Bardwell Lab

Read the press release on our 2022 Life Science Alliance article here:

How a protein breaks free to cause deadly cancers

Our new paper has been published in Life Science Alliance:

ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1

by A. Jane Bardwell et al., in collaboration with the labs of Scott Atwood, Kavita Sarin and Marian Waterman

CLICK HERE TO READ IT

Read the Press Release HERE

The recent group of undergraduates doing research in the Bardwell lab are doing great:

• Kristine Nguyen has been accepted to Medical School at UC Riverside !
• Teray Williams has been accepted to Nursing School at UCLA !
• Maria De Lourdes Andrade Ludena has been accepted to the Cellular and Molecular Biosciences PhD Program at UCI !

Congrats undergrads!

Our latest manuscript is out as a preprint on BioRxiv:

ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1

by A. Jane Bardwell et al., in collaboration with the labs of Scott Atwood, Kavita Sarin and Marian Waterman

CLICK HERE TO READ IT

Former Bardwell Lab grad student Leonila Lagunes has been awarded the prestigious UC President’s Postdoctoral Fellowship!  Read more HERE.

Leo is currently a postdoctoral fellow in the lab of Eric Deeds in the Department of Integrative Biology and Physiology at UCLA.

Former Bardwell lab graduate student Leonila Lagunes‘ first author publication, entitled “Effect of magnitude and variability of energy of activation in multisite ultrasensitive biochemical processes,” has now been published in PLoS Computational Biology.

The study is in collaboration with Professor German Enciso.

The Bardwell Lab, in collaboration with two other UCI labs, has been awarded a new pilot award from the UCI Institute for Clinical and Translational Studies.

The title of the project is: “Novel Inhibitors of phosphoinositide 3-kinase (PI3K) that target scaffold protein-mediated interactions”.

In collaboration with the laboratories of James Nowick and David Fruman, the team will work on a novel strategy to drug a protein that is one of the most frequently mutated in human cancer.

March 2020

The Bardwell Lab, in collaboration with two other UCI labs, has been awarded a new pilot award from the UCI Chao Family Comprehensive Cancer Center.

In collaboration with the laboratories of James Nowick and David Fruman, the team will work on a novel strategy to drug a protein that is one of the most frequently mutated in human cancer.

The title of the project is: “Novel Inhibitors of phosphoinositide 3-kinase (PI3K) that target scaffold protein-mediated interactions”.

Funds for the project were provided, in part, by participants in the UCI Anti-Cancer Challenge.  We thank those dedicated bikers, runners and walkers !

March 2020

Lee wrote a new ‘Dispatch’ for Current Biology, entitled “Cancer Mutations: Molecular MEKanisms”. It has just been published. Between now and 28 April, anyone can access the article by clicking HERE.

January 2020

The Bardwell lab has been awarded a new grant from the University of California Cancer Research Coordinating Committee (CRCC), on the topic of “Novel Links Between Wnt Signaling, Centrosomes, and Cancer”.  This project is in collaboration with the lab of Marian Waterman.

We gratefully thank the CRCC donors as well as those Californians who made voluntary contributions.