Select Recent Publications
- Lara-Gonzalez, P, Variyar S*, Moghareh, S*, Nguyen, ACN*, Kizhedathu, A, Budrewicz, J, Schlientz, A, Varshney, N, Bellaart, A, Oegema, K, Bardwell, L and Desai, A (2024) Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses, Journal of Cell Biology 223 (11): e202308034. (Read press release HERE)
- Bardwell, L, and Thorner, J (2023) Mitogen-activated protein kinase (MAPK) cascades–A yeast perspective. Enzymes. 54:137-170.
- Bardwell AJ, Paul, M, Yoneda, KC, Andrade-Ludena, MD, Nguyen, OT, Fruman, DA, and Bardwell L (2023) The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase, Biochemical Journal, 480 (10): 729–750. (Cover Article)
- Bardwell AJ, Wu, B, Sarin KY, Waterman ML, Atwood SX, and Bardwell L (2022) ERK2 MAP kinase regulates SUFU binding by multisite phosphoryaltion of GLI1. Life Science Alliance 5(11):e202101353 DOI: 10.26508/lsa.202101353. (Read press release HERE)
- The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1. Nature Cell Biology 24:74-87. doi: 10.1038/s41556-021-00813-8.
- Lagunes, L, Bardwell L and Enciso, GA. (2020) Effect of magnitude and variability of energy of activation in multisite ultrasensitive biochemical processes. PLoS Computational Biology, 16:e1007966.
- Bardwell L (2020) Cancer Mutations: Molecular MEKanisms. Current Biology Volume 30, Issue 5, 9 March 2020, Pages R222-R224
- Bardwell L (2019) Pseudokinases: Flippping the ATP for AMPylation. Current Biology 29:R16–R37
- Syed, A, Lukacsovich, T, Pomeroy, M, Bardwell AJ, … Bardwell L, Marsh, JL, MacGregor, GR (2019) Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila. Developmental Biology, 445: 37-53.
- Bardwell, AJ, Lagunes, L, Zebarjedi, R, and Bardwell, L (2017) The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2. J. Biol. Chem., 292: 8750-8761
- Bardwell AJ and Bardwell, L (2015) Two hydrophobic residues can determine the specificity of MAP kinase docking interactions. J. Biol. Chem., 290:26661-266674
- Mattson-Hoss MK, Niitani Y, Gordon EA, Jun Y, Bardwell, L, Tomishige M, and Gross SP (2014) CK2 activates kinesin via induction of a conformational change. Proc Natl Acad Sci USA 2014 111:7000-7005.
- Gordon EA, Whisenant, TC, Zeller, M, Kaake, RM, Gordon, WM, Krotee, P, Patel, V., Huang, L, Baldi, P and Bardwell, L (2013), Combining docking site and phosphosite predictions to find new substrates: Identification of Smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate, Cellular Signalling,25:2518-2529.
- Chan, C, Liu, X, Wang, L, Bardwell, L, Nie, Q, Enciso, G (2012) Protein Scaffolds Can Enhance the Bistability of Multisite Phosphorylation Systems PLoS Computational Biology 8(6): e1002551.
- Xu, J, Reddy, Anand, P, Shu, Z, Cermelli, S, Mattson, MK, Tripathy, SK, Hoss, MT, James, NS, King, SJ, Huang, L, Bardwell, L and Gross, SP (2012) Casein Kinase 2 Reverses Tail-Independent Inactivation of Kinesin-1, Nature Communications, 3:754.
- Chou, C-S, Bardwell, L, Nie, Q and Yi, TM (2011) Noise filtering tradeoffs in spatial gradient sensing and cell polarization response. BMC Systems Biology, 5:196.
- Bernardo, AS, Faial, T, Gardner, L, Niakan, KK, Ortmann, D, Senner, CE, Callery, EM, Trotter, MW, Hemberger, M, Smith, JC, Bardwell, L, Moffett, A, Pedersen, RA (2011) BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell, 9:144-55.
- Bardwell, L (2011) Synthetic Biology: Modulating the MAP kinase module. Current Biology, 21:R249-51.
- Whisenant, TM, Benz, R, Ho, DM, Rogers, JM, Kaake, RM, Gordon, EA, Huang, L, Baldi, P, and Bardwell, L (2010) Computational prediction and experimental verification of novel MAP kinase substrates including Gli transcription factors. PLoS Computational Biology, 6:e10009084.
- Haney, S., Bardwell, L+, and Nie, Q+ (2010) Ultrasensitive responses and specificity of cell signaling. BMC Systems Biology, 4:119.
- Liu, X, Bardwell, L+ and Nie, Q+ (2010) A combination of multisite phosphorylation and substrate sequestration produces switch-like responses. Biophysical Journal, 98:1396-407.
- Bardwell, AJ, Frankson, E and Bardwell, L (2009) Selectivity of docking sites in MAPK kinases. J. Biol. Chem. 284:13165-73.
All of Lee’s Publications via MyBibliography
All of Lee’s Publications via ORCID