 10.1007/978-1-4020-6191-2_4.PMID: 18193635 Review.
  217. Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. J Am Chem Soc. 2008 Jan 30;130(4):1154-5. doi: 10.1021/ja710487q. Epub 2008 Jan 8.PMID: 18179220
  218. Kim YK, Wassef L, Hamberger L, Piantedosi R, Palczewski K, Blaner WS, Quadro L. Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. J Biol Chem. 2008 Feb 29;283(9):5611-21. doi: 10.1074/jbc.M708885200. Epub 2007 Dec 19.PMID: 18093970 
  219. Maeda A, Maeda T, Sun W, Zhang H, Baehr W, Palczewski K. Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19565-70. doi: 10.1073/pnas.0707477104. Epub 2007 Nov 28.PMID: 18048336 
  220. Whorton MR, Jastrzebska B, Park PS, Fotiadis D, Engel A, Palczewski K, Sunahara RK. Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem. 2008 Feb 15;283(7):4387-94. doi: 10.1074/jbc.M703346200. Epub 2007 Nov 22.PMID: 18033822 
  221. Stephen R, Bereta G, Golczak M, Palczewski K, Sousa MC. Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1. Structure. 2007 Nov;15(11):1392-402. doi: 10.1016/j.str.2007.09.013.PMID: 17997965 
  222. Schonthaler HB, Lampert JM, Isken A, Rinner O, Mader A, Gesemann M, Oberhauser V, Golczak M, Biehlmaier O, Palczewski K, Neuhauss SC, von Lintig J. Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci. 2007 Oct;26(7):1940-9. doi: 10.1111/j.1460-9568.2007.05801.x. Epub 2007 Sep 14.PMID: 17868371 
  223. Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K.Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15123-8. doi: 10.1073/pnas.0706367104. Epub 2007 Sep 11.PMID: 17848510 
  224. Park PS, Lodowski DT, Palczewski K. Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. Annu Rev Pharmacol Toxicol. 2008;48:107-41. doi: 10.1146/annurev.pharmtox.48.113006.094630.PMID: 17848137 Review.
  225. Lodowski DT, Salom D, Le Trong I, Teller DC, Ballesteros JA, Palczewski K, Stenkamp RE. Reprint of “Crystal packing analysis of Rhodopsin crystals” [J. Struct. Biol. 158 (2007) 455-462]. J Struct Biol. 2007 Aug;159(2):253-60. doi: 10.1016/S1047-8477(07)00166-9.PMID: 17660064
  226. Li N, Salom D, Zhang L, Harris T, Ballesteros JA, Golczak M, Jastrzebska B, Palczewski K, Kurahara C, Juan T, Jordan S, Salon JA. Heterologous expression of the adenosine A1 receptor in transgenic mouse retina. Biochemistry. 2007 Jul 17;46(28):8350-9. doi: 10.1021/bi700154h. Epub 2007 Jun 20.PMID: 17580959
  227. Kiser PD, Lodowski DT, Palczewski K. Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):457-61. doi: 10.1107/S1744309107020295. Epub 2007 May 5.PMID: 17554162 
  228. Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics. 2007 May 30;8:177. doi: 10.1186/1471-2105-8-177.PMID: 17537266 
  229. Nickell S, Park PS, Baumeister W, Palczewski K. J Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography. Cell Biol. 2007 Jun 4;177(5):917-25. doi: 10.1083/jcb.200612010. Epub 2007 May 29.PMID: 17535966 
  230. Sun W, Gerth C, Maeda A, Lodowski DT, Van Der Kraak L, Saperstein DA, Héon E, Palczewski K. Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. Vision Res. 2007 Jul;47(15):2055-66. doi: 10.1016/j.visres.2007.04.005. Epub 2007 May 21.PMID: 17512964 
  231. Moise AR, Noy N, Palczewski K, Blaner WS. Delivery of retinoid-based therapies to target tissues. Biochemistry. 2007 Apr 17;46(15):4449-58. doi: 10.1021/bi7003069. Epub 2007 Mar 23.PMID: 17378589 Review.
  232. Lodowski DT, Salom D, Le Trong I, Teller DC, Ballesteros JA, Palczewski K, Stenkamp RE. Crystal packing analysis of Rhodopsin crystals. J Struct Biol. 2007 Jun;158(3):455-62. doi: 10.1016/j.jsb.2007.01.017. Epub 2007 Feb 9.PMID: 17374491 
  233. Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev. 2007 Mar;59(1):5-13. doi: 10.1124/pr.59.1.5.PMID: 17329545 Review.
  234. Park PS, Sapra KT, Koliński M, Filipek S, Palczewski K, Muller DJ. Stabilizing effect of Zn2+ in native bovine rhodopsin. J Biol Chem. 2007 Apr 13;282(15):11377-85. doi: 10.1074/jbc.M610341200. Epub 2007 Feb 15.PMID: 17303564 
  235. Ridge KD, Palczewski K. Visual rhodopsin sees the light: structure and mechanism of G protein signaling. J Biol Chem. 2007 Mar 30;282(13):9297-9301. doi: 10.1074/jbc.R600032200. Epub 2007 Feb 8.PMID: 17289671  Review.
  236. Baehr W, Karan S, Maeda T, Luo DG, Li S, Bronson JD, Watt CB, Yau KW, Frederick JM, Palczewski K. The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem. 2007 Mar 23;282(12):8837-47. doi: 10.1074/jbc.M610369200. Epub 2007 Jan 25.PMID: 17255100 
  237. Moise AR, Isken A, Domínguez M, de Lera AR, von Lintig J, Palczewski K. Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol. Biochemistry. 2007 Feb 20;46(7):1811-20. doi: 10.1021/bi062147u. Epub 2007 Jan 25.PMID: 17253779 
  238. Moise AR, Golczak M, Imanishi Y, Palczewski K. Topology and membrane association of lecithin: retinol acyltransferase. J Biol Chem. 2007 Jan 19;282(3):2081-90. doi: 10.1074/jbc.M608315200. Epub 2006 Nov 19.PMID: 17114808 
  239. Isken A, Holzschuh J, Lampert JM, Fischer L, Oberhauser V, Palczewski K, von Lintig J Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryo. J Biol Chem. 2007 Jan 12;282(2):1144-51. doi: 10.1074/jbc.M609109200. Epub 2006 Nov 10.PMID: 17098734 
  240. Palczewski K, Hofmann KP, Baehr W. Rhodopsin–advances and perspectives. Vision Res. 2006 Dec;46(27):4425-6. doi: 10.1016/j.visres.2006.10.009.PMID: 17098052 
  241. Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. doi: 10.1073/pnas.0608022103. Epub 2006 Oct 23.PMID: 17060607 
  242. Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K. Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem. 2006 Dec 8;281(49):37697-704. doi: 10.1074/jbc.M608375200. Epub 2006 Oct 10.PMID: 17032653 
  243. Maeda A, Maeda T, Palczewski K. Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4540-6. doi: 10.1167/iovs.06-0215.PMID: 17003450 
  244. Travis GH, Golczak M, Moise AR, Palczewski K. Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol. 2007;47:469-512. doi: 10.1146/annurev.pharmtox.47.120505.105225.PMID: 16968212 Review.
  245. Modzelewska A, Filipek S, Palczewski K, Park PS. Arrestin interaction with rhodopsin: conceptual models. Cell Biochem Biophys. 2006;46(1):1-15. doi: 10.1385/CBB:46:1:1.PMID: 16943619
  246. Domínguez M, Alvarez R, Pérez M, Palczewski K, de Lera AR. The role of the 11-cis-retinal ring methyl substituents in visual pigment formation. Chembiochem. 2006 Nov;7(11):1815-25. doi: 10.1002/cbic.200600207.PMID: 16941510
  247. Haire SE, Pang J, Boye SL, Sokal I, Craft CM, Palczewski K, Hauswirth WW, Semple-Rowland SL. Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3745-53. doi: 10.1167/iovs.06-0086.PMID: 16936082 
  248. Maeda A, Maeda T, Golczak M, Imanishi Y, Leahy P, Kubota R, Palczewski K. Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Mol Pharmacol. 2006 Oct;70(4):1220-9. doi: 10.1124/mol.106.026823. Epub 2006 Jul 12.PMID: 16837623 
  249. Salom D, Le Trong I, Pohl E, Ballesteros JA, Stenkamp RE, Palczewski K, Lodowski DT. Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals. J Struct Biol. 2006 Dec;156(3):497-504. doi: 10.1016/j.jsb.2006.05.003. Epub 2006 Jun 2.PMID: 16837211
  250. Tu DC, Owens LA, Anderson L, Golczak M, Doyle SE, McCall M, Menaker M, Palczewski K, Van Gelder RN. Inner retinal photoreception independent of the visual retinoid cycle. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10426-10431. doi: 10.1073/pnas.0600917103. Epub 2006 Jun 20.PMID: 16788071 
  251. Palczewski K. G protein-coupled receptor rhodopsin. Annu Rev Biochem. 2006;75:743-67. doi: 10.1146/annurev.biochem.75.103004.142743.PMID: 16756510 Review.
  252. Zhu L, Imanishi Y, Filipek S, Alekseev A, Jastrzebska B, Sun W, Saperstein DA, Palczewski K. Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. J Biol Chem. 2006 Aug 4;281(31):22289-22298. doi: 10.1074/jbc.M602664200. Epub 2006 May 31.PMID: 16737970 
  253. Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, Sokal I, Palczewski K, Jacobson SG, Semple-Rowland SL. Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med. 2006 Jun;3(6):e201. doi: 10.1371/journal.pmed.0030201. Epub 2006 May 23.PMID: 16700630 
  254. Stephen R, Palczewski K, Sousa MC. The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. J Mol Biol. 2006 Jun 2;359(2):266-75. doi: 10.1016/j.jmb.2006.03.042. Epub 2006 Apr 3.PMID: 16626734 
  255. Fotiadis D, Jastrzebska B, Philippsen A, Müller DJ, Palczewski K, Engel A. Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Curr Opin Struct Biol. 2006 Apr;16(2):252-9. doi: 10.1016/j.sbi.2006.03.013. Epub 2006 Mar 29.PMID: 16567090 Review.
  256. Maeda A, Maeda T, Imanishi Y, Golczak M, Moise AR, Palczewski K. Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters. Biochemistry. 2006 Apr 4;45(13):4210-9. doi: 10.1021/bi052382x.PMID: 16566595 
  257. Tanuj Sapra K, Park PS, Filipek S, Engel A, Müller DJ, Palczewski K. Detecting molecular interactions that stabilize native bovine rhodopsin. J Mol Biol. 2006 Apr 21;358(1):255-69. doi: 10.1016/j.jmb.2006.02.008. Epub 2006 Feb 20.PMID: 16519899
  258. Jastrzebska B, Fotiadis D, Jang GF, Stenkamp RE, Engel A, Palczewski K. Functional and structural characterization of rhodopsin oligomers. J Biol Chem. 2006 Apr 28;281(17):11917-22. doi: 10.1074/jbc.M600422200. Epub 2006 Feb 22.PMID: 16495215 
  259. Mansoor SE, Palczewski K, Farrens DL. Rhodopsin self-associates in asolectin liposomes. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3060-5. doi: 10.1073/pnas.0511010103. Epub 2006 Feb 21.PMID: 16492772 
  260. Park PS, Palczewski K. Imaging G protein-coupled receptor islands. Nat Chem Biol. 2005 Sep;1(4):184-5. doi: 10.1038/nchembio0905-184.PMID: 16408027 
  261. Zhang L, Salom D, He J, Okun A, Ballesteros J, Palczewski K, Li N. Expression of functional G protein-coupled receptors in photoreceptors of transgenic Xenopus laevis. Biochemistry. 2005 Nov 8;44(44):14509-18. doi: 10.1021/bi051386z.PMID: 16262251
  262. Batten ML, Imanishi Y, Tu DC, Doan T, Zhu L, Pang J, Glushakova L, Moise AR, Baehr W, Van Gelder RN, Hauswirth WW, Rieke F, Palczewski K. Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med. 2005 Nov;2(11):e333. doi: 10.1371/journal.pmed.0020333. Epub 2005 Nov 1.PMID: 16250670 
  263. Maeda T, Lem J, Palczewski K, Haeseleer F. A critical role of CaBP4 in the cone synapse. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4320-7. doi: 10.1167/iovs.05-0478.PMID: 16249514 
  264. Acland GM, Aguirre GD, Bennett J, Aleman TS, Cideciyan AV, Bennicelli J, Dejneka NS, Pearce-Kelling SE, Maguire AM, Palczewski K, Hauswirth WW, Jacobson SG. Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther. 2005 Dec;12(6):1072-82. doi: 10.1016/j.ymthe.2005.08.008. Epub 2005 Oct 14.PMID: 16226919 
  265. Golczak M, Imanishi Y, Kuksa V, Maeda T, Kubota R, Palczewski K. Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle. J Biol Chem. 2005 Dec 23;280(51):42263-73. doi: 10.1074/jbc.M509351200. Epub 2005 Oct 10.PMID: 16216874 
  266. Wingard JN, Chan J, Bosanac I, Haeseleer F, Palczewski K, Ikura M, Ames JB. Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels. J Biol Chem. 2005 Nov 11;280(45):37461-70. doi: 10.1074/jbc.M508541200. Epub 2005 Sep 7.PMID: 16147998 
  267. O’Byrne SM, Wongsiriroj N, Libien J, Vogel S, Goldberg IJ, Baehr W, Palczewski K, Blaner WS. Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J Biol Chem. 2005 Oct 21;280(42):35647-57. doi: 10.1074/jbc.M507924200. Epub 2005 Aug 22.PMID: 16115871 
  268. Bartl FJ, Fritze O, Ritter E, Herrmann R, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. Partial agonism in a G Protein-coupled receptor: role of the retinal ring structure in rhodopsin activation. J Biol Chem. 2005 Oct 7;280(40):34259-67. doi: 10.1074/jbc.M505260200. Epub 2005 Jul 18.PMID: 16027155 
  269. Park PS, Palczewski K. Diversifying the repertoire of G protein-coupled receptors through oligomerization. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8793-4. doi: 10.1073/pnas.0504016102. Epub 2005 Jun 13.PMID: 15956197
  270. Stenkamp RE, Teller DC, Palczewski K. Rhodopsin: a structural primer for G-protein coupled receptors. Arch Pharm (Weinheim). 2005 Jun;338(5-6):209-16. doi: 10.1002/ardp.200400995.PMID: 15952240 Review.
  271. Golczak M, Kuksa V, Maeda T, Moise AR, Palczewski K. Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8162-7. doi: 10.1073/pnas.0503318102. Epub 2005 May 25.PMID: 15917330 
  272. Moise AR, Kuksa V, Blaner WS, Baehr W, Palczewski K. Metabolism and transactivation activity of 13,14-dihydroretinoic acid. J Biol Chem. 2005 Jul 29;280(30):27815-25. doi: 10.1074/jbc.M503520200. Epub 2005 May 23.PMID: 15911617 
  273. Jacobson SG, Aleman TS, Cideciyan AV, Sumaroka A, Schwartz SB, Windsor EA, Traboulsi EI, Heon E, Pittler SJ, Milam AH, Maguire AM, Palczewski K, Stone EM, Bennett J. Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6177-82. doi: 10.1073/pnas.0500646102. Epub 2005 Apr 18.PMID: 15837919 
  274. Moise AR, von Lintig J, Palczewski K. Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids. Trends Plant Sci. 2005 Apr;10(4):178-86. doi: 10.1016/j.tplants.2005.02.006.PMID: 15817419 Review.
  275. Sokal I, Dupps WJ, Grassi MA, Brown J Jr, Affatigato LM, Roychowdhury N, Yang L, Filipek S, Palczewski K, Stone EM, Baehr W. A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD). Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1124-32. doi: 10.1167/iovs.04-1431.PMID: 15790869 
  276. Suda K, Filipek S, Palczewski K, Engel A, Fotiadis D. The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. Mol Membr Biol. 2004 Nov-Dec;21(6):435-46. doi: 10.1080/09687860400020291.PMID: 15764373 
  277. Maeda A, Maeda T, Imanishi Y, Kuksa V, Alekseev A, Bronson JD, Zhang H, Zhu L, Sun W, Saperstein DA, Rieke F, Baehr W, Palczewski K. Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005 May 13;280(19):18822-32. doi: 10.1074/jbc.M501757200. Epub 2005 Mar 8.PMID: 15755727 
  278. Maeda A, Crabb JW, Palczewski K. Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Biochemistry. 2005 Jan 18;44(2):480-9. doi: 10.1021/bi048016f.PMID: 15641772 
  279. Kim TS, Maeda A, Maeda T, Heinlein C, Kedishvili N, Palczewski K, Nelson PS. Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. J Biol Chem. 2005 Mar 11;280(10):8694-704. doi: 10.1074/jbc.M413172200. Epub 2005 Jan 4.PMID: 15634683 
  280. Park PS, Filipek S, Wells JW, Palczewski K. Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry. 2004 Dec 21;43(50):15643-56. doi: 10.1021/bi047907k.PMID: 15595821 Review.
  281. Nishiguchi KM, Sokal I, Yang L, Roychowdhury N, Palczewski K, Berson EL, Dryja TP, Baehr W. A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration. Invest Ophthalmol Vis Sci. 2004 Nov;45(11):3863-70. doi: 10.1167/iovs.04-0590.PMID: 15505030 
  282. astrzebska B, Maeda T, Zhu L, Fotiadis D, Filipek S, Engel A, Stenkamp RE, Palczewski K. Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem. 2004 Dec 24;279(52):54663-75. doi: 10.1074/jbc.M408691200. Epub 2004 Oct 15.PMID: 15489507 
  283. Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W. Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). J Mol Evol. 2004 Aug;59(2):204-217. doi: 10.1007/s00239-004-2614-y.PMID: 15486694 
  284. Tu DC, Batten ML, Palczewski K, Van Gelder RN. Nonvisual photoreception in the chick iris. Science. 2004 Oct 1;306(5693):129-31. doi: 10.1126/science.1101484.PMID: 15459395
  285. Zhu L, Jang GF, Jastrzebska B, Filipek S, Pearce-Kelling SE, Aguirre GD, Stenkamp RE, Acland GM, Palczewski K. A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor. J Biol Chem. 2004 Dec 17;279(51):53828-39. doi: 10.1074/jbc.M408472200. Epub 2004 Sep 30.PMID: 15459196 
  286. Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci. 2004 Oct;7(10):1079-87. doi: 10.1038/nn1320. Epub 2004 Sep 26.PMID: 15452577 
  287. Subramanian L, Crabb JW, Cox J, Durussel I, Walker TM, van Ginkel PR, Bhattacharya S, Dellaria JM, Palczewski K, Polans AS. Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma. Biochemistry. 2004 Sep 7;43(35):11175-86. doi: 10.1021/bi048848d.PMID: 15366927 
  288. Moise AR, Kuksa V, Imanishi Y, Palczewski K. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. J Biol Chem. 2004 Nov 26;279(48):50230-42. doi: 10.1074/jbc.M409130200. Epub 2004 Sep 9.PMID: 15358783 
  289. Liang Y, Fotiadis D, Maeda T, Maeda A, Modzelewska A, Filipek S, Saperstein DA, Engel A, Palczewski K. Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem. 2004 Nov 12;279(46):48189-96. doi: 10.1074/jbc.M408362200. Epub 2004 Aug 26.PMID: 15337746 
  290. Mammen A, Simpson PJ, Nighorn A, Imanishi Y, Palczewski K, Ronnett GV, Moon C. Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1131-9. doi: 10.1016/j.bbrc.2004.07.123.PMID: 15336960
  291. Palczewski K, Sokal I, Baehr W. Guanylate cyclase-activating proteins: structure, function, and diversity. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1123-30. doi: 10.1016/j.bbrc.2004.07.122.PMID: 15336959 Review.
  292. Imanishi Y, Gerke V, Palczewski K. Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. J Cell Biol. 2004 Aug 16;166(4):447-53. doi: 10.1083/jcb.200405110.PMID: 15314061 Review.
  293. Filipek S, Krzysko KA, Fotiadis D, Liang Y, Saperstein DA, Engel A, Palczewski K. A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci. 2004 Jun;3(6):628-38. doi: 10.1039/b315661c. Epub 2004 Feb 27.PMID: 15170495
  294. Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. The G protein-coupled receptor rhodopsin in the native membrane. FEBS Lett. 2004 Apr 30;564(3):281-288. doi: 10.1016/S0014-5793(04)00194-2.PMID: 15111110 
  295. Aleman TS, Jacobson SG, Chico JD, Scott ML, Cheung AY, Windsor EA, Furushima M, Redmond TM, Bennett J, Palczewski K, Cideciyan AV. Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1259-71. doi: 10.1167/iovs.03-1230.PMID: 15037595
  296. Imanishi Y, Batten ML, Piston DW, Baehr W, Palczewski K. Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol. 2004 Feb 2;164(3):373-83. doi: 10.1083/jcb.200311079. Epub 2004 Jan 26.PMID: 14745001 
  297. Sokal I, Alekseev A, Palczewski K. Photoreceptor guanylate cyclase variants: cGMP production under control. Acta Biochim Pol. 2003;50(4):1075-95.PMID: 14739996 Review.
  298. Batten ML, Imanishi Y, Maeda T, Tu DC, Moise AR, Bronson D, Possin D, Van Gelder RN, Baehr W, Palczewski K. Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem. 2004 Mar 12;279(11):10422-32. doi: 10.1074/jbc.M312410200. Epub 2003 Dec 18.PMID: 14684738 
  299. Teller DC, Stenkamp RE, Palczewski K. Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transfer. FEBS Lett. 2003 Nov 27;555(1):151-9. doi: 10.1016/s0014-5793(03)01152-9.PMID: 14630336 
  300. Driessen C, Winkens H, Haeseleer F, Palczewski K, Janssen J. Novel targeting strategy for generating mouse models with defects in the retinoid cycle. Vision Res. 2003 Dec;43(28):3075-9. doi: 10.1016/s0042-6989(03)00483-8.PMID: 14611944 
  301. Kuksa V, Imanishi Y, Batten M, Palczewski K, Moise AR. Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization. Vision Res. 2003 Dec;43(28):2959-81. doi: 10.1016/s0042-6989(03)00482-6.PMID: 14611933 
  302. Baehr W, Wu SM, Bird AC, Palczewski K. The retinoid cycle and retina disease. Vision Res. 2003 Dec;43(28):2957-8. doi: 10.1016/j.visres.2003.10.001.PMID: 14611932 
  303. Ridge KD, Abdulaev NG, Sousa M, Palczewski K. Phototransduction: crystal clear. Trends Biochem Sci. 2003 Sep;28(9):479-87. doi: 10.1016/S0968-0004(03)00172-5.PMID: 13678959 Review.
  304. Marmor MF, Haeseleer F, Palczewski K. Albipunctate retinopathy with cone dysfunction and no abnormality in the RDH5 or RLBP1 genes. Retina. 2003 Aug;23(4):543-6. doi: 10.1097/00006982-200308000-00018.PMID: 12972770 
  305. Ballesteros J, Palczewski K. G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin. Curr Opin Drug Discov Devel. 2001 Sep;4(5):561-74.PMID: 12825452 Review.
  306. Maeda T, Imanishi Y, Palczewski K. Rhodopsin phosphorylation: 30 years later. Prog Retin Eye Res. 2003 Jul;22(4):417-34. doi: 10.1016/s1350-9462(03)00017-x.PMID: 12742390 Review.
  307. Maeda T, Van Hooser JP, Driessen CA, Filipek S, Janssen JJ, Palczewski K. Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo. J Neurochem. 2003 May;85(4):944-56. doi: 10.1046/j.1471-4159.2003.01741.x.PMID: 12716426 
  308. Schädel SA, Heck M, Maretzki D, Filipek S, Teller DC, Palczewski K, Hofmann KP. Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin. J Biol Chem. 2003 Jul 4;278(27):24896-24903. doi: 10.1074/jbc.M302115200. Epub 2003 Apr 21.PMID: 12707280 
  309. Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, Engel A. Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem. 2003 Jun 13;278(24):21655-21662. doi: 10.1074/jbc.M302536200. Epub 2003 Mar 27.PMID: 12663652 
  310. Mirzadegan T, Benkö G, Filipek S, Palczewski K. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry. 2003 Mar 18;42(10):2759-67. doi: 10.1021/bi027224+.PMID: 12627940 Review.
  311. Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2290-5. doi: 10.1073/pnas.0435715100. Epub 2003 Feb 24.PMID: 12601165 
  312. Haeseleer F, Palczewski K. Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Adv Exp Med Biol. 2002;514:303-17. doi: 10.1007/978-1-4615-0121-3_18.PMID: 12596929 Review.
  313. Filipek S, Teller DC, Palczewski K, Stenkamp R. The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. Annu Rev Biophys Biomol Struct. 2003;32:375-97. doi: 10.1146/annurev.biophys.32.110601.142520. Epub 2003 Feb 5.PMID: 12574068 Review.
  314. Noorwez SM, Kuksa V, Imanishi Y, Zhu L, Filipek S, Palczewski K, Kaushal S. Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa. J Biol Chem. 2003 Apr 18;278(16):14442-14450. doi: 10.1074/jbc.M300087200. Epub 2003 Feb 1.PMID: 12566452 
  315. Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature. 2003 Jan 9;421(6919):127-8. doi: 10.1038/421127a.PMID: 12520290 
  316. Sokal I, Hu G, Liang Y, Mao M, Wensel TG, Palczewski K. Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475. J Biol Chem. 2003 Mar 7;278(10):8316-25. doi: 10.1074/jbc.M211782200. Epub 2002 Dec 23.PMID: 12499365 
  317. Filipek S, Stenkamp RE, Teller DC, Palczewski K. G protein-coupled receptor rhodopsin: a prospectus. Annu Rev Physiol. 2003;65:851-79. doi: 10.1146/annurev.physiol.65.092101.142611. Epub 2002 May 1.PMID: 12471166 Review.
  318. Heck M, Schädel SA, Maretzki D, Bartl FJ, Ritter E, Palczewski K, Hofmann KP. Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II. J Biol Chem. 2003 Jan 31;278(5):3162-9. doi: 10.1074/jbc.M209675200. Epub 2002 Nov 9.PMID: 12427735 
  319. Stenkamp RE, Filipek S, Driessen CA, Teller DC, Palczewski K. Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors. Biochim Biophys Acta. 2002 Oct 11;1565(2):168-82. doi: 10.1016/s0005-2736(02)00567-9.PMID: 12409193  Review.
  320. Stenkamp RE, Teller DC, Palczewski K. Crystal structure of rhodopsin: a G-protein-coupled receptor. Chembiochem. 2002 Oct 4;3(10):963-7. doi: 10.1002/1439-7633(20021004)3:10<963::AID-CBIC963>3.0.CO;2-9.PMID: 12362360 Review. 
  321. Haeseleer F, Jang GF, Imanishi Y, Driessen CAGG, Matsumura M, Nelson PS, Palczewski K. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. J Biol Chem. 2002 Nov 22;277(47):45537-45546. doi: 10.1074/jbc.M208882200. Epub 2002 Sep 10.PMID: 12226107 
  322. Maeda A, Maeda T, Ohguro H, Palczewski K, Sato N. Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. Eur J Immunol. 2002 Aug;32(8):2300-7. doi: 10.1002/1521-4141(200208)32:8<2300::AID-IMMU2300>3.0.CO;2-7.PMID: 12209643 
  323. Kuksa V, Bartl F, Maeda T, Jang GF, Ritter E, Heck M, Preston Van Hooser J, Liang Y, Filipek S, Gelb MH, Hofmann KP, Palczewski K. Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals. J Biol Chem. 2002 Nov 1;277(44):42315-42324. doi: 10.1074/jbc.M206014200. Epub 2002 Aug 9.PMID: 12176994 
  324. Yang J, McBride S, Mak DO, Vardi N, Palczewski K, Haeseleer F, Foskett JK. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7711-6. doi: 10.1073/pnas.102006299. PMID: 12032348 
  325. Howes KA, Pennesi ME, Sokal I, Church-Kopish J, Schmidt B, Margolis D, Frederick JM, Rieke F, Palczewski K, Wu SM, Detwiler PB, Baehr W. GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J. 2002 Apr 2;21(7):1545-54. doi: 10.1093/emboj/21.7.1545.PMID: 11927539 
  326. Van Hooser JP, Liang Y, Maeda T, Kuksa V, Jang GF, He YG, Rieke F, Fong HK, Detwiler PB, Palczewski K. Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem. 2002 May 24;277(21):19173-82. doi: 10.1074/jbc.M112384200. Epub 2002 Mar 15.PMID: 11897783 
  327. Lee A, Westenbroek RE, Haeseleer F, Palczewski K, Scheuer T, Catterall WA. Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Nat Neurosci. 2002 Mar;5(3):210-7. doi: 10.1038/nn805.PMID: 11865310 
  328. Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002 Jan;15(1):63-78. doi: 10.1046/j.0953-816x.2001.01835.x.PMID: 11860507 
  329. Haeseleer F, Imanishi Y, Sokal I, Filipek S, Palczewski K. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun. 2002 Jan 18;290(2):615-23. doi: 10.1006/bbrc.2001.6228.PMID: 11785943 Review.
  330. Palczewski K. Crystal Structure of Rhodopsin: Implication for Vision and Beyond. Mechanisms of Acti. ScientificWorldJournal. 2002 Jan 5;2:106-107. doi: 10.1100/tsw.2002.50. eCollection 2002.PMID: 29973825
  331. Sokal I, Alekseev A, Baehr W, Haeseleer F, Palczewski K. Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators. Biochemistry. 2002 Jan 8;41(1):251-7. doi: 10.1021/bi015606u.PMID: 11772023 
  332. Haeseleer F, Imanishi Y, Saperstein DA, Palczewski K. Gene transfer mediated by recombinant baculovirus into mouse eye. Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3294-300.PMID: 11726636 
  333. Sokal I, Pulvermüller A, Buczyłko J, Hofmann KP, Palczewski K. Rhodopsin and its kinase. Methods Enzymol. 2002;343:578-600. doi: 10.1016/s0076-6879(02)43159-x.PMID: 11665593
  334. McBee JK, Van Hooser JP, Jang GF, Palczewski K. Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. J Biol Chem. 2001 Dec 21;276(51):48483-93. doi: 10.1074/jbc.M105840200. Epub 2001 Oct 16.PMID: 11604395 
  335. Li N, Sokal I, Bronson JD, Palczewski K, Baehr W. Identification of functional regions of guanylate cyclase-activating protein 1 (GCAP1) using GCAP1/GCIP chimeras. Biol Chem. 2001 Aug;382(8):1179-88. doi: 10.1515/BC.2001.148.PMID: 11592399
  336. Sokal I, Li N, Klug CS, Filipek S, Hubbell WL, Baehr W, Palczewski K. Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies. J Biol Chem. 2001 Nov 16;276(46):43361-73. doi: 10.1074/jbc.M103614200. Epub 2001 Aug 27.PMID: 11524415 
  337. Okada T, Palczewski K. Crystal structure of rhodopsin: implications for vision and beyond. Curr Opin Struct Biol. 2001 Aug;11(4):420-6. doi: 10.1016/s0959-440x(00)00227-x.PMID: 11495733 Review.
  338. Mendez A, Burns ME, Sokal I, Dizhoor AM, Baehr W, Palczewski K, Baylor DA, Chen J. Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9948-53. doi: 10.1073/pnas.171308998. Epub 2001 Aug 7.PMID: 11493703 
  339. Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry. 2001 Jul 3;40(26):7761-72. doi: 10.1021/bi0155091.PMID: 11425302 Review. 
  340. Jang GF, Van Hooser JP, Kuksa V, McBee JK, He YG, Janssen JJ, Driessen CA, Palczewski K. Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. J Biol Chem. 2001 Aug 31;276(35):32456-65. doi: 10.1074/jbc.M104949200. Epub 2001 Jun 20.PMID: 11418621 
  341. Yan W, Jang GF, Haeseleer F, Esumi N, Chang J, Kerrigan M, Campochiaro M, Campochiaro P, Palczewski K, Zack DJ. Cloning and characterization of a human beta,beta-carotene-15,15′-dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics. 2001 Mar 1;72(2):193-202. doi: 10.1006/geno.2000.6476.PMID: 11401432
  342. McBee JK, Palczewski K, Baehr W, Pepperberg DR. Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog Retin Eye Res. 2001 Jul;20(4):469-529. doi: 10.1016/s1350-9462(01)00002-7.PMID: 11390257 Review.
  343. Okada T, Ernst OP, Palczewski K, Hofmann KP. Activation of rhodopsin: new insights from structural and biochemical studies. Trends Biochem Sci. 2001 May;26(5):318-24. doi: 10.1016/s0968-0004(01)01799-6.PMID: 11343925 Review.
  344. Jang GF, Kuksa V, Filipek S, Bartl F, Ritter E, Gelb MH, Hofmann KP, Palczewski K. Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein. J Biol Chem. 2001 Jul 13;276(28):26148-53. doi: 10.1074/jbc.M102212200. Epub 2001 Apr 20.PMID: 11316815 
  345. Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K. Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. J Biol Chem. 2001 Jun 22;276(25):22287-95. doi: 10.1074/jbc.M011539200. Epub 2001 Apr 5.PMID: 11292825 
  346. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Mol Cell Endocrinol. 2001 Jan 22;171(1-2):111-7. doi: 10.1016/s0303-7207(00)00417-2.PMID: 11165019
  347. Cideciyan AV, Haeseleer F, Fariss RN, Aleman TS, Jang GF, Verlinde CLMJ, Marmor MF, Jacobson SG, Palczewski K. Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Vis Neurosci. 2000 Sep-Oct;17(5):667-678. doi: 10.1017/s0952523800175029.PMID: 11153648 
  348. Sokal I, Li N, Verlinde CL, Haeseleer F, Baehr W, Palczewski K. Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). Biochim Biophys Acta. 2000 Dec 20;1498(2-3):233-51. doi: 10.1016/s0167-4889(00)00099-9.PMID: 11108966 
  349. Imamoto Y, Kataoka M, Tokunaga F, Palczewski K. Light-induced conformational changes of rhodopsin probed by fluorescent alexa594 immobilized on the cytoplasmic surface. Biochemistry. 2000 Dec 12;39(49):15225-33. doi: 10.1021/bi0018685.PMID: 11106502 
  350. McBee JK, Kuksa V, Alvarez R, de Lera AR, Prezhdo O, Haeseleer F, Sokal I, Palczewski K. Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins. Biochemistry. 2000 Sep 19;39(37):11370-80. doi: 10.1021/bi001061c.PMID: 10985782 
  351. Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M. Crystal structure of rhodopsin: A G protein-coupled receptor. Science. 2000 Aug 4;289(5480):739-45. doi: 10.1126/science.289.5480.739.PMID: 10926528
  352. Jang GF, McBee JK, Alekseev AM, Haeseleer F, Palczewski K. Stereoisomeric specificity of the retinoid cycle in the vertebrate retina. J Biol Chem. 2000 Sep 8;275(36):28128-38. doi: 10.1074/jbc.M004488200.PMID: 10871622 
  353. Van Hooser JP, Aleman TS, He YG, Cideciyan AV, Kuksa V, Pittler SJ, Stone EM, Jacobson SG, Palczewski K. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8623-8. doi: 10.1073/pnas.150236297.PMID: 10869443 
  354. Driessen CA, Winkens HJ, Hoffmann K, Kuhlmann LD, Janssen BP, Van Vugt AH, Van Hooser JP, Wieringa BE, Deutman AF, Palczewski K, Ruether K, Janssen JJ. Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters. Mol Cell Biol. 2000 Jun;20(12):4275-87. doi: 10.1128/MCB.20.12.4275-4287.2000.PMID: 10825191 
  355. Mukherjee S, Gurevich VV, Jones JC, Casanova JE, Frank SR, Maizels ET, Bader MF, Kahn RA, Palczewski K, Aktories K, Hunzicker-Dunn M. The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5901-6. doi: 10.1073/pnas.100127097.PMID: 10811902 
  356. Okada T, Le Trong I, Fox BA, Behnke CA, Stenkamp RE, Palczewski K. X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. J Struct Biol. 2000 May;130(1):73-80. doi: 10.1006/jsbi.1999.4209.PMID: 10806093
  357. Whitten ME, Yokoyama K, Schieltz D, Ghomashchi F, Lam D, Yates JR 3rd, Palczewski K, Gelb MH. Structural analysis of protein prenyl groups and associated C-terminal modifications. Methods Enzymol. 2000;316:436-51. doi: 10.1016/s0076-6879(00)16741-2.PMID: 10800693
  358. Haeseleer F, Palczewski K. Short-chain dehydrogenases/reductases in retina. Methods Enzymol. 2000;316:372-83. doi: 10.1016/s0076-6879(00)16736-9.PMID: 10800688 
  359. Saari JC, Garwin GG, Haeseleer F, Jang GF, Palczewski K. Phase partition and high-performance liquid chromatography assays of retinoid dehydrogenases. Methods Enzymol. 2000;316:359-71. doi: 10.1016/s0076-6879(00)16735-7.PMID: 10800687
  360. Stecher H, Palczewski K. Multienzyme analysis of visual cycle. Methods Enzymol. 2000;316:330-44. doi: 10.1016/s0076-6879(00)16733-3.PMID: 10800685
  361. Palczewski K, Polans AS, Baehr W, Ames JB. Ca(2+)-binding proteins in the retina: structure, function, and the etiology of human visual diseases. Bioessays. 2000 Apr;22(4):337-50. doi: 10.1002/(SICI)1521-1878(200004)22:4<337::AID-BIES4>3.0.CO;2-Z.PMID: 10723031 Review.
  362. Haeseleer F, Sokal I, Verlinde CL, Erdjument-Bromage H, Tempst P, Pronin AN, Benovic JL, Fariss RN, Palczewski K. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem. 2000 Jan 14;275(2):1247-60. doi: 10.1074/jbc.275.2.1247.PMID: 10625670 
  363. Palczewski K, Verlinde CL, Haeseleer F. Molecular mechanism of visual transduction. Novartis Found Symp. 1999;224:191-204; discussion 204-7. doi: 10.1002/9780470515693.ch11. PMID: 10614052
  364. Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 1999 Nov 15;240(1):23-34. doi: 10.1016/s0378-1119(99)00393-5.PMID: 10564809
  365. Stecher H, Prezhdo O, Das J, Crouch RK, Palczewski K. Isomerization of all-trans-9- and 13-desmethylretinol by retinal pigment epithelial cells. Biochemistry. 1999 Oct 12;38(41):13542-50. doi: 10.1021/bi9913294.PMID: 10521261
  366. Palczewski K, Van Hooser JP, Garwin GG, Chen J, Liou GI, Saari JC. Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry. 1999 Sep 14;38(37):12012-9. doi: 10.1021/bi990504d.PMID: 10508404
  367. Zhao X, Yokoyama K, Whitten ME, Huang J, Gelb MH, Palczewski K. A novel form of rhodopsin kinase from chicken retina and pineal gland. FEBS Lett. 1999 Jul 2;454(1-2):115-21. doi: 10.1016/s0014-5793(99)00764-4.PMID: 10413107 
  368. Sokal I, Otto-Bruc AE, Surgucheva I, Verlinde CL, Wang CK, Baehr W, Palczewski K. Conformational changes in guanylyl cyclase-activating protein 1 (GCAP1) and its tryptophan mutants as a function of calcium concentration. J Biol Chem. 1999 Jul 9;274(28):19829-37. doi: 10.1074/jbc.274.28.19829.PMID: 10391927 .
  369. Ames JB, Dizhoor AM, Ikura M, Palczewski K, Stryer L. Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases. J Biol Chem. 1999 Jul 2;274(27):19329-37. doi: 10.1074/jbc.274.27.19329.PMID: 10383444 
  370. Mukherjee S, Palczewski K, Gurevich VV, Hunzicker-Dunn M. beta-arrestin-dependent desensitization of luteinizing hormone/choriogonadotropin receptor is prevented by a synthetic peptide corresponding to the third intracellular loop of the receptor. J Biol Chem. 1999 May 7;274(19):12984-9. doi: 10.1074/jbc.274.19.12984.PMID: 10224047 
  371. Stecher H, Gelb MH, Saari JC, Palczewski K. Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein. J Biol Chem. 1999 Mar 26;274(13):8577-85. doi: 10.1074/jbc.274.13.8577.PMID: 10085092 
  372. Wolbring G, Baehr W, Palczewski K, Schnetkamp PP. Light inhibition of bovine retinal rod guanylyl cyclase mediated by beta gamma-transducin. Biochemistry. 1999 Mar 2;38(9):2611-6. doi: 10.1021/bi9825596.PMID: 10052930
  373. Haeseleer F, Sokal I, Li N, Pettenati M, Rao N, Bronson D, Wechter R, Baehr W, Palczewski K. Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily. J Biol Chem. 1999 Mar 5;274(10):6526-35. doi: 10.1074/jbc.274.10.6526.PMID: 10037746 
  374. Sokal I, Haeseleer F, Arendt A, Adman ET, Hargrave PA, Palczewski K. Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1. Biochemistry. 1999 Feb 2;38(5):1387-93. doi: 10.1021/bi982512k.PMID: 9931003
  375. Mukherjee S, Palczewski K, Gurevich V, Benovic JL, Banga JP, Hunzicker-Dunn M. A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):493-8. doi: 10.1073/pnas.96.2.493.PMID: 9892661 
  376. Ohguro H, Yoshida N, Shindou H, Crabb JW, Palczewski K, Tsuda M. Identification of a single phosphorylation site within octopus rhodopsin. Photochem Photobiol. 1998 Dec;68(6):824-8.PMID: 9867032
  377. Otto-Bruc AE, Fariss RN, Van Hooser JP, Palczewski K. Phosphorylation of photolyzed rhodopsin is calcium-insensitive in retina permeabilized by alpha-toxin. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15014-9. doi: 10.1073/pnas.95.25.15014.PMID: 9844007 
  378. Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. J Biol Chem. 1998 Aug 21;273(34):21790-9. doi: 10.1074/jbc.273.34.21790.PMID: 9705317 
  379. Sokal I, Li N, Surgucheva I, Warren MJ, Payne AM, Bhattacharya SS, Baehr W, Palczewski K. GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy. Mol Cell. 1998 Jul;2(1):129-33. doi: 10.1016/s1097-2765(00)80121-5.PMID: 9702199 
  380. Saari JC, Garwin GG, Van Hooser JP, Palczewski K. Reduction of all-trans-retinal limits regeneration of visual pigment in mice. Vision Res. 1998 May;38(10):1325-33. doi: 10.1016/s0042-6989(97)00198-3.PMID: 9667000 
  381. Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5351-6. doi: 10.1073/pnas.95.9.5351.PMID: 9560279 
  382. Moon C, Jaberi P, Otto-Bruc A, Baehr W, Palczewski K, Ronnett GV. Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J Neurosci. 1998 May 1;18(9):3195-205. doi: 10.1523/JNEUROSCI.18-09-03195.1998.PMID: 9547228 
  383. Li N, Fariss RN, Zhang K, Otto-Bruc A, Haeseleer F, Bronson D, Qin N, Yamazaki A, Subbaraya I, Milam AH, Palczewski K, Baehr W. Guanylate-cyclase-inhibitory protein is a frog retinal Ca2+-binding protein related to mammalian guanylate-cyclase-activating proteins. Eur J Biochem. 1998 Mar 15;252(3):591-9. doi: 10.1046/j.1432-1327.1998.2520591.x.PMID: 9546678 
  384. Zhao X, Huang J, Khani SC, Palczewski K. Molecular forms of human rhodopsin kinase (GRK1). J Biol Chem. 1998 Feb 27;273(9):5124-31. doi: 10.1074/jbc.273.9.5124.PMID: 9478965 
  385. Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K, Baehr W. A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1271-6. doi: 10.1073/pnas.95.3.1271.PMID: 9448321 
  386. Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):328-33. doi: 10.1073/pnas.95.1.328.PMID: 9419375 
  387. Rudnicka-Nawrot M, Surgucheva I, Hulmes JD, Haeseleer F, Sokal I, Crabb JW, Baehr W, Palczewski K. Changes in biological activity and folding of guanylate cyclase-activating protein 1 as a function of calcium. Biochemistry. 1998 Jan 6;37(1):248-57. doi: 10.1021/bi972306x.PMID: 9425045
  388. Johnson WC Jr, Palczewski K, Gorczyca WA, Riazance-Lawrence JH, Witkowska D, Polans AS. Calcium binding to recoverin: implications for secondary structure and membrane association. Biochim Biophys Acta. 1997 Oct 17;1342(2):164-74. doi: 10.1016/s0167-4838(97)00091-5.PMID: 9392525
  389. Palczewski K. GTP-binding-protein-coupled receptor kinases–two mechanistic models. Eur J Biochem. 1997 Sep 1;248(2):261-9. doi: 10.1111/j.1432-1033.1997.00261.x.PMID: 9346277. Review.
  390. Palczewski K, Saari JC. Activation and inactivation steps in the visual transduction pathway. Curr Opin Neurobiol. 1997 Aug;7(4):500-4. doi: 10.1016/s0959-4388(97)80029-3.PMID: 9287193 Review.
  391. Pulvermüller A, Maretzki D, Rudnicka-Nawrot M, Smith WC, Palczewski K, Hofmann KP. Functional differences in the interaction of arrestin and its splice variant, p44, with rhodopsin. Biochemistry. 1997 Jul 29;36(30):9253-60. doi: 10.1021/bi970772g.PMID: 9230059
  392. Otto-Bruc A, Fariss RN, Haeseleer F, Huang J, Buczyłko J, Surgucheva I, Baehr W, Milam AH, Palczewski K. Localization of guanylate cyclase-activating protein 2 in mammalian retinas. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4727-32. doi: 10.1073/pnas.94.9.4727.PMID: 9114059 
  393. Otto-Bruc A, Buczylko J, Surgucheva I, Subbaraya I, Rudnicka-Nawrot M, Crabb JW, Arendt A, Hargrave PA, Baehr W, Palczewski K. Functional reconstitution of photoreceptor guanylate cyclase with native and mutant forms of guanylate cyclase-activating protein 1. Biochemistry. 1997 Apr 8;36(14):4295-302. doi: 10.1021/bi963000d.PMID: 9100025
  394. Zhao X, Haeseleer F, Fariss RN, Huang J, Baehr W, Milam AH, Palczewski K. Molecular cloning and localization of rhodopsin kinase in the mammalian pineal. Vis Neurosci. 1997 Mar-Apr;14(2):225-32. doi: 10.1017/s0952523800011366.PMID: 9147475
  395. Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, Palczewski K, Baehr W. The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1). Genomics. 1997 Feb 1;39(3):312-22. doi: 10.1006/geno.1996.4513.PMID: 9119368 
  396. Polans A, Baehr W, Palczewski K. Turned on by Ca2+! The physiology and pathology of Ca(2+)-binding proteins in the retina. Trends Neurosci. 1996 Dec;19(12):547-54. doi: 10.1016/s0166-2236(96)10059-x.PMID: 8961484 Review.
  397. Palczewski K, Smith WC. Splice variants of arrestins. Exp Eye Res. 1996 Nov;63(5):599-602. doi: 10.1006/exer.1996.0151.PMID: 8994364 
  398. Buczyłko J, Saari JC, Crouch RK, Palczewski K. Mechanisms of opsin activation. J Biol Chem. 1996 Aug 23;271(34):20621-30. doi: 10.1074/jbc.271.34.20621.PMID: 8702809 
  399. Duda T, Goraczniak R, Surgucheva I, Rudnicka-Nawrot M, Gorczyca WA, Palczewski K, Sitaramayya A, Baehr W, Sharma RK. Calcium modulation of bovine photoreceptor guanylate cyclase. Biochemistry. 1996 Jul 2;35(26):8478-82. doi: 10.1021/bi960752z.PMID: 8679607
  400. Langlois G, Chen CK, Palczewski K, Hurley JB, Vuong TM. Responses of the phototransduction cascade to dim light. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4677-82. doi: 10.1073/pnas.93.10.4677.PMID: 8643463 
  401. Semple-Rowland SL, Gorczyca WA, Buczylko J, Helekar BS, Ruiz CC, Subbaraya I, Palczewski K, Baehr W. Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina. FEBS Lett. 1996 Apr 29;385(1-2):47-52. doi: 10.1016/0014-5793(96)00345-6.PMID: 8641465 
  402. Jäger S, Palczewski K, Hofmann KP. Opsin/all-trans-retinal complex activates transducin by different mechanisms than photolyzed rhodopsin. Biochemistry. 1996 Mar 5;35(9):2901-8. doi: 10.1021/bi9524068.PMID: 8608127
  403. Ohguro H, Rudnicka-Nawrot M, Buczyłko J, Zhao X, Taylor JA, Walsh KA, Palczewski K. Structural and enzymatic aspects of rhodopsin phosphorylation. J Biol Chem. 1996 Mar 1;271(9):5215-24. doi: 10.1074/jbc.271.9.5215.PMID: 8617805 
  404. Smith WC, Adamus G, Van Der Wel H, Timmers A, Palczewski K, Ulshafer RJ, Hargrave PA, McDowell JH. Alligator rhodopsin: sequence and biochemical properties. Exp Eye Res. 1995 Nov;61(5):569-78. doi: 10.1016/s0014-4835(05)80051-x.PMID: 8654500
  405. Gorczyca WA, Polans AS, Surgucheva IG, Subbaraya I, Baehr W, Palczewski K. Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransduction. J Biol Chem. 1995 Sep 15;270(37):22029-36. doi: 10.1074/jbc.270.37.22029.PMID: 7665624.
  406. Zhao X, Palczewski K, Ohguro H. Mechanism of rhodopsin phosphorylation. Biophys Chem. 1995 Sep-Oct;56(1-2):183-8. doi: 10.1016/0301-4622(95)00031-r.PMID: 7662865 Review.
  407. Ohguro H, Palczewski K. Separation of phospho- and non-phosphopeptides using reverse phase column chromatography. FEBS Lett. 1995 Jul 24;368(3):452-4. doi: 10.1016/0014-5793(95)00710-q.PMID: 7635197 
  408. Palczewski K, “Rhodopsin Kinase,” In: Haeberli A (ed.): Human Protein Data. Copyright © 1995 VCH Verlagsges. mbH, Weinheim
  409. Palczewski K, Ohguro H, Premont RT, Inglese J. Rhodopsin kinase autophosphorylation. Characterization of site-specific mutations. J Biol Chem. 1995 Jun 23;270(25):15294-8. doi: 10.1074/jbc.270.25.15294.PMID: 7797516 
  410. Ohguro H, Van Hooser JP, Milam AH, Palczewski K. Rhodopsin phosphorylation and dephosphorylation in vivo. J Biol Chem. 1995 Jun 16;270(24):14259-62. doi: 10.1074/jbc.270.24.14259.PMID: 7782279 
  411. Kozak CA, Danciger M, Bowes C, Adamson MC, Palczewski K, Polans AS, Farber DB. Localization of three genes expressed in retina on mouse chromosome 11. Mamm Genome. 1995 Feb;6(2):142-4. doi: 10.1007/BF00303262.PMID: 7767000 
  412. Subbaraya I, Ruiz CC, Helekar BS, Zhao X, Gorczyca WA, Pettenati MJ, Rao PN, Palczewski K, Baehr W. Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. J Biol Chem. 1994 Dec 9;269(49):31080-9.PMID: 7983048 
  413. Ohguro H, Palczewski K, Walsh KA, Johnson RS. Topographic study of arrestin using differential chemical modifications and hydrogen/deuterium exchange. Protein Sci. 1994 Dec;3(12):2428-34. doi: 10.1002/pro.5560031226.PMID: 7756996 
  414. Palczewski K, Jäger S, Buczyłko J, Crouch RK, Bredberg DL, Hofmann KP, Asson-Batres MA, Saari JC. Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction. Biochemistry. 1994 Nov 22;33(46):13741-50. doi: 10.1021/bi00250a027.PMID: 7947785
  415. Morrison RS, Shi E, Kan M, Yamaguchi F, McKeehan W, Rudnicka-Nawrot M, Palczewski K. Inositolhexakisphosphate (InsP6): an antagonist of fibroblast growth factor receptor binding and activity. In Vitro Cell Dev Biol Anim. 1994 Nov;30A(11):783-9. doi: 10.1007/BF02631302.PMID: 7881632
  416. Palczewski K. Structure and functions of arrestins. Protein Sci. 1994 Sep;3(9):1355-61. doi: 10.1002/pro.5560030901.PMID: 7833798 Review.
  417. Palczewski K. Is vertebrate phototransduction solved? New insights into the molecular mechanism of phototransduction. Invest Ophthalmol Vis Sci. 1994 Sep;35(10):3577-81.PMID: 7522225 Review. 
  418. Johnson RS, Ohguro H, Palczewski K, Hurley JB, Walsh KA, Neubert TA. Heterogeneous N-acylation is a tissue- and species-specific posttranslational modification. J Biol Chem. 1994 Aug 19;269(33):21067-71.PMID: 8063726 
  419. Palczewski K, Subbaraya I, Gorczyca WA, Helekar BS, Ruiz CC, Ohguro H, Huang J, Zhao X, Crabb JW, Johnson RS, et al. Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein. Neuron. 1994 Aug;13(2):395-404. doi: 10.1016/0896-6273(94)90355-7.PMID: 7520254
  420. Robinson PR, Buczyłko J, Ohguro H, Palczewski K. Opsins with mutations at the site of chromophore attachment constitutively activate transducin but are not phosphorylated by rhodopsin kinase. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5411-5. doi: 10.1073/pnas.91.12.5411.PMID: 8202499 
  421. Smith WC, Milam AH, Dugger D, Arendt A, Hargrave PA, Palczewski K. A splice variant of arrestin. Molecular cloning and localization in bovine retina. J Biol Chem. 1994 Jun 3;269(22):15407-10.PMID: 7515057 
  422. Gorczyca WA, Gray-Keller MP, Detwiler PB, Palczewski K. Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4014-8. doi: 10.1073/pnas.91.9.4014.PMID: 7909609 
  423. Gorczyca WA, Van Hooser JP, Palczewski K. Nucleotide inhibitors and activators of retinal guanylyl cyclase. Biochemistry. 1994 Mar 22;33(11):3217-22. doi: 10.1021/bi00177a011.PMID: 7511001
  424. Polans AS, Palczewski K, Asson-Batres MA, Ohguro H, Witkowska D, Haley TL, Baizer L, Crabb JW. Purification and primary structure of Capl, an S-100-related calcium-binding protein isolated from bovine retina. J Biol Chem. 1994 Feb 25;269(8):6233-40.PMID: 8119967 
  425. Ohguro H, Johnson RS, Ericsson LH, Walsh KA, Palczewski K. Control of rhodopsin multiple phosphorylation. Biochemistry. 1994 Feb 1;33(4):1023-8. doi: 10.1021/bi00170a022.PMID: 8305429
  426. Palczewski K, Buczylko J, Ohguro H, Annan RS, Carr SA, Crabb JW, Kaplan MW, Johnson RS, Walsh KA. Characterization of a truncated form of arrestin isolated from bovine rod outer segments. Protein Sci. 1994 Feb;3(2):314-24. doi: 10.1002/pro.5560030215.PMID: 8003967 
  427. Pulvermüller A, Palczewski K, Hofmann KP. Interaction between photoactivated rhodopsin and its kinase: stability and kinetics of complex formation. Biochemistry. 1993 Dec 28;32(51):14082-8. doi: 10.1021/bi00214a002.PMID: 8260489
  428. Saari JC, Bredberg DL, Garwin GG, Buczyłko J, Wheeler T, Palczewski K. Assays of retinoid dehydrogenases by phase partition. Anal Biochem. 1993 Aug 15;213(1):128-32. doi: 10.1006/abio.1993.1395.PMID: 8238865
  429. Adamus G, Arendt A, Hargrave PA, Heyduk T, Palczewski K. The kinetics of multiphosphorylation of rhodopsin. Arch Biochem Biophys. 1993 Aug 1;304(2):443-7. doi: 10.1006/abbi.1993.1373.PMID: 8346919
  430. Ohguro H, Palczewski K, Ericsson LH, Walsh KA, Johnson RS. Sequential phosphorylation of rhodopsin at multiple sites. Biochemistry. 1993 Jun 1;32(21):5718-24. doi: 10.1021/bi00072a030.PMID: 8504090
  431. Ohguro H, Chiba S, Igarashi Y, Matsumoto H, Akino T, Palczewski K. Beta-arrestin and arrestin are recognized by autoantibodies in sera from multiple sclerosis patients. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3241-5. doi: 10.1073/pnas.90.8.3241.PMID: 8475065 
  432. Morrison RS, Giordano S, Yamaguchi F, Hendrickson S, Berger MS, Palczewski K. Basic fibroblast growth factor expression is required for clonogenic growth of human glioma cells. J Neurosci Res. 1993 Apr 1;34(5):502-9. doi: 10.1002/jnr.490340503.PMID: 8478985
  433. Palczewski K, Buczyłko J, Lebioda L, Crabb JW, Polans AS. Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin. J Biol Chem. 1993 Mar 15;268(8):6004-13.PMID: 8383684 
  434. Gray-Keller MP, Polans AS, Palczewski K, Detwiler PB. The effect of recoverin-like calcium-binding proteins on the photoresponse of retinal rods. Neuron. 1993 Mar;10(3):523-31. doi: 10.1016/0896-6273(93)90339-s.PMID: 8461139
  435. Polans AS, Burton MD, Haley TL, Crabb JW, Palczewski K. Recoverin, but not visinin, is an autoantigen in the human retina identified with a cancer-associated retinopathy. Invest Ophthalmol Vis Sci. 1993 Jan;34(1):81-90.PMID: 8425844
  436. Palczewski K, Buczyłko J, Van Hooser P, Carr SA, Huddleston MJ, Crabb JW. Identification of the autophosphorylation sites in rhodopsin kinase. J Biol Chem. 1992 Sep 15;267(26):18991-8.PMID: 1527025 
  437. Hofmann KP, Pulvermüller A, Buczyłko J, Van Hooser P, Palczewski K. The role of arrestin and retinoids in the regeneration pathway of rhodopsin. J Biol Chem. 1992 Aug 5;267(22):15701-6.PMID: 1386362 
  438. Palczewski K, Riazance-Lawrence JH, Johnson WC Jr. Structural properties of arrestin studied by chemical modification and circular dichroism. Biochemistry. 1992 Apr 28;31(16):3902-6. doi: 10.1021/bi00131a003.PMID: 1567843
  439. Palczewski K, Rispoli G, Detwiler PB. The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction. Neuron. 1992 Jan;8(1):117-26. doi: 10.1016/0896-6273(92)90113-r.PMID: 1309646
  440. Palczewski K, Pulvermüller A, Buczylko J, Gutmann C, Hofmann KP. Binding of inositol phosphates to arrestin. FEBS Lett. 1991 Dec 16;295(1-3):195-9. doi: 10.1016/0014-5793(91)81416-6.PMID: 1765153 
  441. Palczewski K, Pulvermüller A, Buczyłko J, Hofmann KP. Phosphorylated rhodopsin and heparin induce similar conformational changes in arrestin. J Biol Chem. 1991 Oct 5;266(28):18649-54.PMID: 1917988 
  442. Palczewski K, Benovic JL. G-protein-coupled receptor kinases. Trends Biochem Sci. 1991 Oct;16(10):387-91. doi: 10.1016/0968-0004(91)90157-q.PMID: 1664548 Review.
  443. Lorenz W, Inglese J, Palczewski K, Onorato JJ, Caron MG, Lefkowitz RJ. The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8715-9. doi: 10.1073/pnas.88.19.8715.PMID: 1656454 
  444. Palczewski K, Buczyłko J, Imami NR, McDowell JH, Hargrave PA. Role of the carboxyl-terminal region of arrestin in binding to phosphorylated rhodopsin. J Biol Chem. 1991 Aug 15;266(23):15334-9.PMID: 1651326 
  445. Palczewski K, Buczyłko J, Kaplan MW, Polans AS, Crabb JW. Mechanism of rhodopsin kinase activation. J Biol Chem. 1991 Jul 15;266(20):12949-55.PMID: 2071581 
  446. Ragazzi E, Shryock J, Palczewski K. Properties of solubilized and reconstituted A1 adenosine receptors from bovine brain. Pharmacol Res. 1991 Jul;24(1):15-23. doi: 10.1016/1043-6618(91)90060-b.PMID: 1946140
  447. Palczewski K, Farber DB, Hargrave PA. Elevated level of protein phosphatase 2A activity in retinas of rd mice. Exp Eye Res. 1991 Jul;53(1):101-5. doi: 10.1016/0014-4835(91)90151-4.PMID: 1652453
  448. Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, Benovic JL. Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry. 1991 May 28;30(21):5118-25. doi: 10.1021/bi00235a002.PMID: 1645191
  449. Buczyłko J, Gutmann C, Palczewski K. Regulation of rhodopsin kinase by autophosphorylation. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2568-72. doi: 10.1073/pnas.88.6.2568.PMID: 2006192 
  450. Palczewski K, Hargrave PA. Studies of ligand binding to arrestin. J Biol Chem. 1991 Mar 5;266(7):4201-6.PMID: 1999413 
  451. Polans AS, Buczyłko J, Crabb J, Palczewski K. A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy. J Cell Biol. 1991 Mar;112(5):981-9. doi: 10.1083/jcb.112.5.981.PMID: 1999465 
  452. Adamus G, Zam ZS, Arendt A, Palczewski K, McDowell JH, Hargrave PA. Anti-rhodopsin monoclonal antibodies of defined specificity: characterization and application. Vision Res. 1991;31(1):17-31. doi: 10.1016/0042-6989(91)90069-h.PMID: 2006550
  453. Fukada Y, Kokame K, Okano T, Shichida Y, Yoshizawa T, McDowell JH, Hargrave PA, Palczewski K. Phosphorylation of iodopsin, chicken red-sensitive cone visual pigment. Biochemistry. 1990 Oct 30;29(43):10102-6. doi: 10.1021/bi00495a013.PMID: 2271641
  454. Palczewski K, Kahn N, Hargrave PA. Nucleoside inhibitors of rhodopsin kinase. Biochemistry. 1990 Jul 3;29(26):6276-82. doi: 10.1021/bi00478a024.PMID: 2207073
  455. Lebioda L, Hargrave PA, Palczewski K. X-ray crystal structure of sangivamycin, a potent inhibitor of protein kinases. FEBS Lett. 1990 Jun 18;266(1-2):102-4. doi: 10.1016/0014-5793(90)81517-r.PMID: 2365059 
  456. Litchfield DW, Arendt A, Lozeman FJ, Krebs EG, Hargrave PA, Palczewski K. Synthetic phosphopeptides are substrates for casein kinase II. FEBS Lett. 1990 Feb 12;261(1):117-20. doi: 10.1016/0014-5793(90)80650-8.PMID: 2307228 
  457. Palczewski K, Carruth ME, Adamus G, McDowell JH, Hargrave PA. Molecular, enzymatic and functional properties of rhodopsin kinase from rat pineal gland. Vision Res. 1990;30(8):1129-37. doi: 10.1016/0042-6989(90)90170-p.PMID: 2402884
  458. Palczewski K, Arendt A, McDowell JH, Hargrave PA. Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations. Biochemistry. 1989 Oct 31;28(22):8764-70. doi: 10.1021/bi00448a013.PMID: 2605220
  459. Palczewski K, McDowell JH, Jakes S, Ingebritsen TS, Hargrave PA. Regulation of rhodopsin dephosphorylation by arrestin. J Biol Chem. 1989 Sep 25;264(27):15770-3.PMID: 2550422 
  460. Arendt A, Palczewski K, Moore WT, Caprioli RM, McDowell JH, Hargrave PA. Synthesis of phosphopeptides containing O-phosphoserine or O-phosphothreonine. Int J Pept Protein Res. 1989 Jun;33(6):468-76. doi: 10.1111/j.1399-3011.1989.tb00225.x.PMID: 2506143
  461. Palczewski K, Hargrave PA, McDowell JH, Ingebritsen TS. The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin. Biochemistry. 1989 Jan 24;28(2):415-9. doi: 10.1021/bi00428a001.PMID: 2540796
  462. Palczewski K, McDowell JH, Hargrave PA. Purification and characterization of rhodopsin kinase. J Biol Chem. 1988 Oct 5;263(28):14067-73.PMID: 2844754 
  463. Palczewski K, McDowell JH, Hargrave PA. Rhodopsin kinase: substrate specificity and factors that influence activity. Biochemistry. 1988 Apr 5;27(7):2306-13. doi: 10.1021/bi00407a010.PMID: 3382623
  464. Palczewski K, Kochman M. Photoaffinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 8-azido-1,N6-ethenoadenosine 5′-triphosphate. Biochemistry. 1987 Jun 16;26(12):3466-71. doi: 10.1021/bi00386a033.PMID: 3651392
  465. Palczewski K, Hargrave PA, Folta EJ, Kochman M. Affinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 5′-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine. Eur J Biochem. 1985 Jan 15;146(2):309-14. doi: 10.1111/j.1432-1033.1985.tb08654.x.PMID: 3967660 
  466. Palczewski K, Hargrave PA, Kochman M. o-Phthalaldehyde, a fluorescence probe of aldolase active site. Eur J Biochem. 1983 Dec 15;137(3):429-35. doi: 10.1111/j.1432-1033.1983.tb07846.x.PMID: 6662105 
  467. Buczylko J, K. Palczewski, M. Kochman, Purification and properties of porcine brain aldolase C. Intl J Biochem 1983, 15, 453–61