Yilin Hu

Department of Molecular Biology & Biochemistry




Selected Publications



Rettberg LA, Wilcoxen J, Lee CC, Stiebritz MT, Tanifuji K, Britt RD, Hu Y (2018) Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB. Nature Communications 9: 2824.

Stiebritz MT, Hiller, CJ, Sickerman NS, Lee CC, Tanifuji K, Ohki Y, Hu Y (2018) Ambient conversion of CO2 to hydrocarbons by biogenic and synthetic [Fe4S4] clusters. Nature Catalysis 1: 444–451.

Tanifuji K, Lee CC, Sickerman NS, Tatsumi K, Ohki Y, Hu Y, Ribbe MW (2018) Tracing the ‘ninth sulfur’ of the nitrogenase cofactor via a semi-synthetic approach. Nature Chemistry 10: 568-572.

Lee CC, Wilcoxen J, Hiller CJ, Britt RD, Hu Y (2018) Evaluation of the catalytic relevance of the CO-bound states of V-nitrogenase. Angew. Chem. Int. Ed. Engl. 57: 3411-3414.



Sickerman NS, Ribbe MW, Hu Y (2017) Nitrogenase cofactor assembly: An elemental inventory. Acc. Chem. Res. 50:2834-2841.

Hiller CJ, Stiebritz MT, Lee CC, Liedtke J, Hu Y (2017) Tuning electron flux through nitrogenase with methanogen iron protein homologues. Chemistry 23:16152-16156.

Sickerman NS, Tanifuji K, Lee CC, Ohki Y, Tatsumi K, Ribbe MW, Hu Y (2017) Reduction of C1 substrates to hydrocarbons by the homometallic precursor and synthetic mimic of the nitrogenase cofactor. J. Am. Chem. Soc. 139:603-606.

Rebelein JG, Stiebritz MT, Lee CC, Hu Y (2017) Activation and reduction of carbon dioxide by nitrogenase iron proteins. Nature Chemical Biology 13:147-149.



Fay AW, Blank MA, Rebelein JG, Lee CC, Ribbe MW, Hedman B, Hodgson KO, Hu Y (2016) Assembly scaffold NifEN: A structural and functional homolog of the nitrogenase catalytic component. Proc. Natl. Acad. Sci. USA 113:9504-9508.

Rebelein JG, Lee CC, Hu Y, Ribbe MW (2016) The in vivo hydrocarbon formation by vanadium nitrogenase follows a secondary metabolic pathway. Nature Communications 7:13641.



Fay AW, Wiig JA, Lee CC, Hu Y (2015) Identification and characterization of functional homologs of nitrogenase cofactor biosynthesis protein NifB from methanogens. Proc. Natl. Acad. Sci. USA 112:14829-14833.