Publications

BIBLIOGRAPHY: PUBLISHED AND IN PRESS: 

1. An, M., A. Raguram, S. W. Du, S. Banskota, J. R. Davis, G. A. Newby, K. Palczewski, D. R. Liu. Transient in vivo delivery of prime editor protein and pegRNA with engineered virus-like particles. (2023) Nature Biotechnology (in press)
2. Engfer ZJ, Lewandowski D, Dong Z, Palczewska G, Zhang J, Kordecka K, Płaczkiewicz J, Panas D, Foik AT, Tabaka M, Palczewski K. Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2314698120. doi: 10.1073/pnas.2314698120.
3. Wu A, Salom D, Hong JD, Tworak A, Watanabe K, Pardon E, Steyaert J, Kandori H, Katayama K, Kiser PD, Palczewski K. Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun. 2023 Aug 25;14(1):5209. doi: 10.1038/s41467-023-40911-9.
4. Tworak A, Kolesnikov AV, Hong JD, Choi EH, Luu JC, Palczewska G, Dong Z, Lewandowski D, Brooks MJ, Campello L, Swaroop A, Kiser PD, Kefalov VJ, Palczewski K. Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia. Cell Rep. 2023 Aug 15;42(8):112982. doi: 10.1016/j.celrep.2023.112982.
5. Hong, J. D. and K. Palczewski. A short story on how chromophore is hydrolyzed from rhodopsin for recycling. Bioessays. 2023 Jul 16:e2300068.
6. Gulati, S., K. Palczewski. Rhodopsin dimers in the Retinal Rod Outer Segment. In “Cryo-electron microscopy in structural biology” (Editor Krishnarao Appasani). Taylor & Francis Group., CRC Press, Inc. Boca Raton, Florida, USA (in press)
7. Choi E. H., S. Suh, A. E. Sears, R. Holubowicz, A. W. Browne, K. Palczewski. Genome-Editing in Treatment of Ocular Diseases. Exp Mol Med. 2023 Aug 1. doi: 10.1038/s12276-023-01057-2.
8. Holubowicz R. and K. Palczewski.  Saving eyesight, one gene at a time. Trends Mol Med. 2023 May 9:S1471-4914(23)00090-4. doi: 10.1016/j.molmed.2023.04.008
9. Luu, J. C., A. Saadane, H. Leinonen, E. H. Choi, F. Gao, D. Lewandowski, M. Halabi, C. L. Sander, A. Wu, J. M. Wang, R. Singh, S. Gao, E. M. Lessieur, Z. Dong, G. Palczewska, R. F. Mullins, N. S. Peachey, P.D. Kiser, M. Tabaka, T. S. Kern, and K. Palczewski. Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2221045120. doi: 10.1073/pnas.2221045120. Epub 2023 May 1.PMID: 37126699
10. Bogusławski J, Tomczewski S, Dąbrowski M, Komar K, Milkiewicz J, Palczewska G, Palczewski K, Wojtkowski M. In vivo imaging of the human retina using a two-photon excited fluorescence ophthalmoscope. STAR Protoc. 2023 Apr 13;4(2):102225. doi: 10.1016/j.xpro.2023.102225. 
11. Du, S. W., K. Palczewski. Eye on genome editing. J Exp Med. 2023 May 1;220(5):e20230146. doi: 10.1084/jem.20230146.
12. Palczewska, G., M. Wojtkowski, K. Palczewski. From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation. Prog Retin Eye Res. 2023 Feb 12;93:101170. doi: 10.1016/j.preteyeres.2023.101170. PMID: 36787681 
13. Poria, D., A. V. Kolesnikov, T. J. Lee, D. Salom, K. Palczewski, V. J. Kefalov. Investigating the role of rhodopsin F45L mutation in mouse rod photoreceptor signaling and survival. eNeuro. 2023 Feb 21:ENEURO.0330-22.2023. doi: 10.1523/ENEURO.0330-22.2023
14. Yan, A. L.; S. W. Du, and K. Palczewski. Genome editing, a superior therapy for inherited retinal diseases. 2023 Feb 15;206:108192. doi: 10.1016/j.visres.2023.108192. Online ahead of print.PMID: 36804635
15. Dhankhar, D., D. Salom, K. Palczewski, P. M. Rentzepis. Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature. Proc Natl Acad Sci U S A. 2023; 120(1):e2214276120
16. Hong, J. D., D. Salom, M. A. Kochman, A. Kubas, P. Kiser, K. Palczewski. Chromophore hydrolysis and release from photoactivated rhodopsin in native membranes. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2213911119.  And Profile of Krzysztof Palczewski. Ravindran S.Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2215599119
17. Huh C.Y. L., H. Leinonen, J. Zhang, J. Zeitoun, T. Nakayama, J. P. Peach, J. Z. Kiser, K. Palczewski, P. D. Kiser, S. P. Gandhi. Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration.  Curr Biol. 2022 Sep 16:S0960-9822(22)01449-X 
18. Gulati S. and K. Palczewski. Structural view of G protein-coupled receptor signaling in the retinal rod outer segment. (2022) Trends Biochem Sci. 2022 Sep 23:S0968-0004(22)00235-3. doi: 10.1016/j.tibs.2022.08.010 
19. Sun D., W. Sun, S-Q. Gao, J. Lehrer, A. Naderi, S. Lee, C. Wei, A. L. Schilb, J. Scheidt, R. C. Hall, E. I. Traboulsi, K. Palczewski, Z-R. Lu. Effective gene therapy of Stargardt disease with PEG-ECO/pGRK1-ABCA4-S/MAR nanoparticles. Mol Ther Nucleic Acids. 2022 Aug 24;29:823-835. doi: 10.1016/j.omtn.2022.08.026 
20. Susie Suh, E. H. Choi, A. Raguram, D. R. Liu, K. Palczewski. Precision genome editing in the eye. 2022 Proc. Natl. Acad. Sci. ;119(39):e2210104119 
21. Kolesnikov, A.V. J. Luu, H. Jin, K. Palczewski, V. J. Kefalov. Deletion of Protein Phosphatase 2A Accelerates Retinal Degeneration in GRK1- and Arr1-Deficient Mice. Invest Ophthalmol Vis Sci. 2022 Jul 8;63(8):18. doi: 10.1167/iovs.63.8.18 
22. Leinonen H, Lyon DC, Palczewski K, Foik AT. Visual System Hyperexcitability and Compromised V1 Receptive Field Properties in Early-Stage Retinitis Pigmentosa in Mice. eNeuro. 2022 Jun 27;9(3):ENEURO.0107-22.2022. doi: 10.1523/ENEURO.0107-22.2022. Print 2022 May-Jun.PMID: 35701168  
23. Tarban N, Halász H, Gogolák P, Garabuczi É, Moise AR, Palczewski K, Sarang Z, Szondy Z. Regenerating Skeletal Muscle Compensates for the Impaired Macrophage Functions Leading to Normal Muscle Repair in Retinol Saturase Null Mice. Cells. 2022 Apr 13;11(8):1333. doi: 10.3390/cells11081333.PMID: 35456012  
24. Chen S, Getter T, Salom D, Wu D, Quetschlich D, Chorev DS, Palczewski K, Robinson CV. Capturing a rhodopsin receptor signalling cascade across a native membrane. Nature. 2022 Apr;604(7905):384-390. doi: 10.1038/s41586-022-04547-x. Epub 2022 Apr 6.PMID: 35388214  
25. Choi EH, Suh S, Foik AT, Leinonen H, Newby GA, Gao XD, Banskota S, Hoang T, Du SW, Dong Z, Raguram A, Kohli S, Blackshaw S, Lyon DC, Liu DR, Palczewski K. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nat Commun. 2022 Apr 5;13(1):1830. doi: 10.1038/s41467-022-29490-3.PMID: 35383196  
26. Banskota S, Raguram A, Suh S, Du SW, Davis JR, Choi EH, Wang X, Nielsen SC, Newby GA, Randolph PB, Osborn MJ, Musunuru K, Palczewski K, Liu DR. Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Cell. 2022 Jan 20;185(2):250-265.e16. doi: 10.1016/j.cell.2021.12.021. Epub 2022 Jan 11.PMID: 35021064  
27. Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu J, Lee J, Ma X, Bieberich E, Blackshaw S, Saghatelian A, Lyon DC, Skowronska-Krawczyk D, Tabaka M, Palczewski K. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. JCI Insight. 2022 Feb 22;7(4):e156301. doi: 10.1172/jci.insight.156301.PMID: 35015730  
28. Cheng C, Weiss L, Leinonen H, Shmara A, Yin HZ, Ton T, Do A, Lee J, Ta L, Mohanty E, Vargas J, Weiss J, Palczewski K, Kimonis V. VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy. J Transl Med. 2022 Jan 8;20(1):21. doi: 10.1186/s12967-021-03186-6.PMID: 34998409  
29. Pöge M, Mahamid J, Imanishi SS, Plitzko JM, Palczewski K, Baumeister W. Determinants shaping the nanoscale architecture of the mouse rod outer segment. Elife. 2021 Dec 21;10:e72817. doi: 10.7554/eLife.72817.PMID: 34931611  
30. Boguslawski J, Palczewska G, Tomczewski S, Milkiewicz J, Kasprzycki P, Stachowiak D, Komar K, Marzejon MJ, Sikorski BL, Hudzikowski A, Głuszek A, Łaszczych Z, Karnowski K, Soboń G, Palczewski K, Wojtkowski M. In vivo imaging of the human eye using a 2-photon-exd fluorescence scanning laser ophthalmoscope. J Clin Invest. 2022 Jan 18;132(2):e154218. doi: 10.1172/JCI154218.PMID: 34847075  
31. Getter T, Kemp A, Vinberg F, Palczewski K. Identification of small-molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization. J Biol Chem. 2021 Dec;297(6):101401. doi: 10.1016/j.jbc.2021.101401. Epub 2021 Nov 11.PMID: 34774799  
32. Du SW, Palczewski K. MicroRNA regulation of critical retinal pigment epithelial functions. Trends Neurosci. 2022 Jan;45(1):78-90. doi: 10.1016/j.tins.2021.10.008. Epub 2021 Nov 6.PMID: 34753606  Review. 
33. Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA; 99 Lives Consortium, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, Vincent A, Mahroo OA, Kiser PD, Petersen-Jones SM. A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Hum Mol Genet. 2022 Apr 22;31(8):1263-1277. doi: 10.1093/hmg/ddab316.PMID: 34726233 
34. Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure. 2022 Feb 3;30(2):263-277.e5. doi: 10.1016/j.str.2021.10.002. Epub 2021 Oct 21.PMID: 34678158 
35. Kochman MA, Palczewski K, Kubas A. Theoretical Study of the Photoisomerization Mechanism of All-Trans-Retinyl Acetate. J Phys Chem A. 2021 Sep 30;125(38):8358-8372. doi: 10.1021/acs.jpca.1c05533. Epub 2021 Sep 21.PMID: 34546761  
36. Kern TS, Du Y, Tang J, Lee CA, Liu H, Dreffs A, Leinonen H, Antonetti DA, Palczewski K. Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies. Mol Pharmacol. 2021 Nov;100(5):470-479. doi: 10.1124/molpharm.121.000278. Epub 2021 Aug 15.PMID: 34393108  
37. Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, Palczewski K. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol. 2021 Aug 2;220(8):e202101063. doi: 10.1083/jcb.202101063. Epub 2021 Jun 16.PMID: 34132745  
38. Blum E, Zhang J, Zaluski J, Einstein DE, Korshin EE, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J Med Chem. 2021 Jun 24;64(12):8287-8302. doi: 10.1021/acs.jmedchem.1c00279. Epub 2021 Jun 3.PMID: 34081480  
39. Gulati S, Palczewski K. New focus on regulation of the rod photoreceptor phosphodiesterase. Curr Opin Struct Biol. 2021 Aug;69:99-107. doi: 10.1016/j.sbi.2021.03.016. Epub 2021 May 1.PMID: 33945959 Review. 
40. Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6. J Pharmacol Exp Ther. 2021 Jul;378(1):31-41. doi: 10.1124/jpet.120.000486. Epub 2021 Apr 30.PMID: 33931547  
41. Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021 May 10;6(9):e146604. doi: 10.1172/jci.insight.146604.PMID: 33784255  
42. Yu G, Gao SQ, Dong Z, Sheng L, Sun D, Zhang N, Zhang J, Margeivicus S, Fu P, Golczak M, Maeda A, Palczewski K, Lu ZR. Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice. Bioconjug Chem. 2021 Mar 17;32(3):572-583. doi: 10.1021/acs.bioconjchem.1c00043. Epub 2021 Mar 7.PMID: 33677964  
43. Marzejon MJ, Kornaszewski Ł, Bogusławski J, Ciąćka P, Martynow M, Palczewska G, Maćkowski S, Palczewski K, Wojtkowski M, Komar K. Two-photon microperimetry with picosecond pulses. Biomed Opt Express. 2020 Dec 17;12(1):462-479. doi: 10.1364/BOE.411168. eCollection 2021 Jan 1.PMID: 33659083  
44. Sun D, Sun W, Gao SQ, Wei C, Naderi A, Schilb AL, Scheidt J, Lee S, Kern TS, Palczewski K, Lu ZR. Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model. J Control Release. 2021 Feb 10;330:329-340. doi: 10.1016/j.jconrel.2020.12.010. Epub 2020 Dec 21.PMID: 33358976  
45. Łabuz G, Rayamajhi A, Khoramnia R, Palczewska G, Palczewski K, Holschbach A, Auffarth GU. THE LOSS OF INFRARED LIGHT SENSITIVITY OF PHOTORECEPTOR CELLS MEASURED WITH TWO-PHOTON EXCITATION AS AN INDICATOR OF DIABETIC RETINOPATHY: A Pilot Study. Retina. 2021 Jun 1;41(6):1302-1308. doi: 10.1097/IAE.0000000000003032.PMID: 33323904  
46. Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. Function of mammalian M-cones depends on the level of CRALBP in Müller cells. J Gen Physiol. 2021 Jan 4;153(1):e202012675. doi: 10.1085/jgp.202012675.PMID: 33216847  
47. Kiser PD, Palczewski K. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. J Biol Chem. 2021 Jan-Jun;296:100072. doi: 10.1074/jbc.REV120.014405. Epub 2020 Nov 23.PMID: 33187985   
48. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2020 Nov;4(11):1119. doi: 10.1038/s41551-020-00652-2.PMID: 33122854 
49. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021 Feb;5(2):169-178. doi: 10.1038/s41551-020-00632-6. Epub 2020 Oct 19.PMID: 33077938  
50. Leinonen H, Pham NC, Boyd T, Santoso J, Palczewski K, Vinberg F. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. Elife. 2020 Sep 22;9:e59422. doi: 10.7554/eLife.59422.PMID: 32960171  
51. Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. FASEB J. 2020 Oct;34(10):13918-13934. doi: 10.1096/fj.202000796RR. Epub 2020 Aug 28.PMID: 32860273  
52. Łabuz G, Rayamajhi A, Usinger J, Komar K, Merz P, Khoramnia R, Palczewska G, Palczewski K, Auffarth GU. Clinical Application of Infrared-Light Microperimetry in the Assessment of Scotopic-Eye Sensitivity. Transl Vis Sci Technol. 2020 Jul 7;9(8):7. doi: 10.1167/tvst.9.8.7. eCollection 2020 Jul.PMID: 32855854  
53. Palczewska G, Boguslawski J, Stremplewski P, Kornaszewski L, Zhang J, Dong Z, Liang XX, Gratton E, Vogel A, Wojtkowski M, Palczewski K. Noninvasive two-photon optical biopsy of retinal fluorophores. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22532-22543. doi: 10.1073/pnas.2007527117. Epub 2020 Aug 26.PMID: 32848058  
54. Palczewski K, Kiser PD. Shedding new light on the generation of the visual chromophore. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):19629-19638. doi: 10.1073/pnas.2008211117. Epub 2020 Aug 5.PMID: 32759209  Review. 
55. Blum E, Zhang J, Korshin E, Palczewski K, Gruzman A. Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases. Bioorg Med Chem Lett. 2020 Sep 15;30(18):127421. doi: 10.1016/j.bmcl.2020.127421. Epub 2020 Jul 18.PMID: 32717613  
56. Luu J, Kallestad L, Hoang T, Lewandowski D, Dong Z, Blackshaw S, Palczewski K. Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model. Hum Mol Genet. 2020 Aug 29;29(15):2611-2624. doi: 10.1093/hmg/ddaa158.PMID: 32691052  
57. Han X, Hofmann L, de la Fuente M, Alexander N, Palczewski K; INVENT Consortium, Nieman MT. PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153. Blood. 2020 Nov 5;136(19):2217-2228. doi: 10.1182/blood.2019004634.PMID: 32575122  
58. Choi EH, Daruwalla A, Suh S, Leinonen H, Palczewski K. Retinoids in the visual cycle: role of the retinal G protein-coupled receptor. J Lipid Res. 2021;62:100040. doi: 10.1194/jlr.TR120000850. Epub 2021 Feb 6.PMID: 32493732  Review. 
59. Sun D, Schur RM, Sears AE, Gao SQ, Sun W, Naderi A, Kern T, Palczewski K, Lu ZR. Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium. ACS Appl Bio Mater. 2020 May 18;3(5):3078-3086. doi: 10.1021/acsabm.0c00130. Epub 2020 Apr 3.PMID: 34327311  No abstract available. 
60. Corral-Serrano JC, Lamers IJC, van Reeuwijk J, Duijkers L, Hoogendoorn ADM, Yildirim A, Argyrou N, Ruigrok RAA, Letteboer SJF, Butcher R, van Essen MD, Sakami S, van Beersum SEC, Palczewski K, Cheetham ME, Liu Q, Boldt K, Wolfrum U, Ueffing M, Garanto A, Roepman R, Collin RWJ. PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Proc Natl Acad Sci U S A. 2020 May 5;117(18):9922-9931. doi: 10.1073/pnas.1903125117. Epub 2020 Apr 20.PMID: 32312818  
61. Valdez-Lopez JC, Gulati S, Ortiz EA, Palczewski K, Robinson PR. Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation. PLoS One. 2020 Apr 1;15(4):e0228121. doi: 10.1371/journal.pone.0228121. eCollection 2020.PMID: 32236094  
62. Sarang Z, Sághy T, Budai Z, Ujlaky-Nagy L, Bedekovics J, Beke L, Méhes G, Nagy G, Rühl R, Moise AR, Palczewski K, Szondy Z. Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity. Biomolecules. 2019 Nov 13;9(11):737. doi: 10.3390/biom9110737.PMID: 31766264  
63. Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019 Dec 13;294(50):19137-19154. doi: 10.1074/jbc.RA119.011169. Epub 2019 Nov 6.PMID: 31694912  
64. Kallestad L, Blackshaw S, Khalil AM, Palczewski K. Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium. Sci Rep. 2019 Oct 15;9(1):14821. doi: 10.1038/s41598-019-51379-3.PMID: 31616038  
65. Sun D, Schur RM, Sears AE, Gao SQ, Vaidya A, Sun W, Maeda A, Kern T, Palczewski K, Lu ZR. Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles. Mol Ther. 2020 Jan 8;28(1):293-303. doi: 10.1016/j.ymthe.2019.09.010. Epub 2019 Sep 12.PMID: 31611143  
66. Ruminski D, Palczewska G, Nowakowski M, Zielińska A, Kefalov VJ, Komar K, Palczewski K, Wojtkowski M. Two-photon microperimetry: sensitivity of human photoreceptors to infrared light. Biomed Opt Express. 2019 Aug 9;10(9):4551-4567. doi: 10.1364/BOE.10.004551. eCollection 2019 Sep 1.PMID: 31565509  
67. Kahremany S, Sander CL, Tochtrop GP, Kubas A, Palczewski K. Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis. Org Biomol Chem. 2019 Sep 21;17(35):8125-8139. doi: 10.1039/c9ob01645g. Epub 2019 Aug 28.PMID: 31455964  
68. Vinberg F, Palczewska G, Zhang J, Komar K, Wojtkowski M, Kefalov VJ, Palczewski K. Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience. 2019 Sep 15;416:100-108. doi: 10.1016/j.neuroscience.2019.07.047. Epub 2019 Aug 7.PMID: 31400484  
69. Zhao DY, Pöge M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K. Cryo-EM structure of the native rhodopsin dimer in nanodiscs. J Biol Chem. 2019 Sep 27;294(39):14215-14230. doi: 10.1074/jbc.RA119.010089. Epub 2019 Aug 9.PMID: 31399513  
70. Kahremany S, Kubas A, Tochtrop GP, Palczewski K. Catalytic synthesis of 9-cis-retinoids: mechanistic insights. Dalton Trans. 2019 Jul 16;48(28):10581-10595. doi: 10.1039/c9dt02189b.PMID: 31218312  
71. Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. Stereospecific modulation of dimeric rhodopsin. FASEB J. 2019 Aug;33(8):9526-9539. doi: 10.1096/fj.201900443RR. Epub 2019 May 23.PMID: 31121099  
72. Mustafi D, Arbabi A, Ameri H, Palczewski K. Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention. Pharmaceuticals (Basel). 2019 May 17;12(2):74. doi: 10.3390/ph12020074.PMID: 31108889  
73. Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. J Biol Chem. 2019 Jun 14;294(24):9461-9475. doi: 10.1074/jbc.RA119.008697. Epub 2019 May 9.PMID: 31073029  
74. Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS. Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1538-1546. doi: 10.1167/iovs.18-26433.PMID: 30994864  
75. Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K. Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates. J Biol Chem. 2019 May 17;294(20):8123-8133. doi: 10.1074/jbc.RA118.006835. Epub 2019 Apr 4.PMID: 30948514  
76. Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K. A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1442-1453. doi: 10.1167/iovs.19-26560.PMID: 30947334  
77. Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L. Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Sci Adv. 2019 Feb 27;5(2):eaav4322. doi: 10.1126/sciadv.aav4322. eCollection 2019 Feb.PMID: 30820458  
78. Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. Specificity of the chromophore-binding site in human cone opsins. J Biol Chem. 2019 Apr 12;294(15):6082-6093. doi: 10.1074/jbc.RA119.007587. Epub 2019 Feb 15.PMID: 30770468  
79. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 Apr;33(4):5782-5792. doi: 10.1096/fj.201802493R. Epub 2019 Jan 15.PMID: 30645148  
80. Sakami S, Imanishi Y, Palczewski K. Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. FASEB J. 2019 Mar;33(3):3680-3692. doi: 10.1096/fj.201801662R. Epub 2018 Nov 21.PMID: 30462532  
81. Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State. J Neurosci. 2019 Jan 9;39(2):212-223. doi: 10.1523/JNEUROSCI.1980-18.2018. Epub 2018 Nov 20.PMID: 30459230  
82. Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 Oct 22;475(20):3171-3188. doi: 10.1042/BCJ20180193.PMID: 30352831  Review. 
83. Palczewska G, Kern TS, Palczewski K. Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. Methods Mol Biol. 2019;1834:333-343. doi: 10.1007/978-1-4939-8669-9_21.PMID: 30324453  
84. Sakami S, Palczewski K. Immuno-TEM/STEM in Retinal Research. Methods Mol Biol. 2019;1834:311-332. doi: 10.1007/978-1-4939-8669-9_20.PMID: 30324452  
85. Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. Exploring a new ligand binding site of G protein-coupled receptors. Chem Sci. 2018 Jul 13;9(31):6480-6489. doi: 10.1039/c8sc01680a. eCollection 2018 Aug 21.PMID: 30310578  
86. Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F. A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness. iScience. 2018 Jun 29;4:1-19. doi: 10.1016/j.isci.2018.05.001. Epub 2018 May 5.PMID: 30240733  
87. Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. JCI Insight. 2018 Sep 6;3(17):e121555. doi: 10.1172/jci.insight.121555. eCollection 2018 Sep 6.PMID: 30185665  
88. Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration. Mol Pharmacol. 2018 Oct;94(4):1132-1144. doi: 10.1124/mol.118.112581. Epub 2018 Jul 17.PMID: 30018116  
89. Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 May 18;9(1):1996. doi: 10.1038/s41467-018-04432-0.PMID: 29777099  
90. Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun. 2018 May 17;9(1):1976. doi: 10.1038/s41467-018-04261-1.PMID: 29773803  
91. Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 Jul 1;27(13):2225-2243. doi: 10.1093/hmg/ddy128.PMID: 29659842  
92. Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A. An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. Med Chem. 2018;14(7):688-694. doi: 10.2174/1573406414666180412154952.PMID: 29651942  
93. Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018 Apr 2;150(4):571-590. doi: 10.1085/jgp.201711815. Epub 2018 Mar 2.PMID: 29500274  
94. Luu J, Palczewski K. Human aging and disease: Lessons from age-related macular degeneration. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):2866-2872. doi: 10.1073/pnas.1721033115. Epub 2018 Feb 26.PMID: 29483257  
95. Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K. Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs. Mol Pharmacol. 2018 May;93(5):438-452. doi: 10.1124/mol.117.111294. Epub 2018 Feb 16.PMID: 29453250  
96. Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models. FASEB J. 2018 Jun;32(6):3289-3300. doi: 10.1096/fj.201701250R. Epub 2018 Jan 24.PMID: 29401616  
97. Owen TS, Salom D, Sun W, Palczewski K. Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry. 2018 Feb 13;57(6):1022-1030. doi: 10.1021/acs.biochem.7b01118. Epub 2018 Jan 29.PMID: 29320632  
98. Murashova GA, Mancuso CA, Canfield JL, Sakami S, Palczewski K, Palczewska G, Dantus M. Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser. Biomed Opt Express. 2017 Oct 26;8(11):5228-5242. doi: 10.1364/BOE.8.005228. eCollection 2017 Nov 1.PMID: 29188116  
99. Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21.PMID: 29162627  
100. Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. Context-dependent compensation among phosphatidylserine-recognition receptors. Sci Rep. 2017 Nov 7;7(1):14623. doi: 10.1038/s41598-017-15191-1.PMID: 29116131  
101. Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9675-E9684. doi: 10.1073/pnas.1712405114. Epub 2017 Oct 23.PMID: 29078372  
102. Murashova GA, Mancuso CA, Sakami S, Palczewski K, Palczewska G, Dantus M. Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser. Proc SPIE Int Soc Opt Eng. 2017 Mar;10069:100692K. doi: 10.1117/12.2252457.PMID: 28989217  
103. Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K. Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. J Biol Chem. 2017 Dec 1;292(48):19826-19839. doi: 10.1074/jbc.M117.812677. Epub 2017 Oct 4.PMID: 28978645  
104. Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S. Designing Safer Analgesics via μ-Opioid Receptor Pathways. Trends Pharmacol Sci. 2017 Nov;38(11):1016-1037. doi: 10.1016/j.tips.2017.08.004. Epub 2017 Sep 19.PMID: 28935293  Review. 
105. Sears AE, Bernstein PS, Cideciyan AV, Hoyng C, Charbel Issa P, Palczewski K, Rosenfeld PJ, Sadda S, Schraermeyer U, Sparrow JR, Washington I, Scholl HPN. Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness. Transl Vis Sci Technol. 2017 Sep 14;6(5):6. doi: 10.1167/tvst.6.5.6. eCollection 2017 Sep.PMID: 28920007  Review. 
106. Alexander NS, Palczewski K. Crowd sourcing difficult problems in protein science. Protein Sci. 2017 Nov;26(11):2118-2125. doi: 10.1002/pro.3247. Epub 2017 Aug 29.PMID: 28762619  Review. 
107. Tonade D, Liu H, Palczewski K, Kern TS. Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. 2017 Oct;60(10):2111-2120. doi: 10.1007/s00125-017-4381-5. Epub 2017 Jul 28.PMID: 28755268  
108. Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber’s Congenital Amaurosis. Mol Ther Nucleic Acids. 2017 Jun 16;7:42-52. doi: 10.1016/j.omtn.2017.02.005. Epub 2017 Feb 28.PMID: 28624218  
109. Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ. The role of retinol dehydrogenase 10 in the cone visual cycle. Sci Rep. 2017 May 24;7(1):2390. doi: 10.1038/s41598-017-02549-8.PMID: 28539612  
110. Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017 Jun 6;56(22):2836-2852. doi: 10.1021/acs.biochem.7b00251. Epub 2017 May 19.PMID: 28493664  
111. Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. J Biol Chem. 2017 Jun 30;292(26):10983-10997. doi: 10.1074/jbc.M117.780478. Epub 2017 May 9.PMID: 28487362  
112. Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther. 2017 Jul;362(1):131-145. doi: 10.1124/jpet.117.240721. Epub 2017 May 5.PMID: 28476927  
113. Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K. Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry. 2017 May 2;56(17):2338-2348. doi: 10.1021/acs.biochem.7b00165. Epub 2017 Apr 21.PMID: 28402104  
114. Palczewski K. Skunkworks project for Big Pharma. Pharmacol Res. 2017 Oct;124:167-168. doi: 10.1016/j.phrs.2017.03.022. Epub 2017 Mar 28.PMID: 28363722  No abstract available. 
115. Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2608-E2615. doi: 10.1073/pnas.1617446114. Epub 2017 Mar 13.PMID: 28289214  
116. Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Hum Mol Genet. 2016 Oct 15;25(20):4376-4388. doi: 10.1093/hmg/ddw268.PMID: 28172828  
117. Sharma R, Schwarz C, Hunter JJ, Palczewska G, Palczewski K, Williams DR. Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):604-613. doi: 10.1167/iovs.16-20061.PMID: 28129424  
118. Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K. MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. J Biol Chem. 2017 Feb 24;292(8):3366-3378. doi: 10.1074/jbc.M116.770024. Epub 2017 Jan 19.PMID: 28104803  
119. Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 Jan 15;26(2):305-319. doi: 10.1093/hmg/ddw387.PMID: 28065882  
120. Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW. A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins. 

Biochemistry. 2017 Jan 10;56(1):61-72. doi: 10.1021/acs.biochem.6b00877. Epub 2016 Nov 29.PMID: 28045251  

1. Schwarz C, Sharma R, Fischer WS, Chung M, Palczewska G, Palczewski K, Williams DR, Hunter JJ. Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomed Opt Express. 2016 Nov 16;7(12):5148-5169. doi: 10.1364/BOE.7.005148. eCollection 2016 Dec 1.PMID: 28018732  
2. Kiser PD, Palczewski K. Retinoids and Retinal Diseases. Annu Rev Vis Sci. 2016 Oct;2:197-234. doi: 10.1146/annurev-vision-111815-114407. Epub 2016 Jul 18.PMID: 27917399  Review. 
3. Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K. Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium. J Biol Chem. 2016 Dec 23;291(52):26937-26949. doi: 10.1074/jbc.M116.764563. Epub 2016 Nov 14.PMID: 27875314  
4. Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa. Pharmacol Res. 2017 Jan;115:1-13. doi: 10.1016/j.phrs.2016.10.031. Epub 2016 Nov 9.PMID: 27838510  
5. Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K. Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. Biochemistry. 2016 Nov 29;55(47):6545-6557. doi: 10.1021/acs.biochem.6b00907. Epub 2016 Nov 16.PMID: 27809489  
6. Chen Y, Kern TS, Kiser PD, Palczewski K. Eyes on systems pharmacology. Pharmacol Res. 2016 Dec;114:39-41. doi: 10.1016/j.phrs.2016.09.026. Epub 2016 Oct 5.PMID: 27720767  No abstract available. 
7. Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ. Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Nucleic Acids Res. 2016 Dec 1;44(21):10467-10479. doi: 10.1093/nar/gkw846. Epub 2016 Sep 20.PMID: 27655633  
8. Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS. Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4272-81. doi: 10.1167/iovs.16-19415.PMID: 27548901  
9. Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci Signal. 2016 Jul 26;9(438):ra74. doi: 10.1126/scisignal.aag0245.PMID: 27460988  
10. Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. The Molecular Mechanism of P2Y1 Receptor Activation. Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10331-5. doi: 10.1002/anie.201605147. Epub 2016 Jul 27.PMID: 27460867  
11. Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J Biol Chem. 2016 Sep 9;291(37):19401-12. doi: 10.1074/jbc.M116.744912. Epub 2016 Jul 24.PMID: 27453555  
12. Alexander NS, Palczewska G, Stremplewski P, Wojtkowski M, Kern TS, Palczewski K. Image registration and averaging of low laser power two-photon fluorescence images of mouse retina. Biomed Opt Express. 2016 Jun 20;7(7):2671-91. doi: 10.1364/BOE.7.002671. eCollection 2016 Jul 1.PMID: 27446697  
13. Yuan S, Peng Q, Palczewski K, Vogel H, Filipek S. Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor. Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8661-5. doi: 10.1002/anie.201603766. Epub 2016 May 31.PMID: 27244650  
14. Sears AE, Palczewski K. Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle. Biochemistry. 2016 Jun 7;55(22):3082-91. doi: 10.1021/acs.biochem.6b00319. Epub 2016 May 23.PMID: 27183166  Review. 
15. Comitato A, Di Salvo MT, Turchiano G, Montanari M, Sakami S, Palczewski K, Marigo V. Dominant and recessive mutations in rhodopsin activate different cell death pathways. Hum Mol Genet. 2016 Jul 1;25(13):2801-2812. doi: 10.1093/hmg/ddw137. Epub 2016 May 5.PMID: 27149983 Free article. 
16. Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage. J Biol Chem. 2016 Jun 17;291(25):12951-9. doi: 10.1074/jbc.M115.713248. Epub 2016 Apr 18.PMID: 27129240  
17. Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, Fischer DF, Bürli RW, MacLeod AM, Harte WE, Palczewski K, Imanishi Y. A small molecule mitigates hearing loss in a mouse model of Usher syndrome III. Nat Chem Biol. 2016 Jun;12(6):444-51. doi: 10.1038/nchembio.2069. Epub 2016 Apr 25.PMID: 27110679  
18. Sharma R, Schwarz C, Williams DR, Palczewska G, Palczewski K, Hunter JJ. In Vivo Two-Photon Fluorescence Kinetics of Primate Rods and Cones. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):647-57. doi: 10.1167/iovs.15-17946.PMID: 26903225  
19. Sharma R, Williams DR, Palczewska G, Palczewski K, Hunter JJ. Two-Photon Autofluorescence Imaging Reveals Cellular Structures Throughout the Retina of the Living Primate Eye. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):632-46. doi: 10.1167/iovs.15-17961.PMID: 26903224  
20. Hofmann L, Gulati S, Sears A, Stewart PL, Palczewski K. An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device. Anal Biochem. 2016 Apr 15;499:63-65. doi: 10.1016/j.ab.2016.01.016. Epub 2016 Feb 4.PMID: 26851339  
21. Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. The Biochemical Basis of Vitamin A3 Production in Arthropod Vision. ACS Chem Biol. 2016 Apr 15;11(4):1049-57. doi: 10.1021/acschembio.5b00967. Epub 2016 Feb 2.PMID: 26811964  
22. Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. J Biol Chem. 2015 Dec 18;290(51):30212-23. doi: 10.1074/jbc.M115.696799. Epub 2015 Oct 23.PMID: 26499794  
23. Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J Biol Chem. 2015 Nov 27;290(48):29035-44. doi: 10.1074/jbc.M115.682310. Epub 2015 Oct 14.PMID: 26468292  
24. Stremplewski P, Komar K, Palczewski K, Wojtkowski M, Palczewska G. Periscope for noninvasive two-photon imaging of murine retina in vivo. Biomed Opt Express. 2015 Aug 13;6(9):3352-61. doi: 10.1364/BOE.6.003352. eCollection 2015 Sep 1.PMID: 26417507  
25. Sundermeier TR, Palczewski K. The impact of microRNA gene regulation on the survival and function of mature cell types in the eye. FASEB J. 2016 Jan;30(1):23-33. doi: 10.1096/fj.15-279745. Epub 2015 Sep 23.PMID: 26399786  Review. 
26. Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. 2015 Nov 6;290(45):27239-27247. doi: 10.1074/jbc.M115.682096. Epub 2015 Sep 21.PMID: 26391396  
27. Kolesnikov AV, Maeda A, Tang PH, Imanishi Y, Palczewski K, Kefalov VJ. Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. J Physiol. 2015 Nov 15;593(22):4923-41. doi: 10.1113/JP271285. Epub 2015 Oct 18.PMID: 26350353  
28. Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. J Biol Chem. 2015 Oct 16;290(42):25728-44. doi: 10.1074/jbc.M115.662684. Epub 2015 Sep 1.PMID: 26330551  
29. Alexander NS, Palczewska G, Palczewski K. Semi-automated discrimination of retinal pigmented epithelial cells in two-photon fluorescence images of mouse retinas. Biomed Opt Express. 2015 Jul 23;6(8):3032-52. doi: 10.1364/BOE.6.003032. eCollection 2015 Aug 1.PMID: 26309765  
30. Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski K, Lu ZR. Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells. Macromol Biosci. 2015 Dec;15(12):1663-72. doi: 10.1002/mabi.201500192. Epub 2015 Aug 13.PMID: 26271011  
31. Jacobson SG, Cideciyan AV, Aguirre GD, Roman AJ, Sumaroka A, Hauswirth WW, Palczewski K. Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert Opin Orphan Drugs. 2015 May 4;3(5):563-575. doi: 10.1517/21678707.2015.1030393.PMID: 26246977  
32. Schur RM, Sheng L, Sahu B, Yu G, Gao S, Yu X, Maeda A, Palczewski K, Lu ZR. Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments. Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4936-42. doi: 10.1167/iovs.15-16522.PMID: 26225634  
33. Orban T, Johnson WM, Dong Z, Maeda T, Maeda A, Sakai T, Tsuneoka H, Mieyal JJ, Palczewski K. Serum levels of lipid metabolites in age-related macular degeneration. FASEB J. 2015 Nov;29(11):4579-88. doi: 10.1096/fj.15-275289. Epub 2015 Jul 17.PMID: 26187344  
34. Hofmann L, Palczewski K. Advances in understanding the molecular basis of the first steps in color vision. Prog Retin Eye Res. 2015 Nov;49:46-66. doi: 10.1016/j.preteyeres.2015.07.004. Epub 2015 Jul 15.PMID: 26187035  Review. 
35. Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, von Lintig J, Palczewski K, Kern TS. Retinylamine Benefits Early Diabetic Retinopathy in Mice. J Biol Chem. 2015 Aug 28;290(35):21568-79. doi: 10.1074/jbc.M115.655555. Epub 2015 Jul 2.PMID: 26139608  
36. Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 2015 Jul 1;125(7):2781-94. doi: 10.1172/JCI80950. Epub 2015 Jun 15.PMID: 26075817  
37. Yuan S, Palczewski K, Peng Q, Kolinski M, Vogel H, Filipek S. The mechanism of ligand-induced activation or inhibition of μ- and κ-opioid receptors. Angew Chem Int Ed Engl. 2015 Jun 22;54(26):7560-3. doi: 10.1002/anie.201501742. Epub 2015 May 12.PMID: 25968837 
38. Baker BY, Gulati S, Shi W, Wang B, Stewart PL, Palczewski K. Crystallization of proteins from crude bovine rod outer segments. Methods Enzymol. 2015;557:439-58. doi: 10.1016/bs.mie.2014.11.045. Epub 2015 Mar 17.PMID: 25950977  
39. Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11(6):409-15. doi: 10.1038/nchembio.1799. Epub 2015 Apr 20.PMID: 25894083  
40. Chen Y, Palczewski K. Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders. Annu Rev Pharmacol Toxicol. 2016;56:273-98. doi: 10.1146/annurev-pharmtox-010715-103033. Epub 2015 Mar 23.PMID: 25839098  Review. 
41. Chen Y, Tang H, Seibel W, Papoian R, Li X, Lambert NA, Palczewski K. A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2553-67. doi: 10.1167/iovs.14-16298.PMID: 25783607  
42. Zhang N, Tsybovsky Y, Kolesnikov AV, Rozanowska M, Swider M, Schwartz SB, Stone EM, Palczewska G, Maeda A, Kefalov VJ, Jacobson SG, Cideciyan AV, Palczewski K. Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations. Hum Mol Genet. 2015 Jun 1;24(11):3220-37. doi: 10.1093/hmg/ddv073. Epub 2015 Feb 24.PMID: 25712131  
43. Hofmann L, Palczewski K. The G protein-coupled receptor rhodopsin: a historical perspective. Methods Mol Biol. 2015;1271:3-18. doi: 10.1007/978-1-4939-2330-4_1.PMID: 25697513  
44. Du Y, Cramer M, Lee CA, Tang J, Muthusamy A, Antonetti DA, Jin H, Palczewski K, Kern TS. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May;29(5):2194-204. doi: 10.1096/fj.14-269431. Epub 2015 Feb 9.PMID: 25667222  
45. Mustafi D, Kikano S, Palczewski K. Serial block face-scanning electron microscopy: a method to study retinal degenerative phenotypes. Curr Protoc Mouse Biol. 2014 Dec 11;4(4):197-204. doi: 10.1002/9780470942390.mo140169.PMID: 25621191  
46. Puntel A, Maeda A, Golczak M, Gao SQ, Yu G, Palczewski K, Lu ZR. Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles. Biomaterials. 2015 Mar;44:103-10. doi: 10.1016/j.biomaterials.2014.12.019. Epub 2015 Jan 12.PMID: 25617130  
47. Kevany BM, Zhang N, Jastrzebska B, Palczewski K. Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration. Hum Mol Genet. 2015 May 1;24(9):2627-40. doi: 10.1093/hmg/ddv025. Epub 2015 Jan 23.PMID: 25616964  
48. Zhang J, Dong Z, Mundla SR, Hu XE, Seibel W, Papoian R, Palczewski K, Golczak M. Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration. Mol Pharmacol. 2015;87(3):477-91. doi: 10.1124/mol.114.096560. Epub 2014 Dec 23.PMID: 25538117  
49. Salom D, Cao P, Yuan Y, Miyagi M, Feng Z, Palczewski K. Isotopic labeling of mammalian G protein-coupled receptors heterologously expressed in Caenorhabditis elegans. Anal Biochem. 2015 Mar 1;472:30-6. doi: 10.1016/j.ab.2014.11.008. Epub 2014 Nov 20.PMID: 25461480  
50. Palczewska G, Vinberg F, Stremplewski P, Bircher MP, Salom D, Komar K, Zhang J, Cascella M, Wojtkowski M, Kefalov VJ, Palczewski K. Human infrared vision is triggered by two-photon chromophore isomerization. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5445-54. doi: 10.1073/pnas.1410162111. Epub 2014 Dec 1.PMID: 25453064  
51. Yu G, Wu X, Ayat N, Maeda A, Gao SQ, Golczak M, Palczewski K, Lu ZR. Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice. Biomacromolecules. 2014 Dec 8;15(12):4570-8. doi: 10.1021/bm501352s. Epub 2014 Nov 20.PMID: 25390360  
52. Golczak M, Sears AE, Kiser PD, Palczewski K. LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. Nat Chem Biol. 2015 Jan;11(1):26-32. doi: 10.1038/nchembio.1687. Epub 2014 Nov 10.PMID: 25383759  
53. Palczewski K. Chemistry and biology of the initial steps in vision: the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2014 Oct 22;55(10):6651-72. doi: 10.1167/iovs.14-15502.PMID: 25338686  
54. Chiang WC, Kroeger H, Sakami S, Messah C, Yasumura D, Matthes MT, Coppinger JA, Palczewski K, LaVail MM, Lin JH. Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Mol Neurobiol. 2015 Aug;52(1):679-95. doi: 10.1007/s12035-014-8881-8. Epub 2014 Oct 2.PMID: 25270370  
55. Park S, Li C, Haeseleer F, Palczewski K, Ames JB. Structural insights into activation of the retinal L-type Ca²⁺ channel (Cav1.4) by Ca²⁺-binding protein 4 (CaBP4). J Biol Chem. 2014 Nov 7;289(45):31262-73. doi: 10.1074/jbc.M114.604439. Epub 2014 Sep 25.PMID: 25258313  
56. Sundermeier TR, Jin H, Kleinjan ML, Mustafi D, Licatalosi DD, Palczewski K. Argonaute high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation reveals a snapshot of miRNA gene regulation in the mammalian retina. Biochemistry. 2014 Sep 23;53(37):5831-3. doi: 10.1021/bi500966b. Epub 2014 Sep 15.PMID: 25204418  
57. Yuan S, Filipek S, Palczewski K, Vogel H. Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway. Nat Commun. 2014 Sep 9;5:4733. doi: 10.1038/ncomms5733.PMID: 25203160 Free article. 
58. Baker BY, Shi W, Wang B, Palczewski K. High-resolution crystal structures of the photoreceptor glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with three and four-bound NAD molecules. Protein Sci. 2014 Nov;23(11):1629-39. doi: 10.1002/pro.2543. Epub 2014 Sep 25.PMID: 25176140  
59. Palczewska G, Golczak M, Williams DR, Hunter JJ, Palczewski K. Endogenous fluorophores enable two-photon imaging of the primate eye. Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4438-47. doi: 10.1167/iovs.14-14395.PMID: 24970255  
60. Palczewska G, Dong Z, Golczak M, Hunter JJ, Williams DR, Alexander NS, Palczewski K. Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye. Nat Med. 2014 Jul;20(7):785-9. doi: 10.1038/nm.3590. Epub 2014 Jun 22.PMID: 24952647  
61. Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Mol Pharmacol. 2014 Aug;86(2):231-42. doi: 10.1124/mol.114.093070. Epub 2014 Jun 9.PMID: 24913940  
62. Amengual J, Zhang N, Kemerer M, Maeda T, Palczewski K, Von Lintig J. STRA6 is critical for cellular vitamin A uptake and homeostasis. Hum Mol Genet. 2014 Oct 15;23(20):5402-17. doi: 10.1093/hmg/ddu258. Epub 2014 May 22.PMID: 24852372  
63. Comar WD, Schubert SM, Jastrzebska B, Palczewski K, Smith AW.J Time-resolved fluorescence spectroscopy measures clustering and mobility of a G protein-coupled receptor opsin in live cell membranes. Am Chem Soc. 2014 Jun 11;136(23):8342-9. doi: 10.1021/ja501948w. Epub 2014 Jun 2.PMID: 24831851  
64. Sundermeier TR, Zhang N, Vinberg F, Mustafi D, Kohno H, Golczak M, Bai X, Maeda A, Kefalov VJ, Palczewski K. DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. FASEB J. 2014 Aug;28(8):3780-91. doi: 10.1096/fj.14-254292. Epub 2014 May 8.PMID: 24812086  
65. Maeda A, Palczewska G, Golczak M, Kohno H, Dong Z, Maeda T, Palczewski K. Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1428-37. doi: 10.1073/pnas.1317986111. Epub 2014 Mar 24.PMID: 24706832  
66. Orban T, Jastrzebska B, Palczewski K. Structural approaches to understanding retinal proteins needed for vision. Curr Opin Cell Biol. 2014 Apr;27:32-43. doi: 10.1016/j.ceb.2013.11.001. Epub 2013 Nov 28.PMID: 24680428  Review. 
67. Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K. Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO). J Biol Chem. 2014 May 2;289(18):12286-99. doi: 10.1074/jbc.M114.552836. Epub 2014 Mar 19.PMID: 24648526  
68. Tsybovsky Y, Palczewski K. Expression, purification and structural properties of ABC transporter ABCA4 and its individual domains. Protein Expr Purif. 2014 May;97:50-60. doi: 10.1016/j.pep.2014.02.010. Epub 2014 Feb 28.PMID: 24583180  
69. Wang B, Tsybovsky Y, Palczewski K, Chance MR. Reliable determination of site-specific in vivo protein N-glycosylation based on collision-induced MS/MS and chromatographic retention time. J Am Soc Mass Spectrom. 2014 May;25(5):729-41. doi: 10.1007/s13361-013-0823-6. Epub 2014 Feb 19.PMID: 24549892  
70. Tu X, Palczewski K. The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements. J Struct Biol. 2014 Apr;186(1):86-94. doi: 10.1016/j.jsb.2014.02.001. Epub 2014 Feb 12.PMID: 24531000  
71. Sundermeier TR, Vinberg F, Mustafi D, Bai X, Kefalov VJ, Palczewski K. R9AP overexpression alters phototransduction kinetics in iCre75 mice. Invest Ophthalmol Vis Sci. 2014 Mar 6;55(3):1339-47. doi: 10.1167/iovs.13-13564.PMID: 24526444  
72. Chen Y, Jastrzebska B, Cao P, Zhang J, Wang B, Sun W, Yuan Y, Feng Z, Palczewski K. Inherent instability of the retinitis pigmentosa P23H mutant opsin. J Biol Chem. 2014 Mar 28;289(13):9288-303. doi: 10.1074/jbc.M114.551713. Epub 2014 Feb 10.PMID: 24515108  
73. Wu X, Yu G, Luo C, Maeda A, Zhang N, Sun D, Zhou Z, Puntel A, Palczewski K, Lu ZR. Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration. ACS Nano. 2014 Jan 28;8(1):153-61. doi: 10.1021/nn4054107. Epub 2013 Dec 20.PMID: 24350906  
74. Bolze CS, Helbling RE, Owen RL, Pearson AR, Pompidor G, Dworkowski F, Fuchs MR, Furrer J, Golczak M, Palczewski K, Cascella M, Stocker A. Human cellular retinaldehyde-binding protein has secondary thermal 9-cis-retinal isomerase activity. J Am Chem Soc. 2014 Jan 8;136(1):137-46. doi: 10.1021/ja411366w. Epub 2013 Dec 20.PMID: 24328211  
75. Chen Y, Palczewska G, Mustafi D, Golczak M, Dong Z, Sawada O, Maeda T, Maeda A, Palczewski K. Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. J Clin Invest. 2013 Dec;123(12):5119-34. doi: 10.1172/JCI69076. Epub 2013 Nov 15.PMID: 24231350  
76. Sakami S, Kolesnikov AV, Kefalov VJ, Palczewski K. P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet. 2014 Apr 1;23(7):1723-41. doi: 10.1093/hmg/ddt561. Epub 2013 Nov 7.PMID: 24214395  
77. Kevany BM, Tsybovsky Y, Campuzano ID, Schnier PD, Engel A, Palczewski K. Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells. J Biol Chem. 2013 Dec 20;288(51):36272-84. doi: 10.1074/jbc.M113.520700. Epub 2013 Nov 6.PMID: 24196967  
78. Salom D, Padayatti PS, Palczewski K. Crystallization of G protein-coupled receptors. Methods Cell Biol. 2013;117:451-68. doi: 10.1016/B978-0-12-408143-7.00024-4.PMID: 24143992  
79. Maeda T, Lee MJ, Palczewska G, Marsili S, Tesar PJ, Palczewski K, Takahashi M, Maeda A. Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo. J Biol Chem. 2013 Nov 29;288(48):34484-93. doi: 10.1074/jbc.M113.518571. Epub 2013 Oct 15.PMID: 24129572  
80. Amengual J, Widjaja-Adhi MAK, Rodriguez-Santiago S, Hessel S, Golczak M, Palczewski K, von Lintig J. Two carotenoid oxygenases contribute to mammalian provitamin A metabolism. J Biol Chem. 2013 Nov 22;288(47):34081-34096. doi: 10.1074/jbc.M113.501049. Epub 2013 Oct 8.PMID: 24106281  
81. Du Y, Veenstra A, Palczewski K, Kern TS. Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16586-91. doi: 10.1073/pnas.1314575110. Epub 2013 Sep 25.PMID: 24067647  
82. Sharma R, Yin L, Geng Y, Merigan WH, Palczewska G, Palczewski K, Williams DR, Hunter JJ. In vivo two-photon imaging of the mouse retina. Biomed Opt Express. 2013 Jul 9;4(8):1285-93. doi: 10.1364/BOE.4.001285. eCollection 2013.PMID: 24009992  
83. Helbling RE, Bolze CS, Golczak M, Palczewski K, Stocker A, Cascella M. Cellular retinaldehyde binding protein-different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates. J Phys Chem B. 2013 Sep 19;117(37):10719-29. doi: 10.1021/jp405410t. Epub 2013 Sep 10.PMID: 23964907 
84. Mustafi D, Kevany BM, Genoud C, Bai X, Palczewski K. Photoreceptor phagocytosis is mediated by phosphoinositide signaling. FASEB J. 2013 Nov;27(11):4585-95. doi: 10.1096/fj.13-237537. Epub 2013 Aug 2.PMID: 23913857  
85. Kiser PD, Golczak M, Palczewski K. Chemistry of the retinoid (visual) cycle. Chem Rev. 2014 Jan 8;114(1):194-232. doi: 10.1021/cr400107q. Epub 2013 Jul 11.PMID: 23905688  Review. No abstract available. 
86. Sui X, Kiser PD, Lintig Jv, Palczewski K. Structural basis of carotenoid cleavage: from bacteria to mammals. Arch Biochem Biophys. 2013 Nov 15;539(2):203-13. doi: 10.1016/j.abb.2013.06.012. Epub 2013 Jul 1.PMID: 23827316  Review. 
87. Kowatz T, Babino D, Kiser P, Palczewski K, von Lintig J. Characterization of human β,β-carotene-15,15′-monooxygenase (BCMO1) as a soluble monomeric enzyme. Arch Biochem Biophys. 2013 Nov 15;539(2):214-22. doi: 10.1016/j.abb.2013.05.007. Epub 2013 May 29.PMID: 23727499  
88. Palczewski K, Orban T. From atomic structures to neuronal functions of g protein-coupled receptors. Annu Rev Neurosci. 2013 Jul 8;36:139-64. doi: 10.1146/annurev-neuro-062012-170313. Epub 2013 May 15.PMID: 23682660  Review. 
89. Palczewski K, Kiser PD. Biochemistry. As good as chocolate. Science. 2013 May 3;340(6132):562-3. doi: 10.1126/science.1238521.PMID: 23641106  No abstract available. 
90. Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem. 2013 May 24;288(21):15326-41. doi: 10.1074/jbc.M112.448712. Epub 2013 Apr 9.PMID: 23572532  
91. Mustafi D, Kevany BM, Bai X, Maeda T, Sears JE, Khalil AM, Palczewski K. Evolutionarily conserved long intergenic non-coding RNAs in the eye. Hum Mol Genet. 2013 Aug 1;22(15):2992-3002. doi: 10.1093/hmg/ddt156. Epub 2013 Apr 4.PMID: 23562822  
92. Tsybovsky Y, Orban T, Molday RS, Taylor D, Palczewski K. Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. Structure. 2013 May 7;21(5):854-60. doi: 10.1016/j.str.2013.03.001. Epub 2013 Apr 4.PMID: 23562398  
93. Tian M, Zallocchi M, Wang W, Chen CK, Palczewski K, Delimont D, Cosgrove D, Peng YW. Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors. PLoS One. 2013;8(3):e58832. doi: 10.1371/journal.pone.0058832. Epub 2013 Mar 28.PMID: 23555598  
94. Jastrzebska B, Ringler P, Palczewski K, Engel A. The rhodopsin-transducin complex houses two distinct rhodopsin molecules. J Struct Biol. 2013 May;182(2):164-72. doi: 10.1016/j.jsb.2013.02.014. Epub 2013 Feb 28.PMID: 23458690  
95. Yan J, Kaur S, DeLucia M, Hao C, Mehrens J, Wang C, Golczak M, Palczewski K, Gronenborn AM, Ahn J, Skowronski J. Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem. 2013 Apr 12;288(15):10406-17. doi: 10.1074/jbc.M112.443796. Epub 2013 Feb 20.PMID: 23426366  
96. Padayatti PS, Wang L, Gupta S, Orban T, Sun W, Salom D, Jordan SR, Palczewski K, Chance MR. A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Mol Cell Proteomics. 2013 May;12(5):1259-71. doi: 10.1074/mcp.M112.025536. Epub 2013 Feb 1.PMID: 23378516  
97. Jastrzebska B, Salom D, Jin H, Cao P, Sun W, Palczewski K, Feng Z. Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans. Methods Enzymol. 2013;520:239-56. doi: 10.1016/B978-0-12-391861-1.00011-3.PMID: 23332703  
98. Jastrzebska B, Orban T, Golczak M, Engel A, Palczewski K. Asymmetry of the rhodopsin dimer in complex with transducin. FASEB J. 2013 Apr;27(4):1572-84. doi: 10.1096/fj.12-225383. Epub 2013 Jan 9.PMID: 23303210  
99. Maeda A, Palczewski K. Retinal degeneration in animal models with a defective visual cycle. Drug Discov Today Dis Models. 2013 Winter;10(4):e163-e172. doi: 10.1016/j.ddmod.2014.01.001.PMID: 25210527  
100. Vahedi-Faridi A, Jastrzebska B, Palczewski K, Engel A. 3D imaging and quantitative analysis of small solubilized membrane proteins and their complexes by transmission electron microscopy. Microscopy (Oxf). 2013 Feb;62(1):95-107. doi: 10.1093/jmicro/dfs091. Epub 2012 Dec 23.PMID: 23267047  
101. Latek D, Modzelewska A, Trzaskowski B, Palczewski K, Filipek S. G protein-coupled receptors–recent advances. Acta Biochim Pol. 2012;59(4):515-29. Epub 2012 Dec 18.PMID: 23251911  Review. 
102. Maeda T, Dong Z, Jin H, Sawada O, Gao S, Utkhede D, Monk W, Palczewska G, Palczewski K. QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles. Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):455-66. doi: 10.1167/iovs.12-11152.PMID: 23249702  
103. Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest. 2013 Jan;123(1):121-37. doi: 10.1172/JCI66176. Epub 2012 Dec 10.PMID: 23221340  
104. Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2747-56. doi: 10.1073/pnas.1212025109. Epub 2012 Sep 24.PMID: 23012475  
105. Gao SQ, Maeda T, Okano K, Palczewski K. A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids. Invest Ophthalmol Vis Sci. 2012 Sep 19;53(10):6314-23. doi: 10.1167/iovs.12-10279.PMID: 22918645  
106. Tu X, Palczewski K. Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration. J Struct Biol. 2012 Dec;180(3):439-46. doi: 10.1016/j.jsb.2012.07.011. Epub 2012 Aug 7.PMID: 22892318  
107. Mustafi D, Maeda T, Kohno H, Nadeau JH, Palczewski K. Inflammatory priming predisposes mice to age-related retinal degeneration. J Clin Invest. 2012 Aug;122(8):2989-3001. doi: 10.1172/JCI64427. Epub 2012 Jul 17.PMID: 22797304  
108. Hachiya A, Marchand B, Kirby KA, Michailidis E, Tu X, Palczewski K, Ong YT, Li Z, Griffin DT, Schuckmann MM, Tanuma J, Oka S, Singh K, Kodama EN, Sarafianos SG. HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors. J Biol Chem. 2012 Aug 24;287(35):29988-99. doi: 10.1074/jbc.M112.351551. Epub 2012 Jul 2.PMID: 22761416  
109. Amengual J, Golczak M, Palczewski K, von Lintig J.Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein. J Biol Chem. 2012 Jul 13;287(29):24216-27. doi: 10.1074/jbc.M112.353979. Epub 2012 May 27.PMID: 22637576  
110. Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J Biol Chem. 2012 Jul 6;287(28):23790-807. doi: 10.1074/jbc.M112.361550. Epub 2012 May 17.PMID: 22605381  
111. Orban T, Jastrzebska B, Gupta S, Wang B, Miyagi M, Chance MR, Palczewski K. Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein. Structure. 2012 May 9;20(5):826-40. doi: 10.1016/j.str.2012.03.017.PMID: 22579250  
112. Sexton TJ, Golczak M, Palczewski K, Van Gelder RN. Melanopsin is highly resistant to light and chemical bleaching in vivo. J Biol Chem. 2012 Jun 15;287(25):20888-97. doi: 10.1074/jbc.M111.325969. Epub 2012 Apr 30.PMID: 22547062  
113. Orban T, Huang CC, Homan KT, Jastrzebska B, Tesmer JJ, Palczewski K. Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1).Biochemistry. 2012 Apr 24;51(16):3404-11. doi: 10.1021/bi300295y. Epub 2012 Apr 11.PMID: 22480180  
114. Sundermeier TR, Palczewski K. The physiological impact of microRNA gene regulation in the retina. Cell Mol Life Sci. 2012 Aug;69(16):2739-50. doi: 10.1007/s00018-012-0976-7. Epub 2012 Mar 30.PMID: 22460583  Review. 
115. Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. J Biol Chem. 2012 Apr 13;287(16):13356-70. doi: 10.1074/jbc.M112.347518. Epub 2012 Feb 22.PMID: 22356908  
116. Padayatti P, Palczewska G, Sun W, Palczewski K, Salom D. Imaging of protein crystals with two-photon microscopy. Biochemistry. 2012 Feb 28;51(8):1625-37. doi: 10.1021/bi201682q. Epub 2012 Feb 16.PMID: 22324807  
117. Okano K, Maeda A, Chen Y, Chauhan V, Tang J, Palczewska G, Sakai T, Tsuneoka H, Palczewski K, Maeda T. Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage. J Neurochem. 2012 Apr;121(1):146-56. doi: 10.1111/j.1471-4159.2012.07647.x. Epub 2012 Feb 9.PMID: 22220722  
118. Maeda A, Golczak M, Chen Y, Okano K, Kohno H, Shiose S, Ishikawa K, Harte W, Palczewska G, Maeda T, Palczewski K. Primary amines protect against retinal degeneration in mouse models of retinopathies. Nat Chem Biol. 2011 Dec 25;8(2):170-8. doi: 10.1038/nchembio.759.PMID: 22198730  
119. Chen Y, Okano K, Maeda T, Chauhan V, Golczak M, Maeda A, Palczewski K. Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem. 2012 Feb 10;287(7):5059-69. doi: 10.1074/jbc.M111.315432. Epub 2011 Dec 19.PMID: 22184108  
120. Salom D, Wang B, Dong Z, Sun W, Padayatti P, Jordan S, Salon JA, Palczewski K. Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells. Biochemistry. 2012 Jan 10;51(1):214-24. doi: 10.1021/bi201707v. Epub 2011 Dec 20.PMID: 22145929  
121. Salom D, Cao P, Sun W, Kramp K, Jastrzebska B, Jin H, Feng Z, Palczewski K. Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans. FASEB J. 2012 Feb;26(2):492-502. doi: 10.1096/fj.11-197780. Epub 2011 Nov 16.PMID: 22090314  
122. Cao P, Sun W, Kramp K, Zheng M, Salom D, Jastrzebska B, Jin H, Palczewski K, Feng Z. Light-sensitive coupling of rhodopsin and melanopsin to G(i/o) and G(q) signal transduction in Caenorhabditis elegans. FASEB J. 2012 Feb;26(2):480-91. doi: 10.1096/fj.11-197798. Epub 2011 Nov 16.PMID: 22090313  
123. Palczewski K. J Chemistry and biology of vision. Biol Chem. 2012 Jan 13;287(3):1612-9. doi: 10.1074/jbc.R111.301150. Epub 2011 Nov 10.PMID: 22074921  Review. 
124. Palczewski K. Thematic minireview series on focus on vision. J Biol Chem. 2012 Jan 13;287(3):1610-1. doi: 10.1074/jbc.R111.322347. Epub 2011 Nov 10.PMID: 22074916  No abstract available. 
125. Baker BY, Palczewski K. Detergents stabilize the conformation of phosphodiesterase 6. Biochemistry. 2011 Nov 8;50(44):9520-31. doi: 10.1021/bi2014695. Epub 2011 Oct 14.PMID: 21978030  
126. Salon JA, Lodowski DT, Palczewski K. The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev. 2011 Dec;63(4):901-37. doi: 10.1124/pr.110.003350.PMID: 21969326  Review. 
127. Jastrzebska B, Ringler P, Lodowski DT, Moiseenkova-Bell V, Golczak M, Müller SA, Palczewski K, Engel A.Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization. J Struct Biol. 2011 Dec;176(3):387-94. doi: 10.1016/j.jsb.2011.08.016. Epub 2011 Sep 6.PMID: 21925606  
128. Maeda T, Perusek L, Amengual J, Babino D, Palczewski K, von Lintig J. Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis. Mol Pharmacol. 2011 Nov;80(5):943-52. doi: 10.1124/mol.111.074732. Epub 2011 Aug 23.PMID: 21862692  
129. Zhu Q, Sun W, Okano K, Chen Y, Zhang N, Maeda T, Palczewski K. Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina. J Biol Chem. 2011 Sep 9;286(36):31749-60. doi: 10.1074/jbc.M111.259028. Epub 2011 Jul 15.PMID: 21768104  
130. Tsybovsky Y, Wang B, Quazi F, Molday RS, Palczewski K. Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4. Biochemistry. 2011 Aug 16;50(32):6855-66. doi: 10.1021/bi200774w. Epub 2011 Jul 8.PMID: 21721517  
131. Mustafi D, Kevany BM, Genoud C, Okano K, Cideciyan AV, Sumaroka A, Roman AJ, Jacobson SG, Engel A, Adams MD, Palczewski K. Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB J. 2011 Sep;25(9):3157-76. doi: 10.1096/fj.11-186767. Epub 2011 Jun 9.PMID: 21659555  
132. Peshenko IV, Olshevskaya EV, Savchenko AB, Karan S, Palczewski K, Baehr W, Dizhoor AM. Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. Biochemistry. 2011 Jun 28;50(25):5590-600. doi: 10.1021/bi200491b. Epub 2011 Jun 6.PMID: 21598940  
133. Jastrzebska B, Palczewski K, Golczak M. Role of bulk water in hydrolysis of the rhodopsin chromophore. J Biol Chem. 2011 May 27;286(21):18930-7. doi: 10.1074/jbc.M111.234583. Epub 2011 Apr 1.PMID: 21460218  
134. Orban T, Palczewska G, Palczewski K. Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues. J Biol Chem. 2011 May 13;286(19):17248-58. doi: 10.1074/jbc.M110.195198. Epub 2011 Mar 25.PMID: 21454509  
135. Bereta G, Palczewski K. Heterogeneous N-terminal acylation of retinal proteins results from the retina’s unusual lipid metabolism. Biochemistry. 2011 May 10;50(18):3764-76. doi: 10.1021/bi200245t. Epub 2011 Apr 11.PMID: 21449552  
136. Kiser PD, Golczak M, Maeda A, Palczewski K. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012 Jan;1821(1):137-51. doi: 10.1016/j.bbalip.2011.03.005. Epub 2011 Apr 5.PMID: 21447403  Review. 
137. Mustafi D, Avishai A, Avishai N, Engel A, Heuer A, Palczewski K. Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. J Neurosci Methods. 2011 May 15;198(1):70-6. doi: 10.1016/j.jneumeth.2011.03.013. Epub 2011 Mar 23.PMID: 21439323  
138. Jastrzebska B, Debinski A, Filipek S, Palczewski K.Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function. Prog Lipid Res. 2011 Jul;50(3):267-77. doi: 10.1016/j.plipres.2011.03.002. Epub 2011 Mar 22.PMID: 21435354  Review. 
139. Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J Biol Chem. 2011 Apr 29;286(17):15543-55. doi: 10.1074/jbc.M111.228551. Epub 2011 Mar 7.PMID: 21383019  
140. Hunter JJ, Masella B, Dubra A, Sharma R, Yin L, Merigan WH, Palczewska G, Palczewski K, Williams DR. Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy. Biomed Opt Express. 2010 Dec 17;2(1):139-48. doi: 10.1364/BOE.2.000139.PMID: 21326644  
141. Palczewski K. Focus on vision: 3 decades of remarkable contributions to biology and medicine. FASEB J. 2011 Feb;25(2):439-43. doi: 10.1096/fj.11-0202ufm.PMID: 21282210  
142. Huang CC, Orban T, Jastrzebska B, Palczewski K, Tesmer JJ. Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. Biochemistry. 2011 Mar 22;50(11):1940-9. doi: 10.1021/bi101606e. Epub 2011 Feb 22.PMID: 21265573  
143. Sakami S, Maeda T, Bereta G, Okano K, Golczak M, Sumaroka A, Roman AJ, Cideciyan AV, Jacobson SG, Palczewski K. Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem. 2011 Mar 25;286(12):10551-67. doi: 10.1074/jbc.M110.209759. Epub 2011 Jan 11.PMID: 21224384  
144. Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA. J Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. Biol Chem. 2011 Feb 18;286(7):5607-13. doi: 10.1074/jbc.M110.188433. Epub 2010 Dec 15.PMID: 21159775  
145. Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J. A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J. 2011 Mar;25(3):948-59. doi: 10.1096/fj.10-173906. Epub 2010 Nov 24.PMID: 21106934  
146. Palczewska G, Maeda T, Imanishi Y, Sun W, Chen Y, Williams DR, Piston DW, Maeda A, Palczewski K. Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Nat Med. 2010 Dec;16(12):1444-9. doi: 10.1038/nm.2260. Epub 2010 Nov 14.PMID: 21076393  
147. Palczewski K. Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Arch Ophthalmol. 2010 Nov;128(11):1483-5. doi: 10.1001/archophthalmol.2010.245.PMID: 21060052  No abstract available. 
148. Lodowski DT, Palczewski K, Miyagi M. Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange. Biochemistry. 2010 Nov 9;49(44):9425-7. doi: 10.1021/bi101502v. Epub 2010 Oct 15.PMID: 20939497  
149. Li H, Palczewski K, Baehr W, Clagett-Dame M. Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. Biol Reprod. 2011 Feb;84(2):336-41. doi: 10.1095/biolreprod.110.086157. Epub 2010 Sep 29.PMID: 20881313  
150. Huang J, Xu Z, Wang D, Ogata CM, Palczewski K, Lee X, Young NM. Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. Glycobiology. 2010 Dec;20(12):1643-53. doi: 10.1093/glycob/cwq118. Epub 2010 Sep 8.PMID: 20826825  
151. Tsybovsky Y, Molday RS, Palczewski K. The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol. 2010;703:105-25. doi: 10.1007/978-1-4419-5635-4_8.PMID: 20711710  Review. 
152. Golczak M, Palczewski K. An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase. J Biol Chem. 2010 Sep 17;285(38):29217-22. doi: 10.1074/jbc.M110.152314. Epub 2010 Jul 12.PMID: 20628054  
153. Pulagam LP, Palczewski K. Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane. J Biol Chem. 2010 Sep 17;285(38):29446-56. doi: 10.1074/jbc.M110.151407. Epub 2010 Jul 13.PMID: 20628051  
154. Goc A, Chami M, Lodowski DT, Bosshart P, Moiseenkova-Bell V, Baehr W, Engel A, Palczewski K. Structural characterization of the rod cGMP phosphodiesterase 6. J Mol Biol. 2010 Aug 20;401(3):363-73. doi: 10.1016/j.jmb.2010.06.044. Epub 2010 Jul 1.PMID: 20600113  
155. Lobo GP, Amengual J, Li HN, Golczak M, Bonet ML, Palczewski K, von Lintig J. Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner. J Biol Chem. 2010 Sep 3;285(36):27891-9. doi: 10.1074/jbc.M110.132571. Epub 2010 Jun 23.PMID: 20573961  
156. Imanishi Y, Palczewski K. Visualization of retinoid storage and trafficking by two-photon microscopy. Methods Mol Biol. 2010;652:247-61. doi: 10.1007/978-1-60327-325-1_14.PMID: 20552433  
157. Golczak M, Bereta G, Maeda A, Palczewski K. Molecular biology and analytical chemistry methods used to probe the retinoid cycle. Methods Mol Biol. 2010;652:229-45. doi: 10.1007/978-1-60327-325-1_13.PMID: 20552432  
158. Palczewski K. Oligomeric forms of G protein-coupled receptors (GPCRs). Trends Biochem Sci. 2010 Nov;35(11):595-600. doi: 10.1016/j.tibs.2010.05.002. Epub 2010 Jun 9.PMID: 20538466  
159. Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 Jul 15;26(14):1804-5. doi: 10.1093/bioinformatics/btq264. Epub 2010 May 25.PMID: 20501551  
160. Palczewski K. Retinoids for treatment of retinal diseases. Trends Pharmacol Sci. 2010 Jun;31(6):284-95. doi: 10.1016/j.tips.2010.03.001.PMID: 20435355  Review. 
161. Jastrzebska B, Tsybovsky Y, Palczewski K. Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J. 2010 Apr 28;428(1):1-10. doi: 10.1042/BJ20100270.PMID: 20423327  Review. 
162. Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8428-33. doi: 10.1073/pnas.1000640107. Epub 2010 Apr 19.PMID: 20404157  
163. Kiser PD, Palczewski K. Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res. 2010 Sep;29(5):428-42. doi: 10.1016/j.preteyeres.2010.03.002. Epub 2010 Mar 19.PMID: 20304090  Review. 
164. von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci. 2010 Jul;35(7):400-10. doi: 10.1016/j.tibs.2010.01.005. Epub 2010 Feb 24.PMID: 20188572  Review. 
165. Cao P, Yuan Y, Pehek EA, Moise AR, Huang Y, Palczewski K, Feng Z. Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. 
166. PLoS One. 2010 Feb 19;5(2):e9312. doi: 10.1371/journal.pone.0009312.PMID: 20174477  
167. Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, Palczewski K. Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure. 2010 Jan 13;18(1):116-26. doi: 10.1016/j.str.2009.11.008.PMID: 20152158  
168. Kevany BM, Palczewski K. Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda). 2010 Feb;25(1):8-15. doi: 10.1152/physiol.00038.2009.PMID: 20134024  Review. 
169. Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010 Mar 26;285(13):9667-9682. doi: 10.1074/jbc.M109.063941. Epub 2010 Jan 25.PMID: 20100834  
170. Lobo GP, Hessel S, Eichinger A, Noy N, Moise AR, Wyss A, Palczewski K, von Lintig J. ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production. FASEB J. 2010 Jun;24(6):1656-66. doi: 10.1096/fj.09-150995. Epub 2010 Jan 8.PMID: 20061533  
171. Orban T, Gupta S, Palczewski K, Chance MR. Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. Biochemistry. 2010 Feb 9;49(5):827-34. doi: 10.1021/bi901889t.PMID: 20047303  Review. 
172. O’Byrne SM, Kako Y, Deckelbaum RJ, Hansen IH, Palczewski K, Goldberg IJ, Blaner WS. Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E862-70. doi: 10.1152/ajpendo.00491.2009. Epub 2009 Dec 29.PMID: 20040693  
173. Moise AR, Lobo GP, Erokwu B, Wilson DL, Peck D, Alvarez S, Domínguez M, Alvarez R, Flask CA, de Lera AR, von Lintig J, Palczewski K. Increased adiposity in the retinol saturase-knockout mouse. FASEB J. 2010 Apr;24(4):1261-70. doi: 10.1096/fj.09-147207. Epub 2009 Nov 25.PMID: 19940255  
174. Bereta G, Wang B, Kiser PD, Baehr W, Jang GF, Palczewski K. A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. J Biol Chem. 2010 Jan 15;285(3):1899-908. doi: 10.1074/jbc.M109.061713. Epub 2009 Nov 9.PMID: 19901021  
175. Kiser PD, Lorimer GH, Palczewski K. Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt 10):967-71. doi: 10.1107/S1744309109032928. Epub 2009 Sep 18.PMID: 19851000  
176. Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17325-30. doi: 10.1073/pnas.0906600106. Epub 2009 Oct 5.PMID: 19805034  
177. Moise AR, Alvarez S, Domínguez M, Alvarez R, Golczak M, Lobo GP, von Lintig J, de Lera AR, Palczewski K. Activation of retinoic acid receptors by dihydroretinoids. Mol Pharmacol. 2009 Dec;76(6):1228-37. doi: 10.1124/mol.109.060038. Epub 2009 Sep 21.PMID: 19770350  
178. Angel TE, Gupta S, Jastrzebska B, Palczewski K, Chance MR. Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14367-72. doi: 10.1073/pnas.0901074106. Epub 2009 Aug 13.PMID: 19706523  
179. Maeda A, Golczak M, Maeda T, Palczewski K. Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5435-43. doi: 10.1167/iovs.09-3944. Epub 2009 Jun 24.PMID: 19553623  
180. Mustafi D, Engel AH, Palczewski K. Structure of cone photoreceptors. Prog Retin Eye Res. 2009 Jul;28(4):289-302. doi: 10.1016/j.preteyeres.2009.05.003. Epub 2009 Jun 6.PMID: 19501669  Review. 
181. Maeda T, Maeda A, Matosky M, Okano K, Roos S, Tang J, Palczewski K. Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4917-25. doi: 10.1167/iovs.09-3581. Epub 2009 Jun 3.PMID: 19494204  
182. Maeda A, Shiose S, Okano K, Matosky M, Maeda T, Palczewski K. WITHDRAWN: Retinol dehydrogenase RDH11 protects the mouse retina from light-induced degeneration. Invest Ophthalmol Vis Sci. 2009 Aug 13. doi: 10.1167/iovs.09-3749. Online ahead of print.PMID: 19458342 
183. Angel TE, Chance MR, Palczewski K. Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8555-60. doi: 10.1073/pnas.0903545106. Epub 2009 May 11.PMID: 19433801  
184. Tian G, Zhou Y, Hajkova D, Miyagi M, Dinculescu A, Hauswirth WW, Palczewski K, Geng R, Alagramam KN, Isosomppi J, Sankila EM, Flannery JG, Imanishi Y. Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton. J Biol Chem. 2009 Jul 10;284(28):18980-93. doi: 10.1074/jbc.M109.003160. Epub 2009 May 7.PMID: 19423712  
185. Geng R, Geller SF, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Jones SM, Wright CG, Melki S, Imanishi Y, Palczewski K, Alagramam KN, Flannery JG. Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Hum Mol Genet. 2009 Aug 1;18(15):2748-60. doi: 10.1093/hmg/ddp210. Epub 2009 May 3.PMID: 19414487  
186. Jastrzebska B, Goc A, Golczak M, Palczewski K. Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex. Biochemistry. 2009 Jun 16;48(23):5159-70. doi: 10.1021/bi900284x.PMID: 19413332  
187. Maeda T, Maeda A, Casadesus G, Palczewski K, Margaron P. Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4368-78. doi: 10.1167/iovs.09-3700. Epub 2009 Apr 30.PMID: 19407008  
188. Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 2009 May 26;48(20):4294-304. doi: 10.1021/bi900417b.PMID: 19348429  
189. Lodowski DT, Palczewski K. Chemokine receptors and other G protein-coupled receptors. Curr Opin HIV AIDS. 2009 Mar;4(2):88-95. doi: 10.1097/COH.0b013e3283223d8d.PMID: 19339946  Review. 
190. Maeda T, Cideciyan AV, Maeda A, Golczak M, Aleman TS, Jacobson SG, Palczewski K. Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. Hum Mol Genet. 2009 Jun 15;18(12):2277-87. doi: 10.1093/hmg/ddp163. Epub 2009 Apr 1.PMID: 19339306  
191. Maeda A, Maeda T, Golczak M, Chou S, Desai A, Hoppel CL, Matsuyama S, Palczewski K. Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J Biol Chem. 2009 May 29;284(22):15173-83. doi: 10.1074/jbc.M900322200. Epub 2009 Mar 20.PMID: 19304658  
192. Lodowski DT, Angel TE, Palczewski K. Comparative analysis of GPCR crystal structures. Photochem Photobiol. 2009 Mar-Apr;85(2):425-30. doi: 10.1111/j.1751-1097.2008.00516.x. Epub 2009 Jan 19.PMID: 19192200  Review. 
193. Baehr W, Palczewski K. Focus on molecules: guanylate cyclase-activating proteins (GCAPs). Exp Eye Res. 2009 Jun 15;89(1):2-3. doi: 10.1016/j.exer.2008.12.016. Epub 2009 Jan 8.PMID: 19162008  No abstract available. 
194. Cideciyan AV, Swider M, Aleman TS, Tsybovsky Y, Schwartz SB, Windsor EA, Roman AJ, Sumaroka A, Steinberg JD, Jacobson SG, Stone EM, Palczewski K. ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet. 2009 Mar 1;18(5):931-41. doi: 10.1093/hmg/ddn421. Epub 2008 Dec 12.PMID: 19074458  
195. Salom D, Wu N, Sun W, Dong Z, Palczewski K, Jordan S, Salon JA. Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry. 2008 Dec 16;47(50):13296-307. doi: 10.1021/bi8018527.PMID: 19053287 
196. Li C, Chan J, Haeseleer F, Mikoshiba K, Palczewski K, Ikura M, Ames JB. Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. J Biol Chem. 2009 Jan 23;284(4):2472-81. doi: 10.1074/jbc.M806513200. Epub 2008 Nov 13.PMID: 19008222  
197. Goc A, Angel TE, Jastrzebska B, Wang B, Wintrode PL, Palczewski K. Different properties of the native and reconstituted heterotrimeric G protein transducin. Biochemistry. 2008 Nov 25;47(47):12409-19. doi: 10.1021/bi8015444.PMID: 18975915  
198. Mustafi D, Palczewski K. Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors.Mol Pharmacol. 2009 Jan;75(1):1-12. doi: 10.1124/mol.108.051938. Epub 2008 Oct 22.PMID: 18945819  Review. 
199. Jastrzebska B, Golczak M, Fotiadis D, Engel A, Palczewski K. Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin. FASEB J. 2009 Feb;23(2):371-81. doi: 10.1096/fj.07-114835. Epub 2008 Sep 30.PMID: 18827025  
200. Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K. Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry. 2008 Sep 16;47(37):9856-65. doi: 10.1021/bi800905v. Epub 2008 Aug 23.PMID: 18722466  
201. Maeda T, Maeda A, Leahy P, Saperstein DA, Palczewski K. Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):322-33. doi: 10.1167/iovs.08-2301. Epub 2008 Aug 15.PMID: 18708622  
202. Jiang L, Wheaton D, Bereta G, Zhang K, Palczewski K, Birch DG, Baehr W. A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Res. 2008 Oct;48(23-24):2425-32. doi: 10.1016/j.visres.2008.07.016. Epub 2008 Sep 16.PMID: 18706439  
203. Maeda A, Maeda T, Golczak M, Palczewski K. Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem. 2008 Sep 26;283(39):26684-93. doi: 10.1074/jbc.M804505200. Epub 2008 Jul 25.PMID: 18658157  
204. Imanishi Y, Sun W, Maeda T, Maeda A, Palczewski K. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem. 2008 Sep 5;283(36):25091-102. doi: 10.1074/jbc.M802981200. Epub 2008 Jul 7.PMID: 18606814  
205. Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci. 2008 Apr 9;28(15):4008-14. doi: 10.1523/JNEUROSCI.0317-08.2008.PMID: 18400900  
206. Wongsiriroj N, Piantedosi R, Palczewski K, Goldberg IJ, Johnston TP, Li E, Blaner WS. The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem. 2008 May 16;283(20):13510-9. doi: 10.1074/jbc.M800777200. Epub 2008 Mar 17.PMID: 18348983  
207. Stephen R, Filipek S, Palczewski K, Sousa MC. Ca2+ -dependent regulation of phototransduction. Photochem Photobiol. 2008 Jul-Aug;84(4):903-10. doi: 10.1111/j.1751-1097.2008.00323.x. Epub 2008 Mar 12.PMID: 18346093  Review. 
208. Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ. Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem. 2008 May 16;283(20):14053-62. doi: 10.1074/jbc.M708974200. Epub 2008 Mar 13.PMID: 18339619  
209. Müller DJ, Wu N, Palczewski K. Vertebrate membrane proteins: structure, function, and insights from biophysical approaches. Pharmacol Rev. 2008 Mar;60(1):43-78. doi: 10.1124/pr.107.07111. Epub 2008 Mar 5.PMID: 18321962  Review. 
210. Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y, Palczewski K, von Lintig J. RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metab. 2008 Mar;7(3):258-68. doi: 10.1016/j.cmet.2008.01.009.PMID: 18316031  
211. Sapra KT, Park PS, Palczewski K, Muller DJ. Mechanical properties of bovine rhodopsin and bacteriorhodopsin: possible roles in folding and function. Langmuir. 2008 Feb 19;24(4):1330-7. doi: 10.1021/la702299z.PMID: 18266338  
212. Golczak M, Maeda A, Bereta G, Maeda T, Kiser PD, Hunzelmann S, von Lintig J, Blaner WS, Palczewski K. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem. 2008 Apr 11;283(15):9543-54. doi: 10.1074/jbc.M708982200. Epub 2008 Jan 14.PMID: 18195010  
213. Baehr W, Palczewski K. Guanylate cyclase-activating proteins and retina disease. Subcell Biochem. 2007;45:71-91. doi: 10.1007/978-1-4020-6191-2_4.PMID: 18193635 Review. 
214. Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. J Am Chem Soc. 2008 Jan 30;130(4):1154-5. doi: 10.1021/ja710487q. Epub 2008 Jan 8.PMID: 18179220  No abstract available. 
215. Kim YK, Wassef L, Hamberger L, Piantedosi R, Palczewski K, Blaner WS, Quadro L. Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. J Biol Chem. 2008 Feb 29;283(9):5611-21. doi: 10.1074/jbc.M708885200. Epub 2007 Dec 19.PMID: 18093970  
216. Maeda A, Maeda T, Sun W, Zhang H, Baehr W, Palczewski K. Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19565-70. doi: 10.1073/pnas.0707477104. Epub 2007 Nov 28.PMID: 18048336  
217. Whorton MR, Jastrzebska B, Park PS, Fotiadis D, Engel A, Palczewski K, Sunahara RK. Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem. 2008 Feb 15;283(7):4387-94. doi: 10.1074/jbc.M703346200. Epub 2007 Nov 22.PMID: 18033822  
218. Stephen R, Bereta G, Golczak M, Palczewski K, Sousa MC. Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1. Structure. 2007 Nov;15(11):1392-402. doi: 10.1016/j.str.2007.09.013.PMID: 17997965  
219. Schonthaler HB, Lampert JM, Isken A, Rinner O, Mader A, Gesemann M, Oberhauser V, Golczak M, Biehlmaier O, Palczewski K, Neuhauss SC, von Lintig J. Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci. 2007 Oct;26(7):1940-9. doi: 10.1111/j.1460-9568.2007.05801.x. Epub 2007 Sep 14.PMID: 17868371  
220. Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K.Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15123-8. doi: 10.1073/pnas.0706367104. Epub 2007 Sep 11.PMID: 17848510  
221. Park PS, Lodowski DT, Palczewski K. Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. Annu Rev Pharmacol Toxicol. 2008;48:107-41. doi: 10.1146/annurev.pharmtox.48.113006.094630.PMID: 17848137  Review. 
222. Lodowski DT, Salom D, Le Trong I, Teller DC, Ballesteros JA, Palczewski K, Stenkamp RE. Reprint of “Crystal packing analysis of Rhodopsin crystals” [J. Struct. Biol. 158 (2007) 455-462]. J Struct Biol. 2007 Aug;159(2):253-60. doi: 10.1016/S1047-8477(07)00166-9.PMID: 17660064 
223. Li N, Salom D, Zhang L, Harris T, Ballesteros JA, Golczak M, Jastrzebska B, Palczewski K, Kurahara C, Juan T, Jordan S, Salon JA. Heterologous expression of the adenosine A1 receptor in transgenic mouse retina. Biochemistry. 2007 Jul 17;46(28):8350-9. doi: 10.1021/bi700154h. Epub 2007 Jun 20.PMID: 17580959 
224. Kiser PD, Lodowski DT, Palczewski K. Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):457-61. doi: 10.1107/S1744309107020295. Epub 2007 May 5.PMID: 17554162  
225. Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics. 2007 May 30;8:177. doi: 10.1186/1471-2105-8-177.PMID: 17537266  
226. Nickell S, Park PS, Baumeister W, Palczewski K. J Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography. Cell Biol. 2007 Jun 4;177(5):917-25. doi: 10.1083/jcb.200612010. Epub 2007 May 29.PMID: 17535966  
227. Sun W, Gerth C, Maeda A, Lodowski DT, Van Der Kraak L, Saperstein DA, Héon E, Palczewski K. Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. Vision Res. 2007 Jul;47(15):2055-66. doi: 10.1016/j.visres.2007.04.005. Epub 2007 May 21.PMID: 17512964  
228. Moise AR, Noy N, Palczewski K, Blaner WS. Delivery of retinoid-based therapies to target tissues. Biochemistry. 2007 Apr 17;46(15):4449-58. doi: 10.1021/bi7003069. Epub 2007 Mar 23.PMID: 17378589  Review. 
229. Lodowski DT, Salom D, Le Trong I, Teller DC, Ballesteros JA, Palczewski K, Stenkamp RE. Crystal packing analysis of Rhodopsin crystals. J Struct Biol. 2007 Jun;158(3):455-62. doi: 10.1016/j.jsb.2007.01.017. Epub 2007 Feb 9.PMID: 17374491  
230. Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev. 2007 Mar;59(1):5-13. doi: 10.1124/pr.59.1.5.PMID: 17329545 Review. 
231. Park PS, Sapra KT, Koliński M, Filipek S, Palczewski K, Muller DJ. Stabilizing effect of Zn2+ in native bovine rhodopsin. J Biol Chem. 2007 Apr 13;282(15):11377-85. doi: 10.1074/jbc.M610341200. Epub 2007 Feb 15.PMID: 17303564  
232. Ridge KD, Palczewski K. Visual rhodopsin sees the light: structure and mechanism of G protein signaling. J Biol Chem. 2007 Mar 30;282(13):9297-9301. doi: 10.1074/jbc.R600032200. Epub 2007 Feb 8.PMID: 17289671 Free article. Review. 
233. Baehr W, Karan S, Maeda T, Luo DG, Li S, Bronson JD, Watt CB, Yau KW, Frederick JM, Palczewski K. The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem. 2007 Mar 23;282(12):8837-47. doi: 10.1074/jbc.M610369200. Epub 2007 Jan 25.PMID: 17255100  
234. Moise AR, Isken A, Domínguez M, de Lera AR, von Lintig J, Palczewski K. Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol. Biochemistry. 2007 Feb 20;46(7):1811-20. doi: 10.1021/bi062147u. Epub 2007 Jan 25.PMID: 17253779  
235. Moise AR, Golczak M, Imanishi Y, Palczewski K. Topology and membrane association of lecithin: retinol acyltransferase. J Biol Chem. 2007 Jan 19;282(3):2081-90. doi: 10.1074/jbc.M608315200. Epub 2006 Nov 19.PMID: 17114808 Free article. 
236. Isken A, Holzschuh J, Lampert JM, Fischer L, Oberhauser V, Palczewski K, von Lintig J Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryo. J Biol Chem. 2007 Jan 12;282(2):1144-51. doi: 10.1074/jbc.M609109200. Epub 2006 Nov 10.PMID: 17098734 Free article. 
237. Palczewski K, Hofmann KP, Baehr W. Rhodopsin–advances and perspectives. Vision Res. 2006 Dec;46(27):4425-6. doi: 10.1016/j.visres.2006.10.009.PMID: 17098052 Free article. No abstract available. 
238. Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. doi: 10.1073/pnas.0608022103. Epub 2006 Oct 23.PMID: 17060607  
239. Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K. Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem. 2006 Dec 8;281(49):37697-704. doi: 10.1074/jbc.M608375200. Epub 2006 Oct 10.PMID: 17032653  
240. Maeda A, Maeda T, Palczewski K. Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4540-6. doi: 10.1167/iovs.06-0215.PMID: 17003450  
241. Travis GH, Golczak M, Moise AR, Palczewski K. Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol. 2007;47:469-512. doi: 10.1146/annurev.pharmtox.47.120505.105225.PMID: 16968212  Review. 
242. Modzelewska A, Filipek S, Palczewski K, Park PS. Arrestin interaction with rhodopsin: conceptual models. Cell Biochem Biophys. 2006;46(1):1-15. doi: 10.1385/CBB:46:1:1.PMID: 16943619 
243. Domínguez M, Alvarez R, Pérez M, Palczewski K, de Lera AR. The role of the 11-cis-retinal ring methyl substituents in visual pigment formation. Chembiochem. 2006 Nov;7(11):1815-25. doi: 10.1002/cbic.200600207.PMID: 16941510 
244. Haire SE, Pang J, Boye SL, Sokal I, Craft CM, Palczewski K, Hauswirth WW, Semple-Rowland SL. Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3745-53. doi: 10.1167/iovs.06-0086.PMID: 16936082  
245. Maeda A, Maeda T, Golczak M, Imanishi Y, Leahy P, Kubota R, Palczewski K. Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Mol Pharmacol. 2006 Oct;70(4):1220-9. doi: 10.1124/mol.106.026823. Epub 2006 Jul 12.PMID: 16837623  
246. Salom D, Le Trong I, Pohl E, Ballesteros JA, Stenkamp RE, Palczewski K, Lodowski DT. Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals. J Struct Biol. 2006 Dec;156(3):497-504. doi: 10.1016/j.jsb.2006.05.003. Epub 2006 Jun 2.PMID: 16837211 
247. Tu DC, Owens LA, Anderson L, Golczak M, Doyle SE, McCall M, Menaker M, Palczewski K, Van Gelder RN. Inner retinal photoreception independent of the visual retinoid cycle. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10426-10431. doi: 10.1073/pnas.0600917103. Epub 2006 Jun 20.PMID: 16788071  
248. Palczewski K. G protein-coupled receptor rhodopsin. Annu Rev Biochem. 2006;75:743-67. doi: 10.1146/annurev.biochem.75.103004.142743.PMID: 16756510  Review. 
249. Zhu L, Imanishi Y, Filipek S, Alekseev A, Jastrzebska B, Sun W, Saperstein DA, Palczewski K. Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. J Biol Chem. 2006 Aug 4;281(31):22289-22298. doi: 10.1074/jbc.M602664200. Epub 2006 May 31.PMID: 16737970  
250. Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, Sokal I, Palczewski K, Jacobson SG, Semple-Rowland SL. Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med. 2006 Jun;3(6):e201. doi: 10.1371/journal.pmed.0030201. Epub 2006 May 23.PMID: 16700630  
251. Stephen R, Palczewski K, Sousa MC. The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. J Mol Biol. 2006 Jun 2;359(2):266-75. doi: 10.1016/j.jmb.2006.03.042. Epub 2006 Apr 3.PMID: 16626734  
252. Fotiadis D, Jastrzebska B, Philippsen A, Müller DJ, Palczewski K, Engel A. Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Curr Opin Struct Biol. 2006 Apr;16(2):252-9. doi: 10.1016/j.sbi.2006.03.013. Epub 2006 Mar 29.PMID: 16567090 Review. 
253. Maeda A, Maeda T, Imanishi Y, Golczak M, Moise AR, Palczewski K. Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters. Biochemistry. 2006 Apr 4;45(13):4210-9. doi: 10.1021/bi052382x.PMID: 16566595  
254. Tanuj Sapra K, Park PS, Filipek S, Engel A, Müller DJ, Palczewski K. Detecting molecular interactions that stabilize native bovine rhodopsin. J Mol Biol. 2006 Apr 21;358(1):255-69. doi: 10.1016/j.jmb.2006.02.008. Epub 2006 Feb 20.PMID: 16519899 
255. Jastrzebska B, Fotiadis D, Jang GF, Stenkamp RE, Engel A, Palczewski K. Functional and structural characterization of rhodopsin oligomers. J Biol Chem. 2006 Apr 28;281(17):11917-22. doi: 10.1074/jbc.M600422200. Epub 2006 Feb 22.PMID: 16495215  
256. Mansoor SE, Palczewski K, Farrens DL. Rhodopsin self-associates in asolectin liposomes. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3060-5. doi: 10.1073/pnas.0511010103. Epub 2006 Feb 21.PMID: 16492772  
257. Park PS, Palczewski K. Imaging G protein-coupled receptor islands. Nat Chem Biol. 2005 Sep;1(4):184-5. doi: 10.1038/nchembio0905-184.PMID: 16408027 No abstract available. 
258. Zhang L, Salom D, He J, Okun A, Ballesteros J, Palczewski K, Li N. Expression of functional G protein-coupled receptors in photoreceptors of transgenic Xenopus laevis. Biochemistry. 2005 Nov 8;44(44):14509-18. doi: 10.1021/bi051386z.PMID: 16262251 
259. Batten ML, Imanishi Y, Tu DC, Doan T, Zhu L, Pang J, Glushakova L, Moise AR, Baehr W, Van Gelder RN, Hauswirth WW, Rieke F, Palczewski K. Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med. 2005 Nov;2(11):e333. doi: 10.1371/journal.pmed.0020333. Epub 2005 Nov 1.PMID: 16250670  
260. Maeda T, Lem J, Palczewski K, Haeseleer F. A critical role of CaBP4 in the cone synapse. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4320-7. doi: 10.1167/iovs.05-0478.PMID: 16249514  
261. Acland GM, Aguirre GD, Bennett J, Aleman TS, Cideciyan AV, Bennicelli J, Dejneka NS, Pearce-Kelling SE, Maguire AM, Palczewski K, Hauswirth WW, Jacobson SG. Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther. 2005 Dec;12(6):1072-82. doi: 10.1016/j.ymthe.2005.08.008. Epub 2005 Oct 14.PMID: 16226919  
262. Golczak M, Imanishi Y, Kuksa V, Maeda T, Kubota R, Palczewski K. Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle. J Biol Chem. 2005 Dec 23;280(51):42263-73. doi: 10.1074/jbc.M509351200. Epub 2005 Oct 10.PMID: 16216874 Free article. 
263. Wingard JN, Chan J, Bosanac I, Haeseleer F, Palczewski K, Ikura M, Ames JB. Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels. J Biol Chem. 2005 Nov 11;280(45):37461-70. doi: 10.1074/jbc.M508541200. Epub 2005 Sep 7.PMID: 16147998  
264. O’Byrne SM, Wongsiriroj N, Libien J, Vogel S, Goldberg IJ, Baehr W, Palczewski K, Blaner WS. Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J Biol Chem. 2005 Oct 21;280(42):35647-57. doi: 10.1074/jbc.M507924200. Epub 2005 Aug 22.PMID: 16115871  
265. Bartl FJ, Fritze O, Ritter E, Herrmann R, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. Partial agonism in a G Protein-coupled receptor: role of the retinal ring structure in rhodopsin activation. J Biol Chem. 2005 Oct 7;280(40):34259-67. doi: 10.1074/jbc.M505260200. Epub 2005 Jul 18.PMID: 16027155 Free article. 
266. Park PS, Palczewski K. Diversifying the repertoire of G protein-coupled receptors through oligomerization. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8793-4. doi: 10.1073/pnas.0504016102. Epub 2005 Jun 13.PMID: 15956197  No abstract available. 
267. Stenkamp RE, Teller DC, Palczewski K. Rhodopsin: a structural primer for G-protein coupled receptors. Arch Pharm (Weinheim). 2005 Jun;338(5-6):209-16. doi: 10.1002/ardp.200400995.PMID: 15952240 Review. 
268. Golczak M, Kuksa V, Maeda T, Moise AR, Palczewski K. Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8162-7. doi: 10.1073/pnas.0503318102. Epub 2005 May 25.PMID: 15917330  
269. Moise AR, Kuksa V, Blaner WS, Baehr W, Palczewski K. Metabolism and transactivation activity of 13,14-dihydroretinoic acid. J Biol Chem. 2005 Jul 29;280(30):27815-25. doi: 10.1074/jbc.M503520200. Epub 2005 May 23.PMID: 15911617  
270. Jacobson SG, Aleman TS, Cideciyan AV, Sumaroka A, Schwartz SB, Windsor EA, Traboulsi EI, Heon E, Pittler SJ, Milam AH, Maguire AM, Palczewski K, Stone EM, Bennett J. Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6177-82. doi: 10.1073/pnas.0500646102. Epub 2005 Apr 18.PMID: 15837919  
271. Moise AR, von Lintig J, Palczewski K. Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids. Trends Plant Sci. 2005 Apr;10(4):178-86. doi: 10.1016/j.tplants.2005.02.006.PMID: 15817419 Review. 
272. Sokal I, Dupps WJ, Grassi MA, Brown J Jr, Affatigato LM, Roychowdhury N, Yang L, Filipek S, Palczewski K, Stone EM, Baehr W. A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD). Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1124-32. doi: 10.1167/iovs.04-1431.PMID: 15790869  
273. Suda K, Filipek S, Palczewski K, Engel A, Fotiadis D. The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. Mol Membr Biol. 2004 Nov-Dec;21(6):435-46. doi: 10.1080/09687860400020291.PMID: 15764373  
274. Maeda A, Maeda T, Imanishi Y, Kuksa V, Alekseev A, Bronson JD, Zhang H, Zhu L, Sun W, Saperstein DA, Rieke F, Baehr W, Palczewski K. Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005 May 13;280(19):18822-32. doi: 10.1074/jbc.M501757200. Epub 2005 Mar 8.PMID: 15755727  
275. Maeda A, Crabb JW, Palczewski K. Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Biochemistry. 2005 Jan 18;44(2):480-9. doi: 10.1021/bi048016f.PMID: 15641772  
276. Kim TS, Maeda A, Maeda T, Heinlein C, Kedishvili N, Palczewski K, Nelson PS. Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. J Biol Chem. 2005 Mar 11;280(10):8694-704. doi: 10.1074/jbc.M413172200. Epub 2005 Jan 4.PMID: 15634683  
277. Park PS, Filipek S, Wells JW, Palczewski K. Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry. 2004 Dec 21;43(50):15643-56. doi: 10.1021/bi047907k.PMID: 15595821  Review. 
278. Nishiguchi KM, Sokal I, Yang L, Roychowdhury N, Palczewski K, Berson EL, Dryja TP, Baehr W. A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration. Invest Ophthalmol Vis Sci. 2004 Nov;45(11):3863-70. doi: 10.1167/iovs.04-0590.PMID: 15505030  
279. astrzebska B, Maeda T, Zhu L, Fotiadis D, Filipek S, Engel A, Stenkamp RE, Palczewski K. Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem. 2004 Dec 24;279(52):54663-75. doi: 10.1074/jbc.M408691200. Epub 2004 Oct 15.PMID: 15489507  
280. Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W. Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). J Mol Evol. 2004 Aug;59(2):204-217. doi: 10.1007/s00239-004-2614-y.PMID: 15486694  
281. Tu DC, Batten ML, Palczewski K, Van Gelder RN. Nonvisual photoreception in the chick iris. Science. 2004 Oct 1;306(5693):129-31. doi: 10.1126/science.1101484.PMID: 15459395 
282. Zhu L, Jang GF, Jastrzebska B, Filipek S, Pearce-Kelling SE, Aguirre GD, Stenkamp RE, Acland GM, Palczewski K. A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor. J Biol Chem. 2004 Dec 17;279(51):53828-39. doi: 10.1074/jbc.M408472200. Epub 2004 Sep 30.PMID: 15459196  
283. Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci. 2004 Oct;7(10):1079-87. doi: 10.1038/nn1320. Epub 2004 Sep 26.PMID: 15452577  
284. Subramanian L, Crabb JW, Cox J, Durussel I, Walker TM, van Ginkel PR, Bhattacharya S, Dellaria JM, Palczewski K, Polans AS. Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma. Biochemistry. 2004 Sep 7;43(35):11175-86. doi: 10.1021/bi048848d.PMID: 15366927  
285. Moise AR, Kuksa V, Imanishi Y, Palczewski K. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. J Biol Chem. 2004 Nov 26;279(48):50230-42. doi: 10.1074/jbc.M409130200. Epub 2004 Sep 9.PMID: 15358783  
286. Liang Y, Fotiadis D, Maeda T, Maeda A, Modzelewska A, Filipek S, Saperstein DA, Engel A, Palczewski K. Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem. 2004 Nov 12;279(46):48189-96. doi: 10.1074/jbc.M408362200. Epub 2004 Aug 26.PMID: 15337746  
287. Mammen A, Simpson PJ, Nighorn A, Imanishi Y, Palczewski K, Ronnett GV, Moon C. Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1131-9. doi: 10.1016/j.bbrc.2004.07.123.PMID: 15336960 
288. Palczewski K, Sokal I, Baehr W. Guanylate cyclase-activating proteins: structure, function, and diversity. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1123-30. doi: 10.1016/j.bbrc.2004.07.122.PMID: 15336959 Review. 
289. Imanishi Y, Gerke V, Palczewski K. Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. J Cell Biol. 2004 Aug 16;166(4):447-53. doi: 10.1083/jcb.200405110.PMID: 15314061  Review. 
290. Filipek S, Krzysko KA, Fotiadis D, Liang Y, Saperstein DA, Engel A, Palczewski K. A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci. 2004 Jun;3(6):628-38. doi: 10.1039/b315661c. Epub 2004 Feb 27.PMID: 15170495 
291. Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. The G protein-coupled receptor rhodopsin in the native membrane. FEBS Lett. 2004 Apr 30;564(3):281-288. doi: 10.1016/S0014-5793(04)00194-2.PMID: 15111110  
292. Aleman TS, Jacobson SG, Chico JD, Scott ML, Cheung AY, Windsor EA, Furushima M, Redmond TM, Bennett J, Palczewski K, Cideciyan AV. Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1259-71. doi: 10.1167/iovs.03-1230.PMID: 15037595 
293. Imanishi Y, Batten ML, Piston DW, Baehr W, Palczewski K. Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol. 2004 Feb 2;164(3):373-83. doi: 10.1083/jcb.200311079. Epub 2004 Jan 26.PMID: 14745001  
294. Sokal I, Alekseev A, Palczewski K. Photoreceptor guanylate cyclase variants: cGMP production under control. Acta Biochim Pol. 2003;50(4):1075-95.PMID: 14739996  Review. 
295. Batten ML, Imanishi Y, Maeda T, Tu DC, Moise AR, Bronson D, Possin D, Van Gelder RN, Baehr W, Palczewski K. Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem. 2004 Mar 12;279(11):10422-32. doi: 10.1074/jbc.M312410200. Epub 2003 Dec 18.PMID: 14684738  
296. Teller DC, Stenkamp RE, Palczewski K. Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transfer. FEBS Lett. 2003 Nov 27;555(1):151-9. doi: 10.1016/s0014-5793(03)01152-9.PMID: 14630336  
297. Driessen C, Winkens H, Haeseleer F, Palczewski K, Janssen J. Novel targeting strategy for generating mouse models with defects in the retinoid cycle. Vision Res. 2003 Dec;43(28):3075-9. doi: 10.1016/s0042-6989(03)00483-8.PMID: 14611944 Free article. 
298. Kuksa V, Imanishi Y, Batten M, Palczewski K, Moise AR. Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization. Vision Res. 2003 Dec;43(28):2959-81. doi: 10.1016/s0042-6989(03)00482-6.PMID: 14611933 Free article. 
299. Baehr W, Wu SM, Bird AC, Palczewski K. The retinoid cycle and retina disease. Vision Res. 2003 Dec;43(28):2957-8. doi: 10.1016/j.visres.2003.10.001.PMID: 14611932 Free article. No abstract available. 
300. Ridge KD, Abdulaev NG, Sousa M, Palczewski K. Phototransduction: crystal clear. Trends Biochem Sci. 2003 Sep;28(9):479-87. doi: 10.1016/S0968-0004(03)00172-5.PMID: 13678959 Review. 
301. Marmor MF, Haeseleer F, Palczewski K. Albipunctate retinopathy with cone dysfunction and no abnormality in the RDH5 or RLBP1 genes. Retina. 2003 Aug;23(4):543-6. doi: 10.1097/00006982-200308000-00018.PMID: 12972770 No abstract available. 
302. Ballesteros J, Palczewski K. G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin. Curr Opin Drug Discov Devel. 2001 Sep;4(5):561-74.PMID: 12825452  Review. 
303. Maeda T, Imanishi Y, Palczewski K. Rhodopsin phosphorylation: 30 years later. Prog Retin Eye Res. 2003 Jul;22(4):417-34. doi: 10.1016/s1350-9462(03)00017-x.PMID: 12742390 Review. 
304. Maeda T, Van Hooser JP, Driessen CA, Filipek S, Janssen JJ, Palczewski K. Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo. J Neurochem. 2003 May;85(4):944-56. doi: 10.1046/j.1471-4159.2003.01741.x.PMID: 12716426  
305. Schädel SA, Heck M, Maretzki D, Filipek S, Teller DC, Palczewski K, Hofmann KP. Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin. J Biol Chem. 2003 Jul 4;278(27):24896-24903. doi: 10.1074/jbc.M302115200. Epub 2003 Apr 21.PMID: 12707280  
306. Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, Engel A. Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem. 2003 Jun 13;278(24):21655-21662. doi: 10.1074/jbc.M302536200. Epub 2003 Mar 27.PMID: 12663652  
307. Mirzadegan T, Benkö G, Filipek S, Palczewski K. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry. 2003 Mar 18;42(10):2759-67. doi: 10.1021/bi027224+.PMID: 12627940  Review. 
308. Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2290-5. doi: 10.1073/pnas.0435715100. Epub 2003 Feb 24.PMID: 12601165  
309. Haeseleer F, Palczewski K. Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Adv Exp Med Biol. 2002;514:303-17. doi: 10.1007/978-1-4615-0121-3_18.PMID: 12596929 Review. 
310. Filipek S, Teller DC, Palczewski K, Stenkamp R. The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. Annu Rev Biophys Biomol Struct. 2003;32:375-97. doi: 10.1146/annurev.biophys.32.110601.142520. Epub 2003 Feb 5.PMID: 12574068  Review. 
311. Noorwez SM, Kuksa V, Imanishi Y, Zhu L, Filipek S, Palczewski K, Kaushal S. Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa. J Biol Chem. 2003 Apr 18;278(16):14442-14450. doi: 10.1074/jbc.M300087200. Epub 2003 Feb 1.PMID: 12566452  
312. Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature. 2003 Jan 9;421(6919):127-8. doi: 10.1038/421127a.PMID: 12520290 No abstract available. 
313. Sokal I, Hu G, Liang Y, Mao M, Wensel TG, Palczewski K. Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475. J Biol Chem. 2003 Mar 7;278(10):8316-25. doi: 10.1074/jbc.M211782200. Epub 2002 Dec 23.PMID: 12499365 Free article. 
314. Filipek S, Stenkamp RE, Teller DC, Palczewski K. G protein-coupled receptor rhodopsin: a prospectus. Annu Rev Physiol. 2003;65:851-79. doi: 10.1146/annurev.physiol.65.092101.142611. Epub 2002 May 1.PMID: 12471166  Review. 
315. Heck M, Schädel SA, Maretzki D, Bartl FJ, Ritter E, Palczewski K, Hofmann KP. Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II. J Biol Chem. 2003 Jan 31;278(5):3162-9. doi: 10.1074/jbc.M209675200. Epub 2002 Nov 9.PMID: 12427735  
316. Stenkamp RE, Filipek S, Driessen CA, Teller DC, Palczewski K. Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors. Biochim Biophys Acta. 2002 Oct 11;1565(2):168-82. doi: 10.1016/s0005-2736(02)00567-9.PMID: 12409193 Free article. Review. 
317. Stenkamp RE, Teller DC, Palczewski K. Crystal structure of rhodopsin: a G-protein-coupled receptor. Chembiochem. 2002 Oct 4;3(10):963-7. doi: 10.1002/1439-7633(20021004)3:10<963::AID-CBIC963>3.0.CO;2-9.PMID: 12362360 Review. No abstract available. 
318. Haeseleer F, Jang GF, Imanishi Y, Driessen CAGG, Matsumura M, Nelson PS, Palczewski K. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. J Biol Chem. 2002 Nov 22;277(47):45537-45546. doi: 10.1074/jbc.M208882200. Epub 2002 Sep 10.PMID: 12226107  
319. Maeda A, Maeda T, Ohguro H, Palczewski K, Sato N. Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. Eur J Immunol. 2002 Aug;32(8):2300-7. doi: 10.1002/1521-4141(200208)32:8<2300::AID-IMMU2300>3.0.CO;2-7.PMID: 12209643 Free article. 
320. Kuksa V, Bartl F, Maeda T, Jang GF, Ritter E, Heck M, Preston Van Hooser J, Liang Y, Filipek S, Gelb MH, Hofmann KP, Palczewski K. Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals. J Biol Chem. 2002 Nov 1;277(44):42315-42324. doi: 10.1074/jbc.M206014200. Epub 2002 Aug 9.PMID: 12176994  
321. Yang J, McBride S, Mak DO, Vardi N, Palczewski K, Haeseleer F, Foskett JK. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7711-6. doi: 10.1073/pnas.102006299.PMID: 12032348  
322. Howes KA, Pennesi ME, Sokal I, Church-Kopish J, Schmidt B, Margolis D, Frederick JM, Rieke F, Palczewski K, Wu SM, Detwiler PB, Baehr W. GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J. 2002 Apr 2;21(7):1545-54. doi: 10.1093/emboj/21.7.1545.PMID: 11927539  
323. Van Hooser JP, Liang Y, Maeda T, Kuksa V, Jang GF, He YG, Rieke F, Fong HK, Detwiler PB, Palczewski K. Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem. 2002 May 24;277(21):19173-82. doi: 10.1074/jbc.M112384200. Epub 2002 Mar 15.PMID: 11897783  
324. Lee A, Westenbroek RE, Haeseleer F, Palczewski K, Scheuer T, Catterall WA. Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Nat Neurosci. 2002 Mar;5(3):210-7. doi: 10.1038/nn805.PMID: 11865310  
325. Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002 Jan;15(1):63-78. doi: 10.1046/j.0953-816x.2001.01835.x.PMID: 11860507  
326. Haeseleer F, Imanishi Y, Sokal I, Filipek S, Palczewski K. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun. 2002 Jan 18;290(2):615-23. doi: 10.1006/bbrc.2001.6228.PMID: 11785943 Review. 
327. Palczewski K. Crystal Structure of Rhodopsin: Implication for Vision and Beyond. Mechanisms of Acti. ScientificWorldJournal. 2002 Jan 5;2:106-107. doi: 10.1100/tsw.2002.50. eCollection 2002.PMID: 29973825  No abstract available. 
328. Sokal I, Alekseev A, Baehr W, Haeseleer F, Palczewski K. Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators. Biochemistry. 2002 Jan 8;41(1):251-7. doi: 10.1021/bi015606u.PMID: 11772023  
329. Haeseleer F, Imanishi Y, Saperstein DA, Palczewski K. Gene transfer mediated by recombinant baculovirus into mouse eye. Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3294-300.PMID: 11726636  
330. Sokal I, Pulvermüller A, Buczyłko J, Hofmann KP, Palczewski K. Rhodopsin and its kinase. Methods Enzymol. 2002;343:578-600. doi: 10.1016/s0076-6879(02)43159-x.PMID: 11665593  No abstract available. 
331. McBee JK, Van Hooser JP, Jang GF, Palczewski K. Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. J Biol Chem. 2001 Dec 21;276(51):48483-93. doi: 10.1074/jbc.M105840200. Epub 2001 Oct 16.PMID: 11604395  
332. Li N, Sokal I, Bronson JD, Palczewski K, Baehr W. Identification of functional regions of guanylate cyclase-activating protein 1 (GCAP1) using GCAP1/GCIP chimeras. Biol Chem. 2001 Aug;382(8):1179-88. doi: 10.1515/BC.2001.148.PMID: 11592399 
333. Sokal I, Li N, Klug CS, Filipek S, Hubbell WL, Baehr W, Palczewski K. Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies. J Biol Chem. 2001 Nov 16;276(46):43361-73. doi: 10.1074/jbc.M103614200. Epub 2001 Aug 27.PMID: 11524415  
334. Okada T, Palczewski K. Crystal structure of rhodopsin: implications for vision and beyond. Curr Opin Struct Biol. 2001 Aug;11(4):420-6. doi: 10.1016/s0959-440x(00)00227-x.PMID: 11495733 Review. 
335. Mendez A, Burns ME, Sokal I, Dizhoor AM, Baehr W, Palczewski K, Baylor DA, Chen J. Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9948-53. doi: 10.1073/pnas.171308998. Epub 2001 Aug 7.PMID: 11493703  
336. Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry. 2001 Jul 3;40(26):7761-72. doi: 10.1021/bi0155091.PMID: 11425302  Review. No abstract available. 
337. Jang GF, Van Hooser JP, Kuksa V, McBee JK, He YG, Janssen JJ, Driessen CA, Palczewski K. Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. J Biol Chem. 2001 Aug 31;276(35):32456-65. doi: 10.1074/jbc.M104949200. Epub 2001 Jun 20.PMID: 11418621  
338. Yan W, Jang GF, Haeseleer F, Esumi N, Chang J, Kerrigan M, Campochiaro M, Campochiaro P, Palczewski K, Zack DJ. Cloning and characterization of a human beta,beta-carotene-15,15′-dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics. 2001 Mar 1;72(2):193-202. doi: 10.1006/geno.2000.6476.PMID: 11401432 
339. McBee JK, Palczewski K, Baehr W, Pepperberg DR. Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog Retin Eye Res. 2001 Jul;20(4):469-529. doi: 10.1016/s1350-9462(01)00002-7.PMID: 11390257 Review. 
340. Okada T, Ernst OP, Palczewski K, Hofmann KP. Activation of rhodopsin: new insights from structural and biochemical studies. Trends Biochem Sci. 2001 May;26(5):318-24. doi: 10.1016/s0968-0004(01)01799-6.PMID: 11343925 Review. 
341. Jang GF, Kuksa V, Filipek S, Bartl F, Ritter E, Gelb MH, Hofmann KP, Palczewski K. Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein. J Biol Chem. 2001 Jul 13;276(28):26148-53. doi: 10.1074/jbc.M102212200. Epub 2001 Apr 20.PMID: 11316815  
342. Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K. Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. J Biol Chem. 2001 Jun 22;276(25):22287-95. doi: 10.1074/jbc.M011539200. Epub 2001 Apr 5.PMID: 11292825  
343. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Mol Cell Endocrinol. 2001 Jan 22;171(1-2):111-7. doi: 10.1016/s0303-7207(00)00417-2.PMID: 11165019 
344. Cideciyan AV, Haeseleer F, Fariss RN, Aleman TS, Jang GF, Verlinde CLMJ, Marmor MF, Jacobson SG, Palczewski K. Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Vis Neurosci. 2000 Sep-Oct;17(5):667-678. doi: 10.1017/s0952523800175029.PMID: 11153648  
345. Sokal I, Li N, Verlinde CL, Haeseleer F, Baehr W, Palczewski K. Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). Biochim Biophys Acta. 2000 Dec 20;1498(2-3):233-51. doi: 10.1016/s0167-4889(00)00099-9.PMID: 11108966 Free article. 
346. Imamoto Y, Kataoka M, Tokunaga F, Palczewski K. Light-induced conformational changes of rhodopsin probed by fluorescent alexa594 immobilized on the cytoplasmic surface. Biochemistry. 2000 Dec 12;39(49):15225-33. doi: 10.1021/bi0018685.PMID: 11106502  
347. McBee JK, Kuksa V, Alvarez R, de Lera AR, Prezhdo O, Haeseleer F, Sokal I, Palczewski K. Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins. Biochemistry. 2000 Sep 19;39(37):11370-80. doi: 10.1021/bi001061c.PMID: 10985782  
348. Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M. Crystal structure of rhodopsin: A G protein-coupled receptor. Science. 2000 Aug 4;289(5480):739-45. doi: 10.1126/science.289.5480.739.PMID: 10926528 
349. Jang GF, McBee JK, Alekseev AM, Haeseleer F, Palczewski K. Stereoisomeric specificity of the retinoid cycle in the vertebrate retina. J Biol Chem. 2000 Sep 8;275(36):28128-38. doi: 10.1074/jbc.M004488200.PMID: 10871622  
350. Van Hooser JP, Aleman TS, He YG, Cideciyan AV, Kuksa V, Pittler SJ, Stone EM, Jacobson SG, Palczewski K. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8623-8. doi: 10.1073/pnas.150236297.PMID: 10869443  
351. Driessen CA, Winkens HJ, Hoffmann K, Kuhlmann LD, Janssen BP, Van Vugt AH, Van Hooser JP, Wieringa BE, Deutman AF, Palczewski K, Ruether K, Janssen JJ. Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters. Mol Cell Biol. 2000 Jun;20(12):4275-87. doi: 10.1128/MCB.20.12.4275-4287.2000.PMID: 10825191  
352. Mukherjee S, Gurevich VV, Jones JC, Casanova JE, Frank SR, Maizels ET, Bader MF, Kahn RA, Palczewski K, Aktories K, Hunzicker-Dunn M. The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5901-6. doi: 10.1073/pnas.100127097.PMID: 10811902  
353. Okada T, Le Trong I, Fox BA, Behnke CA, Stenkamp RE, Palczewski K. X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. J Struct Biol. 2000 May;130(1):73-80. doi: 10.1006/jsbi.1999.4209.PMID: 10806093 
354. Whitten ME, Yokoyama K, Schieltz D, Ghomashchi F, Lam D, Yates JR 3rd, Palczewski K, Gelb MH. Structural analysis of protein prenyl groups and associated C-terminal modifications. Methods Enzymol. 2000;316:436-51. doi: 10.1016/s0076-6879(00)16741-2.PMID: 10800693  No abstract available. 
355. Haeseleer F, Palczewski K. Short-chain dehydrogenases/reductases in retina. Methods Enzymol. 2000;316:372-83. doi: 10.1016/s0076-6879(00)16736-9.PMID: 10800688 No abstract available. 
356. Saari JC, Garwin GG, Haeseleer F, Jang GF, Palczewski K. Phase partition and high-performance liquid chromatography assays of retinoid dehydrogenases. Methods Enzymol. 2000;316:359-71. doi: 10.1016/s0076-6879(00)16735-7.PMID: 10800687  No abstract available. 
357. Stecher H, Palczewski K. Multienzyme analysis of visual cycle. Methods Enzymol. 2000;316:330-44. doi: 10.1016/s0076-6879(00)16733-3.PMID: 10800685  No abstract available. 
358. Palczewski K, Polans AS, Baehr W, Ames JB. Ca(2+)-binding proteins in the retina: structure, function, and the etiology of human visual diseases. Bioessays. 2000 Apr;22(4):337-50. doi: 10.1002/(SICI)1521-1878(200004)22:4<337::AID-BIES4>3.0.CO;2-Z.PMID: 10723031 Review. 
359. Haeseleer F, Sokal I, Verlinde CL, Erdjument-Bromage H, Tempst P, Pronin AN, Benovic JL, Fariss RN, Palczewski K. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem. 2000 Jan 14;275(2):1247-60. doi: 10.1074/jbc.275.2.1247.PMID: 10625670  
360. Palczewski K, Verlinde CL, Haeseleer F. Molecular mechanism of visual transduction. Novartis Found Symp. 1999;224:191-204; discussion 204-7. doi: 10.1002/9780470515693.ch11.PMID: 10614052 
361. Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 1999 Nov 15;240(1):23-34. doi: 10.1016/s0378-1119(99)00393-5.PMID: 10564809 
362. Stecher H, Prezhdo O, Das J, Crouch RK, Palczewski K. Isomerization of all-trans-9- and 13-desmethylretinol by retinal pigment epithelial cells. Biochemistry. 1999 Oct 12;38(41):13542-50. doi: 10.1021/bi9913294.PMID: 10521261 
363. Palczewski K, Van Hooser JP, Garwin GG, Chen J, Liou GI, Saari JC. Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry. 1999 Sep 14;38(37):12012-9. doi: 10.1021/bi990504d.PMID: 10508404 
364. Zhao X, Yokoyama K, Whitten ME, Huang J, Gelb MH, Palczewski K. A novel form of rhodopsin kinase from chicken retina and pineal gland. FEBS Lett. 1999 Jul 2;454(1-2):115-21. doi: 10.1016/s0014-5793(99)00764-4.PMID: 10413107 Free article. 
365. Sokal I, Otto-Bruc AE, Surgucheva I, Verlinde CL, Wang CK, Baehr W, Palczewski K. Conformational changes in guanylyl cyclase-activating protein 1 (GCAP1) and its tryptophan mutants as a function of calcium concentration. J Biol Chem. 1999 Jul 9;274(28):19829-37. doi: 10.1074/jbc.274.28.19829.PMID: 10391927 Free article. 
366. Ames JB, Dizhoor AM, Ikura M, Palczewski K, Stryer L. Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases. J Biol Chem. 1999 Jul 2;274(27):19329-37. doi: 10.1074/jbc.274.27.19329.PMID: 10383444 Free article. 
367. Mukherjee S, Palczewski K, Gurevich VV, Hunzicker-Dunn M. beta-arrestin-dependent desensitization of luteinizing hormone/choriogonadotropin receptor is prevented by a synthetic peptide corresponding to the third intracellular loop of the receptor. J Biol Chem. 1999 May 7;274(19):12984-9. doi: 10.1074/jbc.274.19.12984.PMID: 10224047 Free article. 
368. Stecher H, Gelb MH, Saari JC, Palczewski K. Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein. J Biol Chem. 1999 Mar 26;274(13):8577-85. doi: 10.1074/jbc.274.13.8577.PMID: 10085092 Free article. 
369. Wolbring G, Baehr W, Palczewski K, Schnetkamp PP. Light inhibition of bovine retinal rod guanylyl cyclase mediated by beta gamma-transducin. Biochemistry. 1999 Mar 2;38(9):2611-6. doi: 10.1021/bi9825596.PMID: 10052930 
370. Haeseleer F, Sokal I, Li N, Pettenati M, Rao N, Bronson D, Wechter R, Baehr W, Palczewski K. Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily. J Biol Chem. 1999 Mar 5;274(10):6526-35. doi: 10.1074/jbc.274.10.6526.PMID: 10037746 Free article. 
371. Sokal I, Haeseleer F, Arendt A, Adman ET, Hargrave PA, Palczewski K. Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1. Biochemistry. 1999 Feb 2;38(5):1387-93. doi: 10.1021/bi982512k.PMID: 9931003 
372. Mukherjee S, Palczewski K, Gurevich V, Benovic JL, Banga JP, Hunzicker-Dunn M. A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):493-8. doi: 10.1073/pnas.96.2.493.PMID: 9892661  
373. Ohguro H, Yoshida N, Shindou H, Crabb JW, Palczewski K, Tsuda M. Identification of a single phosphorylation site within octopus rhodopsin. Photochem Photobiol. 1998 Dec;68(6):824-8.PMID: 9867032 
374. Otto-Bruc AE, Fariss RN, Van Hooser JP, Palczewski K. Phosphorylation of photolyzed rhodopsin is calcium-insensitive in retina permeabilized by alpha-toxin. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15014-9. doi: 10.1073/pnas.95.25.15014.PMID: 9844007  
375. Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. J Biol Chem. 1998 Aug 21;273(34):21790-9. doi: 10.1074/jbc.273.34.21790.PMID: 9705317 Free article. 
376. Sokal I, Li N, Surgucheva I, Warren MJ, Payne AM, Bhattacharya SS, Baehr W, Palczewski K. GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy. Mol Cell. 1998 Jul;2(1):129-33. doi: 10.1016/s1097-2765(00)80121-5.PMID: 9702199 Free article. 
377. Saari JC, Garwin GG, Van Hooser JP, Palczewski K. Reduction of all-trans-retinal limits regeneration of visual pigment in mice. Vision Res. 1998 May;38(10):1325-33. doi: 10.1016/s0042-6989(97)00198-3.PMID: 9667000 Free article. 
378. Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5351-6. doi: 10.1073/pnas.95.9.5351.PMID: 9560279  
379. Moon C, Jaberi P, Otto-Bruc A, Baehr W, Palczewski K, Ronnett GV. Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J Neurosci. 1998 May 1;18(9):3195-205. doi: 10.1523/JNEUROSCI.18-09-03195.1998.PMID: 9547228  
380. Li N, Fariss RN, Zhang K, Otto-Bruc A, Haeseleer F, Bronson D, Qin N, Yamazaki A, Subbaraya I, Milam AH, Palczewski K, Baehr W. Guanylate-cyclase-inhibitory protein is a frog retinal Ca2+-binding protein related to mammalian guanylate-cyclase-activating proteins. Eur J Biochem. 1998 Mar 15;252(3):591-9. doi: 10.1046/j.1432-1327.1998.2520591.x.PMID: 9546678 Free article. 
381. Zhao X, Huang J, Khani SC, Palczewski K. Molecular forms of human rhodopsin kinase (GRK1). J Biol Chem. 1998 Feb 27;273(9):5124-31. doi: 10.1074/jbc.273.9.5124.PMID: 9478965 Free article. 
382. Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K, Baehr W. A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1271-6. doi: 10.1073/pnas.95.3.1271.PMID: 9448321  
383. Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):328-33. doi: 10.1073/pnas.95.1.328.PMID: 9419375  
384. Rudnicka-Nawrot M, Surgucheva I, Hulmes JD, Haeseleer F, Sokal I, Crabb JW, Baehr W, Palczewski K. Changes in biological activity and folding of guanylate cyclase-activating protein 1 as a function of calcium. Biochemistry. 1998 Jan 6;37(1):248-57. doi: 10.1021/bi972306x.PMID: 9425045 
385. Johnson WC Jr, Palczewski K, Gorczyca WA, Riazance-Lawrence JH, Witkowska D, Polans AS. Calcium binding to recoverin: implications for secondary structure and membrane association. Biochim Biophys Acta. 1997 Oct 17;1342(2):164-74. doi: 10.1016/s0167-4838(97)00091-5.PMID: 9392525 
386. Palczewski K. GTP-binding-protein-coupled receptor kinases–two mechanistic models. Eur J Biochem. 1997 Sep 1;248(2):261-9. doi: 10.1111/j.1432-1033.1997.00261.x.PMID: 9346277 Free article. Review. 
387. Palczewski K, Saari JC. Activation and inactivation steps in the visual transduction pathway. Curr Opin Neurobiol. 1997 Aug;7(4):500-4. doi: 10.1016/s0959-4388(97)80029-3.PMID: 9287193 Review. 
388. Pulvermüller A, Maretzki D, Rudnicka-Nawrot M, Smith WC, Palczewski K, Hofmann KP. Functional differences in the interaction of arrestin and its splice variant, p44, with rhodopsin. Biochemistry. 1997 Jul 29;36(30):9253-60. doi: 10.1021/bi970772g.PMID: 9230059 
389. Otto-Bruc A, Fariss RN, Haeseleer F, Huang J, Buczyłko J, Surgucheva I, Baehr W, Milam AH, Palczewski K. Localization of guanylate cyclase-activating protein 2 in mammalian retinas. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4727-32. doi: 10.1073/pnas.94.9.4727.PMID: 9114059  
390. Otto-Bruc A, Buczylko J, Surgucheva I, Subbaraya I, Rudnicka-Nawrot M, Crabb JW, Arendt A, Hargrave PA, Baehr W, Palczewski K. Functional reconstitution of photoreceptor guanylate cyclase with native and mutant forms of guanylate cyclase-activating protein 1. Biochemistry. 1997 Apr 8;36(14):4295-302. doi: 10.1021/bi963000d.PMID: 9100025 
391. Zhao X, Haeseleer F, Fariss RN, Huang J, Baehr W, Milam AH, Palczewski K. Molecular cloning and localization of rhodopsin kinase in the mammalian pineal. Vis Neurosci. 1997 Mar-Apr;14(2):225-32. doi: 10.1017/s0952523800011366.PMID: 9147475 
392. Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, Palczewski K, Baehr W. The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1). Genomics. 1997 Feb 1;39(3):312-22. doi: 10.1006/geno.1996.4513.PMID: 9119368 Free article. 
393. Polans A, Baehr W, Palczewski K. Turned on by Ca2+! The physiology and pathology of Ca(2+)-binding proteins in the retina. Trends Neurosci. 1996 Dec;19(12):547-54. doi: 10.1016/s0166-2236(96)10059-x.PMID: 8961484 Review. 
394. Palczewski K, Smith WC. Splice variants of arrestins. Exp Eye Res. 1996 Nov;63(5):599-602. doi: 10.1006/exer.1996.0151.PMID: 8994364 No abstract available. 
395. Buczyłko J, Saari JC, Crouch RK, Palczewski K. Mechanisms of opsin activation. J Biol Chem. 1996 Aug 23;271(34):20621-30. doi: 10.1074/jbc.271.34.20621.PMID: 8702809 Free article. 
396. Duda T, Goraczniak R, Surgucheva I, Rudnicka-Nawrot M, Gorczyca WA, Palczewski K, Sitaramayya A, Baehr W, Sharma RK. Calcium modulation of bovine photoreceptor guanylate cyclase. Biochemistry. 1996 Jul 2;35(26):8478-82. doi: 10.1021/bi960752z.PMID: 8679607 
397. Langlois G, Chen CK, Palczewski K, Hurley JB, Vuong TM. Responses of the phototransduction cascade to dim light. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4677-82. doi: 10.1073/pnas.93.10.4677.PMID: 8643463  
398. Semple-Rowland SL, Gorczyca WA, Buczylko J, Helekar BS, Ruiz CC, Subbaraya I, Palczewski K, Baehr W. Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina. FEBS Lett. 1996 Apr 29;385(1-2):47-52. doi: 10.1016/0014-5793(96)00345-6.PMID: 8641465 Free article. 
399. Jäger S, Palczewski K, Hofmann KP. Opsin/all-trans-retinal complex activates transducin by different mechanisms than photolyzed rhodopsin. Biochemistry. 1996 Mar 5;35(9):2901-8. doi: 10.1021/bi9524068.PMID: 8608127 
400. Ohguro H, Rudnicka-Nawrot M, Buczyłko J, Zhao X, Taylor JA, Walsh KA, Palczewski K. Structural and enzymatic aspects of rhodopsin phosphorylation. J Biol Chem. 1996 Mar 1;271(9):5215-24. doi: 10.1074/jbc.271.9.5215.PMID: 8617805 Free article. 
401. Smith WC, Adamus G, Van Der Wel H, Timmers A, Palczewski K, Ulshafer RJ, Hargrave PA, McDowell JH. Alligator rhodopsin: sequence and biochemical properties. Exp Eye Res. 1995 Nov;61(5):569-78. doi: 10.1016/s0014-4835(05)80051-x.PMID: 8654500 
402. Gorczyca WA, Polans AS, Surgucheva IG, Subbaraya I, Baehr W, Palczewski K. Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransduction. J Biol Chem. 1995 Sep 15;270(37):22029-36. doi: 10.1074/jbc.270.37.22029.PMID: 7665624 Free article. 
403. Zhao X, Palczewski K, Ohguro H. Mechanism of rhodopsin phosphorylation. Biophys Chem. 1995 Sep-Oct;56(1-2):183-8. doi: 10.1016/0301-4622(95)00031-r.PMID: 7662865 Review. 
404. Ohguro H, Palczewski K. Separation of phospho- and non-phosphopeptides using reverse phase column chromatography. FEBS Lett. 1995 Jul 24;368(3):452-4. doi: 10.1016/0014-5793(95)00710-q.PMID: 7635197 Free article. 
405. Palczewski K, Ohguro H, Premont RT, Inglese J. Rhodopsin kinase autophosphorylation. Characterization of site-specific mutations. J Biol Chem. 1995 Jun 23;270(25):15294-8. doi: 10.1074/jbc.270.25.15294.PMID: 7797516 Free article. 
406. Ohguro H, Van Hooser JP, Milam AH, Palczewski K. Rhodopsin phosphorylation and dephosphorylation in vivo. J Biol Chem. 1995 Jun 16;270(24):14259-62. doi: 10.1074/jbc.270.24.14259.PMID: 7782279 Free article. 
407. Kozak CA, Danciger M, Bowes C, Adamson MC, Palczewski K, Polans AS, Farber DB. Localization of three genes expressed in retina on mouse chromosome 11. Mamm Genome. 1995 Feb;6(2):142-4. doi: 10.1007/BF00303262.PMID: 7767000 No abstract available. 
408. Subbaraya I, Ruiz CC, Helekar BS, Zhao X, Gorczyca WA, Pettenati MJ, Rao PN, Palczewski K, Baehr W. Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. J Biol Chem. 1994 Dec 9;269(49):31080-9.PMID: 7983048 Free article. 
409. Ohguro H, Palczewski K, Walsh KA, Johnson RS. Topographic study of arrestin using differential chemical modifications and hydrogen/deuterium exchange. Protein Sci. 1994 Dec;3(12):2428-34. doi: 10.1002/pro.5560031226.PMID: 7756996  
410. Palczewski K, Jäger S, Buczyłko J, Crouch RK, Bredberg DL, Hofmann KP, Asson-Batres MA, Saari JC. Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction. Biochemistry. 1994 Nov 22;33(46):13741-50. doi: 10.1021/bi00250a027.PMID: 7947785 
411. Morrison RS, Shi E, Kan M, Yamaguchi F, McKeehan W, Rudnicka-Nawrot M, Palczewski K. Inositolhexakisphosphate (InsP6): an antagonist of fibroblast growth factor receptor binding and activity. In Vitro Cell Dev Biol Anim. 1994 Nov;30A(11):783-9. doi: 10.1007/BF02631302.PMID: 7881632 
412. Palczewski K. Structure and functions of arrestins. Protein Sci. 1994 Sep;3(9):1355-61. doi: 10.1002/pro.5560030901.PMID: 7833798  Review. 
413. Palczewski K. Is vertebrate phototransduction solved? New insights into the molecular mechanism of phototransduction. Invest Ophthalmol Vis Sci. 1994 Sep;35(10):3577-81.PMID: 7522225 Review. No abstract available. 
414. Johnson RS, Ohguro H, Palczewski K, Hurley JB, Walsh KA, Neubert TA. Heterogeneous N-acylation is a tissue- and species-specific posttranslational modification. J Biol Chem. 1994 Aug 19;269(33):21067-71.PMID: 8063726 Free article. 
415. Palczewski K, Subbaraya I, Gorczyca WA, Helekar BS, Ruiz CC, Ohguro H, Huang J, Zhao X, Crabb JW, Johnson RS, et al. Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein. Neuron. 1994 Aug;13(2):395-404. doi: 10.1016/0896-6273(94)90355-7.PMID: 7520254 
416. Robinson PR, Buczyłko J, Ohguro H, Palczewski K. Opsins with mutations at the site of chromophore attachment constitutively activate transducin but are not phosphorylated by rhodopsin kinase. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5411-5. doi: 10.1073/pnas.91.12.5411.PMID: 8202499  
417. Smith WC, Milam AH, Dugger D, Arendt A, Hargrave PA, Palczewski K. A splice variant of arrestin. Molecular cloning and localization in bovine retina. J Biol Chem. 1994 Jun 3;269(22):15407-10.PMID: 7515057 Free article. 
418. Gorczyca WA, Gray-Keller MP, Detwiler PB, Palczewski K. Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4014-8. doi: 10.1073/pnas.91.9.4014.PMID: 7909609  
419. Gorczyca WA, Van Hooser JP, Palczewski K. Nucleotide inhibitors and activators of retinal guanylyl cyclase. Biochemistry. 1994 Mar 22;33(11):3217-22. doi: 10.1021/bi00177a011.PMID: 7511001 
420. Polans AS, Palczewski K, Asson-Batres MA, Ohguro H, Witkowska D, Haley TL, Baizer L, Crabb JW. Purification and primary structure of Capl, an S-100-related calcium-binding protein isolated from bovine retina. J Biol Chem. 1994 Feb 25;269(8):6233-40.PMID: 8119967 Free article. 
421. Ohguro H, Johnson RS, Ericsson LH, Walsh KA, Palczewski K. Control of rhodopsin multiple phosphorylation. Biochemistry. 1994 Feb 1;33(4):1023-8. doi: 10.1021/bi00170a022.PMID: 8305429 
422. Palczewski K, Buczylko J, Ohguro H, Annan RS, Carr SA, Crabb JW, Kaplan MW, Johnson RS, Walsh KA. Characterization of a truncated form of arrestin isolated from bovine rod outer segments. Protein Sci. 1994 Feb;3(2):314-24. doi: 10.1002/pro.5560030215.PMID: 8003967  
423. Pulvermüller A, Palczewski K, Hofmann KP. Interaction between photoactivated rhodopsin and its kinase: stability and kinetics of complex formation. Biochemistry. 1993 Dec 28;32(51):14082-8. doi: 10.1021/bi00214a002.PMID: 8260489 
424. Saari JC, Bredberg DL, Garwin GG, Buczyłko J, Wheeler T, Palczewski K. Assays of retinoid dehydrogenases by phase partition. Anal Biochem. 1993 Aug 15;213(1):128-32. doi: 10.1006/abio.1993.1395.PMID: 8238865 
425. Adamus G, Arendt A, Hargrave PA, Heyduk T, Palczewski K. The kinetics of multiphosphorylation of rhodopsin. Arch Biochem Biophys. 1993 Aug 1;304(2):443-7. doi: 10.1006/abbi.1993.1373.PMID: 8346919 
426. Ohguro H, Palczewski K, Ericsson LH, Walsh KA, Johnson RS. Sequential phosphorylation of rhodopsin at multiple sites. Biochemistry. 1993 Jun 1;32(21):5718-24. doi: 10.1021/bi00072a030.PMID: 8504090 
427. Ohguro H, Chiba S, Igarashi Y, Matsumoto H, Akino T, Palczewski K. Beta-arrestin and arrestin are recognized by autoantibodies in sera from multiple sclerosis patients. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3241-5. doi: 10.1073/pnas.90.8.3241.PMID: 8475065  
428. Morrison RS, Giordano S, Yamaguchi F, Hendrickson S, Berger MS, Palczewski K. Basic fibroblast growth factor expression is required for clonogenic growth of human glioma cells. J Neurosci Res. 1993 Apr 1;34(5):502-9. doi: 10.1002/jnr.490340503.PMID: 8478985 
429. Palczewski K, Buczyłko J, Lebioda L, Crabb JW, Polans AS. Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin. J Biol Chem. 1993 Mar 15;268(8):6004-13.PMID: 8383684 Free article. 
430. Gray-Keller MP, Polans AS, Palczewski K, Detwiler PB. The effect of recoverin-like calcium-binding proteins on the photoresponse of retinal rods. Neuron. 1993 Mar;10(3):523-31. doi: 10.1016/0896-6273(93)90339-s.PMID: 8461139 
431. Polans AS, Burton MD, Haley TL, Crabb JW, Palczewski K. Recoverin, but not visinin, is an autoantigen in the human retina identified with a cancer-associated retinopathy. Invest Ophthalmol Vis Sci. 1993 Jan;34(1):81-90.PMID: 8425844 
432. Palczewski K, Buczyłko J, Van Hooser P, Carr SA, Huddleston MJ, Crabb JW. Identification of the autophosphorylation sites in rhodopsin kinase. J Biol Chem. 1992 Sep 15;267(26):18991-8.PMID: 1527025 Free article. 
433. Hofmann KP, Pulvermüller A, Buczyłko J, Van Hooser P, Palczewski K. The role of arrestin and retinoids in the regeneration pathway of rhodopsin. J Biol Chem. 1992 Aug 5;267(22):15701-6.PMID: 1386362 Free article. 
434. Palczewski K, Riazance-Lawrence JH, Johnson WC Jr. Structural properties of arrestin studied by chemical modification and circular dichroism. Biochemistry. 1992 Apr 28;31(16):3902-6. doi: 10.1021/bi00131a003.PMID: 1567843 
435. Palczewski K, Rispoli G, Detwiler PB. The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction. Neuron. 1992 Jan;8(1):117-26. doi: 10.1016/0896-6273(92)90113-r.PMID: 1309646 
436. Palczewski K, Pulvermüller A, Buczylko J, Gutmann C, Hofmann KP. Binding of inositol phosphates to arrestin. FEBS Lett. 1991 Dec 16;295(1-3):195-9. doi: 10.1016/0014-5793(91)81416-6.PMID: 1765153 Free article. 
437. Palczewski K, Pulvermüller A, Buczyłko J, Hofmann KP. Phosphorylated rhodopsin and heparin induce similar conformational changes in arrestin. J Biol Chem. 1991 Oct 5;266(28):18649-54.PMID: 1917988 Free article. 
438. Palczewski K, Benovic JL. G-protein-coupled receptor kinases. Trends Biochem Sci. 1991 Oct;16(10):387-91. doi: 10.1016/0968-0004(91)90157-q.PMID: 1664548 Review. 
439. Lorenz W, Inglese J, Palczewski K, Onorato JJ, Caron MG, Lefkowitz RJ. The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8715-9. doi: 10.1073/pnas.88.19.8715.PMID: 1656454  
440. Palczewski K, Buczyłko J, Imami NR, McDowell JH, Hargrave PA. Role of the carboxyl-terminal region of arrestin in binding to phosphorylated rhodopsin. J Biol Chem. 1991 Aug 15;266(23):15334-9.PMID: 1651326 Free article. 
441. Palczewski K, Buczyłko J, Kaplan MW, Polans AS, Crabb JW. Mechanism of rhodopsin kinase activation. J Biol Chem. 1991 Jul 15;266(20):12949-55.PMID: 2071581 Free article. 
442. Ragazzi E, Shryock J, Palczewski K. Properties of solubilized and reconstituted A1 adenosine receptors from bovine brain. Pharmacol Res. 1991 Jul;24(1):15-23. doi: 10.1016/1043-6618(91)90060-b.PMID: 1946140 
443. Palczewski K, Farber DB, Hargrave PA. Elevated level of protein phosphatase 2A activity in retinas of rd mice. Exp Eye Res. 1991 Jul;53(1):101-5. doi: 10.1016/0014-4835(91)90151-4.PMID: 1652453 
444. Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, Benovic JL. Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry. 1991 May 28;30(21):5118-25. doi: 10.1021/bi00235a002.PMID: 1645191 
445. Buczyłko J, Gutmann C, Palczewski K. Regulation of rhodopsin kinase by autophosphorylation. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2568-72. doi: 10.1073/pnas.88.6.2568.PMID: 2006192  
446. Palczewski K, Hargrave PA. Studies of ligand binding to arrestin. J Biol Chem. 1991 Mar 5;266(7):4201-6.PMID: 1999413 Free article. 
447. Polans AS, Buczyłko J, Crabb J, Palczewski K. A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy. J Cell Biol. 1991 Mar;112(5):981-9. doi: 10.1083/jcb.112.5.981.PMID: 1999465  
448. Adamus G, Zam ZS, Arendt A, Palczewski K, McDowell JH, Hargrave PA. Anti-rhodopsin monoclonal antibodies of defined specificity: characterization and application. Vision Res. 1991;31(1):17-31. doi: 10.1016/0042-6989(91)90069-h.PMID: 2006550 
449. Fukada Y, Kokame K, Okano T, Shichida Y, Yoshizawa T, McDowell JH, Hargrave PA, Palczewski K. Phosphorylation of iodopsin, chicken red-sensitive cone visual pigment. Biochemistry. 1990 Oct 30;29(43):10102-6. doi: 10.1021/bi00495a013.PMID: 2271641 
450. Palczewski K, Kahn N, Hargrave PA. Nucleoside inhibitors of rhodopsin kinase. Biochemistry. 1990 Jul 3;29(26):6276-82. doi: 10.1021/bi00478a024.PMID: 2207073 
451. Lebioda L, Hargrave PA, Palczewski K. X-ray crystal structure of sangivamycin, a potent inhibitor of protein kinases. FEBS Lett. 1990 Jun 18;266(1-2):102-4. doi: 10.1016/0014-5793(90)81517-r.PMID: 2365059 Free article. 
452. Litchfield DW, Arendt A, Lozeman FJ, Krebs EG, Hargrave PA, Palczewski K. Synthetic phosphopeptides are substrates for casein kinase II. FEBS Lett. 1990 Feb 12;261(1):117-20. doi: 10.1016/0014-5793(90)80650-8.PMID: 2307228 Free article. 
453. Palczewski K, Carruth ME, Adamus G, McDowell JH, Hargrave PA. Molecular, enzymatic and functional properties of rhodopsin kinase from rat pineal gland. Vision Res. 1990;30(8):1129-37. doi: 10.1016/0042-6989(90)90170-p.PMID: 2402884 
454. Palczewski K, Arendt A, McDowell JH, Hargrave PA. Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations. Biochemistry. 1989 Oct 31;28(22):8764-70. doi: 10.1021/bi00448a013.PMID: 2605220 
455. Palczewski K, McDowell JH, Jakes S, Ingebritsen TS, Hargrave PA. Regulation of rhodopsin dephosphorylation by arrestin. J Biol Chem. 1989 Sep 25;264(27):15770-3.PMID: 2550422 Free article. 
456. Arendt A, Palczewski K, Moore WT, Caprioli RM, McDowell JH, Hargrave PA. Synthesis of phosphopeptides containing O-phosphoserine or O-phosphothreonine. Int J Pept Protein Res. 1989 Jun;33(6):468-76. doi: 10.1111/j.1399-3011.1989.tb00225.x.PMID: 2506143 
457. Palczewski K, Hargrave PA, McDowell JH, Ingebritsen TS. The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin. Biochemistry. 1989 Jan 24;28(2):415-9. doi: 10.1021/bi00428a001.PMID: 2540796 
458. Palczewski K, McDowell JH, Hargrave PA. Purification and characterization of rhodopsin kinase. J Biol Chem. 1988 Oct 5;263(28):14067-73.PMID: 2844754 Free article. 
459. Palczewski K, McDowell JH, Hargrave PA. Rhodopsin kinase: substrate specificity and factors that influence activity. Biochemistry. 1988 Apr 5;27(7):2306-13. doi: 10.1021/bi00407a010.PMID: 3382623 
460. Palczewski K, Kochman M. Photoaffinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 8-azido-1,N6-ethenoadenosine 5′-triphosphate. Biochemistry. 1987 Jun 16;26(12):3466-71. doi: 10.1021/bi00386a033.PMID: 3651392 
461. Palczewski K, Hargrave PA, Folta EJ, Kochman M. Affinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 5′-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine. Eur J Biochem. 1985 Jan 15;146(2):309-14. doi: 10.1111/j.1432-1033.1985.tb08654.x.PMID: 3967660 Free article. 
462. Palczewski K, Hargrave PA, Kochman M. o-Phthalaldehyde, a fluorescence probe of aldolase active site. Eur J Biochem. 1983 Dec 15;137(3):429-35. doi: 10.1111/j.1432-1033.1983.tb07846.x.PMID: 6662105 Free article. 
463. Buczylko J, K. Palczewski, M. Kochman, Purification and properties of porcine brain aldolase C. Intl J Biochem 1983, 15, 453–61